| fgf17b | Stage | Hours | ZFIN expression range | marginal blastomere | superficial blastomere | YSL | presumptive dorsal mesoderm | EVL | margin | anterior axial hypoblast | adaxial cell | segmental plate | tail bud | presumptive telencephalon | somite | myotome | diencephalon | pharyngeal arch 3-7 skeleton | telencephalon | primitive heart tube | pectoral fin bud | heart | pectoral fin | unspecified |
| Zygote | 1-cell | 0 | ||||||||||||||||||||||
| Cleavage | 2-cell | 0.75 | I | I | ||||||||||||||||||||
| 4-cell | 1.0 | I | I | |||||||||||||||||||||
| 8-cell | 1.25 | I | I | |||||||||||||||||||||
| 16-cell | 1.5 | I | I | |||||||||||||||||||||
| 32-cell | 1.75 | I | I | |||||||||||||||||||||
| 64-cell | 2.0 | I | I | |||||||||||||||||||||
| Blastula | 124-cell | 2.25 | I | I | ||||||||||||||||||||
| 256-cell | 2.5 | I | I | |||||||||||||||||||||
| 512-cell | 2.75 | I | I | |||||||||||||||||||||
| 1k-cell | 3.0 | |||||||||||||||||||||||
| High | 3.33 | I | I | |||||||||||||||||||||
| Oblong | 3.66 | I | I | |||||||||||||||||||||
| Sphere | 4.0 | ! | ! | |||||||||||||||||||||
| Dome | 4.33 | ! | ! | |||||||||||||||||||||
| 30% epiboly | 4.66 | ! | ! | |||||||||||||||||||||
| Gastrula | 50%-epiboly | 5.25 | ! | I | ||||||||||||||||||||
| Germ-ring | 5.66 | ! | I | |||||||||||||||||||||
| Shield | 6.0 | ! | ||||||||||||||||||||||
| 75% epiboly stage | 8.0 | |||||||||||||||||||||||
| 90% epiboly | 9.0 | I | ||||||||||||||||||||||
| bud stage | 10.0 | |||||||||||||||||||||||
| Segmentation | 1-4 somites | 10.33 | ||||||||||||||||||||||
| 5-9 somites | 11.66 | |||||||||||||||||||||||
| 10-13 somites | 14.0 | |||||||||||||||||||||||
| 14-19 somites | 16.0 | |||||||||||||||||||||||
| 20-25 somites | 19.0 | ! | ! | ! | I | |||||||||||||||||||
| 26+ somites | 22.0 | ! | ! | I | ||||||||||||||||||||
| Pharyngula | Prim-5 | 24.0 | ||||||||||||||||||||||
| Prim-15 | 30.0 | I | ||||||||||||||||||||||
| Prim-25 | 36.0 | I | ||||||||||||||||||||||
| High-pec | 42.0 | I | I | |||||||||||||||||||||
| Hatching | Long-pec | 48.0 | I | |||||||||||||||||||||
| Pec-fin | 60.0 | I | I |
| Evidence for Interaction | Injection with 5 pg of sqt mRNA induced fgf17b expression throughout the blastomeres at the sphere stage. |
| Target Gene | fgf17b |
| Upstream Gene | ndr1 |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 4 |
| Location of Interaction in evidence | YSL |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | We tested whether fgf17b was similarly regulated by Nodal signaling. As shown in Fig. 3B, injection with 5 pg of sqt mRNA induced fgf17b expression throughout the blastomeres at the sphere stage. |
| Target Gene | fgf17b |
| Upstream Gene | ndr1 |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 4 |
| Location of Interaction in evidence | YSL |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The expression of fgf17b was undetectable in MZoep mutant blastulas. |
| Target Gene | fgf17b |
| Upstream Gene | oep |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 4.66 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | Injection with 5 pg of sqt mRNA induced fgf17b expression throughout the blastomeres at the sphere stage. |
| Target Gene | fgf17b |
| Upstream Gene | ndr1 |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 4.66 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | We tested whether fgf17b was similarly regulated by Nodal signaling. As shown in Fig. 3B, injection with 5 pg of sqt mRNA induced fgf17b expression throughout the blastomeres at the sphere stage. |
| Target Gene | fgf17b |
| Upstream Gene | ndr1 |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 4.66 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The expression of fgf17b was undetectable in MZoep mutant blastulas. |
| Target Gene | fgf17b |
| Upstream Gene | oep |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 4.66 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The expression of fgf17b was undetectable in MZoep mutant blastulas, but detected at a markedly reduced level during the segmentation period. |
| Target Gene | fgf17b |
| Upstream Gene | oep |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 4.66 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The expression of fgf17b was undetectable in MZoep mutant blastulas. |
| Target Gene | fgf17b |
| Upstream Gene | oep |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 4.66 |
| Location of Interaction in evidence | presumptive brain |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The expression of fgf17b was undetectable in MZoep mutant blastulas. |
| Target Gene | fgf17b |
| Upstream Gene | oep |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 4.66 |
| Location of Interaction in evidence | YSL |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The expression of fgf17b was undetectable in MZoep mutant blastulas, but detected at a markedly reduced level during the segmentation period. |
| Target Gene | fgf17b |
| Upstream Gene | oep |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 4.66 |
| Location of Interaction in evidence | YSL |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | activation of the FGF/ERK pathway disrupts endoderm formation in the embryo and antagonizes the ability of an activated form of Tar/Acvr1b to induce endoderm at the animal pole. |
| Target Gene | acvr1b |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Thierry Lepage |
| Journal | Development |
| Year | 2006 |
| Vol | 133 |
| Start Page | 2189 |
| Evidence for Interaction | Injection with 1pg sqt or 10 pg of fgf17b mRNA caused ectopic expression of spr2. |
| Target Gene | sp5l |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 6078 |
| Evidence for Interaction | Injection with 1pg sqt or 10 pg of fgf17b mRNA caused ectopic expression of spr2. |
| Target Gene | sp5l |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 6078 |
| Evidence for Interaction | Injection with 1pg sqt or 10 pg of fgf17b mRNA caused ectopic expression of spr2 |
| Target Gene | sp5l |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 6078 |
| Evidence for Interaction | The expression of follistatin (fst) was enhanced on the dorsal side of the fgf17b injected late gastrulae. |
| Target Gene | fst |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The expression of fst, another dorsal marker, was also enhanced on the dorsal side of the injected late gastrulae. |
| Target Gene | fst |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | After injection of fgf17b, ntl expression was enhanced in the blastodermal margin during gastrulation. |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The results showed that after injection, ntl expression was enhanced in the blastodermal margin during gastrulation and induced in the other areas of the blastoderm at a lower level, indicating a role of fgf17b in mesoderm induction. |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | Injection with 10 pg of fgf17b mRNA resulted in great expansion of ntl expression at the shield stage in 97.6% (n = 42) of the injected embryos. |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The fgf17b overexpression (10 pg) induced chd at the shield stage. |
| Target Gene | chordin |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | Fgf17b overexpression enhanced chd at the shield stage. |
| Target Gene | chordin |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | Fgf17 overexpression (10 pg) inhibited eve1 at the shield stage. |
| Target Gene | eve1 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | After injection of fgf17b, ntl expression was enhanced in the blastodermal margin during gastrulation. |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The results showed that after injection, ntl expression was enhanced in the blastodermal margin during gastrulation and induced in the other areas of the blastoderm at a lower level, indicating a role of fgf17b in mesoderm induction. |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | Injection with 10 pg of fgf17b mRNA resulted in great expansion of ntl expression at the shield stage in 97.6% (n = 42) of the injected embryos. |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | After injection of fgf17b, ntl expression was enhanced in the blastodermal margin during gastrulation. |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | epiblast |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The results showed that after injection, ntl expression was enhanced in the blastodermal margin during gastrulation and induced in the other areas of the blastoderm at a lower level, indicating a role of fgf17b in mesoderm induction. |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | epiblast |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | Injection with 10 pg of fgf17b mRNA resulted in great expansion of ntl expression at the shield stage in 97.6% (n = 42) of the injected embryos. |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | epiblast |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | gata2 showed remarkable reduction of expression on the ventral side of the fgf17b injected embryos. |
| Target Gene | gata2 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | ectoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | gata2 expression showed remarkable reduction of expression on the ventral side of the fgf17b mRNA injected embryos. |
| Target Gene | gata2 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | ectoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | Injection with 10 pg fgf17b mRNA caused expansion of ntl expression in the axial mesoderm of most of the embryos. |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | epiblast |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 6078 |
| Evidence for Interaction | Injection with 10 pg fgf17b mRNA caused expansion of ntl expression in the axial mesoderm of most of the embryos |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | epiblast |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 6078 |
| Evidence for Interaction | Injection with 10 pg fgf17b mRNA caused expansion of ntl expression in the axial mesoderm of most of the embryos. |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 6078 |
| Evidence for Interaction | Injection with 10 pg fgf17b mRNA caused expansion of ntl expression in the axial mesoderm of most of the embryos |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 6078 |
| Evidence for Interaction | bmp2a showed remarkable reduction of expression on the ventral side of the fgf17b injected embryos |
| Target Gene | bmp2a |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | Bmp4 showed remarkable reduction of expression on the ventral side of the FGF17b mRNA injected embryos. |
| Target Gene | bmp4 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | bmp4 showed remarkable reduction of expression on the ventral side of the fgf17b injected embryos. |
| Target Gene | bmp4 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | eve1 showed remarkable reduction of expression on the ventral side of the Fgf17b injected embryos. |
| Target Gene | eve1 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | eve1 showed remarkable reduction of expression on the ventral side of the fgf17b injected embryos. |
| Target Gene | eve1 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | Injection with 10 pg fgf17b mRNA caused expansion of ntl expression in the axial mesoderm of most of the embryos. |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 6078 |
| Evidence for Interaction | Injection with 10 pg fgf17b mRNA caused expansion of ntl expression in the axial mesoderm of most of the embryos |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 6078 |
| Evidence for Interaction | Injection with 1pg sqt or 10 pg of fgf17b mRNA caused ectopic expression of spr2 |
| Target Gene | sp5l |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 6078 |
| Evidence for Interaction | Bmp4 showed remarkable reduction of expression on the ventral side of the FGF17b mRNA injected embryos. |
| Target Gene | bmp4 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | bmp4 showed remarkable reduction of expression on the ventral side of the fgf17b injected embryos. |
| Target Gene | bmp4 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | eve1 showed remarkable reduction of expression on the ventral side of the Fgf17b injected embryos. |
| Target Gene | eve1 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | eve1 showed remarkable reduction of expression on the ventral side of the fgf17b injected embryos. |
| Target Gene | eve1 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | gata2 showed remarkable reduction of expression on the ventral side of the fgf17b injected embryos. |
| Target Gene | gata2 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | gata2 expression showed remarkable reduction of expression on the ventral side of the fgf17b mRNA injected embryos. |
| Target Gene | gata2 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | Injection with 10 pg fgf17b mRNA caused expansion of ntl expression in the axial mesoderm of most of the embryos. |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 6078 |
| Evidence for Interaction | Injection with 10 pg fgf17b mRNA caused expansion of ntl expression in the axial mesoderm of most of the embryos |
| Target Gene | ntl |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 6078 |
| Evidence for Interaction | Injection with 1pg sqt or 10 pg of fgf17b mRNA caused ectopic expression of spr2 |
| Target Gene | sp5l |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | The EMBO Journal |
| Year | 2003 |
| Vol | 22 |
| Start Page | 6078 |
| Evidence for Interaction | The expression of the posterior neuroectodermal marker hoxb1b was expanded by overexpression of any of the tested Fgf17b mRNAs. |
| Target Gene | hoxb1b |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 9 |
| Location of Interaction in evidence | ectoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | overexpression of fgf17b caused the expression domain of the anterior neural marker otx1 to shrink substantially. |
| Target Gene | otx1 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 9 |
| Location of Interaction in evidence | ectoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | During late gastrulation, otx1 was expressed as a large anterodorsal domain. This domain decreased markedly in size in all of the embryos injected with fgf17b mRNA. |
| Target Gene | otx1 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 9 |
| Location of Interaction in evidence | ectoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | When the dose (10 pg) was applied, overexpression of fgf17b caused the expression domain of the anterior neural marker otx1 to shrink substantially. |
| Target Gene | otx1 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 9 |
| Location of Interaction in evidence | ectoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The expression of hoxb1b expanded toward the animal pole in all the fgf17b injected embryos. |
| Target Gene | hoxb1b |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 9 |
| Location of Interaction in evidence | neuroectoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The expression of the posterior neuroectodermal marker hoxb1b was expanded by overexpression of any of the tested Fgf17b mRNAs. |
| Target Gene | hoxb1b |
| Upstream Gene | fgf17b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 9 |
| Location of Interaction in evidence | neuroectoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | triple knockdown of fgf8, Fgf17b and fgf24 resulted in a large increase in the number of endodermal precursors that formed. |
| Target Gene | sox17 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | MASO |
| Time of Interaction in evidence | 10 |
| Location of Interaction in evidence | endoderm |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Thierry Lepage |
| Journal | Development |
| Year | 2006 |
| Vol | 133 |
| Start Page | 2189 |
| Evidence for Interaction | triple knockdown of fgf8, Fgf17b and fgf24 resulted in a large increase in the number of endodermal precursors that formed. |
| Target Gene | sox17 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | MASO |
| Time of Interaction in evidence | 10 |
| Location of Interaction in evidence | endoderm |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Thierry Lepage |
| Journal | Development |
| Year | 2006 |
| Vol | 133 |
| Start Page | 2189 |
| Evidence for Interaction | The expression of fgf17b was undetectable in MZoep mutant blastulas, but detected at a markedly reduced level during the segmentation period. |
| Target Gene | fgf17b |
| Upstream Gene | oep |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 11.66 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The expression of fgf17b was undetectable in MZoep mutant blastulas, but detected at a markedly reduced level during the segmentation period. |
| Target Gene | fgf17b |
| Upstream Gene | oep |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 11.66 |
| Location of Interaction in evidence | presumptive brain |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | 27 genes that are expressed in the dorsal margin in wild type, but lack margin expression in MZoep mutants. |
| Target Gene | fgf17b |
| Upstream Gene | oep |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 5.25 |
| Location of Interaction in evidence | blastomere |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Schier, A. F. |
| Journal | Dev Biol |
| Year | 2007 |
| Vol | 304 |
| Start Page | 525 |