Expression Table

Gene Name: her6
Description: DNA binding
Key: I = Interpolated; X = Not Detected; ? = Inconsistent data; ! = Expressed but no region
Table built from ZFIN data (http://zfin.org/zf_info/downloads.html): Tue Dec 4 14:01:03 PST 2007

her6

Stage

Hours

ZFIN expression range

axis

presumptive segmental plate

neural plate

mesoderm

ectoderm

hindbrain neural plate

forebrain neural keel

midbrain neural keel

optic primordium

periderm

polster

central nervous system

neural crest

somite

myotome

optic vesicle

neural tube

olfactory placode

rhombomere

brain

diencephalon

forebrain

hindbrain

lateral line system

midbrain

optic stalk

pharyngeal arch 3-7 skeleton

telencephalon

otic vesicle

forebrain midbrain boundary

midbrain hindbrain boundary

lens

proctodeum

pectoral fin bud

epidermis

optic tectum

retina

spinal cord

peripheral olfactory organ

pectoral fin musculature

unspecified

Zygote

1-cell

Cleavage

2-cell

0.75

4-cell

1.0

8-cell

1.25

16-cell

1.5

32-cell

1.75

64-cell

2.0

Blastula

124-cell

2.25

256-cell

2.5

512-cell

2.75

1k-cell

3.0

High

3.33

Oblong

3.66

Sphere

4.0

Dome

4.33

30% epiboly

4.66

Gastrula

50%-epiboly

5.25

Germ-ring

5.66

Shield

6.0

75% epiboly stage

8.0

90% epiboly

9.0

bud stage

10.0

Segmentation

1-4 somites

10.33

5-9 somites

11.66

10-13 somites

14.0

14-19 somites

16.0

20-25 somites

19.0

26+ somites

22.0

Pharyngula

Prim-5

24.0

Prim-15

30.0

Prim-25

36.0

High-pec

42.0

Hatching

Long-pec

48.0

Pec-fin

60.0

Literature Evidence

1. Mutant embryo and in-situ hybridization (or Q-PCR) showed the downstream target genes are affected
2. Overexpression of specific genes and in-situ hybridization (or Q-PCR) showed the downstream target genes are affected
3. Morpholino knock-down the expression of specific gene and in-situ hybridization (or Q-PCR) showed the downstream target genes are affected
4. The interaction sites of the input to downstream target genes have been identified by isolated the module and reporter assay (CAT, GFP, beta-galactosidase, leciferase or Q-PCR assay etc.)
5. The interaction sites of the input to downstream target genes have been identified by coinject the Morpholino or over-expression the genes for reporter assay (CAT, GFP, beta-galactosidase, leciferase or Q-PCR assay etc.)
6. The interaction sites of the input to downstream target genes have been identified by mutation the binding sites and reporter assay (CAT, GFP, beta-galactosidase, leciferase or Q-PCR assay etc.)

Evidence for Interaction In rbpja-DBM-injected embryos, her6 expression is suppressed or strongly downregulated in the anterior PSM and in the somites.

Target Gene her6

Upstream Gene rbpja

Interaction Type enhance

Altered model dominant negative

Time of Interaction in evidence 11.66

Location of Interaction in evidence anterior PSM

Evidence for Direct 2

Binding Site Sequence

Location of Site

Last Author David G. Wilkinson

Journal Development

Year 2003

Vol 131

Start Page 1529

Evidence for Interaction In rbpja-DBM-injected embryos, her6 expression is suppressed or strongly downregulated in the anterior PSM and in the somites.

Target Gene her6

Upstream Gene rbpja

Interaction Type enhance

Altered model dominant negative

Time of Interaction in evidence 11.66

Location of Interaction in evidence somites

Evidence for Direct 2

Binding Site Sequence

Location of Site

Last Author David G. Wilkinson

Journal Development

Year 2003

Vol 131

Start Page 1529

Evidence for Interaction In rbpja-DBM-injected embryos, her6 expression is suppressed or strongly downregulated in the anterior PSM and in the somites.

Target Gene her6

Upstream Gene rbpja

Interaction Type enhance

Altered model dominant negative

Time of Interaction in evidence 14

Location of Interaction in evidence anterior PSM

Evidence for Direct 2

Binding Site Sequence

Location of Site

Last Author David G. Wilkinson

Journal Development

Year 2003

Vol 131

Start Page 1529

Evidence for Interaction In rbpja-DBM-injected embryos, her6 expression is suppressed or strongly downregulated in the anterior PSM and in the somites.

Target Gene her6

Upstream Gene rbpja

Interaction Type enhance

Altered model dominant negative

Time of Interaction in evidence 14

Location of Interaction in evidence somites

Evidence for Direct 2

Binding Site Sequence

Location of Site

Last Author David G. Wilkinson

Journal Development

Year 2003

Vol 131

Start Page 1529

Evidence for Interaction	In rbpja-DBM-injected embryos, her6 expression is suppressed or strongly downregulated in the anterior PSM and in the somites.
Target Gene	her6
Upstream Gene	rbpja
Interaction Type	enhance
Altered model	dominant negative
Time of Interaction in evidence	11.66
Location of Interaction in evidence	anterior PSM
Evidence for Direct	2
Binding Site Sequence
Location of Site
Last Author	David G. Wilkinson
Journal	Development
Year	2003
Vol	131
Start Page	1529