dkk1

Type

Gene1

Effect

Gene2

Sentence

Perturbation methods

Time of Interaction in evidence

territories of interaction or Tissue

Evidence for Direct

Authors

Journal

PubYear

Volume

Pages

MedLine Reference

Connectivity

# of References

Found In Pathways

Journal Link

Journal Reference

Mechanism

URN

ISSN

Issue

LocatorString

MedlineTA

PubMonth

p-value [Evol. Bioinformatics 2007:3(197)]

TextPath

Title

Regulation

dkk1

positive

chd

However, Crescent and dkk1 also elicited expansion of the dorsal organizer (Fig. 4) (Hashimoto et al., 2000), which produces the Bmp inhibitors Chordin and Noggin 1.

Zebrafish_Bmp2b_20080727

urn:agi-Regulation:inout-urn:agi-llid:22943:out-urn:agi-llid:8646::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12736214&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=12736214

Regulation

dkk1

unknown

ctnnb1

Dickkopf-1 (dkk1 ) is a secreted protein that negatively modulates the Wnt/beta catenin pathway.

17322405:0

Zebrafish_dkk1 _20080728

urn:agi-Regulation:inout-urn:agi-llid:22943:out-urn:agi-llid:1499::unknown

Regulation

dkk1

negative

ctnnb1

Dickkopf-1 (Dkk-1) has been shown to be a potent inhibitor of Wnt/beta-catenin signaling in a variety of assays and organisms.

epithelia

Caneparo,L.;Huang,Y.L.;Staudt,N.;Tada,M.;ahr1aendt,R.;Kazanskaya,O.;Niehrs,C.;Houart,C.

PNAS

2007

465-80

11867524:0

Zebrafish_dkk1 _20080728

http://www.pnas.org/cgi/content/full/101/1/266

v101 i1 p266

urn:agi-Regulation:inout-urn:agi-llid:22943:out-urn:agi-llid:1499::negative

0890-9369

pmquery:dkk1 +and+zebrafish

Genes Dev

Feb

Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/beta catenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek.

Expression

dkk1

positive

dlx2a

Ectopic expression of dkk1 resulted in ectopic expression of Dlx2 (arrow in D) in the normally Gbx2-positive dT (A).

Zebrafish_irx3a_20080731

urn:agi-Expression:inout-urn:agi-llid:22943:out-urn:agi-llid:1746::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=14522868&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=14522868

Expression

dkk1

positive

emx1

Whereas grafts of animal pole cells from control donor embryos had no effect on the gsc /foxA3 knock-down phenotype (Figs. 7C, G and L), grafts of dkk1 expressing cells at the sphere stage strongly rescue the headless phenotype. 63% of grafted embryos di

Zebrafish_foxa3_20080731

urn:agi-Expression:inout-urn:agi-llid:22943:out-urn:agi-llid:2016::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=16364286&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(05)00812-2

Expression

dkk1

positive

fezf2

The expression of fezl was enhanced in embryos expressing the Wnt inhibitor dkk1 and reduced in embryos expressing Wnt8b.

egg

11025224:3

zebrafish_wnt8b_20080804

urn:agi-Expression:inout-urn:agi-llid:22943:out-urn:agi-llid:55079::positive

Binding

dkk1

neutral

lrp11

Mutant LRP6 binds to Wnt and Dickkopf1 (dkk1 ) but not Mesd1, and dkk1 cannot antagonize Wnt in Cd/Cd cells, resulting in hyperactivity.

egg

Cancer Res

16126904:2

Zebrafish_bmp4_20080727

http://cancerres.aacrjournals.org/cgi/content/full/64/20/7377

v64 i20 p7377

urn:agi-Binding:inout-urn:agi-llid:4040:inout-urn:agi-llid:22943:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15105373&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15105373

Binding

dkk1

neutral

lrp5

Dickkopf1 binds to the LRP5/6 Wnt co-receptor and prevents the formation of active Wnt--Frizzled--LRP5/6 receptor complexes, thus blocking the canonical Wnt--beta-catenin pathway.

Mol. Cell. Biol

11516963:1

Zebrafish_ctnnb1_20080728

http://mcb.asm.org/cgi/content/full/24/11/4757

v24 i11 p4757

urn:agi-Binding:inout-urn:agi-llid:4041:inout-urn:agi-llid:22943:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=15143170&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15143170

0.3700

Regulation

dkk1

positive

nog1

However, Crescent and dkk1 also elicited expansion of the dorsal organizer (Fig. 4) (Hashimoto et al., 2000), which produces the Bmp inhibitors Chordin and Noggin 1.

Zebrafish_Bmp2b_20080727

urn:agi-Regulation:inout-urn:agi-llid:22943:out-urn:agi-llid:9241::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12736214&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=12736214

Expression

dkk1

positive

pax8

Pax8 expression at tailbud stage in wnt8 morphants lack the otic domain.

mutant embryos

ectoderm

Bruce B. Riley

Development

2004

131

923

Expression

dkk1

positive

six3a

It appaears that the presence of dkk1 is required for the expression of six3a, but it is unknown if six3a expression, in turn, requires a distinct inducer.

Zebrafish_irx3a_20080731

urn:agi-Expression:inout-urn:agi-llid:22943:out-urn:agi-llid:6496::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=14522868&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=14522868

Expression

dkk1

negative

wnt

Dickkopf-1 also reduced basal migration, invasion, and proliferation of cytotrophoblasts, suggesting expression of endogenous Wnt ligand(s).

crypt

16565489:8

Zebrafish_dkk1 _20080728

urn:agi-Expression:inout-urn:agi-llid:22943:out-urn:agi-go:0042813::negative

Expression

bon

positive

dkk1

At 50% epiboly, dkk1 expression is seen in all marginal blastomeres in wild-type embryos. In bon–/– embryos, dkk1 expression exhibits a slight dorsal gap.

mutant embryos

5.25

blastoderm

Didier Y. R. Stainier

Development

2003

130

4989

Expression

fezf2

neutral

dkk1

The expression of fezl was enhanced in embryos expressing the Wnt inhibitor dkk1 and reduced in embryos expressing Wnt8b.

egg

11025224:3

zebrafish_wnt8b_20080804

urn:agi-Expression:inout-urn:agi-llid:55079:out-urn:agi-llid:22943::unknown

PromoterBinding

foxh1

neutral

dkk1

Whether Bon and Sur (Foxh1) bind directly to the dkk1 promoter needs to be investigated.

Zebrafish_Bon_20080727

urn:agi-PromoterBinding:inout-urn:agi-llid:8928:out-urn:agi-llid:22943::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12930774&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=12930774

Expression

msxb

neutral

dkk1

We also found that expression of msxb, a marker for the mesenchymal progenitor cells of the regeneration blastema (Poss et al., 2000b), and of shh, which is normally expressed within basal epidermal cells (Poss et al., 2000b), was lost by 72 hpa in dkk1 -

Zebrafish_Axin1_20080727

urn:agi-Expression:inout-urn:agi-llid:60343:out-urn:agi-llid:22943::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17185322&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17185322

Expression

ndr1

positive

dkk1

overexpression of sqt elicited the ectopic expression of gsc and din in the entire blastoderm at the sphere to shield stage, but did not change the expression of boz/dharma. In the sqt mutant embryos, gsc expression was not detected, but din was expressed

mutant embryos

5.25

blastoderm

Didier Y. R. Stainier

Development

2003

130

4989

Expression

oep

positive

dkk1

27 genes that are expressed in the dorsal margin in wild type, but lack margin expression in MZoep mutants.

mutant embryos

5.25

margin

Schier, A. F.

Dev Biol

2007

304

525

Expression

six3a

positive

dkk1

Furthermore, markers of the forebrain (six3), midbrain–hindbrain boundary (pax2.1), and hindbrain rhombomeres 3 and 5 (krox20) were absent in boz din mutants

overexpression

presumptive forebrain

Hirano, T.

Developmental Biology

2000

217

138

Expression

tp73

positive

dkk1

We investigated the p53-related functions of the hDkk-1 gene by studying its response to DNA damage and its modulation of apoptosis in human glioma cells.

11840333:1

Zebrafish_dkk1 _20080728

urn:agi-Expression:inout-urn:agi-llid:7161:out-urn:agi-llid:22943::positive

Expression

wnt

negative

dkk1

Wnts are antagonised by several extracellular inhibitors including the product of the dickkopf1 (dkk1 ) gene, which was identified in Xenopus embryos and is a member of a multigene family.

Wu,W.;Glinka,A.;Delius,H.;Niehrs,C.

1611-4

11137016:2

Zebrafish_ctnnb1_20080728

urn:agi-Expression:inout-urn:agi-go:0042813:out-urn:agi-llid:22943::negative

0960-9822

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2001/01/01:2001/12/31[edat]

Curr Biol

Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling.