eng1a
Type Gene1 Effect Gene2 Sentence Perturbation methods Time of Interaction in evidence territories of interaction or Tissue Evidence for Direct Authors Journal PubYear Volume Pages MedLine Reference Connectivity # of References Found In Pathways Journal Link Journal Reference Mechanism URN ISSN Issue LocatorString MedlineTA PubMonth p-value [Evol. Bioinformatics 2007:3(197)] TextPath Title
PromoterBinding eng1a neutral fgf8a Fibroblast growth factor-8 expression is regulated by intronic engrailed and Pbx1-binding sites.









2 3 Zebrafish_Otx2_20080724


urn:agi-PromoterBinding:inout-urn:agi-llid:2019:out-urn:agi-llid:2253::unknown

digtext:http://ad.doubleclick.net/adi/neurosci.nature.com/curr_back;pos=right;issue=$!issue;lg=no;;sz=120x600;ord=1216903256229?




Expression eng1a positive fgf8a Fibroblast growth factor-8 expression is regulated by intronic engrailed and Pbx1-binding sites.









2 3 Zebrafish_Otx2_20080724


urn:agi-Expression:inout-urn:agi-llid:2019:out-urn:agi-llid:2253::positive

digtext:http://ad.doubleclick.net/adi/neurosci.nature.com/curr_back;pos=right;issue=$!issue;lg=no;;sz=120x600;ord=1216903256229?




Regulation eng1a unknown foxa2 These studies showed that foxa2 antagonized Otx2- and Engrailed-mediated activation of gene transcription (Foucher et al. 2003 and Nakano et al. 2000) and that Oct4 negatively regulated Foxd3-dependent transcription (Guo et al., 2002).









2 1 Zebrafish_FoxH1_20080728


urn:agi-Regulation:inout-urn:agi-llid:2019:out-urn:agi-llid:3170::unknown

digtext:http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=inwardhub&_urlversion=4&_method=citationSearch&_piikey=S1534580704002941&_referrer=www.ncbi.nlm.nih.gov/pubmed/15363409?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa...




Expression eng1a negative pax6a Conversely, ectopic overexpressi on of Engrailed can repress pax6 expression in the forebrain and cause a rostral expansio n of midbrainidentity ( Araki and Nakamura , 1999; Scholpp and Brand, 2001; Scholpp et al., 2003 ).









2 2 Zebrafish GRN from literatures-7-24-2008


urn:agi-Expression:inout-urn:agi-llid:2019:out-urn:agi-llid:5080::negative

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Waskiewicz-AJ-2007.pdf


url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cWaskiewicz-AJ-2007.pdf):pdf
Regulation eng1a unknown pou5f1 These studies showed that foxa2 antagonized Otx2- and Engrailed-mediated activation of gene transcription (Foucher et al. 2003 and Nakano et al. 2000) and that Oct4 negatively regulated Foxd3-dependent transcription (Guo et al., 2002).









2 1 Zebrafish_FoxH1_20080728


urn:agi-Regulation:inout-urn:agi-llid:2019:out-urn:agi-llid:5460::unknown

digtext:http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=inwardhub&_urlversion=4&_method=citationSearch&_piikey=S1534580704002941&_referrer=www.ncbi.nlm.nih.gov/pubmed/15363409?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa...




Expression eng1a negative sox17 In Xenopus, inhibition of pitx2a function using a chimeric Engrailed-pitx2a fusion suppresses sox17 expression in presumptive endoderm and blocks the response of cells to Nodal signalling.









2 7 Zebrafish_Sox32_20080724


urn:agi-Expression:inout-urn:agi-llid:2019:out-urn:agi-llid:64321::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12397099&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=12397099




Binding eng1a neutral wnt1 This suggests that a key role of Wnt-1 signalling is to maintain En expression and that this aspect of the Wnt-1/engrailed interaction has been conserved from flies to mice.



Danielian,P.S.;McMahon,A.P.
1996 383 332-4 8848044:5 2 2 Zebrafish_engrailed_20080728


urn:agi-Binding:inout-urn:agi-llid:7471:inout-urn:agi-llid:2019: 0028-0836 6598 pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])1995/01/01:1997/12/31[edat] Nature Sep

Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development.
Binding eng1a neutral wnt3l The existence of regulatory interactions between Wnt-1, Wnt-3a, and engrailed genes was also examined in this study.



Augustine,K.A.;Liu,E.T.;Sadler,T.W.
1995 51 107-19 7660319:6 2 1 Zebrafish_engrailed_20080728


urn:agi-Binding:inout-urn:agi-llid:89780:inout-urn:agi-llid:2019: 0040-3709 2 pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])1995/01/01:1997/12/31[edat] Teratology Feb

Interactions of Wnt-1 and Wnt-3a are essential for neural tube patterning.
Expression fgf4 positive eng1a Accordingly, exogenous FGF4 can induce expression of engrailed in the chick neural plate (Shamim et al., 1999).









2 5 Zebrafish_Otx2_20080724


urn:agi-Expression:inout-urn:agi-llid:2249:out-urn:agi-llid:2019::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11684654&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=11684654




Regulation gata4 negative eng1a To begin determining the roles that Gata4 and Gata6 play during pancreatic development, we expressed Gata4-Engrailed and Gata6-Engrailed dominant repressor fusion proteins in the pancreatic epithelium and in the islet.

epithelia





16887115:4 2 4 Zebrafish_gata5_20080727


urn:agi-Regulation:inout-urn:agi-llid:2626:out-urn:agi-llid:2019::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17950269&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)01372-3




Regulation gata6 negative eng1a To begin determining the roles that Gata4 and Gata6 play during pancreatic development, we expressed Gata4-Engrailed and Gata6-Engrailed dominant repressor fusion proteins in the pancreatic epithelium and in the islet.

epithelia





16887115:4 2 4 Zebrafish_gata5_20080727


urn:agi-Regulation:inout-urn:agi-llid:2627:out-urn:agi-llid:2019::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17950269&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)01372-3




Expression gdf6a negative eng1a Injection of radar-MO induced a slight expansion of en1 expression in the somites in comparison with normal embryos. MASO 28 somite 3 Hitoshi Okamoto Current Biology 2005 15 480















Expression pax2a positive eng1a Pax5 and pax8 are critically dependent on noi/pax2.1 function at the MHB. mutant embryos 26 midbrain hindbrain boundary 1 Michael Brand Development 1998 125 3049















Regulation pax2a unknown eng1a Pax2 directly regulates the Engrailed genes in the mouse MHB primordium (Song et al., 1996).









2 5 Zebrafish_Otx2_20080724


urn:agi-Regulation:inout-urn:agi-llid:5076:out-urn:agi-llid:2019::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11684654&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=11684654




Expression scube2 positive eng1a myoD expression at the eight-somite stage. Dorsal views of embryos. myoD expression is reduced in the adaxial cells of you mutants. MASO 11.66 somite 3 Hitoshi Okamoto Current Biology 2005 15 480















Expression shha positive eng1a Moreover, although lacking slow twitch muscles, ubo mutants retain the Eng expression characteristic of the Hh-dependent MFFs; and indeed ubiquitous expression of Shh in ubo embryos can elicit the ectopic expression of Eng throughout the myotome, without









2 1 Zebrafish_prdm1_20080731


urn:agi-Expression:inout-urn:agi-llid:6469:out-urn:agi-llid:2022::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15925589&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0014-4827(05)00140-0