Type Gene1 Effect Gene2 Sentence MedLine Reference Time of Interaction in evidence # of References territories of interaction Evidence for Direct Last author Journal Year
Binding fgfr2 neutral il17rd In co-immunoprecipitation assays, the intracellular domain of il17rd interacts with FGF receptors, FGFR1 and FGFR2. 11802164:4
3




Binding fgfr1 neutral il17rd In co-immunoprecipitation assays, the intracellular domain of il17rd interacts with FGF receptors, FGFR1 and FGFR2. 11802164:4
3




Binding fgf8a neutral gbx2 Otx2 , gbx2 and fgf8a interact to position and maintain a mid-hindbrain or ganizer .

30




Binding fgf8a neutral otx2 Otx2 , gbx2 and fgf8a interact to position and maintain a mid-hindbrain or ganizer .

29




Binding fgf8a neutral wnt1 Positive interactions between fgf8a , En1 , Wnt1 and Gbx2 maintain their own expression, whereas negative reciprocal interactions between Otx2 and Gbx2 or fgf8a maintain a sharp Otx2 posterior border at the mesencephalic side of the MHB.

4




Binding fgf8a neutral pax8 It is unclear whether the stronger interaction of pax8 with fgf8a compared to fgf3 reflects functional differences between these ligands or differing degrees of functional disruption.

3




Binding fgf8a neutral tbx1 fgf8a and tbx1 have been shown to interact in patterning the aortic arch, and both genes are required in formation and growth of the outflow tract of the heart. 16696966:0
3




Binding fgf8a neutral gbx1 Otx2, Gbx1 and fgf8a interact to position and maintain a mid-hindbarin organizer.

1




Binding fgf7 neutral hspg2 Despite this, the heparan sulphate of RT101- and JB6-derived perlecan bound fibroblast growth factor-1, -2, -4 and -7 and heparin-binding epidermal growth factor with similar affinity. 11284741:7
4




Binding fgf3 neutral pax8 Interaction of pax8 with fgf3 and fgf8a.

3




Binding fgf3 neutral fgf8a Thus, interactions between the fgf3- and fgf8a-dependent factor, sox9a, and the relatively fgf3- and fgf8a-independent factors (sox9b, dlx3b and dlx4b) are required for formation of the epithelium of the otic vesicle (bottom) and subsequent differentiatio

2




Binding fgf3 neutral hnf1b In order to determine if the vhnf1-fgf3 interaction we observed is dependent on this positive autoregulatory loop, we repeated the vhnf1-fgf3 overexpression experiments in embryos from a val+/– intercross.

2




Binding fgf3 neutral fgf8a Thus, interactions between the fgf3- and fgf8a-dependent factor, sox9a, and the relatively fgf3- and fgf8a-independent factors (sox9b, dlx3b and dlx4b) are required for formation of the epithelium of the otic vesicle (bottom) and subsequent differentiatio

2




Binding fgf17 neutral fgfr1 Among zebrafish Fgf ligands, fgf17b shows the highest homology to mammalian fgf17, which binds receptors Fgfr1-3 (the “c” spliced forms) and Fgfr4 (Olsen et al., 2006).

3




Binding fgf17 neutral fgfr2 Among zebrafish Fgf ligands, fgf17b shows the highest homology to mammalian fgf17, which binds receptors Fgfr1-3 (the “c” spliced forms) and Fgfr4 (Olsen et al., 2006).

3




Binding fgf17 neutral fgfr3 Among zebrafish Fgf ligands, fgf17b shows the highest homology to mammalian fgf17, which binds receptors Fgfr1-3 (the “c” spliced forms) and Fgfr4 (Olsen et al., 2006).

3




Binding fgf17 neutral fgfr4 Among zebrafish Fgf ligands, fgf17b shows the highest homology to mammalian fgf17, which binds receptors Fgfr1-3 (the “c” spliced forms) and Fgfr4 (Olsen et al., 2006).

3




Binding fgf17 neutral fgfr1 Among zebrafish Fgf ligands, fgf17b shows the highest homology to mammalian fgf17, which binds receptors Fgfr1-3 (the “c” spliced forms) and Fgfr4 (Olsen et al., 2006).

3




Binding fgf17 neutral fgfr2 Among zebrafish Fgf ligands, fgf17b shows the highest homology to mammalian fgf17, which binds receptors Fgfr1-3 (the “c” spliced forms) and Fgfr4 (Olsen et al., 2006).

3




Binding fgf17 neutral fgfr3 Among zebrafish Fgf ligands, fgf17b shows the highest homology to mammalian fgf17, which binds receptors Fgfr1-3 (the “c” spliced forms) and Fgfr4 (Olsen et al., 2006).

3




Binding fgf17 neutral fgfr4 Among zebrafish Fgf ligands, fgf17b shows the highest homology to mammalian fgf17, which binds receptors Fgfr1-3 (the “c” spliced forms) and Fgfr4 (Olsen et al., 2006).

3




Binding fgf neutral wnt A similar interaction of the Wnt and FGF signaling pathways was also found to operate in the induction of posterior cell fates during early Xenopus development. 12502739:10236
23




Binding fgf neutral tbx1 Morrow Dissection of tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy Hum.

5




Binding fgf neutral hnf1b Therefore, we were interested in how Fgfs and vhnf1 interact to drive val expression.

2




Binding eng2a neutral fgf8a The isthmic or ganizer is perpetuated by the mutual interaction of fgf8a , En2 and Wnt1 .

3




Binding cyp26a1 neutral fgf Thus, cyp26 has an important role in linking the Fgf, Wnt and RA signals to regulate AP patterning of the neural ectoderm in the late blastula to gastrula embryo in zebrafish. 12183385:10
1




Binding cdh2 neutral fgfr2 This type of N-cadherin/FGF receptor interaction could also be induced by N-cadherin-mediated cell contact. 8977392:10197
6




Binding bmp7 neutral fgf8a However, in the chick fgf8a is only expressed in a ventral, posterior domain within each pouch, which abuts the domain of Bmp7 and is not in contact with the placode (Graham and Begbie, 2000), suggesting that fgf8a and Bmp7 interact to define territories

2




Expression zfhx1 positive fgf8 In contrast to the neuroectodermal markers, the expression of the ventral marker eve1 was prominently reduced. These results indicate that overexpression of Kheper dorsalized and neuralized the ectoderm. overexpression 8 neuroectoderm neuroectoderm 2 Naomasa Miki Developmental Biology 2000
Expression wnt8b neutral fgf3 Together, our results demonstrate that the hindbrain-derived factor Wnt8b from r5 maintains otic fate, and that compromised fgf3 expression and loss of Wnt8b function together mimics the size reduction of the otic vesicle observed in RA-depleted embryos.

1




Expression wnt8a positive fgf3 In wnt8 morphants tbx6 expression is reduced. mutant embryos 10 presumptive brain presumptive ectoderm 1, 3 Bruce B. Riley Development 2003
Expression wnt8a positive fgf8 Vox expression is reduced in the margin of wnt8 mutants/morphants at 40% epiboly. MASO 10 presumptive brain presumptive ectoderm 1, 3 Bruce B. Riley Development 2003
Expression wnt3l positive fgf8a Thus, Wnt3a appaears to control the formation of the fgf8a gradient in an indirect manner. 15342488:10163
14




Expression wnt3l positive fgf3 Regulation of fgf3 and fgf8a expression by Wnt3a/Wnt8 and Cdx1a/cdx4. (A–F) Expression of fgf3 and fgf8a in the tailbud (bud stage) was reduced in the wnt3a/wnt8 (B, E) and cdx1a/cdx4 (C, F) morphant embryos (A, D, wild-type control).

6




Expression wnt2b positive fgf10a Specifically, Wnt2b and Wnt8c signals activate Fgf10 expression in the LPM, and the subsequent induction of fgf8a in the overlying AER by FGF10 signals from the LPM is mediated via epithelial Wnt3a (Kawakami et al. 2001 ). 12502739:10233
3




Expression wnt10b neutral fgf8a This result indicates that fgf8a expression is not dependent on wnt1 or wnt10b.

1




Expression wnt10a positive fgf20a Although we have not tested whether wnt10a activates fgf20a expression directly in the regenerating fin, it is intriguing that fgf20a has been found to be a direct target of Wnt/?-catenin signaling in cultured human cells (Chamorro et al., 2005).

2




Expression wnt1 positive fgf8a Wnt-1 regulates fgf8a expression in the adjacent metencephalon, most likely via a secondary mesencephalic signal. 9056772:4
6




Expression wnt1 neutral fgf8a Wnt-1 regulates fgf8a expression in the adjacent metencephalon, most likely via a secondary mesencephalic signal. 9056772:4
5




Expression wnt positive fgf8a The results of this study suggest that the limbless gene is required for beta-catenin-dependent Wnt signaling in limb ectoderm leading to fgf8a expression and AER formation. 12175366:6
11




Expression wnt positive fgf10a In addition, we show that canonical Wnt signaling is able to modulate the levels of Fgf10 and suppress BMP-induced proliferation in the lacrimal gland. 16126193:4
10




Expression wnt positive fgf3 It remains to be elucidated whether the Wnt/Cdx cascade directly controls the expression of fgf3 and fgf8a or the reduction of fgf3 and fgf8a expression is a secondary consequence of the reduction in posterior tissue.

6




Expression wnt positive fgf Finally, there is evidence for involvement of the Wnt/ eta -catenin pathway in regulating the expression of FGFs ( 33 ). 12791601:10153
3




Expression wnt positive fgf20a We present evidence supporting the conclusions that FGF20 and dkk1 are directly regulated by ?-catenin during development and tumorigenesis, and that continued expression of FGF20 is required to maintain the anchorage-independent growth state established 106100480:11030
3




Expression tbx5 positive fgf10a Tbx5 directly activates the Fgf10 gene via a conserved binding site, providing a simple and direct mechanism for limb bud initiation. 12490567:7
10




Expression tbx5 positive fgf Initially, tbx5 expression in the lateral plate mesoderm appaears to be induced by wnt2ba -mediated signaling and appaears to induce the expression of fgf24 and other Fgf genes.

7




Expression tbx4 positive fgf10a Ectopic Tbx4 induced ectopic bud formation in the esophagus by activating the expression of Fgf10. 12588840:4
3




Expression tbx1 6 positive fgf A likely explanation for reduced FGFR signaling in tbx1 6 and ntl mutants is that tbx1 6 and ntl regulate expression of fgf ligands, as suggested for Brachyury in Xenopus early mesoderm (Isaacs et al., 1994; Schulte-Merker and Smith,1995), and in the li

4




Expression sp9 neutral fgf8a We show that two closely related buttonhead-like zinc-finger transcription factors, Sp8 and Sp9, are expressed in the AER, and regulate fgf8a expression and limb outgrowth. 15358670:2
3




Expression sp9 positive fgf8a Very recently, sp8 and sp9 were found to be involved in regulation of fgf8a expression in the limbs/fins of chick and zebrafish [42].

1




Expression sox7 positive fgf3 These results show that SOX7 is a potent activator of Fgf-3 transcription. 15082719:11
4




Expression shha positive fgf4 We report here that Fgf4 expression in the ridge can be regulated by Shh-expressing cells. 7935794:5
9




Expression shha neutral fgf8a Moreover, following removal of the endoderm, Shh protein can replace this tissue and restore fgf8a expression. 17187772:6
3




Expression shha positive fgf8a Shh was induced in the mesenchyme underlying the posterior end of the fgf8a expression domain, indicating an anterior shift of Shh expression in lx hindlimb buds. 12455637:4
3




Expression shha positive fgf19 In the previous genetic study, we showed that Shh is required for Fgf15 expression in the diencephalon and midbrain. 15614767:2
2




Expression sall4 positive fgf10a As fgf10 expression is first detected 2 hours after sall4 in the pectoral fin primordia (Ng et al., 2002), we addressed the possibility that sall4 is required for fgf10 expression in the developing pectoral fins.

2




Expression sall4 neutral fgf10a Sall4 controls Fgf10 expression in a synergistic manner together with Tbx5 in the forelimbs or with Tbx4 in the hindlimbs via direct effects on the Fgf10 promoter, whereas the effect of Sall4 and tbx1 co-expression on the Fgf10 promoter is additive [12].

1




Expression sall4 positive fgfr2 Furthermore, in the absence of sall4 function, sall1a is able to maintain the posterior domain of fgf10 expression, while following knockdown of sall1a function, sall4 can maintain the anterior domain of fgf10 expression. sall1a and sall4 are required for

1




Expression sall1 positive fgf10a Sall gene family members have redundant functions during pectoral fin development As sall1a could be responsible for the maintenance of the posterior domain of fgf10 expression in the pectoral fin bud of sall4 morphants, we studied fgf10 expression in sal

1




Expression sall1 positive fgfr2 We therefore investigated if the expression of an FGF receptor is regulated by sall1a and sall4.

1




Expression runx2a neutral fgf3 An analogous situation is in place in mammalian tooth morphogenesis where Runx2 in the epithelium regulates expression of fgf3 in the mesenchyme (Aberg et al.,[2004]).

1




Expression runx2a positive fgf3 An analogous situation is in place in mammalian tooth morphogenesis where Runx2 in the epithelium regulates expression of fgf3 in the mesenchyme (Aberg et al.,[2004]).

1




Expression ra negative fgf8a We provide evidence showing that RA acts on the signalling epithelium of the 1(st) PA, gradually reducing the expression of endothelin-1 and fgf8a. 17551590:4
5




Expression ra positive fgf8a In the absence of RA signalling, expression of fgf8a in both anterior psm and somites is reduced (Fig. 8C; 96%, n = 28), whereas ectopic RA strongly increases fgf8a expression in these domains (Fig. 8D; 97%, n = 30).

1




Expression ptc1 negative fgf8a In turn, O TX proteins produced in p2, p1 and the mes may serv e to repress fgf8a gene expression, thus preventing the fgf8a expression domain from spreading anteriorly (Fig. 5A).

2




Expression prdm1a positive fgf10a Since blimp-1 expression also requires Fgf24 activity, this would indicate that Blimp-1 could be needed for inducing the expression of fgf10 in the mesenchyme, in response to Fgf24 signaling.

5




Expression pou5f1 positive fgf8 In wild-type embryos, pax2.1 expression is activated in the MHB primordium at about 80-90% epiboly in two lateral domains. By the end of gastrulation, the bilateral pax2.1 domains have merged at the midline. In spgm793 mutants, pax2.1 expression reduced. mutant embryos 9 r1 rhombomere 1 Michael Brand Development 2002
Expression pou5f1 positive fgf4 Furthermore, overexpressing OCT3 stimulated endogenous FGF-4 expression in MCF7 breast cancer cell line. 12841847:9
23




Expression pou5f1 neutral fgf8a Our results also suggest the possibility that Oct4 participates either in the regulation of fgf8a expression or on the modulation of fgf8a signaling activity.

1




Expression pou5f1 positive fgf8a In addition, we found that Oct4 had a strong specific influence on fgf8a expression in most of its endogenous domains, including regions outside the brain.

1




Expression pea3 positive fgf We conclude that both the transcriptional onset and maintenance of these factors are tightly coupled to Fgf signaling and propose that erm and pea3 transcription is a direct readout of cells to Fgf levels. 11520667:7
12




Expression pbx1a positive fgf8a J Neurobiol 36:559–571 3.0.CO;2-V&link_type=DOI" [CrossRef] [Medline] Gemel J, Jacobsen C, MacArthur CA 1999 Fibroblast growth factor-8 expression is regulated by intronic engrailed and Pbx1-binding sites. 12403831:10376
4




Expression pax5 neutral fgf8a Pax5, which normally is e xpressed only in postmitotic cells in thespinal cord (Asano and Gruss, 1992), was induced in the same dorsal ventricular spinal cord cells that expressed Wnt1, fgf8a, En1 and En2 (data not sho wn).

3




Expression pax5 positive fgf8a The present study has shown that Pax-5 can induce fgf8a, Wnt-1 and En-2 expression.

2




Expression pax2a positive fgf8 In noi -/ - mutants expression is initiated normally, but maintenance of expression becomes abnormal from the 6-somite stage onwards. mutant embryos 11.66 MHB midbrain hindbrain boundary 1 Michael Brand Development 1998
Expression pax2a positive fgf8a Previous studies have demonstrated that ectopic Pax2 expression could efficiently induce endogenous fgf8a transcription only in Gbx2 + hindbrain cells adjacent to ectopic Otx2-expressing cells (Ye et al., 2001) (Fig. 7F).

7




Expression pax2a neutral fgf8a In addition, in ovo transfection studies in chick embryos showed that Pax2 is necessary and sufficient for the expression of fgf8a, which is an essential regulatory growth factor gene for MHB development (Okafuji et al., 1999 and Ye et al., 2001).

2




Expression otx2 positive fgf8 During gastrula stages, three parallel pathways (Pax,Wnt and Fgf) are activated around the otx2/gbx1 interface in response to patterning signals. response to patterning signals 10 MHB midbrain hindbrain boundary
Michael Brand Mechanisms of Development 2003
Expression otx2 positive fgf8a Ectopic Otx2 and Gbx2 repressed endogenous expression of fgf8a in the isthmus, but induced fgf8a expression at the interface between Otx2 and Gbx2 expression. 10704829:7
9




Expression otx2 negative fgf8a The adjacent anterior Otx2 positive cells receive a lower level of fgf8a and this induces midbrain development.

4




Expression oep positive fgf3 casanova endodermal expression is not initiated or maintained in blastula (B, 40% epiboly) nor during gastrulation (D, 70-80% epiboly) in Zoep homozygous mutants. mutant embryos 5.25 margin margin 1 Schier, A. F. Dev Biol 2007
Expression oep positive fgf17 A similar gap in the expression domain of mezzo was also observed in embryos lacking zygotic transcripts of oep. mutant embryos 5.25 blastomere blastomere 1 Schier, A. F. Dev Biol 2007
Expression oep positive fgf8 27 genes that are expressed in the dorsal margin in wild type, but lack margin expression in MZoep mutants. mutant embryos 5.25 blastomere blastomere 1 Schier, A. F. Dev Biol 2007
Expression ntl neutral fgf Since Xenopus brachyury is proposed to regulate fgf expression, and FGF signaling is required for tbx1 6 expression, we analyzed the involvement of the FGF signaling pathway in these genetic interactions. 14651930:4
6




Expression ntl positive fgf Since Xenopus brachyury is proposed to regulate fgf expression, and FGF signaling is required for tbx1 6 expression, we analyzed the involvement of the FGF signaling pathway in these genetic interactions. 14651930:4
6




Expression nog1 positive fgf8a Because noggin can induce fgf8a expression, we examined noggin and BMP signaling in the Emx2 mutant. 15509764:9
3




Expression nog1 negative fgf Expression of both Wnt and FGF components was inhibited by activation of noggin, suggesting that BMP signalling lies upstream of both Wnt and FGF. 18329638:6
1




Expression ndr1 positive fgf17 overexpression of sqt elicited the ectopic expression of chd in the entire blastoderm at the sphere to shield stage. In the sqt mutant embryos din was expressed at reduced levels throughout the sphere and shield stages. overexpression 4 YSL YSL 2 Anming Meng Developmental Biology 2004
Expression myod1 positive fgf8a An analysis of the relative spatio-temporal expression patterns of fgf8a and myoD finally suggests that localised RA synthesis in somites may control fgf8a expression, which in turn activates myoD expression in somites.

1




Expression mafba neutral fgf3 This is in sharp contrast to the mouse, in which fgf3 is normally expressed in r5 and r6 because of positive regulation by kreisler, the mouse ortholog of val. 12399318:9
1




Expression lmx1b positive fgf8a As Lmx1b induced Wnt1 and Wnt1 induced fgf8a expression in turn, Wnt1 may be involved in non cell-autonomous induction of fgf8a expression by Lmx1b. 12399317:9
4




Expression lft1 neutral fgf8a Expression of lefty1 was not affected in the embryos overexpressing fgf8a (data not shown), indicating that the loss of endodermal precursors caused by fgf8a was not a consequence of interfering with Nodal expression.

8




Expression lef1 positive fgf10a These data suggest that the expression of fgf3 and Fgf10 requires LEF1-dependent epithelial signals or mesenchymal expression of Lef1 . 12502739:10052
2




Expression lef1 positive fgf3 These data suggest that the expression of fgf3 and Fgf10 requires LEF1-dependent epithelial signals or mesenchymal expression of Lef1 . 12502739:10052
2




Expression lef1 positive fgf4 A putative LEF1/TCF binding site was identified in a region upstream of two enhancers in the 3' untranslated region (UTR) of the Fgf4 gene (Fig. 4 A). 12502739:10128
2




Expression lef1 positive fgf4 A putative LEF1/TCF binding site was identified in a region upstream of two enhancers in the 3' untranslated region (UTR) of the Fgf4 gene (Fig. 4 A). 12502739:10128
2




Expression igf1rb positive fgf8 Injection of DN-IGF-1R mRNA caused a reduction in Six3.1 expression in the anterior neural plate. dominant negative 16 MHB midbrain hindbrain boundary 2 LUCY BYRNES Int. J. Dev. Biol. 2004
Expression igf1 positive fgf8 Increased fgf8 expression is detected in the telencephalon and midbrain/ hindbrain domains in IGF-1 injected embryos overexpression 11.66 MHB midbrain hindbrain boundary 2 LUCY BYRNES Int. J. Dev. Biol. 2004
Expression hoxb6b positive fgf3 We also show that hox-1 genes are both required and sufficient to drive fgf3 expression in r4.

1




Expression hoxb6b positive fgf8a Hox-1 paralogs cooperate with Pbx proteins to upregulate expression of fgf3 and fgf8a in r4, which in turn induce expression of val/Kr in r5/r6.

1




Expression hmx3 negative fgf8a Scale bars: 50 µm. (G-I) Posterior follistatin exprcssion is either duplicated at the anterior of the otic vesicle or extends medially along the length of the otic vesicle in posteriorised ears (arrows). (J,K) Anterior nkx5.1 expression is reduced to a sm

3




Expression gbx2 negative fgf8 In gbx2 expression embryos, the expression of wnt1 in the future posterior midbrain was abrogated. overexpression 28 telencephalon telencephalon 2 Kyo Yamasu Developmental Dynamics 2003
Expression gbx2 positive fgf8a Ectopic Otx2 and Gbx2 repressed endogenous expression of fgf8a in the isthmus, but induced fgf8a expression at the interface between Otx2 and Gbx2 expression. 10704829:7
10




Expression gbx2 neutral fgf8a Likewise, ectopic expression of Gbx2 in the chick embryo11 leads to the expression of fgf8a in ectopic locations.

3




Expression gbx1 positive fgf8 During gastrula stages, three parallel pathways (Pax,Wnt and Fgf) are activated around the otx2/gbx1 interface in response to patterning signals. response to patterning signals 10 neuroectoderm neuroectoderm
Michael Brand Mechanisms of Development 2003
Expression gata4 positive fgf3 In undifferentiated F9 cells, gata-4 expression stimulates the fgf-3 promoter, whereas in differentiated F9 cells already expressing gata-4, no further increase in promoter activity was observed. 10358083:7
4




Expression foxi1 negative fgf Misexpression of fgf8a affects the expression of foxi1 and dlx3b We and others recently showed that loss of both Foxi1 and Dlx3b together ablates all indications of otic induction even in the presence of a fully functional Fgf signaling pathway [24,28].

1




Expression fgfr3 neutral fgfr2 In detail, fgfr1-3 differ in the extent of their expression domain along the telencephalic ventricle, defining a domain of fgfr1-3 expression (subpallium and midline of the pallium), a domain expressing fgfr2 only (anterior aspects of the dorsal and later

1




Expression fgfr3 neutral fgfr2 In detail, fgfr1-3 differ in the extent of their expression domain along the telencephalic ventricle, defining a domain of fgfr1-3 expression (subpallium and midline of the pallium), a domain expressing fgfr2 only (anterior aspects of the dorsal and later

1




Expression fgfr2 positive bmp4 Effect of DBP Exposure on mRNA Expression of Androgen Receptor, Bone Morphogenetic Protein 4, Fibroblast Growth Factor Receptor 2 and Fibroblast Growth Factor 10 Prenatal exposure to DBP resulted in altered mRNA expression of the androgen receptor (AR), b 15829613:10186
3




Expression fgfr2 negative otx2 However, XFD had no clear effect on Otx2 expression (Fig. 4 B ), which is contradictory to the report that XFD totally inhibits Otx2 expression in neuralized AC (Launay et al., 1996 ). 9278524:10143
3




Expression fgfr2 negative cyp26a1 To generate conditions that correspond to both gain and reduction of function of Fgf signaling, fgf3 and dominant-negative Fgf-receptor (XFD) (Amaya et al., 1991) mRNAs were injected into one- to two-cell stage embryos. fgf3 mRNA injection led to suppress

2




Expression fgfr2 positive fgf10a Effect of DBP Exposure on mRNA Expression of Androgen Receptor, Bone Morphogenetic Protein 4, Fibroblast Growth Factor Receptor 2 and Fibroblast Growth Factor 10 Prenatal exposure to DBP resulted in altered mRNA expression of the androgen receptor (AR), b 15829613:10186
2




Expression fgfr2 negative hoxa1a The XFD injection greatly reduces hoxa-1 expression (G).

2




Expression fgfr2 positive fgf10a Effect of DBP Exposure on mRNA Expression of Androgen Receptor, Bone Morphogenetic Protein 4, Fibroblast Growth Factor Receptor 2 and Fibroblast Growth Factor 10 Prenatal exposure to DBP resulted in altered mRNA expression of the androgen receptor (AR), b 15829613:10186
2




Expression fgfr2 neutral fgfr3 In detail, fgfr1-3 differ in the extent of their expression domain along the telencephalic ventricle, defining a domain of fgfr1-3 expression (subpallium and midline of the pallium), a domain expressing fgfr2 only (anterior aspects of the dorsal and later

1




Expression fgfr2 neutral gbx2 For that, we co-expressed Otx2 or Gbx2 with a dominant negative form of the FGF receptor(XFD), conjugated these caps with caps expressing Gbx2 or Otx2, respectively, and analyzed their ability to express En2.

1




Expression fgfr2 neutral otx2 For that, we co-expressed Otx2 or Gbx2 with a dominant negative form of the FGF receptor(XFD), conjugated these caps with caps expressing Gbx2 or Otx2, respectively, and analyzed their ability to express En2.

1




Expression fgfr2 neutral fgfr3 In detail, fgfr1-3 differ in the extent of their expression domain along the telencephalic ventricle, defining a domain of fgfr1-3 expression (subpallium and midline of the pallium), a domain expressing fgfr2 only (anterior aspects of the dorsal and later

1




Expression fgfr1 neutral fgfr2 In contrast, FGFR-1 expression does not vary substantially under the conditions shown to affect FGFR-2 expression. 7593222:9
3




Expression fgfr1 neutral fgfr2 In contrast, FGFR-1 expression does not vary substantially under the conditions shown to affect FGFR-2 expression. 7593222:9
3




Expression fgfr1 positive cdh1 Although it has been proposed that Snail expression downstream of FGFR1 is required for the normal repression of E-cadherin expression during early embryonic development ( Ciruna and Rossant, 2001 ), we did not detect induction of Snail expression or inhi 16301332:10227
2




Expression fgfr1 negative chd More importantly, suppressing FGF signaling with XFD sharply reduces expression of chordin at the start of gastrulation (Figs. 7C and D) and throughout the gastrula period (data not shown).

2




Expression fgfr1 negative otx2 In contrast, MZoep embryos injected with XFD have diminished expression of otx2 at the six-somite stage (Figs. 4C and D). otx2 expression was also measured by real-time PCR in both wild-type and MZoep XFD-injected embryos at the six-somite stage (Fig. 4I)

2




Expression fgfr1 neutral fgfr3 In detail, fgfr1-3 differ in the extent of their expression domain along the telencephalic ventricle, defining a domain of fgfr1-3 expression (subpallium and midline of the pallium), a domain expressing fgfr2 only (anterior aspects of the dorsal and later

1




Expression fgfr1 positive ntl To determine whether Fgfr1 is required for earlier expression of Brachyury at the streak, chimeric embryos were examined at E6.5 (Figures 5H–5J).

1




Expression fgfr1 positive pdx1 Transgenic mice carrying a dominant-negative form of FGFR1c under the control of a pdx-1 promoter, developed diabetes with age and showed a decreased number of ? cells (Hart et al., 2000).

1




Expression fgfr1 positive snai1a Dev Cell 1 (2001), pp. 37–49 The authors demonstrate that FGF signals mediated by the FGFR1 receptor regulate Sna gene expression, thereby controlling E-cadherin expression in the mesoderm (see also [30]) and regulating morphogenetic cell movements during

1




Expression fgfr1 neutral spry4 We show that fgf8a and fgf3 act in vivo to induce the expression of Spry4, which antagonizes their activity by acting downstream of FGFR1.

1




Expression fgfr1 positive tbx6 This suggests that tbx6 expression is positively regulated by FGFR1.

1




Expression fgfr1 neutral fgfr3 In detail, fgfr1-3 differ in the extent of their expression domain along the telencephalic ventricle, defining a domain of fgfr1-3 expression (subpallium and midline of the pallium), a domain expressing fgfr2 only (anterior aspects of the dorsal and later

1




Expression fgfr positive dusp6 We show here that in mouse embryos, Fibroblast growth factor receptors (FGFRs) are required for transcription of dusp6, which encodes MKP3, an extracellular signal-regulated kinase (ERK)-specific MKP. 17164422:3
5




Expression fgfr negative spry2 Spry2 is a feedback inhibitor of Fgf signalling. (A) Wild-type expression of spry2. (B) Inhibition of Fgf signalling by injection of RNA encoding dn-fgfr abolishes spry2 expression. (C) Ubiquitous or (D) localised (arrowhead) overexpression of fgf8a RNA i

3




Expression fgf8a positive gbx2 fgf8a is induced at the border of the Otx2 and Gbx2 expression domain, overlappaing with Gbx2 expression. 15906236:7
18




Expression fgf8a negative otx2 However, in the absence of Gbx2, fgf8a can nevertheless repress Otx2 expression in midbrain explants. 11124114:8
13




Expression fgf8a positive pax2a In this study, by implanting fgf8a-beads in the chick neural tube, we show that fgf8a induces a heterogeneous pattern of Pax2 expression in the diencephalon. 16289837:3
11




Expression fgf8a positive wnt1 It was previously shown that fgf8a can induce ectopic Wnt1 expression in the chick embryo (Crossley et al., 1996 ); however, we failed to see induction of Wnt1 in v2 explants. 101001225:11192
11




Expression fgf8a positive fgf Beside positive autoregulatory circuits, fgf8a triggers expression of the Fgf target gene sprouty, a negative feedback modulator of Fgf signaling at the MHB (Furthauer et al., 2001).

10




Expression fgf8a positive fgf Beside positive autoregulatory circuits, fgf8a triggers expression of the Fgf target gene sprouty, a negative feedback modulator of Fgf signaling at the MHB (Furthauer et al., 2001).

10




Expression fgf8a positive fgf10a Furthermore, since FGF10 and Shh expression is modulated by fgf8a levels, we postulated that exogenous FGF10, Shh, or FGF10 + Shh peptide supplementation in vitro would largely "rescue" the abnormal SMG phenotype associated with decreased fgf8a signaling. 15063181:10
9




Expression fgf8a positive foxi1 However, Phillips et al. have shown that misexpression of fgf3 or fgf8a leads to ectopic foxi1 expression (2003), similar to the ectopic expression of pax8 shown here, suggesting that FGF signaling may directly or in-directly control expression of foxi1 t

9




Expression fgf8a positive otx2 fgf8a induces formation of an ectopic isthmic organizer andisthmocerebellar development via a repressive ef fect on Otx2 expression.

9




Expression fgf8a positive pax8 Furthermore, fgf3/8 require foxi1 to induce ectopic pax8 expression and otic vesicle formation.

9




Expression fgf8a positive fgf10a Furthermore, since FGF10 and Shh expression is modulated by fgf8a levels, we postulated that exogenous FGF10, Shh, or FGF10 + Shh peptide supplementation in vitro would largely "rescue" the abnormal SMG phenotype associated with decreased fgf8a signaling. 15063181:10
9




Expression fgf8a positive myod1 Here, we show that fgf8a signalling in the somite is required for myod expression and terminal differentiation of a subset of fast muscle cells in the zebrafish lateral somite. 16120642:1
7




Expression fgf8a negative sox17 fgf8a or CA-Ras overexpression decrease the expression of sox17 and of casanova/sox32.

7




Expression fgf8a positive spry4 Through gain- and loss-of-function experiments, we demonstrate that fgf8a and fgf3 act in vivo to induce the expression of Spry4, which in turn can inhibit activity of these growth factors. 11493538:1
7




Expression fgf8a positive tbx5 fgf8a, which is expressed in the intermediate mesoderm, is thought to initiate forelimb formation by activating wnt2b, which then induces the expression of tbx5 in the adjacent lateral plate mesoderm. 12810598:1
7




Expression fgf8a positive hoxa2b fgf8a signaling from the isthmus alters Hoxa2 expression and consequently branchial arch patterning, demonstrating that neural crest cells are patterned by environmental signals. 11847340:4
6




Expression fgf8a neutral gata4 In addition, fgf8a is suf f icient to restore gata4 expression in the endogenous domain.

5




Expression fgf8a neutral gbx2 Onset of gbx2 expression is dependent on fgf8a signaling In contrast to gbx1, our analysis of gbx2 expression in the MHB mutants shows that gbx2 is dependent on spg (pou2) and ace (fgf8a) function. 10518499:5
5




Expression fgf8a negative aldh1a2 fgf8a treatment of rostral PSM explants was shown to prevent raldh2 expression ( 28 ). 16055560:10128
4




Expression fgf8a positive eng2a Ectopic expression of fgf8a in the mesencephalon is sufficient to activate expression of Engrailed-2 (En-2) and ELF-1, two genes normally expressed in a decreasing caudal to rostral gradient in the posterior mesencephalon. 9056772:5
4




Expression fgf8a positive fgf3 Moreover, dental epithelium as well as beads soaked in FGF1, FGF2 or fgf8a induce fgf3 expression in dental mesenchyme in an Msx1-dependent manner. 9753686:4
4




Expression fgf8a positive fgfr4 Conversely, over-expression of fgf8a in somites promotes FGFR4 expression and muscle differentiation in this tissue. 12223412:4
4




Expression fgf8a positive pax5 Thus, fgf8a-regulated expression of Pax5 is dependent on EN proteins, and a factor other than fgf8a could be involved in initiating normal Pax5 expression in the mesencephalon/metencephalon. 11124114:5
4




Expression fgf8a positive pea3 Finally, we provide evidence that fgf8a also regulates Erm and Pea3 expression in the nasal placodes. 12086464:5
4




Expression fgf8a neutral shha Shh is locally expressed in pharyngeal endoderm, adjacent to the fgf8a-expressing ectoderm, and is thus a candidate signal regulating ectodermal fgf8a expression. 17187772:4
4




Expression fgf8a negative tbx5 Further experiments are needed to determine whether Tbx5 expression is repressed by fgf8a signaling.

4




Expression fgf8a positive fgf3 Moreover, dental epithelium as well as beads soaked in FGF1, FGF2 or fgf8a induce fgf3 expression in dental mesenchyme in an Msx1-dependent manner. 9753686:4
4




Expression fgf8a positive fgfr4 Conversely, over-expression of fgf8a in somites promotes FGFR4 expression and muscle differentiation in this tissue. 12223412:4
4




Expression fgf8a positive dusp6 Differences in the activation of Mkp3 transcription in the isthmus and the repression with FGF receptor inhibition suggest that fgf8a protein controls Mkp3 transcription. 16111546:4
3




Expression fgf8a neutral fgf10a Secondly, Fgf24, which is expressed in the zebrafish LPM, activates fgf10 expression in the LPM, and thirdly, Fgf4 and fgf8a, which are expressed in the chicken and mouse AER, direct outgrowth of the limb bud and maintain Fgf10 expression in the mesenchym

3




Expression fgf8a positive hsp70 Using a transgenic line that allows us to misexpress fgf8a under the control of the zebrafish temperature-inducible hsp70 promoter, we readdressed the role of Fgf signaling and otic competence during placode induction. 17239227:4
3




Expression fgf8a positive isl1 RA Is Required to Limit fgf8a Expression and Fibroblast Growth Factor Signaling in the Posterior Cardiac Field Recent studies indicate that fgf8a is expressed at high levels in an early cardiac domain overlappaing the Isl1+ domain and that fgf8a is requir

3




Expression fgf8a positive msxe Locally appalied FGF-4, -8, and -9 stimulated intensely the expression of Msx-1 but not Msx-2 in the isolated dental mesenchyme. 9520113:9
3




Expression fgf8a negative myod1 Even when initiation of myod expression in the lateral somite is ablated by fgf8a MO, an fgf8a bead implanted above the somites can rescue myod expression (Fig. 3C).

3




Expression fgf8a positive ntl In fact, overexpression of fgf8a in the entire PSM of chick embryos causes an increase in the expression of Brachyury in the posterior PSM and suppresses morphological segmentation (Dubrulle et al. 2001 ). 15905406:10020
3




Expression fgf8a positive sox3 Thus, like the otic markers, either fgf3 or fgf8a is required for the placodal expression of sox3.

3




Expression fgf8a neutral fgf10a Secondly, Fgf24, which is expressed in the zebrafish LPM, activates fgf10 expression in the LPM, and thirdly, Fgf4 and fgf8a, which are expressed in the chicken and mouse AER, direct outgrowth of the limb bud and maintain Fgf10 expression in the mesenchym

3




Expression fgf8a neutral bmp4 These fgf8a expression domains are closely associated with tissues expressing bmp4 and Shh. 11734354:3
2




Expression fgf8a positive myf5 Both Hedgehog and fgf8a, signals that induce muscle formation within the somite, suppress Pax3/7 and promote expression of myogenic regulatory factors (MRFs) myf5 and myod in specific muscle precursor cell populations. 17094960:6
2




Expression fgf8a neutral myod1 Thus, fgf8a is expressed in the somite during the formation of early muscle fibre populations and correlates in space and time with the expression of myod in lateral fast muscle precursors.

2




Expression fgf8a positive nkx2.5 Like gata5, the growth factor fgf8a is also important for the initial induction of nkx2.5 expression. fgf8a expression can be detected in nkx2.5-expressing precardiac mesoderm and neighboring cells during early somitogenesis, and mutation of the acerebell

2




Expression fgf8a neutral pax2a Implantation of fgf8a-soaked beads into chick embryos showed further that fgf8a acts in this positive feedback loop maintaining Pax2 expression in the isthmus (Martinez et al., 1999).

2




Expression fgf8a neutral pax5 Thus, fgf8a-regulated expression of Pax5 is dependent on EN proteins, and a factor other than fgf8a could be involved in initiating normal Pax5 expression in the mesencephalon/metencephalon. 11124114:5
2




Expression fgf8a neutral pea3 Finally, we provide evidence that fgf8a also regulates Erm and Pea3 expression in the nasal placodes.

2




Expression fgf8a negative sox3 Loss of both fgf3 and fgf8a is needed to inhibit all placodal sox3 expression. (A–F) Wild type or ace/fgf8a mutant embryos were analysed by double in situ hybridization at 12 hpf for sox3 (red) and pax2a (blue) expression with or without injection of a mo

2




Expression fgf8a positive wnt2b First, fgf8a, which is expressed in the chicken IM, initiates WNT2B expression in the IM.

2




Expression fgf8a positive aldh1a2 The reduced expression of raldh2 in ace mutants may reflect a somite differentiation defect in ace mutants or a positive control of raldh2 expression by fgf8a.

1




Expression fgf8a positive bmp2a Our study shows that, in addition to the known organizer factors, FGF-8 is a dorsalizingfactor that affects the BMP signaling pathway by negatively regulating the expression of the bmp2 and bmp4 genes.

1




Expression fgf8a negative bmp2a Our study shows that, in addition to the known organizer factors, FGF-8 is a dorsalizingfactor that affects the BMP signaling pathway by negatively regulating the expression of the bmp2 and bmp4 genes.

1




Expression fgf8a positive bmp4 Our study shows that, in addition to the known organizer factors, FGF-8 is a dorsalizingfactor that affects the BMP signaling pathway by negatively regulating the expression of the bmp2 and bmp4 genes.

1




Expression fgf8a negative bmp4 Our study shows that, in addition to the known organizer factors, FGF-8 is a dorsalizingfactor that affects the BMP signaling pathway by negatively regulating the expression of the bmp2 and bmp4 genes.

1




Expression fgf8a positive dlx3b Misexpression of fgf8a affects the expression of foxi1 and dlx3b We and others recently showed that loss of both Foxi1 and Dlx3b together ablates all indications of otic induction even in the presence of a fully functional Fgf signaling pathway [24,28].

1




Expression fgf8a neutral dusp6 fgf8a is necessary for Mkp3 expression in vertebrate limb/fin buds.

1




Expression fgf8a positive ef1 Ectopic expression of fgf8a in the mesencephalon is sufficient to activate expression of Engrailed-2 (En-2) and ELF-1, two genes normally expressed in a decreasing caudal to rostral gradient in the posterior mesencephalon. 9056772:5
1




Expression fgf8a positive emx2 Furthermore, we present evidence that fgf8a can regulate regionalization of the prosencephalon through inhibition of Otx2 and Emx2 expression.

1




Expression fgf8a negative gbx2 We next examined whether the effects of dominant negative forms of Xiro1 on Otx2 (Fig. 7A) and fgf8a expression were consequence of the suppression of Gbx2 expression in the injected embryos (Fig. 7C).

1




Expression fgf8a positive gdf5 Indirect loss of Bapx1 by repression from fgf8a beads leads to loss of this specific domain of Gdf5 expression as the jaw joint fails to form.

1




Expression fgf8a positive glceb Based on our results an activation of Fgf-8 mediated pathway following ectopic Glce expression seems unlikely since an expansion rather than a reduction of ventral structures has been observed in embryos overexpressing the enzyme.

1




Expression fgf8a negative hoxa2b In addition, fgf8a can repress Hoxa2 expression in r2, indicating fgf8a could be involved in positioning the r1–2 border.

1




Expression fgf8a positive ins Double injection of fgf3 and fgf8a morpholinos seemed to result in further reduction of insulin expression (Fig. 3L).

1




Expression fgf8a negative ins Injection of fgf3 and fgf8a morpholinos severely reduced insulin expression (Fig. 9F).

1




Expression fgf8a positive myog As fgf8a blockade prevents lateral myogenin expression, an explanation could be that in zebrafish, as in mice, Myod drives myogenin expression in the lateral somite (Bergstrom et al., 2002; Rudnicki et al., 1993).

1




Expression fgf8a negative myog Ablation of fgf8a signalling decreases myogenin expression in the lateral somite, although significant expression remains in both adaxial cells and medial regions (Fig. 3A; 42/45, 49/49 and 22/30; fgf8a MO, SU5402 and ace embryos, respectively).

1




Expression fgf8a positive nkx3.2 Previously, fgf8a has been shown to negatively regulate the expression of Bapx1 at the level of Hensen's node at stage 4 in the chick, where Bapx1 has an asymmetrical expression [Schneider et al., 1999].

1