| foxh1 | Stage | Hours | ZFIN expression range | ventral mesoderm | notochord | presumptive diencephalon | diencephalon | unspecified |
| Zygote | 1-cell | 0 | ||||||
| Cleavage | 2-cell | 0.75 | ||||||
| 4-cell | 1.0 | |||||||
| 8-cell | 1.25 | |||||||
| 16-cell | 1.5 | |||||||
| 32-cell | 1.75 | |||||||
| 64-cell | 2.0 | |||||||
| Blastula | 124-cell | 2.25 | ||||||
| 256-cell | 2.5 | |||||||
| 512-cell | 2.75 | |||||||
| 1k-cell | 3.0 | |||||||
| High | 3.33 | |||||||
| Oblong | 3.66 | |||||||
| Sphere | 4.0 | |||||||
| Dome | 4.33 | |||||||
| 30% epiboly | 4.66 | |||||||
| Gastrula | 50%-epiboly | 5.25 | ||||||
| Germ-ring | 5.66 | |||||||
| Shield | 6.0 | |||||||
| 75% epiboly stage | 8.0 | |||||||
| 90% epiboly | 9.0 | |||||||
| bud stage | 10.0 | |||||||
| Segmentation | 1-4 somites | 10.33 | I | |||||
| 5-9 somites | 11.66 | I | ||||||
| 10-13 somites | 14.0 | I | ||||||
| 14-19 somites | 16.0 | |||||||
| 20-25 somites | 19.0 | X | ||||||
| 26+ somites | 22.0 | X | ||||||
| Pharyngula | Prim-5 | 24.0 | X | |||||
| Prim-15 | 30.0 | X | ||||||
| Prim-25 | 36.0 | X | ||||||
| High-pec | 42.0 | X | ||||||
| Hatching | Long-pec | 48.0 | X | |||||
| Pec-fin | 60.0 |
| Evidence for Interaction | bik is induced in bon and MZsur;bon and MZsur;bon/+ but not in foxh1 mutant embryos. |
| Target Gene | bhik |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | Expression of gsc in prechordal plateprogenitors is weakly reduced in bon, strongly reduced in foxh1 and absent in foxh1;bon mutant embryos. |
| Target Gene | gsc |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | Expression of gsc in prechordal plate progenitors is weakly reduced in bon, strongly reduced in Mzsur and absent in MZsur;bon mutant embryos. |
| Target Gene | gsc |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | Expression of cas in endodermalprogenitors is strongly reduced in bon and foxh1;bon mutant embryos. |
| Target Gene | sox32 |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | Expression of cas in endodermal progenitors is strongly reduced in bonand MZsur;bon mutant embryos. |
| Target Gene | sox32 |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | bon expression is strongly, but not completely, reduced in MZsur and MZsur; bon double mutant embryos. |
| Target Gene | bon |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | We found that bon expression is unaffected in bon mutants and strongly, but not completely, reduced in foxh1 and foxh1; bon mutants |
| Target Gene | bon |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | bik, mezzo and bon are expressed in bon but strongly downregulated in foxh1 and foxh1;bon embryos |
| Target Gene | bon |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | Similarly, we found that mezzo expression was variably affected in foxh1, the variation correlating with the strength of the foxh1 phenotype. Two maternal genes implicated in Nodal signalling (oep and schmalspur) are thus critically required for normal ex |
| Target Gene | og9x |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Thierry Lepage |
| Journal | Development |
| Year | 2002 |
| Vol | 129 |
| Start Page | 4901 |
| Evidence for Interaction | We found that og9x expression was variably affected in schmalspur (MZsur), the variation correlating with the strength of the MZsur phenotype . Two maternal genes implicated in Nodal signalling (oep and schmalspur) are thus critically required for normal |
| Target Gene | og9x |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Thierry Lepage |
| Journal | Development |
| Year | 2002 |
| Vol | 129 |
| Start Page | 4901 |
| Evidence for Interaction | Expression of mezzo is notaffected in bonMO but downregulated in foxh1 |
| Target Gene | og9x |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | Expression of og9x is notaffected in bonMO but downregulated in foxh1 mutant. |
| Target Gene | og9x |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | bik is not in MZsur mutant (foxh1) embryos. |
| Target Gene | bhik |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 5.66 |
| Location of Interaction in evidence | axis |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | Embryos are at 60% epiboly. Shown is a dorsal view with the animal pole up. In embryos injected with FastSID mRNA, blastodermal 10J3 expression is strongly reduced. |
| Target Gene | sox32 |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | dominant negative |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Frédéric Rosa |
| Journal | GENES & DEVELOPMENT |
| Year | 2001 |
| Vol | 15 |
| Start Page | 1487 |
| Evidence for Interaction | In embryos injected with FastSID (foxh1) mRNA, blastodermal 10J3 (sox32) expression is strongly reduced. |
| Target Gene | sox32 |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | dominant negative |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Frédéric Rosa |
| Journal | GENES & DEVELOPMENT |
| Year | 2001 |
| Vol | 15 |
| Start Page | 1487 |
| Evidence for Interaction | Therefore, we tested the expression of the lim1 gene in maternal-zygotic (MZ) sur mutant embryos and found that these embryos were substantially deficient in lim1 expression. |
| Target Gene | lhx1a |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1, 2 |
| Binding Site Sequence | First Intron |
| Location of Site | TGTGTATT, TGTGCATT, TGTGTACA |
| Last Author | Igor B. Dawid |
| Journal | Development dynamics |
| Year | 2002 |
| Vol | 225 |
| Start Page | 448 |
| Evidence for Interaction | test of the the lim1 gene expression in maternal-zygotic (MZ) sur mutant embryos showed that these embryos were substantially deficient in lim1 expression . |
| Target Gene | lhx1a |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 5, 6 |
| Binding Site Sequence | First Intron |
| Location of Site | TGTGTATT, TGTGCATT, TGTGTACA |
| Last Author | Igor B. Dawid |
| Journal | Development dynamics |
| Year | 2002 |
| Vol | 225 |
| Start Page | 448 |
| Evidence for Interaction | Therefore, we tested the expression of the lim1 gene in maternal-zygotic (MZ) sur mutant embryos and found that these embryos were substantially deficient in lim1 expression. |
| Target Gene | lhx1a |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1, 2 |
| Binding Site Sequence | First Intron |
| Location of Site | TGTGTATT, TGTGCATT, TGTGTACA |
| Last Author | Igor B. Dawid |
| Journal | Development dynamics |
| Year | 2002 |
| Vol | 225 |
| Start Page | 448 |
| Evidence for Interaction | test of the the lim1 gene expression in maternal-zygotic (MZ) sur mutant embryos showed that these embryos were substantially deficient in lim1 expression . |
| Target Gene | lhx1a |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 5, 6 |
| Binding Site Sequence | First Intron |
| Location of Site | TGTGTATT, TGTGCATT, TGTGTACA |
| Last Author | Igor B. Dawid |
| Journal | Development dynamics |
| Year | 2002 |
| Vol | 225 |
| Start Page | 448 |
| Evidence for Interaction | Embryos are at 60% epiboly. Shown is a dorsal view with the animal pole up. In embryos injected with FastSID mRNA, blastodermal 10J3 expression is strongly reduced. |
| Target Gene | sox32 |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | dominant negative |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | YSL |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Frédéric Rosa |
| Journal | GENES & DEVELOPMENT |
| Year | 2001 |
| Vol | 15 |
| Start Page | 1487 |
| Evidence for Interaction | In embryos injected with FastSID (foxh1) mRNA, blastodermal 10J3 (sox32) expression is strongly reduced. |
| Target Gene | sox32 |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | dominant negative |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | YSL |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Frédéric Rosa |
| Journal | GENES & DEVELOPMENT |
| Year | 2001 |
| Vol | 15 |
| Start Page | 1487 |
| Evidence for Interaction | In sur mutant embryos, which display posterior cyclopia similar to igu mutant embryos, pitx2 expression was absent except for a small domain in the polster |
| Target Gene | pitx2a |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | H. Joseph Yost |
| Journal | Development |
| Year | 2000 |
| Vol | 127 |
| Start Page | 1081 |
| Evidence for Interaction | In sur mutant embryos, which display posterior cyclopia similar to igu mutant embryos, pitx2 expression was absent except for a small domain in the polster |
| Target Gene | pitx2a |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 9 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | H. Joseph Yost |
| Journal | Development |
| Year | 2000 |
| Vol | 127 |
| Start Page | 1081 |
| Evidence for Interaction | Lateral view, anterior to the left, dorsal up, of nk2.2 expression in ventral neuroectoderm; normal expression in wild-type and bonMO, reduced anterior expression in foxh1, and lack of expression in foxh1;bonMO . |
| Target Gene | nkx2.2a |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 16 |
| Location of Interaction in evidence | neuroectoderm |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | The expression of nkx2.2a was reduced anterior expression in MZsur, and lack of expression in MZsur;bonMO. |
| Target Gene | nkx2.2a |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 16 |
| Location of Interaction in evidence | neuroectoderm |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | When Smad2 activity was blocked by expression of Fast-1SID, shh and pax-2.1 expression were abolished in the ventral brain and eye, respectively, eminiscent of the cyc mutant phenotype. |
| Target Gene | pax2a |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | overexpression dominant negative |
| Time of Interaction in evidence | 24 |
| Location of Interaction in evidence | brain |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Uwe Strähle |
| Journal | Development |
| Year | 2000 |
| Vol | 127 |
| Start Page | 3889 |
| Evidence for Interaction | When Smad2 activity was blocked by expression of Fast-1SID, shh and pax-2.1 expression were abolished in the ventral brain and eye, respectively, reminiscent of the cyc mutant phenotype. |
| Target Gene | pax2a |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | overexpression dominant negative |
| Time of Interaction in evidence | 24 |
| Location of Interaction in evidence | brain |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Uwe Strähle |
| Journal | Development |
| Year | 2000 |
| Vol | 127 |
| Start Page | 3889 |
| Evidence for Interaction | When Smad2 activity was blocked by expression of Fast-1SID, shh and pax-2.1 expression were abolished in the ventral brain and eye, respectively, reminiscent of the cyc mutant phenotype. |
| Target Gene | pax2a |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | overexpression dominant negative |
| Time of Interaction in evidence | 24 |
| Location of Interaction in evidence | brain |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Uwe Strähle |
| Journal | Development |
| Year | 2000 |
| Vol | 127 |
| Start Page | 3889 |
| Evidence for Interaction | When Smad2 activity was blocked by expression of Fast-1SID, shh and pax-2.1 expression were abolished in the ventral brain and eye, respectively, eminiscent of the cyc mutant phenotype. |
| Target Gene | shha |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | overexpression dominant negative |
| Time of Interaction in evidence | 24 |
| Location of Interaction in evidence | brain |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Uwe Strähle |
| Journal | Development |
| Year | 2000 |
| Vol | 127 |
| Start Page | 3889 |
| Evidence for Interaction | When Smad2 activity was blocked by expression of Fast-1SID, shh expression was abolished in the ventral brain and eye, respectively, (70.0%, n=30). |
| Target Gene | shha |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | overexpression dominant negative |
| Time of Interaction in evidence | 24 |
| Location of Interaction in evidence | brain |
| Evidence for Direct | 4 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Uwe Strähle |
| Journal | Development |
| Year | 2000 |
| Vol | 127 |
| Start Page | 3889 |
| Evidence for Interaction | foxh1 binds to the kdr endothelial enhancer in vitro and functions as a repressor for kdr transcription in cultured cells. |
| Target Gene | kdr |
| Upstream Gene | foxh1 |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 24 |
| Location of Interaction in evidence | vascular endothelial |
| Evidence for Direct | 6 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Jau-Nian Chen |
| Journal | Development Biology |
| Year | 2007 |
| Vol | 304 |
| Start Page | 735 |
| Evidence for Interaction | Expression of shh in head and trunk region, normal expression in wild-type, bon and bonMO but discontinuous weak expression in foxh1 and absence of staining in foxh1;bonMO |
| Target Gene | shha |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 30 |
| Location of Interaction in evidence | head |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | Expression of shh in bonMO, discontinuous weak expression in Mzsur and absence of staining in MZsur;bonMO. |
| Target Gene | shha |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 30 |
| Location of Interaction in evidence | head |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | In foxh1 mutants, dlx2 and shh are expressed in the diencephalon,but the most anterior domains of expression are lost. |
| Target Gene | shha |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 30 |
| Location of Interaction in evidence | |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Wolfgang Driever |
| Journal | The Journal of Neuroscience |
| Year | 2002 |
| Vol | 23 |
| Start Page | 5507 |
| Evidence for Interaction | Expression of shh in head and trunk region, normal expression in wild-type, bon and bonMO but discontinuous weak expression in foxh1 and absence of staining in foxh1;bonMO |
| Target Gene | shha |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 30 |
| Location of Interaction in evidence | trunk |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |
| Evidence for Interaction | Expression of shh in bonMO, discontinuous weak expression in Mzsur and absence of staining in MZsur;bonMO. |
| Target Gene | shha |
| Upstream Gene | foxh1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 30 |
| Location of Interaction in evidence | trunk |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5589 |