| eomes | Stage | Hours | ZFIN expression range | blastodisc | marginal blastomere | diencephalon | telencephalon | retina | whole organism | unspecified |
| Zygote | 1-cell | 0 | ||||||||
| Cleavage | 2-cell | 0.75 | I | |||||||
| 4-cell | 1.0 | I | ||||||||
| 8-cell | 1.25 | I | ||||||||
| 16-cell | 1.5 | I | I | I | ||||||
| 32-cell | 1.75 | I | ||||||||
| 64-cell | 2.0 | I | ||||||||
| Blastula | 124-cell | 2.25 | I | |||||||
| 256-cell | 2.5 | I | I | I | ||||||
| 512-cell | 2.75 | |||||||||
| 1k-cell | 3.0 | I | ||||||||
| High | 3.33 | I | ||||||||
| Oblong | 3.66 | I | ||||||||
| Sphere | 4.0 | |||||||||
| Dome | 4.33 | X | ||||||||
| 30% epiboly | 4.66 | X-I | ||||||||
| Gastrula | 50%-epiboly | 5.25 | X | X-I | ||||||
| Germ-ring | 5.66 | X | X-I | |||||||
| Shield | 6.0 | X | X | |||||||
| 75% epiboly stage | 8.0 | X | ||||||||
| 90% epiboly | 9.0 | X | ||||||||
| bud stage | 10.0 | X | ||||||||
| Segmentation | 1-4 somites | 10.33 | X | |||||||
| 5-9 somites | 11.66 | X | ||||||||
| 10-13 somites | 14.0 | X | ||||||||
| 14-19 somites | 16.0 | |||||||||
| 20-25 somites | 19.0 | ! | ||||||||
| 26+ somites | 22.0 | ! | I | |||||||
| Pharyngula | Prim-5 | 24.0 | ||||||||
| Prim-15 | 30.0 | I | ||||||||
| Prim-25 | 36.0 | I | ||||||||
| High-pec | 42.0 | I | ||||||||
| Hatching | Long-pec | 48.0 | I | |||||||
| Pec-fin | 60.0 | I | I | I | I | I |
| Evidence for Interaction | Coexpression of eomes with bon and gata5 had a dramatic and synergistic effect on the expression of the endodermal differentiation marker sox17. |
| Target Gene | bon |
| Upstream Gene | eomes |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 4.66 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | David Kimelman |
| Journal | Developmental Cell |
| Year | 2005 |
| Vol | 9 |
| Start Page | 523 |
| Evidence for Interaction | Coexpression of eomes with bon and gata5 had a dramatic and synergistic effect on the expression of the endodermal differentiation marker sox17, which was strongly induced in marginal as well as nonmarginal blastomeres while coexpression of eomes with eit |
| Target Gene | bon |
| Upstream Gene | eomes |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 4.66 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 4 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | David Kimelman |
| Journal | Developmental Cell |
| Year | 2005 |
| Vol | 9 |
| Start Page | 523 |
| Evidence for Interaction | Coexpression of eomes with bon and gata5 had a dramatic and synergistic effect on the expression of the endodermal differentiation marker sox17, which was strongly induced in marginal as well as nonmarginal blastomeres while coexpression of eomes with eit |
| Target Gene | gata5 |
| Upstream Gene | eomes |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 4.66 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 4 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | David Kimelman |
| Journal | Developmental Cell |
| Year | 2005 |
| Vol | 9 |
| Start Page | 523 |
| Evidence for Interaction | Ectopic expression of flh (100%, 15/15) was observed in bozmutant embryos following overexpression. |
| Target Gene | flh |
| Upstream Gene | eomes |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5503 |
| Evidence for Interaction | Ectopic expression of gsc (85%, 17/20), chd (100%, 13/13) and flh (100%, 15/15) was observed in bozmutant embryos following overexpression, which showed that nwk/dhm gene function does not appear to be required for eomes to induce expression of organizer- |
| Target Gene | flh |
| Upstream Gene | eomes |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 1, 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5503 |
| Evidence for Interaction | Ectopic expression of gsc was observed in bozmutant embryos following overexpression. |
| Target Gene | gsc |
| Upstream Gene | eomes |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5503 |
| Evidence for Interaction | Normally, gsc is expressed in cells that give rise to the prechordal plate whereas chd is expressed more broadly on the dorsal side of the embryo. Ectopic expression of gsc and chd was detected in eomes- and myc-eomes-injected embryos along the margin at |
| Target Gene | gsc |
| Upstream Gene | eomes |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5503 |
| Evidence for Interaction | Ectopic expression of gsc (85%, 17/20), chd (100%, 13/13) and flh (100%, 15/15) was observed in bozmutant embryos following overexpression, which showed that nwk/dhm gene function does not appear to be required for eomes to induce expression of organizer- |
| Target Gene | gsc |
| Upstream Gene | eomes |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | mesendoderm |
| Evidence for Direct | 1, 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5503 |
| Evidence for Interaction | Ectopic expression of chd was observed in boz mutant embryos following eomes RNA overexpression, which showed that nwk/dhm gene function does not appear to be required for eomes to induce expression of organizer-specific genes. |
| Target Gene | chordin |
| Upstream Gene | eomes |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5503 |
| Evidence for Interaction | Ectopic expression of chd was observed in boz mutant embryos following eomes RNA overexpression, which showed that nwk/dhm gene function does not appear to be required for eomes to induce expression of organizer-specific genes. |
| Target Gene | chordin |
| Upstream Gene | eomes |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5503 |
| Evidence for Interaction | Normally, gsc is expressed in cells that give rise to the prechordal plate whereas chd is expressed more broadly on the dorsal side of the embryo. Ectopic expression of gsc and chd was detected in eomes- and myc-eomes-injected embryos along the margin at |
| Target Gene | chordin |
| Upstream Gene | eomes |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5503 |
| Evidence for Interaction | Ectopic expression of chd (100%, 13/13) was observed in bozmutant embryos following overexpression. |
| Target Gene | chordin |
| Upstream Gene | eomes |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | margin |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5503 |
| Evidence for Interaction | Ectopic expression of flh (100%, 15/15) was observed in bozmutant embryos following overexpression. |
| Target Gene | flh |
| Upstream Gene | eomes |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | presumptive neural plate |
| Evidence for Direct | 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5503 |
| Evidence for Interaction | Ectopic expression of gsc (85%, 17/20), chd (100%, 13/13) and flh (100%, 15/15) was observed in bozmutant embryos following overexpression, which showed that nwk/dhm gene function does not appear to be required for eomes to induce expression of organizer- |
| Target Gene | flh |
| Upstream Gene | eomes |
| Interaction Type | enhance |
| Altered model | overexpression |
| Time of Interaction in evidence | 6 |
| Location of Interaction in evidence | presumptive neural plate |
| Evidence for Direct | 1, 2 |
| Binding Site Sequence | |
| Location of Site | |
| Last Author | Robert K. Ho |
| Journal | Development |
| Year | 2003 |
| Vol | 130 |
| Start Page | 5503 |