| foxb1.2 | Stage | Hours | ZFIN expression range | marginal blastomere | presumptive brain | presumptive neural plate | margin | epiblast | presumptive segmental plate | neural plate | mesoderm | ventral mesoderm | ectoderm | neuroectoderm | midbrain neural keel | neural keel | segmental plate | central nervous system | neural tube | rhombomere | diencephalon | hindbrain | midbrain | midbrain hindbrain boundary | hypothalamus | optic tectum | spinal cord | ventral thalamus | whole organism | unspecified |
| Zygote | 1-cell | 0 | ||||||||||||||||||||||||||||
| Cleavage | 2-cell | 0.75 | ||||||||||||||||||||||||||||
| 4-cell | 1.0 | |||||||||||||||||||||||||||||
| 8-cell | 1.25 | |||||||||||||||||||||||||||||
| 16-cell | 1.5 | |||||||||||||||||||||||||||||
| 32-cell | 1.75 | |||||||||||||||||||||||||||||
| 64-cell | 2.0 | |||||||||||||||||||||||||||||
| Blastula | 124-cell | 2.25 | ||||||||||||||||||||||||||||
| 256-cell | 2.5 | |||||||||||||||||||||||||||||
| 512-cell | 2.75 | |||||||||||||||||||||||||||||
| 1k-cell | 3.0 | |||||||||||||||||||||||||||||
| High | 3.33 | |||||||||||||||||||||||||||||
| Oblong | 3.66 | |||||||||||||||||||||||||||||
| Sphere | 4.0 | ! | ||||||||||||||||||||||||||||
| Dome | 4.33 | ! | ||||||||||||||||||||||||||||
| 30% epiboly | 4.66 | ! | ||||||||||||||||||||||||||||
| Gastrula | 50%-epiboly | 5.25 | ! | ! | ! | ! | ! | |||||||||||||||||||||||
| Germ-ring | 5.66 | ! | ! | ! | ! | ! | I | |||||||||||||||||||||||
| Shield | 6.0 | ! | ! | ! | ! | ! | ||||||||||||||||||||||||
| 75% epiboly stage | 8.0 | ! | ||||||||||||||||||||||||||||
| 90% epiboly | 9.0 | ! | I | ! | I | |||||||||||||||||||||||||
| bud stage | 10.0 | ! | ||||||||||||||||||||||||||||
| Segmentation | 1-4 somites | 10.33 | I | |||||||||||||||||||||||||||
| 5-9 somites | 11.66 | ! | I | |||||||||||||||||||||||||||
| 10-13 somites | 14.0 | ! | ! | I | ||||||||||||||||||||||||||
| 14-19 somites | 16.0 | |||||||||||||||||||||||||||||
| 20-25 somites | 19.0 | I | ! | |||||||||||||||||||||||||||
| 26+ somites | 22.0 | I | ! | |||||||||||||||||||||||||||
| Pharyngula | Prim-5 | 24.0 | ||||||||||||||||||||||||||||
| Prim-15 | 30.0 | I | ||||||||||||||||||||||||||||
| Prim-25 | 36.0 | I | ||||||||||||||||||||||||||||
| High-pec | 42.0 | |||||||||||||||||||||||||||||
| Hatching | Long-pec | 48.0 | ||||||||||||||||||||||||||||
| Pec-fin | 60.0 |
| Evidence for Interaction | Foxb1.2 expression is expanded ventrally in MZ-laf embryos at 70% epiboly, the expansion is more pronounced in more vegetal regions. |
| Target Gene | foxb1.2 |
| Upstream Gene | alk8 |
| Interaction Type | repress |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | epiblast |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Mary C. Mullins |
| Journal | Development |
| Year | 2001 |
| Vol | 128 |
| Start Page | 859 |
| Evidence for Interaction | The expression of the dorsal marker foxb1.2 is expanded laterally and encircles the embryo in marginal regions. |
| Target Gene | foxb1.2 |
| Upstream Gene | smad5 |
| Interaction Type | repress |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | epiblast |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | |
| Journal | |
| Year | |
| Vol | |
| Start Page |
| Evidence for Interaction | Expression of foxb1.2 in wild-type and MZ-laf embryos at 70% epiboly. foxb1.2 expression is expanded ventrally, the expansion is more pronounced in more vegetal regions. |
| Target Gene | foxb1.2 |
| Upstream Gene | alk8 |
| Interaction Type | repress |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Mary C. Mullins |
| Journal | Development |
| Year | 2001 |
| Vol | 128 |
| Start Page | 859 |
| Evidence for Interaction | We found that during mid-gastrulation stages the expression of the dorsal marker foxb1.2 is expanded laterally and encircles the smad5 mutant embryo in marginal regions. |
| Target Gene | foxb1.2 |
| Upstream Gene | smad5 |
| Interaction Type | repress |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Michael Brand |
| Journal | Development |
| Year | 2002 |
| Vol | 129 |
| Start Page | 917 |
| Evidence for Interaction | Foxb1.2 expression is expanded ventrally in MZ-laf embryos at 70% epiboly, the expansion is more pronounced in more vegetal regions. |
| Target Gene | foxb1.2 |
| Upstream Gene | alk8 |
| Interaction Type | repress |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Mary C. Mullins |
| Journal | Development |
| Year | 2001 |
| Vol | 128 |
| Start Page | 859 |
| Evidence for Interaction | The expression of the dorsal marker foxb1.2 is expanded laterally and encircles the embryo in marginal regions. |
| Target Gene | foxb1.2 |
| Upstream Gene | smad5 |
| Interaction Type | repress |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | |
| Journal | |
| Year | |
| Vol | |
| Start Page |
| Evidence for Interaction | Foxb1.2 expression is expanded ventrally in MZ-laf embryos at 70% epiboly, the expansion is more pronounced in more vegetal regions. |
| Target Gene | foxb1.2 |
| Upstream Gene | alk8 |
| Interaction Type | repress |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | neuroectoderm |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Mary C. Mullins |
| Journal | Development |
| Year | 2001 |
| Vol | 128 |
| Start Page | 859 |
| Evidence for Interaction | Expressions of the neuroectodermal genes fkd3, eng3, fgf8 and hoxa-1 were expanded laterally and ventrally in the embryos injected with 50 pg of GFP-kheper RNA, compared to the uninjected control embryos. |
| Target Gene | foxb1.2 |
| Upstream Gene | zfhx1 |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | neuroectoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Naomasa Miki |
| Journal | Developmental Biology |
| Year | 2000 |
| Vol | 228 |
| Start Page | 29 |
| Evidence for Interaction | Expressions of the neuroectodermal genes fkd3 was expanded laterally and ventrally in the embryos injected with 50 pg of GFP-kheper RNA, compared to the uninjected control embryos. |
| Target Gene | foxb1.2 |
| Upstream Gene | zfhx1 |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | neuroectoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Naomasa Miki |
| Journal | Developmental Biology |
| Year | 2000 |
| Vol | 228 |
| Start Page | 29 |
| Evidence for Interaction | Foxb1.2 expression is expanded ventrally in MZ-laf embryos at 70% epiboly, the expansion is more pronounced in more vegetal regions. |
| Target Gene | foxb1.2 |
| Upstream Gene | alk8 |
| Interaction Type | repress |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | presumptive brain |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Mary C. Mullins |
| Journal | Development |
| Year | 2001 |
| Vol | 128 |
| Start Page | 859 |
| Evidence for Interaction | The expression of the dorsal marker foxb1.2 is expanded laterally and encircles the embryo in marginal regions. |
| Target Gene | foxb1.2 |
| Upstream Gene | smad5 |
| Interaction Type | repress |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | presumptive brain |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | |
| Journal | |
| Year | |
| Vol | |
| Start Page |
| Evidence for Interaction | Ectodermal expression of the forkhead domain transcription factor fkd3 is absent from the hindbrain primordium of spg embryos. |
| Target Gene | foxb1.2 |
| Upstream Gene | pou5f1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | hindbrain primordium |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Michael Brand |
| Journal | Development |
| Year | 2002 |
| Vol | 129 |
| Start Page | 917 |
| Evidence for Interaction | In spg embryos, inter-rhombomeric expression is strongly reduced. |
| Target Gene | foxb1.2 |
| Upstream Gene | pou5f1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | inter-rhombomeric |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Michael Brand |
| Journal | Development |
| Year | 2002 |
| Vol | 129 |
| Start Page | 917 |
| Evidence for Interaction | Expressions of the neuroectodermal genes fkd3 was expanded laterally and ventrally in the embryos injected with 50 pg of GFP-kheper RNA, compared to the uninjected control embryos. |
| Target Gene | foxb1.2 |
| Upstream Gene | zfhx1 |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 10.33 |
| Location of Interaction in evidence | neuroectoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Naomasa Miki |
| Journal | Developmental Biology |
| Year | 2000 |
| Vol | 228 |
| Start Page | 29 |
| Evidence for Interaction | Consistent with a loss of RB sensory neurons, both nrd embryos and prdm1 MO embryos display a reduction in foxd3 expression at 11 hpf as compared to wildtype. |
| Target Gene | foxb1.2 |
| Upstream Gene | prdm1 |
| Interaction Type | enhance |
| Altered model | MASO |
| Time of Interaction in evidence | 11.66 |
| Location of Interaction in evidence | RB sensory neurons |
| Evidence for Direct | 1, 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Kristin Bruk Artinger |
| Journal | Developmental Biology |
| Year | 2005 |
| Vol | 278 |
| Start Page | 347 |
| Evidence for Interaction | Consistent with a loss of RB sensory neurons, both nrd embryos and prdm1 MO embryos display a reduction in foxd3 expression at 11 hpf as compared to wildtype. |
| Target Gene | foxb1.2 |
| Upstream Gene | prdm1 |
| Interaction Type | enhance |
| Altered model | MASO |
| Time of Interaction in evidence | 11.66 |
| Location of Interaction in evidence | RB sensory neurons |
| Evidence for Direct | 1, 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Kristin Bruk Artinger |
| Journal | Developmental Biology |
| Year | 2005 |
| Vol | 278 |
| Start Page | 347 |
| Evidence for Interaction | Consistent with a loss of RB sensory neurons, both nrd embryos and prdm1 MO embryos display a reduction in foxd3 expression at 11 hpf as compared to wildtype. |
| Target Gene | foxb1.2 |
| Upstream Gene | prdm1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 11.66 |
| Location of Interaction in evidence | RB sensory neurons |
| Evidence for Direct | 1, 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Kristin Bruk Artinger |
| Journal | Developmental Biology |
| Year | 2005 |
| Vol | 278 |
| Start Page | 347 |
| Evidence for Interaction | Consistent with a loss of RB sensory neurons, both nrd embryos and prdm1 MO embryos display a reduction in foxd3 expression at 11 hpf as compared to wildtype. |
| Target Gene | foxb1.2 |
| Upstream Gene | prdm1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 11.66 |
| Location of Interaction in evidence | RB sensory neurons |
| Evidence for Direct | 1, 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Kristin Bruk Artinger |
| Journal | Developmental Biology |
| Year | 2005 |
| Vol | 278 |
| Start Page | 347 |