Expression Table

Gene Name: Fgf8 (fibroblast growth factor 8 )
Description: growth factor activity
Key: I = Interpolated; X = Not Detected; ? = Inconsistent data; ! = Expressed but no region
Table built from ZFIN data (http://zfin.org/zf_info/downloads.html): Tue Dec 4 14:01:03 PST 2007
fgf8StageHoursZFIN expression rangemarginal blastomeresuperficial blastomerepresumptive brainpresumptive neural plateEVLmarginforerunner cell groupaxisgerm ringshieldpresumptive segmental plateneural platepresumptive cephalic mesodermmesodermectodermneuroectodermhindbrain neural platemidbrain hindbrain boundary neural platepresumptive rhombomere 2presumptive rhombomere 4midbrain hindbrain boundary neural keelneural keelperidermparaxial mesodermsegmental platetail budnotochordtailpresumptive telencephalonsomiteforebrain neural rodmidbrain hindbrain boundary neural rodneural rodheart primordiumeyefloor platefloor plate neural rodneural tubeolfactory placodepharyngeal endodermbasal plate midbrainfloor plate diencephalonfloor plate rhombomere 1floor plate rhombomere 2floor plate rhombomere 3floor plate rhombomere 4floor plate rhombomere 5floor plate rhombomere 6floor plate rhombomere 7floor plate rhombomere 8floor plate telencephalonrhombomere 1rhombomere 2rhombomere 4diencephalonforebrainmidbrainoptic stalkpharyngeal arch 3-7 skeletontelencephalonotic vesicleforebrain midbrain boundarymidbrain hindbrain boundaryhypophysisdorsal fin foldmedian fin foldcerebellumfinhypothalamuspectoral fin budinner earretinaspinal cordtegmentumthyroid primordiumdorsal fin musculaturepectoral finperipheral olfactory organpharyngeal epitheliumretinal ganglion cell layerapical ectodermal ridge pectoral finpectoral fin musculaturemandibular archunspecified
Zygote1-cell0                                                                                     
Cleavage2-cell0.75                                                                                     
4-cell1.0                                                                                     
8-cell1.25                                                                                     
16-cell1.5I                                                                                   I
32-cell1.75I                                                                                   I
64-cell2.0I                                                                                   I
Blastula124-cell2.25                                                                                     
256-cell2.5I                                                                                   I
512-cell2.75I                                                                                   I
1k-cell3.0I                                                                                   I
High3.33I                                                                                   I
Oblong3.66                                                                                     
Sphere4.0     !!                                                                              
Dome4.33     !!                                                                              
30% epiboly4.66 !!                                                                                  
Gastrula50%-epiboly5.25           !!!!       !!                                                             
Germ-ring5.66           !!!!       !!                                                            I
Shield6.0           !!!!       !!                                                             
75% epiboly stage8.0                      !!                                                             
90% epiboly9.0   !                  !!                                                             
bud stage10.0   ! !                                                                               
Segmentation1-4 somites10.33                      II            !                                                
5-9 somites11.66                      II                                                             
10-13 somites14.0        !   !!         I    I                                                        
14-19 somites16.0             !                                                                       
20-25 somites19.0                          I                                      !!  !  !!!          
26+ somites22.0                          I                                             !!!         I
PharyngulaPrim-524.0                                                                      X              
Prim-1530.0                                                                      X    X         
Prim-2536.0                                                                                     
High-pec42.0                                                                             I       
HatchingLong-pec48.0                                                                                     
Pec-fin60.0                                                                                     


Literature Evidence



Evidence for InteractionInhibition of Fgf signalling by microinjection of RNA encoding a dominant negative variant of zebrafish Fgfr1 (dn-fgfr1) causes a severe reduction or complete loss of spry2 expression.
Target Genespry2
Upstream Genefgf8
Interaction Typeenhance
Altered modeldominant negative
Time of Interaction in evidence4.33
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for Interactionoverexpression of fgf8 RNA, either throughout the embryo or at the animal pole (which is far from its endogenous marginal expression) induces ectopic spry2 expression.
Target Genespry2
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence4.33
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for InteractionInhibition of Fgf signalling by microinjection of RNA encoding a dominant negative variant of zebrafish Fgfr1 (dn-fgfr1) causes expansion of ved expression domain.
Target Geneved
Upstream Genefgf8
Interaction Typerepress
Altered modeldominant negative
Time of Interaction in evidence4.66
Location of Interaction in evidenceEVL
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for Interactionfgf8 overexpression abolishes the blastula stage expression of bmp4 in the ventral blastoderm.
Target Genebmp4
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence4.66
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for Interactionfgf8 overexpression abolishes the blastula stage expression of bmp4 in the ventral blastoderm.
Target Genebmp4
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence4.66
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for Interactionfgf8 overexpression abolishes the blastula stage expression of bmp4 in the ventral blastoderm.
Target Genebmp7
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence4.66
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for Interactionfgf8 overexpression abolishes the blastula stage expression of bmp7 in the ventral blastoderm.
Target Genebmp7
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence4.66
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for Interactionfgf8 overexpression abolishes the blastula stage expression of bmp7 in the ventral blastoderm.
Target Genebmp7
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence4.66
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for Interactionfgf8 overexpression abolishes the blastula stage expression of bmp7 in the ventral blastoderm.
Target Genebmp7
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence4.66
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for Interactionfgf8 overexpression abolishes the blastula stage expression of bmp2b in the ventral blastoderm.
Target Genebmp2b
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence4.66
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for InteractionInhibition of Fgf signalling by injection of RNA encoding the Fgf-antagonist Spry2; dn-fgfr1; a dominant-negative variant of the signal transducer Ras or treatment with the pharmacological Fgfr antagonist SU5402, all results in expanded bmp2b expression.
Target Genebmp2b
Upstream Genefgf8
Interaction Typerepress
Altered modeldrug konckdown, dominant negative, antagonist
Time of Interaction in evidence4.66
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for InteractionInjection of fgf8 RNA into the one-cell embryo led to an expansion of mkp3 expression.
Target Genedusp6
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression dominant negative
Time of Interaction in evidence4.66
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorIgor B. Dawid
JournalDevelopment
Year2004
Vol131
Start Page2769



Evidence for InteractionThis is the case, as injection of fgf8 RNA into the one-cell embryo led to an expansion of mkp3 expression. Conversely, inhibition of FGF signaling through the expression of a dominant-negative FGF receptor, XFD, resulted in suppression of mkp3 expression
Target Genedusp6
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression dominant negative
Time of Interaction in evidence4.66
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorIgor B. Dawid
JournalDevelopment
Year2004
Vol131
Start Page2769



Evidence for InteractionInhibition of Fgf signalling by microinjection of RNA encoding a dominant negative variant of zebrafish Fgfr1 (dn-fgfr1) causes a severe reduction or complete loss of spry2 expression.
Target Genespry2
Upstream Genefgf8
Interaction Typeenhance
Altered modeldominant negative
Time of Interaction in evidence4.66
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for Interactionactivation of the FGF/ERK pathway disrupts endoderm formation in the embryo and antagonizes the ability of an activated form of Tar/Acvr1b to induce endoderm at the animal pole.
Target Geneacvr1b
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence5.25
Location of Interaction in evidencemesendoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorThierry Lepage
JournalDevelopment
Year2006
Vol133
Start Page2189



Evidence for Interactionoverexpression of fgf8 elevated ntl expression in the entire embryo.
Target Genentl
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence5.25
Location of Interaction in evidencemesendoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorHiroyuki Takeda
JournalDevelopmental Biology
Year2002
Vol244
Start Page9



Evidence for InteractionFgf signalling is required in vivo to restrict early bmp2b expression to the ventral side of the embryo. This expansion of the bmp2b expression territory results in an increase of Bmp signalling activity as revealed by a strong spreading of ved expression
Target Geneved
Upstream Genefgf8
Interaction Typerepress
Altered modeldominant negative
Time of Interaction in evidence5.25
Location of Interaction in evidenceEVL
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for Interactionoverexpression of fgf8 elevated ntl expression in the entire embryo.
Target Genentl
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence5.25
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorHiroyuki Takeda
JournalDevelopmental Biology
Year2002
Vol244
Start Page9



Evidence for InteractionInjection of fgf8 mRNA induces ectopic sef expression
Target Geneil17rd
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence5.25
Location of Interaction in evidence 
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorIgor B Dawid
Journalbrief communications
Year2002
Vol 
Start Page 



Evidence for InteractionThe fgf8 overexpression (10 pg) induced chd at the shield stage.
Target Genechordin
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence6
Location of Interaction in evidencemesendoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for Interactionfgf8 overexpression induced chd at the shield stage.
Target Genechordin
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence6
Location of Interaction in evidencemesendoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for InteractionThe fgf8 overexpression (10 pg) induced chd at the shield stage.
Target Genechordin
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence6
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for Interactionfgf8 overexpression induced chd at the shield stage.
Target Genechordin
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence6
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for Interactionfgf8 overexpression (10 pg) inhibited eve1 at the shield stage.
Target Geneeve1
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence6
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for Interactionfgf8 overexpression inhibited eve1 at the shield stage.
Target Geneeve1
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence6
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for InteractionThe fgf8 overexpression (10 pg) induced chd at the shield stage.
Target Genechordin
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence6
Location of Interaction in evidenceepiblast
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for Interactionfgf8 overexpression induced chd at the shield stage.
Target Genechordin
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence6
Location of Interaction in evidenceepiblast
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for Interactionfgf8 mis-expression caused a pronounced dorsoventral expansion of gbx2 in the injected half.
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence8
Location of Interaction in evidenceepiblast
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for InteractionIn wild-type embryos, fgf8 mis-expression caused a strong dorsalization of the whole embryo, which is visible as a pronounced dorsoventral expansion of spry4 and gbx2 in the injected half.
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence8
Location of Interaction in evidenceepiblast
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for InteractionIn wild-type embryos, fgf8 mis-expression caused a strong dorsalization of the whole embryo, which is visible as a pronounced dorsoventral expansion of spry4 and gbx2 in the injected half.
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence8
Location of Interaction in evidenceepiblast
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for InteractionGbx2 is lost in both the mesendodermal and the euroectodermal germ layer in fgf8 mutant embryos.
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence8
Location of Interaction in evidencemesendoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for InteractionIn embryos treated with the pharmacological Fgfr antagonist SU5402, the expression of sprouty4 is abolished.
Target Genespry4
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence8
Location of Interaction in evidencemargin
Evidence for Direct 
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for Interactionfgf8 mis-expression caused a pronounced dorsoventral expansion of spry4 in the injected half.
Target Genespry4
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence8
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for Interactionsprouty4 expression at tailbud in non-treatedembryos. In embryos treatedwith SU5402, the expression of sprouty4, an Fgf target, is abolished showing that the inhibition of Fgf signaling was efficient.
Target Genespry4
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence8
Location of Interaction in evidencemargin
Evidence for Direct 
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for InteractionIn wild-type embryos, fgf8 mis-expression caused a strong dorsalization of the whole embryo , which is visible as a pronounced dorsoventral expansion of spry4 and gbx2 in the injected half .
Target Genespry4
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence8
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for InteractionThe hindbrain domain of fgf8 becomes evident by 75% epiboly (8 hpf) in wild-type embryos but was only weakly expressed in most wnt8 morphants even as late as 90% epiboly (9 hpf).
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence8
Location of Interaction in evidencemargin
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionThe hindbrain domain of fgf8 was only weakly expressed in wnt8 morphants even as late as 90% epiboly.
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence8
Location of Interaction in evidencemargin
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionThe hindbrain domain of fgf8 becomes evident by 75% epiboly (8 hpf) in wild-type embryos but was only weakly expressed in most wnt8 morphants even as late as 90% epiboly (9 hpf).
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelMASO
Time of Interaction in evidence8
Location of Interaction in evidencemargin
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionThe hindbrain domain of fgf8 was only weakly expressed in wnt8 morphants even as late as 90% epiboly.
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelMASO
Time of Interaction in evidence8
Location of Interaction in evidencemargin
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionGbx2 is lost in both the mesendodermal and the euroectodermal germ layer in fgf8 mutant embryos.
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence8
Location of Interaction in evidenceneuroectoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for InteractionThe hindbrain domain of fgf8 becomes evident by 75% epiboly (8 hpf) in wild-type embryos but was only weakly expressed in most wnt8 morphants even as late as 90% epiboly (9 hpf).
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence8
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionThe hindbrain domain of fgf8 was only weakly expressed in wnt8 morphants even as late as 90% epiboly.
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence8
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionThe hindbrain domain of fgf8 becomes evident by 75% epiboly (8 hpf) in wild-type embryos but was only weakly expressed in most wnt8 morphants even as late as 90% epiboly (9 hpf).
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelMASO
Time of Interaction in evidence8
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionThe hindbrain domain of fgf8 was only weakly expressed in wnt8 morphants even as late as 90% epiboly.
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelMASO
Time of Interaction in evidence8
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionExpressions of fgf8 was expanded laterally and ventrally in the embryos injected with 50 pg of GFP-kheper RNA, compared to the uninjected control embryos.
Target Genefgf8
Upstream Genezfhx1
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence8
Location of Interaction in evidenceneuroectoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorNaomasa Miki
JournalDevelopmental Biology
Year2000
Vol228
Start Page29



Evidence for InteractionExpressions of the neuroectodermal genes fgf8 was expanded laterally and ventrally in the embryos injected with 50 pg of GFP-kheper RNA, compared to the uninjected control embryos.
Target Genefgf8
Upstream Genezfhx1
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence8
Location of Interaction in evidenceneuroectoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorNaomasa Miki
JournalDevelopmental Biology
Year2000
Vol228
Start Page29



Evidence for Interactionfgf8 mis-expression caused a pronounced dorsoventral expansion of gbx2 in the injected half.
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence8
Location of Interaction in evidencepresumptive brain
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for InteractionIn wild-type embryos, fgf8 mis-expression caused a strong dorsalization of the whole embryo, which is visible as a pronounced dorsoventral expansion of spry4 and gbx2 in the injected half.
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence8
Location of Interaction in evidencepresumptive brain
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for InteractionIn wild-type embryos, fgf8 mis-expression caused a strong dorsalization of the whole embryo, which is visible as a pronounced dorsoventral expansion of spry4 and gbx2 in the injected half.
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence8
Location of Interaction in evidencepresumptive brain
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for InteractionIn embryos treated with the pharmacological Fgfr antagonist SU5402, the expression of sprouty4 is abolished.
Target Genespry4
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence8
Location of Interaction in evidencepresumptive brain
Evidence for Direct 
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for Interactionfgf8 mis-expression caused a pronounced dorsoventral expansion of spry4 in the injected half.
Target Genespry4
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence8
Location of Interaction in evidencepresumptive brain
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for Interactionsprouty4 expression at tailbud in non-treatedembryos. In embryos treatedwith SU5402, the expression of sprouty4, an Fgf target, is abolished showing that the inhibition of Fgf signaling was efficient.
Target Genespry4
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence8
Location of Interaction in evidencepresumptive brain
Evidence for Direct 
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for InteractionIn wild-type embryos, fgf8 mis-expression caused a strong dorsalization of the whole embryo , which is visible as a pronounced dorsoventral expansion of spry4 and gbx2 in the injected half .
Target Genespry4
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence8
Location of Interaction in evidencepresumptive brain
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for InteractionThe hindbrain domain of fgf8 becomes evident by 75% epiboly (8 hpf) in wild-type embryos but was only weakly expressed in most wnt8 morphants even as late as 90% epiboly (9 hpf).
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence8
Location of Interaction in evidencepresumptive brain
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionThe hindbrain domain of fgf8 was only weakly expressed in wnt8 morphants even as late as 90% epiboly.
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence8
Location of Interaction in evidencepresumptive brain
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionThe hindbrain domain of fgf8 becomes evident by 75% epiboly (8 hpf) in wild-type embryos but was only weakly expressed in most wnt8 morphants even as late as 90% epiboly (9 hpf).
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelMASO
Time of Interaction in evidence8
Location of Interaction in evidencepresumptive brain
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionThe hindbrain domain of fgf8 was only weakly expressed in wnt8 morphants even as late as 90% epiboly.
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelMASO
Time of Interaction in evidence8
Location of Interaction in evidencepresumptive brain
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionOnset of gbx2 expression is affected in the ace mutant, albeit in a different way. In ace mutants, expression of gbx2 is already absent at 90% of epiboly.
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence9
Location of Interaction in evidenceectoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for InteractionIn ace mutant s(fgf8 mutant) , gbx2 expression is already absent at 90% of epiboly. gbx1 expression is rescued by wild type cell transplantation into ace mutant
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence9
Location of Interaction in evidenceectoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for InteractionIn ace mutant s(fgf8 mutant) , gbx2 expression is already absent at 90% of epiboly. gbx1 expression is rescued by wild type cell transplantation into ace mutant
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence9
Location of Interaction in evidenceectoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for InteractionGbx2 is lost in both the mesendodermal and the euroectodermal germ layer in ace mutant embryos.
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence9
Location of Interaction in evidencemesendoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for InteractionGbx2 is lost in both the mesendodermal and the euroectodermal germ layer in ace mutant embryos.
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence9
Location of Interaction in evidencemesendoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for Interactionoverexpression of fgf17b caused the expression domain of the anterior neural marker otx1 to shrink substantially, whereas overexpression of fgf8 reduced the otx1 domain size to a lesser degree but clearly decreased its expression level.
Target Geneotx1
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence9
Location of Interaction in evidencemesendoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for Interactionoverexpression of fgf8 or fgf3 reduced the otx2 domain size to a lesser degree but clearly decreased its expression level.
Target Geneotx1
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence9
Location of Interaction in evidencemesendoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for Interactionsprouty4 expression at tailbud in non-treatedembryos. In embryos treatedwith SU5402, the expression of sprouty4, an Fgf target, is abolished showing that the inhibition of Fgf signaling was efficient.
Target Genespry4
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence9
Location of Interaction in evidencemargin
Evidence for Direct 
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for Interactionsprouty4 expression at tailbud in non-treatedembryos. In embryos treatedwith SU5402, the expression of sprouty4, an Fgf target, is abolished showing that the inhibition of Fgf signaling was efficient.
Target Genespry4
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence9
Location of Interaction in evidencemesoderm
Evidence for Direct 
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for InteractionGbx2 is lost in both the mesendodermal and the euroectodermal germ layer in ace mutant embryos.
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence9
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for InteractionGbx2 is lost in both the mesendodermal and the euroectodermal germ layer in ace mutant embryos.
Target Genegbx2
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence9
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for InteractionThe expression of the posterior neuroectodermal marker hoxb1b was expanded, predominantly on the ventral side, by overexpression of any of the tested Fgf mRNAs.
Target Genehoxb1b
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence9
Location of Interaction in evidenceneuroectoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for InteractionThe expression of the posterior neuroectodermal marker hoxb1b was expanded by overexpression of any of the tested fgf8 mRNAs.
Target Genehoxb1b
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence9
Location of Interaction in evidenceneuroectoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for Interactionoverexpression of fgf17b caused the expression domain of the anterior neural marker otx1 to shrink substantially, whereas overexpression of fgf8 reduced the otx1 domain size to a lesser degree but clearly decreased its expression level.
Target Geneotx1
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence9
Location of Interaction in evidenceneuroectoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for Interactionoverexpression of fgf8 or fgf3 reduced the otx2 domain size to a lesser degree but clearly decreased its expression level.
Target Geneotx1
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence9
Location of Interaction in evidenceneuroectoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for Interactionsprouty4 expression at tailbud in non-treatedembryos. In embryos treatedwith SU5402, the expression of sprouty4, an Fgf target, is abolished showing that the inhibition of Fgf signaling was efficient.
Target Genespry4
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence9
Location of Interaction in evidenceneuroectoderm
Evidence for Direct 
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for InteractionThe expression of the posterior neuroectodermal marker hoxb1b was expanded, predominantly on the ventral side, by overexpression of any of the tested Fgf mRNAs.
Target Genehoxb1b
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence9
Location of Interaction in evidencepresumptive brain
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for InteractionThe expression of the posterior neuroectodermal marker hoxb1b was expanded by overexpression of any of the tested fgf8 mRNAs.
Target Genehoxb1b
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence9
Location of Interaction in evidencepresumptive brain
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for Interactionoverexpression of fgf17b caused the expression domain of the anterior neural marker otx1 to shrink substantially, whereas overexpression of fgf8 reduced the otx1 domain size to a lesser degree but clearly decreased its expression level.
Target Geneotx1
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence9
Location of Interaction in evidencepresumptive brain
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for Interactionoverexpression of fgf8 or fgf3 reduced the otx2 domain size to a lesser degree but clearly decreased its expression level.
Target Geneotx1
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence9
Location of Interaction in evidencepresumptive brain
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorAnming Meng
JournalDevelopmental Biology
Year2004
Vol271
Start Page130



Evidence for Interactionsprouty4 expression at tailbud in non-treatedembryos. In embryos treatedwith SU5402, the expression of sprouty4, an Fgf target, is abolished showing that the inhibition of Fgf signaling was efficient.
Target Genespry4
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence9
Location of Interaction in evidencepresumptive brain
Evidence for Direct 
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for Interactionfgf8 expression is not affected in spg embryos at its onset of expression at the MHB, but soon becomes downregulated at around 90% of epiboly. In mutant embryos, fgf8 expression is strongly reduced within r1 and abolished within r2 and r4.
Target Genefgf8
Upstream Genepou5f1
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence9
Location of Interaction in evidencer1
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol129
Start Page917



Evidence for InteractionIn homozygous ace embryos erm expression levels is reduced in various expression domains.
Target Geneerm
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidencedeveloping eye
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2001
Vol107
Start Page105



Evidence for InteractionIn homozygous fgf8 embryos erm expression levels is reduced in various expression domains.
Target Genepea3
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidencedeveloping eye
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2001
Vol107
Start Page105



Evidence for InteractionInjection of fgf8 RNA drastically reduced the number of sox17-expressing cells.
Target Genesox17
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence10
Location of Interaction in evidenceendoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorThierry Lepage
JournalDevelopment
Year2006
Vol133
Start Page2189



Evidence for InteractionInjection of fgf8 RNA drastically reduced the number of sox17-expressing cells.
Target Genesox17
Upstream Genefgf8
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence10
Location of Interaction in evidenceendoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorThierry Lepage
JournalDevelopment
Year2006
Vol133
Start Page2189



Evidence for Interactiontriple knockdown of fgf8, Fgf17b and fgf24 resulted in a large increase in the number of endodermal precursors that formed.
Target Genesox17
Upstream Genefgf8
Interaction Typerepress
Altered modelMASO
Time of Interaction in evidence10
Location of Interaction in evidenceendoderm
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorThierry Lepage
JournalDevelopment
Year2006
Vol133
Start Page2189



Evidence for InteractionIn homozygous ace embryos erm expression levels is reduced in various expression domains.
Target Geneerm
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidenceforebrain
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2001
Vol107
Start Page105



Evidence for InteractionIn homozygous fgf8 embryos erm expression levels is reduced in various expression domains.
Target Genepea3
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidenceforebrain
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2001
Vol107
Start Page105



Evidence for InteractionCareful analyses of myocardial differentiation in fgf8 mutants and pharmacological inhibition studies of Fgf signaling suggest that fgf8 functions to regulate nkx2.5 expression during early somitogenesis.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidencemyocardial precursors
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorDidier Y. R. Stainier
JournalDevelopmental Biology
Year2001
Vol234
Start Page330



Evidence for InteractionThe most severe effect was detected for nkx2.5 expression, which was strongly reduced or absent between the 3-somite and 15-somite stages in acerebellar embryos.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidencecardiovascular system
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionConversely, overexpression of fgf8 RNA, either throughout the embryo or at the animal pole (which is far from its endogenous marginal expression) induces ectopic spry2 expression.
Target Genespry2
Upstream Genefgf8
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence10
Location of Interaction in evidencemargin
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for InteractionThe most severe effect was detected for nkx2.5 expression, which was strongly reduced or absent between the 3-somite and 15-somite stages in acerebellar embryos.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidencemesoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionExpression of pax8 is initiated weakly at the MHB at early somite stages in the mutant embryos and later lost in fgf8 mutants.
Target Genepax8
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidenceMHB
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol130
Start Page6611



Evidence for InteractionIn fgf8 mutant embryos, expression of spry2 is reduced in telencephalon, somites and tail bud, and completely lost at the level of the midbrain-hindbrain boundary (MHB).
Target Genespry2
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidenceMHB
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for InteractionDuring gastrula stages, three parallel pathways (Pax,Wnt and Fgf) are activated around the otx2/gbx1 interface in response to patterning signals.
Target Genefgf8
Upstream Geneotx2
Interaction Typeenhance
Altered modelresponse to patterning signals
Time of Interaction in evidence10
Location of Interaction in evidenceMHB
Evidence for Direct 
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for InteractionDuring gastrula stages, three parallel pathways (Pax,Wnt and Fgf) are activated around the otx2/gbx3 interface in response to patterning signals.
Target Genefgf8
Upstream Geneotx2
Interaction Typeenhance
Altered modelresponse to patterning signals
Time of Interaction in evidence10
Location of Interaction in evidenceMHB
Evidence for Direct 
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for InteractionIn homozygous ace embryos erm expression levels is reduced in various expression domains.
Target Geneerm
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2001
Vol107
Start Page105



Evidence for InteractionWe found that in homozygous ace embryos, erm expression levels is reduced in various expression domains.
Target Geneerm
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2001
Vol107
Start Page105



Evidence for InteractionIn homozygous ace embryos erm expression levels is reduced in various expression domains.
Target Geneerm
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidenceolfactory placcodes
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2001
Vol107
Start Page105



Evidence for InteractionIn homozygous fgf8 embryos erm expression levels is reduced in various expression domains.
Target Genepea3
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2001
Vol107
Start Page105



Evidence for InteractionWe found that in homozygous ace embryos, both erm and pea3 expression levels are reduced or completely lost in various expression domains.
Target Genepea3
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2001
Vol107
Start Page105



Evidence for InteractionIn homozygous fgf8 embryos erm expression levels is reduced in various expression domains.
Target Genepea3
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidenceolfactory placodes
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2001
Vol107
Start Page105



Evidence for InteractionDuring gastrula stages, three parallel pathways (Pax,Wnt and Fgf) are activated around the otx2/gbx1 interface in response to patterning signals.
Target Genefgf8
Upstream Genegbx1
Interaction Typeenhance
Altered modelresponse to patterning signals
Time of Interaction in evidence10
Location of Interaction in evidenceneuroectoderm
Evidence for Direct 
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for InteractionDuring gastrula stages, three parallel pathways (Pax,Wnt and Fgf) are activated around the otx2/gbx1 interface in response to patterning signals. Towards the end of gastrulation, spg ( pou2) expression refines to theMHB territory.At the end of gastrulatio
Target Genefgf8
Upstream Genegbx1
Interaction Typeenhance
Altered modelresponse to patterning signals
Time of Interaction in evidence10
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2003
Vol120
Start Page919



Evidence for InteractionExpression of fgf8 was also delayed in Dfw8 homozygotes, in which expression cannot be detected in the hindbrain until tailbud stage.
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionWnt8 morphants reduced expression of fgf8 at tailbud stage.
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionExpression of fgf8 was also delayed in Dfw8 homozygotes, in which expression cannot be detected in the hindbrain until tailbud stage.
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelMASO
Time of Interaction in evidence10
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionWnt8 morphants reduced expression of fgf8 at tailbud stage.
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelMASO
Time of Interaction in evidence10
Location of Interaction in evidenceneuroectoderm
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionExpression of fgf8 was also delayed in Dfw8 homozygotes, in which expression cannot be detected in the hindbrain until tailbud stage.
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidencepresumptive brain
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionWnt8 morphants reduced expression of fgf8 at tailbud stage.
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10
Location of Interaction in evidencepresumptive brain
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionExpression of fgf8 was also delayed in Dfw8 homozygotes, in which expression cannot be detected in the hindbrain until tailbud stage.
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelMASO
Time of Interaction in evidence10
Location of Interaction in evidencepresumptive brain
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionWnt8 morphants reduced expression of fgf8 at tailbud stage.
Target Genefgf8
Upstream Genewnt8a
Interaction Typeenhance
Altered modelMASO
Time of Interaction in evidence10
Location of Interaction in evidencepresumptive brain
Evidence for Direct1, 3
Binding Site Sequence 
Location of Site 
Last AuthorBruce B. Riley
JournalDevelopment
Year2003
Vol131
Start Page923



Evidence for InteractionWe found that in homozygous ace embryos, both erm and pea3 expression levels are reduced or completely lost in various expression domains.
Target Genepea3
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10.33
Location of Interaction in evidencedeveloping eye
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2001
Vol107
Start Page105



Evidence for InteractionWe found that in homozygous ace embryos, both erm and pea3 expression levels are reduced or completely lost in various expression domains.
Target Genepea3
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10.33
Location of Interaction in evidenceforebrain
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2001
Vol107
Start Page105



Evidence for InteractionDown-regulation of fgf8 was observed in fgf8 morphant.
Target Genefgf8
Upstream Genegbx2
Interaction Typenatural
Altered modelMASO
Time of Interaction in evidence10.33
Location of Interaction in evidenceforebrain
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionAt the three-somite stage, the expression levels of otx2, six3a, pax2.1, fgf8, and krox20 were not affected by MO-gbx2.
Target Genefgf8
Upstream Genegbx2
Interaction Typenatural
Altered modelMASO
Time of Interaction in evidence10.33
Location of Interaction in evidenceforebrain
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionAt the three-somite stage, the expression levels of otx2, six3a, pax2.1, fgf8, and krox20 were not affected by MO-gbx2.
Target Genefgf8
Upstream Genegbx2
Interaction Typenatural
Altered modelMASO
Time of Interaction in evidence10.33
Location of Interaction in evidenceforebrain
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionCareful analyses of myocardial differentiation in ace/fgf8 mutants and pharmacological inhibition studies of Fgf signaling (Reifers et al., 2000) suggest that fgf8 functions to regulate nkx2.5 expression during early somitogenesis (i.e., after the myocard
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10.33
Location of Interaction in evidencemyocardial precursors
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorDidier Y. R. Stainier
JournalDevelopmental Biology
Year2001
Vol234
Start Page330



Evidence for InteractionCareful analyses of myocardial differentiation in ace/fgf8 mutants and pharmacological inhibition studies of Fgf signaling (Reifers et al., 2000) suggest that fgf8 functions to regulate nkx2.5 expression during early somitogenesis (i.e., after the myocard
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10.33
Location of Interaction in evidencemyocardial precursors
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorDidier Y. R. Stainier
JournalDevelopmental Biology
Year2001
Vol234
Start Page330



Evidence for InteractionExpression of the zinc-finger transcription factor gata4 is also clearly reduced in mutant embryos at the 3- to 6- somite stage .
Target Genegata4
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10.33
Location of Interaction in evidencecardiovascular system
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionThe most severe effect was detected for nkx2.5 expression, which was strongly reduced or absent between the 3-somite and 15-somite stages in acerebellar embryos.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10.33
Location of Interaction in evidencecardiovascular system
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionThe most severe effect was detected for nkx2.5 expression, which was strongly reduced or absent between the 3-somite and 15-somite stages in acerebellar embryos.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10.33
Location of Interaction in evidencecardiovascular system
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionExpression of the zinc-finger transcription factor gata4 is also clearly reduced in mutant embryos at the 3- to 6- somite stage .
Target Genegata4
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10.33
Location of Interaction in evidencemesoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionThe most severe effect was detected for nkx2.5 expression, which was strongly reduced or absent between the 3-somite and 15-somite stages in acerebellar embryos.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10.33
Location of Interaction in evidencemesoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionThe most severe effect was detected for nkx2.5 expression, which was strongly reduced or absent between the 3-somite and 15-somite stages in acerebellar embryos.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10.33
Location of Interaction in evidencemesoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionDown-regulation of fgf8 was observed in fgf8 morphant.
Target Genefgf8
Upstream Genegbx2
Interaction Typenatural
Altered modelMASO
Time of Interaction in evidence10.33
Location of Interaction in evidencemidbrain
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionAt the three-somite stage, the expression levels of otx2, six3a, pax2.1, fgf8, and krox20 were not affected by MO-gbx2.
Target Genefgf8
Upstream Genegbx2
Interaction Typenatural
Altered modelMASO
Time of Interaction in evidence10.33
Location of Interaction in evidencemidbrain
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionAt the three-somite stage, the expression levels of otx2, six3a, pax2.1, fgf8, and krox20 were not affected by MO-gbx2.
Target Genefgf8
Upstream Genegbx2
Interaction Typenatural
Altered modelMASO
Time of Interaction in evidence10.33
Location of Interaction in evidencemidbrain
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionIn fgf8/acerebellar mutant embryos, expression of spry2 is reduced in telencephalon, somites and tail bud, and completely lost at the level of the midbrain-hindbrain boundary (MHB) .
Target Genespry2
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10.33
Location of Interaction in evidenceMHB
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorBernard Thisse
JournalDevelopment
Year2004
Vol131
Start Page2853



Evidence for InteractionDown-regulation of fgf8 was observed in fgf8 morphant.
Target Genefgf8
Upstream Genegbx2
Interaction Typenatural
Altered modelMASO
Time of Interaction in evidence10.33
Location of Interaction in evidenceMHB
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionAt the three-somite stage, the expression levels of otx2, six3a, pax2.1, fgf8, and krox20 were not affected by MO-gbx2.
Target Genefgf8
Upstream Genegbx2
Interaction Typenatural
Altered modelMASO
Time of Interaction in evidence10.33
Location of Interaction in evidenceMHB
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionAt the three-somite stage, the expression levels of otx2, six3a, pax2.1, fgf8, and krox20 were not affected by MO-gbx2.
Target Genefgf8
Upstream Genegbx2
Interaction Typenatural
Altered modelMASO
Time of Interaction in evidence10.33
Location of Interaction in evidenceMHB
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionWe found that in homozygous ace embryos, both erm and pea3 expression levels are reduced or completely lost in various expression domains.
Target Genepea3
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence10.33
Location of Interaction in evidenceolfactory placodes
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalMechanisms of Development
Year2001
Vol107
Start Page105



Evidence for InteractionExpressions of fgf8 was expanded laterally and ventrally in the embryos injected with 50 pg of GFP-kheper RNA, compared to the uninjected control embryos.
Target Genefgf8
Upstream Genezfhx1
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence10.33
Location of Interaction in evidenceneuroectoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorNaomasa Miki
JournalDevelopmental Biology
Year2000
Vol228
Start Page29



Evidence for InteractionExpressions of the neuroectodermal genes fgf8 was expanded laterally and ventrally in the embryos injected with 50 pg of GFP-kheper RNA, compared to the uninjected control embryos.
Target Genefgf8
Upstream Genezfhx1
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence10.33
Location of Interaction in evidenceneuroectoderm
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorNaomasa Miki
JournalDevelopmental Biology
Year2000
Vol228
Start Page29



Evidence for InteractionExpression of the zinc-finger transcription factor gata4 is also clearly reduced in mutant embryos at the 3- to 6- somite stage.
Target Genegata4
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence11.66
Location of Interaction in evidencecardiovascular system
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionExpression of the zinc-finger transcription factor gata4 is also clearly reduced in mutant embryos at the 3- to 6- somite stage.
Target Genegata4
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence11.66
Location of Interaction in evidencemesoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionExpression of pax8 is initiated weakly at the MHB at early somite stages in the mutant embryos and later lost in ace mutants.
Target Genepax8
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence11.66
Location of Interaction in evidenceMHB
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2003
Vol130
Start Page6611



Evidence for InteractionExpression of spry4 is not initiated in the fgf8 mutants.
Target Genespry4
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence11.66
Location of Interaction in evidenceMHB
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol130
Start Page6611



Evidence for InteractionIn contrast to pax8, expression of spry4 is not initiated in the mutants. The arrowhead (I) marks the MHB expression domain of spry4 in the wild-type embryo.
Target Genespry4
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence11.66
Location of Interaction in evidenceMHB
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2003
Vol130
Start Page6611



Evidence for InteractionIncreased fgf8 expression is detected in the telencephalon and midbrain/ hindbrain domains in IGF-1 injected embryos
Target Genefgf8
Upstream Geneigf1
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence11.66
Location of Interaction in evidenceMHB
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorLUCY BYRNES
JournalInt. J. Dev. Biol.
Year2004
Vol48
Start Page1131



Evidence for InteractionIncreased fgf8 expression is detected in the telencephalon and midbrain/ hindbrain domains in IGF-1 injected embryos
Target Genefgf8
Upstream Geneigf1
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence11.66
Location of Interaction in evidenceMHB
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorLUCY BYRNES
JournalInt. J. Dev. Biol.
Year2004
Vol48
Start Page1131



Evidence for InteractionIncreased fgf8 expression is detected in the telencephalon and midbrain/ hindbrain domains in IGF-1 injected embryos
Target Genefgf8
Upstream Geneigf1
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence11.66
Location of Interaction in evidenceMHB
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorLUCY BYRNES
JournalInt. J. Dev. Biol.
Year2004
Vol48
Start Page1131



Evidence for InteractionSimilarly, expression of fgf8 in noi -/ - mutants is initiated normally and disappears from the MHB by the 9-somite stage.
Target Genefgf8
Upstream Genepax2a
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence11.66
Location of Interaction in evidenceMHB
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year1998
Vol125
Start Page3049



Evidence for InteractionExpression of fgf8 in noi -/ - mutants is initiated normally and disappears from the MHB by the 9-somite stage.
Target Genefgf8
Upstream Genepax2a
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence11.66
Location of Interaction in evidenceMHB
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year1998
Vol125
Start Page3049



Evidence for InteractionExpression of fgf8 in noi -/ - mutants is initiated normally and disappears from the MHB by the 9-somite stage.
Target Genefgf8
Upstream Genepax2a
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence11.66
Location of Interaction in evidenceMHB
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year1998
Vol125
Start Page3049



Evidence for InteractionExpression of dmbx1 is markedly expanded at early somitogenesis in the fgf8 mutant embryos at the 7- and 9-somite stage.
Target Genedmbx1
Upstream Genefgf8
Interaction Typerepress
Altered modelmutant embryos
Time of Interaction in evidence11.66
Location of Interaction in evidencemesencephalic tectum
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2003
Vol130
Start Page6611



Evidence for InteractionExpression of dmbx1 is markedly expanded at early somitogenesis in the fgf8 mutant embryos.
Target Genedmbx1
Upstream Genefgf8
Interaction Typerepress
Altered modelmutant embryos
Time of Interaction in evidence11.66
Location of Interaction in evidencemesencephalic tectum
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol130
Start Page6611



Evidence for InteractionIncreased fgf8 expression is detected in the telencephalon and midbrain/ hindbrain domains in IGF-1 injected embryos
Target Genefgf8
Upstream Geneigf1
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence11.66
Location of Interaction in evidencetelencephalon
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorLUCY BYRNES
JournalInt. J. Dev. Biol.
Year2004
Vol48
Start Page1131



Evidence for InteractionIncreased fgf8 expression is detected in the telencephalon and midbrain/ hindbrain domains in IGF-1 injected embryos
Target Genefgf8
Upstream Geneigf1
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence11.66
Location of Interaction in evidencetelencephalon
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorLUCY BYRNES
JournalInt. J. Dev. Biol.
Year2004
Vol48
Start Page1131



Evidence for InteractionIncreased fgf8 expression is detected in the telencephalon and midbrain/ hindbrain domains in IGF-1 injected embryos
Target Genefgf8
Upstream Geneigf1
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence11.66
Location of Interaction in evidencetelencephalon
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorLUCY BYRNES
JournalInt. J. Dev. Biol.
Year2004
Vol48
Start Page1131



Evidence for InteractionIn fgf8 mutant embryos the anterior part of nkx2.5 expression is severely reduced and the expression in the posterior subdomain is completely absent.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence14
Location of Interaction in evidencecardiovascular system
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionAt the 11-somite stage the fgf8 expression domain partially overlaps the nkx2.5 domain and reaches further posterior at least to the level of rhombomere 5. In acerebellar mutant embryos the anterior part of nkx2.5 expression is severely reduced and the ex
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence14
Location of Interaction in evidencecardiovascular system
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionAt the 11-somite stage the fgf8 expression domain partially overlaps the nkx2.5 domain and reaches further posterior at least to the level of rhombomere 5. In acerebellar mutant embryos the anterior part of nkx2.5 expression is severely reduced and the ex
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence14
Location of Interaction in evidencecardiovascular system
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionIn fgf8 mutant embryos the anterior part of nkx2.5 expression is severely reduced and the expression in the posterior subdomain is completely absent.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence14
Location of Interaction in evidencemesoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionAt the 11-somite stage the fgf8 expression domain partially overlaps the nkx2.5 domain and reaches further posterior at least to the level of rhombomere 5. In acerebellar mutant embryos the anterior part of nkx2.5 expression is severely reduced and the ex
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence14
Location of Interaction in evidencemesoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionAt the 11-somite stage the fgf8 expression domain partially overlaps the nkx2.5 domain and reaches further posterior at least to the level of rhombomere 5. In acerebellar mutant embryos the anterior part of nkx2.5 expression is severely reduced and the ex
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence14
Location of Interaction in evidencemesoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionThe most severe effect was detected for nkx2.5 expression, which was strongly reduced or absent between the 3-somite and 15-somite stages in fgf8 embryos.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence16
Location of Interaction in evidencecardiovascular system
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionThe most severe effect was detected for nkx2.5 expression, which was strongly reduced or absent between the 3-somite and 15-somite stages in acerebellar embryos.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence16
Location of Interaction in evidencecardiovascular system
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionThe most severe effect was detected for nkx2.5 expression, which was strongly reduced or absent between the 3-somite and 15-somite stages in acerebellar embryos.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence16
Location of Interaction in evidencecardiovascular system
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionThe most severe effect was detected for nkx2.5 expression, which was strongly reduced or absent between the 3-somite and 15-somite stages in fgf8 embryos.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence16
Location of Interaction in evidencemesoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionThe most severe effect was detected for nkx2.5 expression, which was strongly reduced or absent between the 3-somite and 15-somite stages in acerebellar embryos.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence16
Location of Interaction in evidencemesoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionThe most severe effect was detected for nkx2.5 expression, which was strongly reduced or absent between the 3-somite and 15-somite stages in acerebellar embryos.
Target Genenkx2.5
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence16
Location of Interaction in evidencemesoderm
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2000
Vol127
Start Page225



Evidence for InteractionIn DN-IGF- 1R injected embryo, an absence of fgf8 expression was detected in the anterior-most telencephalon region while expression was reduced in the midbrain-hindbrain boundary.
Target Genefgf8
Upstream Geneigf1rb
Interaction Typeenhance
Altered modeldominant negative
Time of Interaction in evidence16
Location of Interaction in evidenceMHB
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorLUCY BYRNES
JournalInt. J. Dev. Biol.
Year2004
Vol48
Start Page1131



Evidence for InteractionLateral view of DN-IGF- 1R injected embryo. An absence of fgf8 expression was detected in the anterior-most telencephalon region while expression was reduced in the midbrain-hindbrain boundary
Target Genefgf8
Upstream Geneigf1rb
Interaction Typeenhance
Altered modeldominant negative
Time of Interaction in evidence16
Location of Interaction in evidenceMHB
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorLUCY BYRNES
JournalInt. J. Dev. Biol.
Year2004
Vol48
Start Page1131



Evidence for InteractionMarkedly upregulated and expanded expression of wnt4 in fgf8 mutants.
Target Genewnt4a
Upstream Genefgf8
Interaction Typerepress
Altered modelmutant embryos
Time of Interaction in evidence19
Location of Interaction in evidenceforebrain
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol130
Start Page6611



Evidence for InteractionEnriched expression of wnt4 at the fore-midbrain region at the 20-somite stage in ace mutants.
Target Genewnt4a
Upstream Genefgf8
Interaction Typerepress
Altered modelmutant embryos
Time of Interaction in evidence19
Location of Interaction in evidenceforebrain
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2003
Vol130
Start Page6611



Evidence for InteractionMarkedly upregulated and expanded expression of wnt4 in fgf8 mutants.
Target Genewnt4a
Upstream Genefgf8
Interaction Typerepress
Altered modelmutant embryos
Time of Interaction in evidence19
Location of Interaction in evidencemidbrain
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2002
Vol130
Start Page6611



Evidence for InteractionEnriched expression of wnt4 at the fore-midbrain region at the 20-somite stage in ace mutants.
Target Genewnt4a
Upstream Genefgf8
Interaction Typerepress
Altered modelmutant embryos
Time of Interaction in evidence19
Location of Interaction in evidencemidbrain
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2003
Vol130
Start Page6611



Evidence for Interactionfgf8 expression in the anterior portion of the hindbrain was essentially intact, although it was downregulated in the dorsal telencephalon and anterior diencephalon.
Target Genefgf8
Upstream Genegbx2
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence24
Location of Interaction in evidencediencephalon
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionIn the embryos injected gbx2 mRNA data, fgf8 was suppressed.
Target Genefgf8
Upstream Genegbx2
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence24
Location of Interaction in evidencediencephalon
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionIn the embryos injected gbx2 mRNA data, fgf8 was suppressed.
Target Genefgf8
Upstream Genegbx2
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence24
Location of Interaction in evidencediencephalon
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionThe regulation of mkp3 expression by FGF is confirmed by the loss of mkp3 mRNA in the MHB of the zebrafish fgf8 mutant, acerebellar (ace), and in the pax2.1 mutant, no isthmus (noi), in which FGF activity within the MHB is lost .
Target Genedusp6
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence24
Location of Interaction in evidenceMHB
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorIgor B. Dawid
JournalDevelopment
Year2004
Vol131
Start Page2769



Evidence for Interactionfgf8 expression in the anterior portion of the hindbrain was essentially intact, although it was downregulated in the dorsal telencephalon and anterior diencephalon.
Target Genefgf8
Upstream Genegbx2
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence24
Location of Interaction in evidencetelencephalon
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionIn the embryos injected gbx2 mRNA data, fgf8 was suppressed.
Target Genefgf8
Upstream Genegbx2
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence24
Location of Interaction in evidencetelencephalon
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionIn the embryos injected gbx2 mRNA data, fgf8 was suppressed.
Target Genefgf8
Upstream Genegbx2
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence24
Location of Interaction in evidencetelencephalon
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionIn the embryos injected gbx2 mRNA data, fgf8 was suppressed.
Target Genefgf8
Upstream Genegbx2
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence28
Location of Interaction in evidencediencephalon
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionIn the embryos injected gbx2 mRNA data, fgf8 was suppressed.
Target Genefgf8
Upstream Genegbx2
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence28
Location of Interaction in evidencediencephalon
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionZath1 expression is not detectable in the upper rhombic lips of ace (fgf8) mutants in comparison with wild-type embryos.
Target Geneatoh1a
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence28
Location of Interaction in evidenceupper rhombic
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorMichael Brand
JournalDevelopment
Year2003
Vol130
Start Page6611



Evidence for InteractionIn the embryos injected gbx2 mRNA data, fgf8 was suppressed.
Target Genefgf8
Upstream Genegbx2
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence28
Location of Interaction in evidencetelencephalon
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionIn the embryos injected gbx2 mRNA data, fgf8 was suppressed.
Target Genefgf8
Upstream Genegbx2
Interaction Typerepress
Altered modeloverexpression
Time of Interaction in evidence28
Location of Interaction in evidencetelencephalon
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorKyo Yamasu
JournalDevelopmental Dynamics
Year2003
Vol228
Start Page433



Evidence for InteractionEmbryos treated with SU5402 show no expression of erm, confirming that other FGF genes are responsible for the remaining expression of both genes in acerebellar mutant embryos.
Target Geneerm
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence30
Location of Interaction in evidencedeveloping eye
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorChristiane Nu¨ sslein-Volhard
JournalCurrent Biology
Year2001
Vol11
Start Page503



Evidence for InteractionEmbryos treated with SU5402 show no expression of erm, confirming that other FGF genes are responsible for the remaining expression of both genes in acerebellar mutant embryos.
Target Geneerm
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence36
Location of Interaction in evidenceforebrain
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorChristiane Nu¨ sslein-Volhard
JournalCurrent Biology
Year2001
Vol11
Start Page503



Evidence for InteractionEmbryos treated with SU5402 show no expression of erm.
Target Geneerm
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence36
Location of Interaction in evidenceupper rhombic
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorChristiane Nu¨ sslein-Volhard
JournalCurrent Biology
Year2001
Vol11
Start Page503



Evidence for InteractionEmbryos treated with SU5402 show no expression of pea3.
Target Genepea3
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence36
Location of Interaction in evidenceupper rhombic
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorChristiane Nu¨ sslein-Volhard
JournalCurrent Biology
Year2001
Vol11
Start Page503



Evidence for InteractionEmbryos treated with SU5402 show no expression of pea3, confirming that other FGF genes are responsible for the remaining expression of both genes in acerebellar mutant embryos.
Target Genepea3
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence36
Location of Interaction in evidence 
Evidence for Direct 
Binding Site Sequence 
Location of Site 
Last AuthorChristiane Nu¨ sslein-Volhard
JournalCurrent Biology
Year2001
Vol11
Start Page503



Evidence for InteractionEmbryos treated with SU5402 show no expression of erm, confirming that other FGF genes are responsible for the remaining expression of both genes in acerebellar mutant embryos.
Target Geneerm
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence36
Location of Interaction in evidenceneuroectoderm
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorChristiane Nu¨ sslein-Volhard
JournalCurrent Biology
Year2001
Vol11
Start Page503



Evidence for InteractionEmbryos treated with SU5402 show no expression of erm, confirming that other FGF genes are responsible for the remaining expression of both genes in acerebellar mutant embryos.
Target Geneerm
Upstream Genefgf8
Interaction Typeenhance
Altered modeldrug knockdown
Time of Interaction in evidence36
Location of Interaction in evidenceolfactory placcodes
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorChristiane Nu¨ sslein-Volhard
JournalCurrent Biology
Year2001
Vol11
Start Page503



Evidence for InteractionIn fgf8 mutant embryos, pax2.1 expression is absent from the midhindbrain border and is reduced in the retina and otic vesicle.
Target Genepax2a
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence48
Location of Interaction in evidencemidhindbrain border
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorDavid Kimelman
JournalDevelopmental Biology
Year2003
Vol264
Start Page456



Evidence for InteractionIn ace (fgf8) mutant embryos, pax2.1 expression is absent from the midhindbrain border and is reduced in the retina and otic vesicle.
Target Genepax2a
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence48
Location of Interaction in evidencemidhindbrain border
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorDavid Kimelman
JournalDevelopmental Biology
Year2003
Vol264
Start Page456



Evidence for InteractionIn ace (fgf8) mutant embryos, pax2.1 expression is absent from the midhindbrain border and is reduced in the retina and otic vesicle.
Target Genepax2a
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence48
Location of Interaction in evidencemidhindbrain border
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorDavid Kimelman
JournalDevelopmental Biology
Year2003
Vol264
Start Page456



Evidence for InteractionIn fgf8 mutant embryos, pax2.1 expression is absent from the midhindbrain border and is reduced in the retina and otic vesicle.
Target Genepax2a
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence48
Location of Interaction in evidenceotic vesicle
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorDavid Kimelman
JournalDevelopmental Biology
Year2003
Vol264
Start Page456



Evidence for InteractionIn ace (fgf8) mutant embryos, pax2.1 expression is absent from the midhindbrain border and is reduced in the retina and otic vesicle.
Target Genepax2a
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence48
Location of Interaction in evidenceotic vesicle
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorDavid Kimelman
JournalDevelopmental Biology
Year2003
Vol264
Start Page456



Evidence for InteractionIn ace (fgf8) mutant embryos, pax2.1 expression is absent from the midhindbrain border and is reduced in the retina and otic vesicle.
Target Genepax2a
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence48
Location of Interaction in evidenceotic vesicle
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorDavid Kimelman
JournalDevelopmental Biology
Year2003
Vol264
Start Page456



Evidence for InteractionIn fgf8 mutant embryos, pax2.1 expression is absent from the midhindbrain border and is reduced in the retina and otic vesicle.
Target Genepax2a
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence48
Location of Interaction in evidenceretina
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorDavid Kimelman
JournalDevelopmental Biology
Year2003
Vol264
Start Page456



Evidence for InteractionIn ace (fgf8) mutant embryos, pax2.1 expression is absent from the midhindbrain border and is reduced in the retina and otic vesicle.
Target Genepax2a
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence48
Location of Interaction in evidenceretina
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorDavid Kimelman
JournalDevelopmental Biology
Year2003
Vol264
Start Page456



Evidence for InteractionIn ace (fgf8) mutant embryos, pax2.1 expression is absent from the midhindbrain border and is reduced in the retina and otic vesicle.
Target Genepax2a
Upstream Genefgf8
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence48
Location of Interaction in evidenceretina
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorDavid Kimelman
JournalDevelopmental Biology
Year2003
Vol264
Start Page456



Evidence for Interaction27 genes that are expressed in the dorsal margin in wild type, but lack margin expression in MZoep mutants.
Target Genefgf8
Upstream Geneoep
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence5.25
Location of Interaction in evidenceblastomere
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorSchier, A. F.
JournalDev Biol
Year2007
Vol304
Start Page525