dharma
Type Gene1 Effect Gene2 Sentence Perturbation methods Time of Interaction in evidence territories of interaction or Tissue Evidence for Direct Authors Journal PubYear Volume Pages MedLine Reference Connectivity # of References Found In Pathways Journal Link Journal Reference Mechanism URN ISSN Issue LocatorString MedlineTA PubMonth p-value [Evol. Bioinformatics 2007:3(197)] TextPath Title
Promoter Binding dharma negative bmp2b overexpression of boz, sqt or cyc is sufficient to induce chd expression. overexpression 4 YSL 4 Wolfgang Driever Development 2003 130 3639















Expression dharma positive chd overexpression of boz/dharma elicited a strong increase in the expression of gsc in the blastoderm margin at the shield stage. overexpression 5.25 margin 2 Wolfgang Driever Development 2003 130 3639















Expression dharma positive col2a1a Iinjection of mRNAs encoding the b-catenin target genes boz/dha strongly inhibited vega2 expression. mutant embryos 22 hypochord 1 Robert K. Ho Developmental Biology 1999 215 190















Expression dharma positive dharma overexpression of either En-boz or boz mRNA induced ectopic chd expression in 50% epiboly stage wild-type embryos. Thus, the En-Boz fusion protein has activities similar to wild-type Boz. overexpression 1.5 blastoderm 2 Robert K. Ho Developmental Biology 1999 215 190















Expression dharma positive emx1 The expression of ved was downregulated by the overexpression of Dha/Boz. mutant embryos 14 forebrain 1 Robert K. Ho Developmental Biology 1999 215 190















Expression dharma negative eve1 Embryos injected with 5 pg of dha/ boz RNA or 5 pg of En-dharma RNA displayed a strongly dorsalized phenotype at 24 hrs and expanded expression of gsc at the shield stage, compared with wild-type embryos . mutant embryos 6 margin 1 Robert K. Ho Developmental Biology 1999 215 190















Expression dharma positive flh In homozygous bozm168 mutant embryos, the dorsal midline expression of ntl is reduced but the ventral lateral expression is unaffected. mutant embryos 8 hypoblast 1 Robert K. Ho Developmental Biology 1999 215 190















Expression dharma positive foxa2 In wild-type embryos, ntl is expressed both in the dorsal axial mesoderm and in the involuting ventral lateral mesoderm. In homozygous bozm168 mutant embryos, the dorsal midline expression of ntl is reduced but the ventral lateral expression is unaffected mutant embryos 8 hypoblast 1 Robert K. Ho Developmental Biology 1999 215 190















Expression dharma positive gsc In the boz mutant embryos, the expression of din was detected at slightly reduced levels at the sphere stage, but was barely detectable at the shield stage. overexpression 5.25 blastoderm 2 Wolfgang Driever Development 2003 130 3639















Expression dharma positive ntl In homozygous dharma mutant embryos, tbx16 is detected in the trunk dorsal midline and the dorsal anterior expression domain is greatly reduced or absent. mutant embryos 8 mesoderm 1 Robert K. Ho Developmental Biology 1999 215 190















Expression dharma positive pax2a Injection of mRNAs encoding the b-catenin target genes boz/dha strongly inhibited vega2 expression. mutant embryos 22 ectoderm 1 Robert K. Ho Developmental Biology 1999 215 190















Expression dharma positive shha The expression of ved was downregulated by the overexpression of Dha/Boz. mutant embryos 11.66 forebrain 1 Robert K. Ho Developmental Biology 1999 215 190















Expression dharma positive tbx16 Mildly affected boz mutants exhibit a loss of eye stalk expression and a reduced midbrain–hindbrain boundary expression of paxb. In severely affected boz embryos, these anterio- neural deficiencies are enhanced to include a loss of midbrain–hindbrain expr mutant embryos 8 hypoblast 1 Robert K. Ho Developmental Biology 1999 215 190















Expression dharma negative ved gsc expression in the wild-type midgastrula is restricted to the cells of the anteriorly migrating prechordal plate. In homozygous bozm168 mutant embryos, gsc expression is reduced or absent. overexpression 6 YSL 2 Hirano, T. Mechanisms of Development 2002 118 125















Expression dharma negative vent overexpression of boz/dharma did not affect the expression of gsc and din at the sphere stage, but elicited a strong increase in the expression of these genes in the blastoderm margin at the shield stage. In the boz mutant embryos, the expression of g overexpression 6 blastoderm 2 Igor B. Dawid genesis 2000 28 58















Expression dharma negative vox gsc expression in the wild-type midgastrula is restricted to the cells of the anteriorly migrating prechordal plate. In homozygous bozm168 mutant embryos, gsc expression is reduced or absent. overexpression 6 YSL 2 Hirano, T. Mechanisms of Development 2002 118 125















Expression axin1 negative dharma Expression of din (chd) at the sphere stage was inhibited by the injection of axin RNA. overexpression 0 blastoderm 2 Hirano, T. Mechanisms of Development 2000 91 293















Expression axin2 negative dharma Expression of din (chd) at the sphere stage was inhibited by the injection of axin RNA. overexpression 1.5 blastoderm 2 Hirano, T. Mechanisms of Development 2000 91 293















Expression ctnnb1 positive dharma Injection of b-catenin RNA elicited the ectopic expression of chd at the sphere and shield stages overexpression 4 YSL 2 Hirano, T. Mechanisms of Development 2000 91 293















Promoter Binding ctnnb1 positive dharma A 1.4-kbp fragment of the dharma promoter region contains consensus sequences for Tcf/Lef binding sites. This promoter region recapitulated the Wnt-dependent and dorsal dharma expression pattern when it was fused to luciferase or GFP. overexpression 5 margin 4 Hirano, T. Dev Biol 2001 231 397















Expression dharma positive dharma overexpression of either En-boz or boz mRNA induced ectopic chd expression in 50% epiboly stage wild-type embryos. Thus, the En-Boz fusion protein has activities similar to wild-type Boz. overexpression 1.5 blastoderm 2 Robert K. Ho Developmental Biology 1999 215 190















Expression six3a positive dharma Neuroectodermal six3 and otx2 expression domains, marking the prospective forebrain and forebrain and midbrain, respectively, were expanded at the 90% epiboly stage (9 hpf) in the dkk1 RNA-injected embryos mutant embryos 10 forebrain 1 Lilianna Solnica-Krezel GENES & DEVELOPMENT 2000 14 3087















Expression ved negative dharma In ved-injected mRNA embryos, bmp2b transcription is strongly up-regulated in the marginal and ventral regions. overexpression 4.66 blastoderm 2 Hirano, T.
2002 118 125















Expression wnt8a negative dharma The hindbrain domain of fgf8 becomes evident by 75% epiboly (8 hpf) in wild-type embryos but was only weakly expressed in most wnt8 morphants even as late as 90% epiboly (9 hpf). mutant embryos 6 YSL 1 Arne C. Lekven Development 2004 131 3991