| eve1 | Stage | Hours | ZFIN expression range | margin | epiblast | hypoblast | mesoderm | ventral mesoderm | tail bud | tail | pharyngeal arch 3-7 skeleton | tooth 4V | whole organism | unspecified |
| Zygote | 1-cell | 0 | ||||||||||||
| Cleavage | 2-cell | 0.75 | ||||||||||||
| 4-cell | 1.0 | |||||||||||||
| 8-cell | 1.25 | |||||||||||||
| 16-cell | 1.5 | |||||||||||||
| 32-cell | 1.75 | |||||||||||||
| 64-cell | 2.0 | |||||||||||||
| Blastula | 124-cell | 2.25 | ||||||||||||
| 256-cell | 2.5 | |||||||||||||
| 512-cell | 2.75 | |||||||||||||
| 1k-cell | 3.0 | X | ||||||||||||
| High | 3.33 | |||||||||||||
| Oblong | 3.66 | |||||||||||||
| Sphere | 4.0 | |||||||||||||
| Dome | 4.33 | |||||||||||||
| 30% epiboly | 4.66 | |||||||||||||
| Gastrula | 50%-epiboly | 5.25 | ||||||||||||
| Germ-ring | 5.66 | I | ||||||||||||
| Shield | 6.0 | X | ||||||||||||
| 75% epiboly stage | 8.0 | I | ||||||||||||
| 90% epiboly | 9.0 | ! | ||||||||||||
| bud stage | 10.0 | |||||||||||||
| Segmentation | 1-4 somites | 10.33 | I | |||||||||||
| 5-9 somites | 11.66 | I | ||||||||||||
| 10-13 somites | 14.0 | I | ||||||||||||
| 14-19 somites | 16.0 | I | ||||||||||||
| 20-25 somites | 19.0 | I | I | |||||||||||
| 26+ somites | 22.0 | I | I | |||||||||||
| Pharyngula | Prim-5 | 24.0 | I | |||||||||||
| Prim-15 | 30.0 | |||||||||||||
| Prim-25 | 36.0 | |||||||||||||
| High-pec | 42.0 | |||||||||||||
| Hatching | Long-pec | 48.0 | X | |||||||||||
| Pec-fin | 60.0 | ?-I |
| Evidence for Interaction | All non-axial-mesoderm markers (eve1, cdx4, tbx6, tbx24, and ved) are strongly reduced or absent in wnt8; bmp2b double mutants |
| Target Gene | eve1 |
| Upstream Gene | wnt8 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Lekven, A.C. |
| Journal | Dev. Biol. |
| Year | 2005 |
| Vol | 287(2) |
| Start Page | 237 |
| Evidence for Interaction | Injection with 4 ng of chd-MO led to expansion of eve1. |
| Target Gene | eve1 |
| Upstream Gene | chordin |
| Interaction Type | repress |
| Altered model | MASO |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | Injection with 4 ng of chd-MO led to expansion of eve1 expression. |
| Target Gene | eve1 |
| Upstream Gene | chordin |
| Interaction Type | repress |
| Altered model | MASO |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 3 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | In homozygous bozm168 mutant embryos at 7 hpf, the eve1 expression domain extends into the dorsal region of the embryo. |
| Target Gene | eve1 |
| Upstream Gene | dharma |
| Interaction Type | repress |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Developmental Biology |
| Year | 1999 |
| Vol | 215 |
| Start Page | 190 |
| Evidence for Interaction | In homozygous bozm168 mutant embryos at 7 hpf, the eve1 expression domain extends into the dorsal region of the embryo. |
| Target Gene | eve1 |
| Upstream Gene | dharma |
| Interaction Type | repress |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Developmental Biology |
| Year | 1999 |
| Vol | 215 |
| Start Page | 190 |
| Evidence for Interaction | Fgf17 overexpression (10 pg) inhibited eve1 at the shield stage. |
| Target Gene | eve1 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | fgf8 overexpression (10 pg) inhibited eve1 at the shield stage. |
| Target Gene | eve1 |
| Upstream Gene | fgf8 |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | fgf8 overexpression inhibited eve1 at the shield stage. |
| Target Gene | eve1 |
| Upstream Gene | fgf8 |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | The expression of the ventral marker eve1 was prominently reduced in the zfhx1 overexpressed embryo. |
| Target Gene | eve1 |
| Upstream Gene | zfhx1 |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Naomasa Miki |
| Journal | Developmental Biology |
| Year | 2000 |
| Vol | 228 |
| Start Page | 29 |
| Evidence for Interaction | In contrast to the neuroectodermal markers, the expression of the ventral marker eve1 was prominently reduced. These results indicate that overexpression of Kheper dorsalized and neuralized the ectoderm. |
| Target Gene | eve1 |
| Upstream Gene | zfhx1 |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Naomasa Miki |
| Journal | Developmental Biology |
| Year | 2000 |
| Vol | 228 |
| Start Page | 29 |
| Evidence for Interaction | Both bmp2b- and bmp4-injected embryos show a significant increase of eve1 mRNA levels. |
| Target Gene | eve1 |
| Upstream Gene | bmp2b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Matthias Hammerschmidt |
| Journal | Developmental Dynamics |
| Year | 1999 |
| Vol | 216 |
| Start Page | 285 |
| Evidence for Interaction | bmp2b-injected embryos show a significant increase of eve1 mRNA levels. |
| Target Gene | eve1 |
| Upstream Gene | bmp2b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Matthias Hammerschmidt |
| Journal | Developmental Dynamics |
| Year | 1999 |
| Vol | 216 |
| Start Page | 285 |
| Evidence for Interaction | eve1 showed remarkable reduction of expression on the ventral side of the Fgf17b injected embryos. |
| Target Gene | eve1 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | eve1 showed remarkable reduction of expression on the ventral side of the fgf17b injected embryos. |
| Target Gene | eve1 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | Both bmp2b- and bmp4-injected embryos show a significant increase of eve1 mRNA levels. |
| Target Gene | eve1 |
| Upstream Gene | bmp2b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Matthias Hammerschmidt |
| Journal | Developmental Dynamics |
| Year | 1999 |
| Vol | 216 |
| Start Page | 285 |
| Evidence for Interaction | bmp2b-injected embryos show a significant increase of eve1 mRNA levels. |
| Target Gene | eve1 |
| Upstream Gene | bmp2b |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Matthias Hammerschmidt |
| Journal | Developmental Dynamics |
| Year | 1999 |
| Vol | 216 |
| Start Page | 285 |
| Evidence for Interaction | eve1 showed remarkable reduction of expression on the ventral side of the Fgf17b injected embryos. |
| Target Gene | eve1 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | eve1 showed remarkable reduction of expression on the ventral side of the fgf17b injected embryos. |
| Target Gene | eve1 |
| Upstream Gene | fgf17b |
| Interaction Type | repress |
| Altered model | overexpression |
| Time of Interaction in evidence | 8 |
| Location of Interaction in evidence | mesoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Anming Meng |
| Journal | Developmental Biology |
| Year | 2004 |
| Vol | 271 |
| Start Page | 130 |
| Evidence for Interaction | By the bud stage, many mfn mutant embryos display a reduction in eve1 expression. |
| Target Gene | eve1 |
| Upstream Gene | tll1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 10 |
| Location of Interaction in evidence | tail bud |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Mary C. Mullins |
| Journal | Development |
| Year | 1999 |
| Vol | 126 |
| Start Page | 3119 |
| Evidence for Interaction | By the bud stage, however, many mfn mutant embryos display a reduction in eve1 expression within the tail bud. |
| Target Gene | eve1 |
| Upstream Gene | tll1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 10 |
| Location of Interaction in evidence | tail bud |
| Evidence for Direct | |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Mary C. Mullins |
| Journal | Development |
| Year | 1999 |
| Vol | 126 |
| Start Page | 3119 |
| Evidence for Interaction | zebrafish recessive maternal effect mutant, ichabod, that results in severe anterior and dorsal defects during early development using in-situ hybridization. |
| Target Gene | eve1 |
| Upstream Gene | Maternal b-catenin |
| Interaction Type | repress |
| Altered model | mutant |
| Time of Interaction in evidence | 5 |
| Location of Interaction in evidence | blastomere |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Weinberg, E. S. |
| Journal | Development |
| Year | 2000 |
| Vol | 127 |
| Start Page | 3899 |
| Evidence for Interaction | By the bud stage, many mfn mutant embryos display a reduction in eve1 expression. |
| Target Gene | eve1 |
| Upstream Gene | tll1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 10 |
| Location of Interaction in evidence | tail bud |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Mary C. Mullins |
| Journal | Development |
| Year | 1999 |
| Vol | 126 |
| Start Page | 3119 |
| Evidence for Interaction | By the bud stage, however, many mfn mutant embryos display a reduction in eve1 expression within the tail bud. |
| Target Gene | eve1 |
| Upstream Gene | tll1 |
| Interaction Type | enhance |
| Altered model | mutant embryos |
| Time of Interaction in evidence | 10 |
| Location of Interaction in evidence | tail bud |
| Evidence for Direct | 1 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Mary C. Mullins |
| Journal | Development |
| Year | 1999 |
| Vol | 126 |
| Start Page | 3119 |