dusp6

Type

Gene1

Effect

Gene2

Sentence

Perturbation methods

Time of Interaction in evidence

territories of interaction or Tissue

Evidence for Direct

Authors

Journal

PubYear

Volume

Pages

MedLine Reference

Connectivity

# of References

Found In Pathways

Journal Link

Journal Reference

Mechanism

URN

ISSN

Issue

LocatorString

MedlineTA

PubMonth

p-value [Evol. Bioinformatics 2007:3(197)]

TextPath

Title

Expression

dusp6

positive

bmp2b

Ectopic expression of mkp3 or mkp3::C292S can suppress or enhance, respectively, the expression of sef (il17rd) at gastrula stage.

overexpression

YSL

Igor B. Dawid

Development

2004

131

2769

Expression

dusp6

positive

bmp4

Ectopic expression of mkp3 resulted in a marked expansion of the ventral markers bmp2b at the shield stage.

MASO

5.25

margin

Igor B. Dawid

Development

2004

131

2769

Expression

dusp6

negative

chd

The expression of bmp4 was diminished in the mkp3 MO injected embryo.

MASO

5.25

margin

Igor B. Dawid

Development

2004

131

2769

Expression

dusp6

negative

ctnnb1

One possibility, that FGF signaling was required for ?-catenin-stimulation of boz, was indeed shown to be the case, as XFD and MKP3 blocked the accumulation of ?-catenin-induced boz transcript in early ichabod embryos (Fig. 8 A-D,L-Q) and MKP3 was effecti

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:1848:out-urn:agi-protfc:catenin::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16873584&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16873584

Expression

dusp6

negative

dusp6

Ectopic expression of mkp3 resulted in a marked expansion of the ventral markers bmp2b at the shield stage.

overexpression

4.66

margin

Igor B. Dawid

Development

2004

131

2769

Expression

dusp6

positive

gata1

Ectopic expression of mkp3 or mkp3::C292S can suppress or enhance, respectively, the expression of spry4 at gastrula stage.

mutant embryos

blood

Igor B. Dawid

Development

2004

131

2769

Expression

dusp6

negative

il17rd

The expression of bmp4 was diminished in the mkp3 Mo injected embryo.

mutant embryos

5.25

margin

Igor B. Dawid

Development

2004

131

2769

Regulation

dusp6

positive

mapk1

We observed a significant upregulation of ERK phosphorylation in the distal mesenchyme of limbs injected with RCAS-Mkp3 siRNA (Fig. 4s), consistent with the downregulation of endogenous Mkp3 expression.

Zebrafish_dusp6_20080728

phosphorylation

urn:agi-Regulation:inout-urn:agi-llid:1848:out-urn:agi-llid:5594::positive:phosphorylation

digtext:http://ad.doubleclick.net/adi/cellbio.nature.com/curr_back;pos=right;lg=no;;sz=120x600;ord=1217216925713?

ProtModification

dusp6

dephosphorylation

mapk1

The dusp6/MKP-3 protein is a dual-specificity phosphatase that dephosphorylates the active form of ERK, making a feedback loop to control ERK activity.

J. Biol. Chem

12759238:1

MAPK-ERK in Growth and Differentiation

http://www.jbc.org/cgi/content/full/276/34/32382

v276 i34 p32382 (2001)

dephosphorylation

urn:agi-ProtModification:inout-urn:agi-llid:1848:out-urn:agi-llid:5594::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15142973&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15142973

ProtModification

dusp6

dephosphorylation

RPS6K

Like CL100/ MKP-1, Pyst1 dephosphorylates and inactivates MAP kinase in vitro and in vivo.

egg

EMBO

8670865:3

Zebrafish_dusp6_20080728

http://emboj.oupjournals.org/cgi/content/full/18/3/664

v18 i3 p664

dephosphorylation

urn:agi-ProtModification:inout-urn:agi-llid:1848:out-urn:agi-go:0004711::unknown:dephosphorylation

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15142973&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15142973

Regulation

dusp6

positive

sox17

In agreement with this conclusion, inhibition of the FGF-ERK pathway by treatment with SU5402, or by co-injection with zebrafish MKP3, potentiated the ability of exogenous Casanova to induce sox17 (Table 4, Fig. 7J).

Zebrafish_Sox32_20080724

urn:agi-Regulation:inout-urn:agi-llid:1848:out-urn:agi-llid:64321::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16672336&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16672336

Expression

dusp6

negative

spry4

The expression of chordin was expanded in dusp6 MASO injetced embryos.

overexpression

5.25

margin

Igor B. Dawid

Development

2004

131

2769

Expression

akt2

positive

dusp6

Expression of Mkp3 is mediated by the PI(3)K/Akt pathway To investigate the regulation of Mkp3 further, we undertook in vitro analyses using 5' upstream sequences of the mouse Mkp3 locus.

Zebrafish_dusp6_20080728

urn:agi-Expression:inout-urn:agi-llid:207:out-urn:agi-llid:1848::positive

digtext:http://ad.doubleclick.net/adi/cellbio.nature.com/curr_back;pos=right;lg=no;;sz=120x600;ord=1217216925713?

Expression

ctnnb1

positive

dusp6

Furthermore, we show that mkp3 expression is initiated by maternal b -catenin activity prior to any detectable FGF/RAS/MAPK signaling.

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:1848::positive

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Igor B. Dawid 2004.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cIgor%20B.%20Dawid%202004.pdf):pdf

Expression

dusp6

negative

dusp6

Ectopic expression of mkp3 resulted in a marked expansion of the ventral markers bmp2b at the shield stage.

overexpression

4.66

margin

Igor B. Dawid

Development

2004

131

2769

Expression

fgf

neutral

dusp6

Expression of Dual Specificity Phosphatase 6 (dusp6, also known as Mkp3) is controlled by FGF signalling throughout development.

Molina,G.A.;Watkins,S.C.;Tsang,M.

2007

17553162:3

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-protfc:fibroblast%20growth%20factor:out-urn:agi-llid:1848::unknown

1471-213X

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2007/01/01:2007/06/30[edat]

BMC Dev Biol

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cIgor%20B.%20Dawid%202004.pdf):pdf

Generation of FGF reporter transgenic zebrafish and their utility in chemical screens.

Expression

fgf

positive

dusp6

We show that FGF signaling regulates Pyst1 expression in developing neural plate and limb bud by ablating and/or transplanting tissue sources of FGFs and by appalying FGF protein or a specific FGFR inhibitor (SU5402).

12814546:4

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-protfc:fibroblast%20growth%20factor:out-urn:agi-llid:1848::positive

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Igor B. Dawid 2004.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cIgor%20B.%20Dawid%202004.pdf):pdf

Expression

fgf4

positive

dusp6

To determine whether FGF4 can induce Mkp3 expression we implanted beads soaked in FGF4 into the flank tissue and monitored Mkp3 expression.

Zebrafish_dusp6_20080728

urn:agi-Expression:inout-urn:agi-llid:2249:out-urn:agi-llid:1848::positive

digtext:http://ad.doubleclick.net/adi/cellbio.nature.com/curr_back;pos=right;lg=no;;sz=120x600;ord=1217216925713?

Expression

fgf8

positive

dusp6

fgf8 overexpression induced chd at the shield stage.

overexpression dominant negative

4.66

margin

Igor B. Dawid

Development

2004

131

2769

Expression

fgf8a

neutral

dusp6

fgf8a is necessary for Mkp3 expression in vertebrate limb/fin buds.

Zebrafish_dusp6_20080728

urn:agi-Expression:inout-urn:agi-llid:2253:out-urn:agi-llid:1848::unknown

digtext:http://ad.doubleclick.net/adi/cellbio.nature.com/curr_back;pos=right;lg=no;;sz=120x600;ord=1217216925713?

Expression

fgf8a

positive

dusp6

Differences in the activation of Mkp3 transcription in the isthmus and the repression with FGF receptor inhibition suggest that fgf8a protein controls Mkp3 transcription.

egg

16111546:4

Zebrafish_dusp6_20080728

urn:agi-Expression:inout-urn:agi-llid:2253:out-urn:agi-llid:1848::positive

digtext:http://ad.doubleclick.net/adi/cellbio.nature.com/curr_back;pos=right;lg=no;;sz=120x600;ord=1217216925713?

Expression

fgfr

positive

dusp6

We show here that in mouse embryos, Fibroblast growth factor receptors (FGFRs) are required for transcription of dusp6, which encodes MKP3, an extracellular signal-regulated kinase (ERK)-specific MKP.

egg

17164422:3

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-go:0005007:out-urn:agi-llid:1848::positive

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Igor B. Dawid 2004.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cIgor%20B.%20Dawid%202004.pdf):pdf

Expression

nkd2

positive

dusp6

A summary of the regulation of canonical Wnt/?-catenin signaling by Nkd1 and Nkd2. (A) The arc of gsc expression at 50% epiboly is a result of both the positive and negative influences of canonical Wnt/?-catenin signaling. (B) Inhibiting maternal canonic

Zebrafish_wnt11_20080731

urn:agi-Expression:inout-urn:agi-llid:85409:out-urn:agi-llid:1848::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17689523&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)00792-0

Expression

nras

positive

dusp6

Expression of mkp3 is lost in the MHB (arrows) in ace , a fgf8a mutant (N), and in noi, a pax2.1 mutant (P). (Q-T) mkp3 expression is regulated by the RAS/MAPK pathway.

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-go:0003930:out-urn:agi-llid:1848::positive

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Igor B. Dawid 2004.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cIgor%20B.%20Dawid%202004.pdf):pdf

Expression

oep

positive

dusp6

Examination of myocardial gene expression reveals that Zoep mutants do not express, or express very little, nkx2.5.

mutant embryos

5.25

blastomere

Schier, A. F.

Dev Biol

2007

304

525

Expression

pax2a

positive

dusp6

The isolation of three additional zebrafish pax2/5/8 genes reported in the accompanying pape supports the latter possibility, since pax5 and pax8 are critically dependent on noi/pax2.2 function at the MHB.

mutant embryos

midbrain hindbrain boundary

Igor B. Dawid

Development

2004

131

2769

Expression

positive

dusp6

It has been documented that Mkp3 expression can also be induced directly by retinoic acid (RA) signaling in Xenopus (Mason et al., 1996; Moreno and Kintner, 2004).

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-cas:302-79-4:out-urn:agi-llid:1848::positive

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Igor B. Dawid 2004.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cIgor%20B.%20Dawid%202004.pdf):pdf

Expression

rps6ka1

positive

dusp6

The cytoplasmic retention of MAPK also occurred in cells expressing much lower amounts of MKP-3 (WT or C/S), as judged by immunofluorescence (data not shown).

EMBO

9927426:10036

Zebrafish GRN from literatures-7-24-2008

http://emboj.oupjournals.org/cgi/content/full/18/3/664

v18 i3 p664

urn:agi-Expression:inout-urn:agi-go:0004711:out-urn:agi-llid:1848::positive

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Igor B. Dawid 2004.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cIgor%20B.%20Dawid%202004.pdf):pdf

Expression

tcf7l1a

negative

dusp6

By contrast, a dominant-negative form of Tcf3 (N-tcf3), the transcriptional partner of ?-catenin, could suppress the initiation of mkp3 expression (Fig. 3N) (Kim et al., 2000; Molenaar et al., 1996).

Zebrafish_dusp6_20080728

urn:agi-Expression:inout-urn:agi-llid:6929:out-urn:agi-llid:1848::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15142973&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15142973