| gata1 | Stage | Hours | ZFIN expression range | presumptive blood | mesoderm | ventral mesoderm | lateral mesoderm | intermediate mesoderm | anterior lateral plate mesoderm | lateral plate mesoderm | posterior lateral mesoderm | posterior lateral plate mesoderm | intermediate cell mass of mesoderm | trunk vasculature | blood island | axial vasculature | blood | intersegmental vessel | nucleate erythrocyte | whole organism | unspecified |
| Zygote | 1-cell | 0 | |||||||||||||||||||
| Cleavage | 2-cell | 0.75 | |||||||||||||||||||
| 4-cell | 1.0 | ||||||||||||||||||||
| 8-cell | 1.25 | ||||||||||||||||||||
| 16-cell | 1.5 | ||||||||||||||||||||
| 32-cell | 1.75 | ||||||||||||||||||||
| 64-cell | 2.0 | ||||||||||||||||||||
| Blastula | 124-cell | 2.25 | |||||||||||||||||||
| 256-cell | 2.5 | ||||||||||||||||||||
| 512-cell | 2.75 | ||||||||||||||||||||
| 1k-cell | 3.0 | ||||||||||||||||||||
| High | 3.33 | ||||||||||||||||||||
| Oblong | 3.66 | ||||||||||||||||||||
| Sphere | 4.0 | ||||||||||||||||||||
| Dome | 4.33 | ||||||||||||||||||||
| 30% epiboly | 4.66 | ||||||||||||||||||||
| Gastrula | 50%-epiboly | 5.25 | |||||||||||||||||||
| Germ-ring | 5.66 | ||||||||||||||||||||
| Shield | 6.0 | ||||||||||||||||||||
| 75% epiboly stage | 8.0 | ||||||||||||||||||||
| 90% epiboly | 9.0 | ||||||||||||||||||||
| bud stage | 10.0 | ? | |||||||||||||||||||
| Segmentation | 1-4 somites | 10.33 | I | ||||||||||||||||||
| 5-9 somites | 11.66 | ||||||||||||||||||||
| 10-13 somites | 14.0 | I | |||||||||||||||||||
| 14-19 somites | 16.0 | I | X | I | |||||||||||||||||
| 20-25 somites | 19.0 | I | I | ||||||||||||||||||
| 26+ somites | 22.0 | I | I | I | |||||||||||||||||
| Pharyngula | Prim-5 | 24.0 | ? | ||||||||||||||||||
| Prim-15 | 30.0 | I | |||||||||||||||||||
| Prim-25 | 36.0 | X | I | ||||||||||||||||||
| High-pec | 42.0 | I | I | ||||||||||||||||||
| Hatching | Long-pec | 48.0 | I | ||||||||||||||||||
| Pec-fin | 60.0 | I | I | I |
| Evidence for Interaction | Cdx4 mRNA injected embryos showed ectopic Gata1 expression near the midline in a stripe that ran parallel to the endogenous blood precursors. |
| Target Gene | gata1 |
| Upstream Gene | cdx4 |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 11.66 |
| Location of Interaction in evidence | blood precursors |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Leonard I. Zon |
| Journal | Nature |
| Year | 2003 |
| Vol | 425 |
| Start Page | 18 |
| Evidence for Interaction | 12-20% of embryos injected with cdx4 mRNA showed ectopic gata1 expression near the midline in a stripe that ran parallel to the endogenous blood precursors. |
| Target Gene | gata1 |
| Upstream Gene | cdx4 |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 11.66 |
| Location of Interaction in evidence | blood precursors |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Leonard I. Zon |
| Journal | Nature |
| Year | 2003 |
| Vol | 425 |
| Start Page | 18 |
| Evidence for Interaction | gata1 is detected by the 6 somite-stage (6s; 12 hpf) in wt trunk IM posterior to somite 6, but we detect no expression in tbx16 trunk IM. |
| Target Gene | gata1 |
| Upstream Gene | tbx16 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 11.66 |
| Location of Interaction in evidence | blood |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Developmental Cell |
| Year | 2004 |
| Vol | 7 |
| Start Page | 251 |
| Evidence for Interaction | kgg tv205 (cdx4) mutants show a decreased number of gata1 erythroid precursors. |
| Target Gene | gata1 |
| Upstream Gene | cdx4 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 11.66 |
| Location of Interaction in evidence | erythroid precursors |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Leonard I. Zon |
| Journal | Nature |
| Year | 2003 |
| Vol | 425 |
| Start Page | 18 |
| Evidence for Interaction | In the cdx4 mutant, kgg, show a decreased number of gata1 erythroid precursorsin blood cells at the 5-somite stage. |
| Target Gene | gata1 |
| Upstream Gene | cdx4 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 11.66 |
| Location of Interaction in evidence | erythroid precursors |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Leonard I. Zon |
| Journal | Nature |
| Year | 2003 |
| Vol | 425 |
| Start Page | 18 |
| Evidence for Interaction | Gata1 is detected by the 6 somite-stage (6s; 12 hpf) in wt trunk IM posterior to somite 6 but is not at 7s (12.5 hpf) in tbx16 mutant, spt. |
| Target Gene | gata1 |
| Upstream Gene | tbx16 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 11.66 |
| Location of Interaction in evidence | IM posterior |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Developmental Cell |
| Year | 2004 |
| Vol | 7 |
| Start Page | 251 |
| Evidence for Interaction | Cdx4 mRNA injected embryos showed ectopic Gata1 expression near the midline in a stripe that ran parallel to the endogenous blood precursors. |
| Target Gene | gata1 |
| Upstream Gene | cdx4 |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 11.66 |
| Location of Interaction in evidence | midline |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Leonard I. Zon |
| Journal | Nature |
| Year | 2003 |
| Vol | 425 |
| Start Page | 18 |
| Evidence for Interaction | 12-20% of embryos injected with cdx4 mRNA showed ectopic gata1 expression near the midline in a stripe that ran parallel to the endogenous blood precursors. |
| Target Gene | gata1 |
| Upstream Gene | cdx4 |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 11.66 |
| Location of Interaction in evidence | midline |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Leonard I. Zon |
| Journal | Nature |
| Year | 2003 |
| Vol | 425 |
| Start Page | 18 |
| Evidence for Interaction | As a control for the activity of zfSCL MO, expression of the blood gene GATA-1 was monitored and a typically reduced and patchy pattern was observed. |
| Target Gene | gata1 |
| Upstream Gene | tal1 |
| Interaction Type | enhance |
| Altered model | MASO |
| Time of Interaction in evidence | 14 |
| Location of Interaction in evidence | blood |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Roger Patient |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 4260 |
| Evidence for Interaction | In the tal1 MO, expression of the blood gene GATA-1 was reduced and patchy pattern was observed. |
| Target Gene | gata1 |
| Upstream Gene | tal1 |
| Interaction Type | enhance |
| Altered model | MASO |
| Time of Interaction in evidence | 14 |
| Location of Interaction in evidence | blood |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Roger Patient |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 4260 |
| Evidence for Interaction | During development, hematopoietic progenitor cells in Trim33 mutants fail to express normal levels of hematopoietic transcription factors, including gata1, and undergo apoptosis. |
| Target Gene | gata1 |
| Upstream Gene | trim33 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 16 |
| Location of Interaction in evidence | hematopoietic progenitor cells |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Zon, L.I. |
| Journal | PLoS Biol. |
| Year | 2004 |
| Vol | 2 |
| Start Page | 237 |
| Evidence for Interaction | Injection of mkp3::C292S resulted in dorsalized embryos, as seen by an elongation of somite stage embryos. At 24 hpf, mkp3::C292S-injected embryos showed a marked reduction in gata1-positive cells and a loss of trunk structures. |
| Target Gene | gata1 |
| Upstream Gene | dusp6 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 24 |
| Location of Interaction in evidence | blood |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Igor B. Dawid |
| Journal | Development |
| Year | 2004 |
| Vol | 131 |
| Start Page | 2769 |
| Evidence for Interaction | mkp3-injected embryos often displayed ventral domains such as the blood islands were expanded as marked by an expansion in the expression of gata1, a blood cell marker. |
| Target Gene | gata1 |
| Upstream Gene | dusp6 |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 24 |
| Location of Interaction in evidence | blood islands |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Igor B. Dawid |
| Journal | Development |
| Year | 2004 |
| Vol | 131 |
| Start Page | 2769 |
| Evidence for Interaction | At 24 hpf, mkp3-injected embryos often displayed a loss of anterior structures and in some instances a complete loss of the head, while ventral domains such as the blood islands were expanded as marked by an expansion in the expression of gata1, a blood c |
| Target Gene | gata1 |
| Upstream Gene | dusp6 |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 24 |
| Location of Interaction in evidence | blood islands |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Igor B. Dawid |
| Journal | Development |
| Year | 2004 |
| Vol | 131 |
| Start Page | 2769 |
| Evidence for Interaction | From 24 hpf, expression of gata1 was lost entirely in Scl depleted embryo. |
| Target Gene | gata1 |
| Upstream Gene | tal1 |
| Interaction Type | enhance |
| Altered model | MASO |
| Time of Interaction in evidence | 24 |
| Location of Interaction in evidence | primitive erythroid lineage |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Roger Patient |
| Journal | blood |
| Year | 2005 |
| Vol | 105 |
| Start Page | 3502 |
| Evidence for Interaction | Expression of Gata1 was lost entirely in the tal1 MO embryos. |
| Target Gene | gata1 |
| Upstream Gene | tal1 |
| Interaction Type | enhance |
| Altered model | MASO |
| Time of Interaction in evidence | 24 |
| Location of Interaction in evidence | primitive erythroid lineage |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Roger Patient |
| Journal | blood |
| Year | 2005 |
| Vol | 105 |
| Start Page | 9 |
| Evidence for Interaction | Circulating embryonic RBCs are absent in spt embryos along with expression of RBC markers, gata1, at 24 hpf. |
| Target Gene | gata1 |
| Upstream Gene | tbx16 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 24 |
| Location of Interaction in evidence | RBC markers |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Developmental Cell |
| Year | 2004 |
| Vol | 7 |
| Start Page | 251 |
| Evidence for Interaction | Circulating embryonic RBCs are absent in spt embryos along with expression of RBC markers, gata1 at 24 hpf. |
| Target Gene | gata1 |
| Upstream Gene | tbx16 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 24 |
| Location of Interaction in evidence | RBC markers |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Developmental Cell |
| Year | 2004 |
| Vol | 7 |
| Start Page | 251 |
| Evidence for Interaction | Injection of mkp3::C292S resulted in dorsalized embryos, as seen by an elongation of somite stage embryos. At 24 hpf, mkp3::C292S-injected embryos showed a marked reduction in gata1-positive cells and a loss of trunk structures. |
| Target Gene | gata1 |
| Upstream Gene | dusp6 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 24 |
| Location of Interaction in evidence | intermediate cell mass |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Igor B. Dawid |
| Journal | Development |
| Year | 2004 |
| Vol | 131 |
| Start Page | 2769 |