Expression Table

Gene Name: dmbx1 (diencephalon/mesencephalon homeobox 1 )
Description: DNA binding
Key: I = Interpolated; X = Not Detected; ? = Inconsistent data; ! = Expressed but no region
Table built from ZFIN data (http://zfin.org/zf_info/downloads.html): Tue Dec 4 14:01:03 PST 2007

dmbx1

Stage

Hours

ZFIN expression range

forebrain neural rod

midbrain neural rod

eye

diencephalon

epiphysis

hindbrain

midbrain

telencephalon

midbrain hindbrain boundary

trigeminal ganglion

cerebellum

optic tectum

caudal tuberculum

granular eminence

medulla oblongata

mesencephalic tectum

torus semicircularis

whole organism

unspecified

Zygote

1-cell

Cleavage

2-cell

0.75

4-cell

1.0

8-cell

1.25

16-cell

1.5

32-cell

1.75

64-cell

2.0

Blastula

124-cell

2.25

256-cell

2.5

512-cell

2.75

1k-cell

3.0

High

3.33

Oblong

3.66

Sphere

4.0

Dome

4.33

30% epiboly

4.66

Gastrula

50%-epiboly

5.25

Germ-ring

5.66

Shield

6.0

75% epiboly stage

8.0

90% epiboly

9.0

bud stage

10.0

Segmentation

1-4 somites

10.33

5-9 somites

11.66

10-13 somites

14.0

14-19 somites

16.0

20-25 somites

19.0

26+ somites

22.0

Pharyngula

Prim-5

24.0

Prim-15

30.0

Prim-25

36.0

High-pec

42.0

Hatching

Long-pec

48.0

Pec-fin

60.0

Literature Evidence

1. Mutant embryo and in-situ hybridization (or Q-PCR) showed the downstream target genes are affected
2. Overexpression of specific genes and in-situ hybridization (or Q-PCR) showed the downstream target genes are affected
3. Morpholino knock-down the expression of specific gene and in-situ hybridization (or Q-PCR) showed the downstream target genes are affected
4. The interaction sites of the input to downstream target genes have been identified by isolated the module and reporter assay (CAT, GFP, beta-galactosidase, leciferase or Q-PCR assay etc.)
5. The interaction sites of the input to downstream target genes have been identified by coinject the Morpholino or over-expression the genes for reporter assay (CAT, GFP, beta-galactosidase, leciferase or Q-PCR assay etc.)
6. The interaction sites of the input to downstream target genes have been identified by mutation the binding sites and reporter assay (CAT, GFP, beta-galactosidase, leciferase or Q-PCR assay etc.)

Evidence for Interaction Expression of dmbx1 is markedly expanded at early somitogenesis in the fgf8 mutant embryos at the 7- and 9-somite stage.

Target Gene dmbx1

Upstream Gene fgf8

Interaction Type repress

Altered model mutant embryos

Time of Interaction in evidence 11.66

Location of Interaction in evidence mesencephalic tectum

Evidence for Direct 1

Binding Site Sequence

Location of Site

Last Author Michael Brand

Journal Development

Year 2003

Vol 130

Start Page 6611

Evidence for Interaction Expression of dmbx1 is markedly expanded at early somitogenesis in the fgf8 mutant embryos.

Target Gene dmbx1

Upstream Gene fgf8

Interaction Type repress

Altered model mutant embryos

Time of Interaction in evidence 11.66

Location of Interaction in evidence mesencephalic tectum

Evidence for Direct 1

Binding Site Sequence

Location of Site

Last Author Michael Brand

Journal Development

Year 2002

Vol 130

Start Page 6611

Evidence for Interaction	Expression of dmbx1 is markedly expanded at early somitogenesis in the fgf8 mutant embryos at the 7- and 9-somite stage.
Target Gene	dmbx1
Upstream Gene	fgf8
Interaction Type	repress
Altered model	mutant embryos
Time of Interaction in evidence	11.66
Location of Interaction in evidence	mesencephalic tectum
Evidence for Direct	1
Binding Site Sequence
Location of Site
Last Author	Michael Brand
Journal	Development
Year	2003
Vol	130
Start Page	6611