dlx3b

Type

Gene1

Effect

Gene2

Sentence

Perturbation methods

Time of Interaction in evidence

territories of interaction or Tissue

Evidence for Direct

Authors

Journal

PubYear

Volume

Pages

MedLine Reference

Connectivity

# of References

Found In Pathways

Journal Link

Journal Reference

Mechanism

URN

ISSN

Issue

LocatorString

MedlineTA

PubMonth

p-value [Evol. Bioinformatics 2007:3(197)]

TextPath

Title

Regulation

dlx3b

negative

bmp4

In fact, in Xenopus, bmp4 activity is highly reduced in embryos injected with EnR-Dlx3hd mRNA (J.W. and K.B.A. unpublished observation).

Zebrafish_Bmp2b_20080727

urn:agi-Regulation:inout-urn:agi-llid:1747:out-urn:agi-llid:652::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15581883&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00657-8

Expression

dlx3b

positive

bmp4

Thus, we cannot rule out the possibility that dlx3b regulates bmp2b gene expression during early gastrulation.

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-llid:1747:out-urn:agi-llid:652::positive

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Kristin Bruk Artinger 2004.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cKristin%20Bruk%20Artinger%202004.pdf):pdf

Regulation

dlx3b

negative

ctnnb1

In addition, Dlx3 can antagonize Wnt/eta-catenin signaling in early development and prevent NC induction in vivo ( 54 , 55 ).

PNAS

12511599:10152

Zebrafish_Chordin_20080727

http://www.pnas.org/cgi/content/full/100/2/532

v100 i2 p532

urn:agi-Regulation:inout-urn:agi-llid:1747:out-urn:agi-llid:1499::negative

digtext:http://www.pnas.org/content/100/2/532.full

Expression

dlx3b

positive

dlx2b

Of interest, Zerucha et al. ([1997]) report that overexpression of truncated forms of dlx3b were found to result in perturbations in dlx5a expression in zebrafish and that cotransfection experiments indicate the ability of dlx3b to activate transcription

Zebrafish_dlx3b_20080728

urn:agi-Expression:inout-urn:agi-llid:1747:out-urn:agi-llid:1749::positive

digtext:http://www3.interscience.wiley.com/blank.html

Binding

dlx3b

neutral

dlx2b

This finding suggests mutually exclusive protein-DNA interactions of Msx2 and Dlx3/Dlx5 at the OC box during the transition from proliferating cells (OC not expressed) to differentiated osteoblasts (OC gene on).

Mol. Cell. Biol

15456894:10417

Zebrafish_dlx3b_20080728

http://mcb.asm.org/cgi/content/full/24/20/9248

v24 i20 p9248

urn:agi-Binding:inout-urn:agi-llid:1749:inout-urn:agi-llid:1747:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17574232&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)01042-1

0.6699

Expression

dlx3b

negative

fgf

Misexpression of fgf8a affects the expression of foxi1 and dlx3b We and others recently showed that loss of both Foxi1 and Dlx3b together ablates all indications of otic induction even in the presence of a fully functional Fgf signaling pathway [24,28].

Zebrafish_dlx3b_20080728

urn:agi-Expression:inout-urn:agi-llid:1747:out-urn:agi-protfc:fibroblast%20growth%20factor::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=17239227&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17239227

Binding

dlx3b

neutral

foxi1

To examine the interactions between foxi1 and dlx3 b/4b during the induction of the otic placode, a tightly staged expression analysis forthe otic precursor marker pax2a was performed (Fig. 4).

Evol. Bioinformatics

Zebrafish GRN from literatures-7-24-2008

http://www.la-press.com/journals.php?pa=abstract&content_id=323

urn:agi-Binding:inout-urn:agi-llid:2299:inout-urn:agi-llid:1747:

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Andreas Fritz 2004.pdf

0.9600

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cAndreas%20Fritz%202004.pdf):pdf

Expression

dlx3b

positive

pax2a

Previously, we have shown that Dlx3b is required for the correct temporal onset of pax2a expression in the preotic region (Liu et al., 2003).

Zebrafish_dlx3b_20080728

urn:agi-Expression:inout-urn:agi-llid:1747:out-urn:agi-llid:5076::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15459102&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15459102

Expression

dlx3b

positive

pax8

Foxi1 and Dlx3b function by regulating pax8 and pax2a expression, respectively, in an Fgf-dependent fashion.

Zebrafish_dlx3b_20080728

urn:agi-Expression:inout-urn:agi-llid:1747:out-urn:agi-llid:7849::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15459102&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15459102

Expression

dlx3b

negative

pax8

Thus, in the absence of dlx3 and dlx7 function, otic placode formation appaears to be blocked after initiation of pax8 transcription in the otic domain but before pax2.1 otic expression.

Zebrafish_pax8_20080730

urn:agi-Expression:inout-urn:agi-llid:1747:out-urn:agi-llid:7849::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12070088&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=12070088

Regulation

dlx3b

negative

sox9a

In addition, Dlx3 can antagonize Wnt/eta-catenin signaling in early development and prevent NC induction in vivo ( 54 , 55 ).

PNAS

12511599:10152

Zebrafish_Chordin_20080727

http://www.pnas.org/cgi/content/full/100/2/532

v100 i2 p532

urn:agi-Regulation:inout-urn:agi-llid:1747:out-urn:agi-llid:6662::negative

digtext:http://www.pnas.org/content/100/2/532.full

Expression

dlx3b

positive

sox9a

Maintenance of Sox9 expression depends on Dlx3 The distal-less related homeobox gene Dlx3 is expressed during the initial stages of sensory placode development and has been implicated in otic placode formation in the zebrafish embryo (Ekker et al., 1992;

Zebrafish_Otx2_20080724

urn:agi-Expression:inout-urn:agi-llid:1747:out-urn:agi-llid:6662::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15084460&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15084460

Expression

dlx3b

negative

sox9a

Dlx3 depletion blocks the otic expression of Sox9. (A) Injection of 30 ng of Dlx3-mo in one animal ventral blastomere at the two-cell stage reduces Sox9 otic expression (injected side, arrow).

Zebrafish_Otx2_20080724

urn:agi-Expression:inout-urn:agi-llid:1747:out-urn:agi-llid:6662::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15084460&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15084460

Expression

acvr1

positive

dlx3b

in alk8 (a type I TGFbeta receptor) MO-injected embryos, vhnf1 expression in the endoderm is significantly reduced.

mutant embryos

ectoderm

Mary C. Mullins

Development

2001

128

859

Expression

dlx1a

neutral

dlx3b

In contrast to the case for zebrafish, mouse, and Xenopus, the initial Dlx gene expressed in the chick otic placode, Dlx3, is not expressed in the ANPB.

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:1745:out-urn:agi-llid:1747::unknown

digtext:http://www3.interscience.wiley.com/blank.html

Expression

fgf

positive

dlx3b

Smaller otic vesicles after misexpression of fgf8a up to midgastrulation stages is presumably due to the effects of Fgf signaling on dorsoventral patterning that subsequently affects expression of the Foxi1 and Dlx3b expression domains.

Zebrafish_dlx3b_20080728

urn:agi-Expression:inout-urn:agi-protfc:fibroblast%20growth%20factor:out-urn:agi-llid:1747::positive

Expression

fgf8a

positive

dlx3b

Zebrafish_dlx3b_20080728

urn:agi-Expression:inout-urn:agi-llid:2253:out-urn:agi-llid:1747::positive

Expression

mef2a

negative

dlx3b

Furthermore, the expression of dlx3b is repressed by mef2ca but activated by edn1.

Zebrafish_dlx3b_20080728

urn:agi-Expression:inout-urn:agi-llid:4205:out-urn:agi-llid:1747::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17574232&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)01042-1

Expression

mef2ca

negative

dlx3b

In the dorsal arch (red), mef2c represses dlx3 expression.

Zebrafish_dlx3b_20080728

urn:agi-Expression:inout-urn:agi-llid:4208:out-urn:agi-llid:1747::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17574232&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)01042-1

Expression

neurog1

positive

dlx3b

In the future lateral region of the cranial region of tailbud stage embryos, neurogenin1 is expressed in the future trigeminal placode which overlaps with the expression of dlx3b (Figs. 9A–C; double arrow).

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:4762:out-urn:agi-llid:1747::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15581883&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00657-8

Expression

six3a

negative

dlx3b

Moreover, six3a was able to suppress the expanded expression of bmp4 and dlx3 caused by the lack of chordin function in the anterior region of co-injected embryos (Fig. 6H,L,P,T,X).

Zebrafish_Otx2_20080724

urn:agi-Expression:inout-urn:agi-llid:6496:out-urn:agi-llid:1747::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15843413&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15843413