ctnnb1

Type

Gene1

Effect

Gene2

Sentence

Perturbation methods

Time of Interaction in evidence

territories of interaction or Tissue

Evidence for Direct

Authors

Journal

PubYear

Volume

Pages

MedLine Reference

Connectivity

# of References

Found In Pathways

Journal Link

Journal Reference

Mechanism

URN

ISSN

Issue

LocatorString

MedlineTA

PubMonth

p-value [Evol. Bioinformatics 2007:3(197)]

TextPath

Title

Regulation

ctnnb1

positive

ankrd6

Diversin did not inhibit axis duplication that is induced by dominant-negative GSK3eta or eta-catenin.

Genes & Dev

12183362:10084

Zebrafish_Axin2_20080727

http://www.genesdev.org/cgi/content/full/16/16/2073

v16 i16 p2073

urn:agi-Regulation:inout-urn:agi-llid:1499:out-urn:agi-llid:22881::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12183362&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=12183362

Regulation

ctnnb1

positive

Beta-catenin affects androgen receptor transcriptional activity and ligand specificity.

Mol. Cell. Biol

16428447:10722

Zebrafish_lef1_20080801

http://mcb.asm.org/cgi/content/full/26/3/929

v26 i3 p929

urn:agi-Regulation:inout-urn:agi-llid:1499:out-urn:agi-llid:367::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=14638683&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=14638683

Expression

ctnnb1

positive

axin1

This finding suggests that another mechanism by which T3 may decrease the stability of eta-catenin is enhancement of the expression of axin.

Mol. Cell. Biol

11533250:10237

AllGenes-Pathway

http://mcb.asm.org/cgi/content/full/21/19/6626

v21 i19 p6626

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:8312::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11940574&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=11940574

Regulation

ctnnb1

positive

axin2

Through analysis of gene expression profiles generated from the colon cancer cell line SW620 with reduced ?-catenin protein levels resulting from antisense oligodeoxynucleotide (ODN) transfection, we found that axin2 and hnkd are ?-catenin-induced target

Zebrafish_Axin2_20080727

urn:agi-Regulation:inout-urn:agi-llid:1499:out-urn:agi-llid:8313::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=11752446&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=11752446

Expression

ctnnb1

neutral

axin2

Analysis of the beta-catenin target genes Axin2 and Tcf-4 confirmed increased beta-catenin-dependent transcription in beta-catenin stabilized mice.

17413044:5

AllGenes-Pathway

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:8313::unknown

Expression

ctnnb1

positive

axin2

TCF binding sites in the AXIN2 promoter played a key role in the ability of beta-catenin to activate AXIN2 transcription.

Leung,J.Y.;Kolligs,F.T.;Wu,R.;Zhai,Y.;Kuick,R.;Hanash,S.;Cho,K.R.;Fearon,E.R.

Mol. Cell. Biol

2002

277

21657-65

11940574:5

AllGenes-Pathway

http://mcb.asm.org/cgi/content/full/25/11/4371

v25 i11 p4371

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:8313::positive

0021-9258

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2002/01/01:2002/12/31[edat]

J Biol Chem

Jun

Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling.

Expression

ctnnb1

negative

bmp4

zebrafish recessive maternal effect mutant, ichabod, that results in severe anterior and dorsal defects during early development using in-situ hybridization.

mutant

blastomere

Weinberg, E. S.

Development

2000

127

3899

Expression

ctnnb1

positive

bmp4

Oncogenic ?-catenin is required for bmp4 expression.

Cancer Res

12019147:10150

Zebrafish_Chordin_20080727

http://cancerres.aacrjournals.org/cgi/content/full/62/10/2744

v62 i10 p2744

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:652::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17686615&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0925-4773(07)00101-3

Expression

ctnnb1

negative

bmp4

W e suggest a molecular pathway for initiation of dorso v entral asymmetry of bmp2b expression in which b -catenin signaling acti v ates boz , which, in turn, represses bmp2b transcription in the prospecti v e organizer .

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:652::negative

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Wolfgang Driever 2003.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cWolfgang%20Driever%202003.pdf):pdf

Expression

ctnnb1

negative

bmp4

Early expression of mouse wnt8, Xwnt8, beta-catenin, or dominant-negative GSK3 induces the expression of neural-specific markers and inhibits the expression of bmp4 in Xenopus ectoderm.

Baker,J.C.;Beddington,R.S.;Harland,R.M.

1999

3149-59

10601040:1

AllGenes-Pathway

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:652::negative

0890-9369

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])1998/01/01:1999/12/31[edat]

Genes Dev

Dec

Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development.

Expression

ctnnb1

positive

ccnd1

McCormick. 1999. ?-Catenin regulates expression of cyclin D1 in colon carcinoma cells.

J. Cell Biol

15716380:10600

Zebrafish_pea3_20080801

http://www.jcb.org/cgi/content/full/168/4/633

v168 i4 p633

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:595::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12702582&db=pubmed&url=http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=12702582

Expression

ctnnb1

neutral

ccnd1

We observed that LICD significantly decreased transcription of cyclin D1, one of the beta-catenin target genes.

Kolligs,F.T.;Bommer,G.;Goke,B.

2002

131-44

17259169:11

zebrafish-36 candidates in cell location

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:595::unknown

0012-2823

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2002/01/01:2002/12/31[edat]

Digestion

Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis.

Expression

ctnnb1

positive

ccnd1

In addition, Ras, PTEN and beta-catenin appaear to modulate cyclin D1 levels.

cortex

Anna,C.H.;Iida,M.;Sills,R.C.;Devereux,T.R.

Cancer Res

2003

190

135-45

15069681:1

113

zebrafish-36 candidates in cell location

http://cancerres.aacrjournals.org/cgi/content/full/64/15/5251

v64 i15 p5251

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:595::positive

0041-008X

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2003/01/01:2003/12/31[edat]

Toxicol appal Pharmacol

Jul

Expression of potential beta-catenin targets, cyclin D1, c-Jun, c-Myc, E-cadherin, and EGFR in chemically induced hepatocellular neoplasms from B6C3F1 mice.

Expression

ctnnb1

negative

cdh1

Increasing nuclear accumulation of beta-catenin correlated with reduced membranous E-cadherin expression and nuclear p53 but not with proliferation.

Prange,W.;Breuhahn,K.;Fischer,F.;Zilkens,C.;Pietsch,T.;Petmecky,K.;Eilers,R.;Dienes,H.P.;Schirmacher,P.

2003

201

250-9

14517842:6

Zebrafish_ctnnb1_20080728

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:999::negative

0022-3417

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2003/01/01:2003/12/31[edat]

J Pathol

Oct

Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes.

Binding

ctnnb1

neutral

cdh1

Moreover, there was a significant reduction in p120 present in the E-cadherin-catenin-p120 complex.

epithelia

Mol. Biol. Cell

12438247:6

113

Zebrafish_rho_20080804

http://www.molbiolcell.org/cgi/content/full/16/9/4386

v16 i9 p4386

urn:agi-Binding:inout-urn:agi-protfc:catenin:inout-urn:agi-llid:999:

digtext:http://ad.doubleclick.net/adi/neurosci.nature.com/curr_back;pos=right;issue=$!issue;lg=no;;sz=120x600;ord=1217816327888?

Expression

ctnnb1

positive

cdx4

We found that TCF4E but not LEF1 supported beta-catenin-dependent activation of the Cdx1 promoter, whereas LEF1 specifically activated the Siamois promoter.

endoderm

EMBO

12446687:4

zebrafish-36 candidates in cell location

http://www.nature.com/emboj/journal/v23/n8/full/7600191a.html

v23 i8 p7600191

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:1044::positive

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Isaacs-HV-2005.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cIsaacs-HV-2005.pdf):pdf

Expression

ctnnb1

positive

chd

Injection of b-catenin RNA elicited the ectopic expression of chd at the sphere and shield stages.

overexpression

blastoderm

Hirano, T.

Mechanisms of Development

2000

293

Expression

ctnnb1

negative

chd

Using embryos transgenic for the TOP-GFP reporter, we show that the two zebrafish beta-catenins have different roles in the organizer and germ-ring regions of the embryo. beta-Catenin-activated transcription in the prospective organizer region specificall

egg

17686615:0

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:8646::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=16216234&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(05)00539-7

Expression

ctnnb1

neutral

chd

In both amphibians and teleosts, chordin (chd) expression in the organizer region is clearly dependent on ?-catenin.

Zebrafish_Chordin_20080727

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:8646::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17686615&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0925-4773(07)00101-3

Expression

ctnnb1

positive

chd

The fact that overexpression of the epimerase alters the pattern but does not prevent the expression of dorsal determinants, is consistent with the idea that Glce acts on D/V axis formation downstream the Wnt/?-catenin pathway that regulates chordin gene

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:8646::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=16156897&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16156897

Expression

ctnnb1

positive

cldn2

Expression of LEF-1 and beta-catenin both enhanced claudin-2 promoter activity.

Mankertz,J.;Hillenbrand,B.;Tavalali,S.;Huber,O.;Fromm,M.;Schulzke,J.D.

2004

314

1001-7

14751232:7

Zebrafish_ctnnb1_20080728

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:9075::positive

0006-291X

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2004/01/01:2004/06/30[edat]

Biochem Biophys Res Commun

Feb

Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity.

Binding

ctnnb1

neutral

ctbp1

We report that the transcriptional coactivator p300 interacts with beta-catenin in vitro and in vivo and is critical for beta-catenin-mediated neoplastic transformation. p300 synergistically activates beta-catenin/TCF transcription, and their biochemical

islet

J. Biol. Chem

11050151:3

HBx-HCC Group4-pre-cancer-L4

http://www.jbc.org/cgi/content/full/275/45/35170

v275 i45 p35170

urn:agi-Binding:inout-urn:agi-llid:2033:inout-urn:agi-llid:1499:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11751639&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=11751639

Expression

ctnnb1

positive

cyp26a1

In addition, injection of stabilized beta-catenin or dnGSK3beta into wild-type embryos induced cyp26a1 expression.

egg

16885356:6

zebrafish-36 candidates in cell location

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:1592::positive

Expression

ctnnb1

positive

dact1

The dorsalizing factors -catenin, Bozozok (Boz), Noggin (Nog), and the mesendoderminducing factor Squint (ndr1 ) are all able to induce ectopic expression of dpr1 and dpr2 .

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:51339::positive

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Waxman-JS-2005.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cWaxman-JS-2005.pdf):pdf

Expression

ctnnb1

positive

dct

Thus, ?-catenin is required for efficient activation of the DCT promoter, but dispensable for the interaction with MITF-M.

Zebrafish_lef1_20080801

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:1638::positive

digtext:http://www.nature.com/emboj/journal/v21/n11/full/7594490a.html

Expression

ctnnb1

positive

dharma

Injection of b-catenin RNA elicited the ectopic expression of chd at the sphere and shield stages

overexpression

YSL

Hirano, T.

Mechanisms of Development

2000

293

Promoter Binding

ctnnb1

positive

dharma

A 1.4-kbp fragment of the dharma promoter region contains consensus sequences for Tcf/Lef binding sites. This promoter region recapitulated the Wnt-dependent and dorsal dharma expression pattern when it was fused to luciferase or GFP.

overexpression

margin

Hirano, T.

Dev Biol

2001

231

397

Expression

ctnnb1

positive

dusp6

Furthermore, we show that mkp3 expression is initiated by maternal b -catenin activity prior to any detectable FGF/RAS/MAPK signaling.

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:1848::positive

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Igor B. Dawid 2004.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cIgor%20B.%20Dawid%202004.pdf):pdf

Binding

ctnnb1

neutral

dvl2l

After activation of the canonical WNT pathway, DVL forms a complex with Axin, apc, GSK-3?, and ?-catenin ( Huelsken and Birchmeier, 2001 ).

J. Cell Biol

110003160:11221

Zebrafish_Bmp2b_20080727

http://www.jcb.org/cgi/content/full/164/2/243

v164 i2 p243

urn:agi-Binding:inout-urn:agi-protfc:catenin:inout-urn:agi-llid:8215:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15269175&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15269175

Binding

ctnnb1

neutral

dvl2l

Dvl, Axin, eta-catenin and GSK form a complex.

Gan,X.Q.;Wang,J.Y.;Xi,Y.;Wu,Z.L.;Li,Y.P.;Li,L.

EMBO

2008

180

1087-100

10428961:10107

Zebrafish_ctnnb1_20080728

http://emboj.oupjournals.org/cgi/content/full/18/15/4233

v18 i15 p4233

urn:agi-Binding:inout-urn:agi-llid:8215:inout-urn:agi-llid:1499:

1540-8140

J Cell Biol

Mar

Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction.

Binding

ctnnb1

neutral

egfr

Using recombinant proteins we demonstrate the interaction of EGF-receptor and beta-catenin in in vitro kinase assays.

mammary

Schroeder,J.A.;Adriance,M.C.;McConnell,E.J.;Thompson,M.C.;Pockaj,B.;Gendler,S.J.

J. Cell Biol

2002

277

22692-8

7962096:4

HBx-HCC Group3-cancer-low-L3

http://www.jcb.org/cgi/content/full/141/1/287

v141 i1 p287

urn:agi-Binding:inout-urn:agi-llid:1956:inout-urn:agi-llid:1499:

0021-9258

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2002/01/01:2002/12/31[edat]

J Biol Chem

Jun

ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas.

Binding

ctnnb1

neutral

erbb2

Elucidation of the association between beta-catenin and c-erbB-2 protein prompted us to investigate whether interference with this interaction can change the invasive phenotype.

peritoneal

Schroeder,J.A.;Adriance,M.C.;McConnell,E.J.;Thompson,M.C.;Pockaj,B.;Gendler,S.J.

EMBO

2002

277

22692-8

8806677:1

HBx-HCC Group3-cancer-low-L3

http://www.nature.com/emboj/journal/v23/n8/full/7600136a.html

v23 i8 p7600136

urn:agi-Binding:inout-urn:agi-llid:2064:inout-urn:agi-llid:1499:

0021-9258

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2002/01/01:2002/12/31[edat]

J Biol Chem

Jun

ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas.

Expression

ctnnb1

negative

eve1

zebrafish recessive maternal effect mutant, ichabod, that results in severe anterior and dorsal defects during early development using in-situ hybridization.

mutant

blastomere

Weinberg, E. S.

Development

2000

127

3899

Regulation

ctnnb1

unknown

fbxw11a

Upregulation of Wnt1 resulted in beta-catenin-mediated activation of Tcf-4, leading to increased beta-TrCP1 expression and NF-kappaaB activity.

smooth muscle

14592850:7

Zebrafish_ctnnb1_20080728

urn:agi-Regulation:inout-urn:agi-llid:1499:out-urn:agi-llid:8945::unknown

Regulation

ctnnb1

positive

fbxw11a

We previously showed that oncogenic beta-catenin activates nuclear factor-kappaaB and inhibits apoptosis by up-regulating beta-transducin repeat-containing protein.

17347903:1

Zebrafish_Axin2_20080727

urn:agi-Regulation:inout-urn:agi-llid:1499:out-urn:agi-llid:8945::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=11809809&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=11809809

Expression

ctnnb1

positive

fgf

Finally, there is evidence for involvement of the Wnt/ eta -catenin pathway in regulating the expression of FGFs ( 33 ).

Endocrin. Metabol

12791601:10153

zebrafish-36 candidates in cell location

http://ajpendo.physiology.org/cgi/content/full/285/1/E1

v285 i1 pE1

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-protfc:fibroblast%20growth%20factor::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12502739&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=12502739

Expression

ctnnb1

positive

fgf20a

These findings show that Wnt/?-catenin signaling is required for initiation of fgf20a expression during regeneration.

Zebrafish_Axin1_20080727

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:26281::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17185322&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17185322

Expression

ctnnb1

positive

fgf3

In agreement with these results, ?-catenin can induce early dorsal expression of fgf3 and fgf8a in ichabod embryos, which lack expression of these genes in the early prospective dorsal domain (Tsang et al., 2004).

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:2248::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16873584&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16873584

Expression

ctnnb1

positive

fgf8a

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:2253::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16873584&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16873584

Binding

ctnnb1

neutral

fhl

Here we show specific interaction of FHL2 with beta-catenin, which requires the intact structure of FHL2 and armadillo repeats 1-9 of beta-catenin.

bone

Genes & Dev

12466281:4

HBx-HCC Group4-pre-cancer-L4

http://www.genesdev.org/cgi/content/full/18/9/1072

v18 i9 p1072

urn:agi-Binding:inout-urn:agi-llid:2274:inout-urn:agi-llid:1499:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12810597&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=12810597

Expression

ctnnb1

neutral

fn1

The Wnt/Wg signal transducer beta-catenin controls fibronectin expression.

Zebrafish_wnt5a_20080731

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:2335::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=12697065&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12697065

Expression

ctnnb1

positive

fn1

Association with beta-catenin enhances the transcriptional activity of T-cell factor-4 (TCF-4), which up-regulates the expression of fibronectin.

epithelia

Renal Phys

15578569:6

Zebrafish_ctnnb1_20080728

http://ajprenal.physiology.org/cgi/content/full/285/1/F130

v285 i1 pF130

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:2335::positive

Expression

ctnnb1

negative

gata2

zebrafish recessive maternal effect mutant, ichabod, that results in severe anterior and dorsal defects during early development using in-situ hybridization.

mutant

blastomere

Weinberg, E. S.

Development

2000

127

3899

Binding

ctnnb1

neutral

gna11

We have studied the mechanisms and consequences of interactions between the Gq and Wnt/beta-catenin pathways.

Li,G.;Iyengar,R.

2002

13254-9

12239346:1

Zebrafish_ctnnb1_20080728

urn:agi-Binding:inout-urn:agi-llid:2776:inout-urn:agi-llid:1499:

0027-8424

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2002/01/01:2002/12/31[edat]

Proc Natl Acad Sci U S A

Oct

Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferation.

Binding

ctnnb1

neutral

grip1

The beta-catenin-GRIP1 interaction represents another potential point of cross-talk between the AR and Wnt signaling pathways.

J. Biol. Chem

14638683:6

Zebrafish_ctnnb1_20080728

http://www.jbc.org/cgi/content/full/280/45/37853

v280 i45 p37853

urn:agi-Binding:inout-urn:agi-llid:23426:inout-urn:agi-llid:1499:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=14638683&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=14638683

Expression

ctnnb1

positive

gsc

Injection of b-catenin RNA elicited the ectopic expression of chd at the sphere and shield stages.

overexpression

blastoderm

Hirano, T.

Mechanisms of Development

2000

293

Regulation

ctnnb1

positive

gsc

Overexpressing beta-catenin in early zebrafish embryos induces goosecoid and ntl, ultimately leading to a duplication of a complete secondary axis.

egg

8562427:3

Zebrafish_ntl_20080801

urn:agi-Regulation:inout-urn:agi-llid:1499:out-urn:agi-llid:145258::positive

Expression

ctnnb1

positive

gsc

However, it was found that the beta-catenin pathway regulated the expression of both endogenous goosecoid, and a goosecoid promoter construct, in a cell non-autonomous manner.

10969734:4

Zebrafish_ctnnb1_20080728

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:145258::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=9889093&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(98)00009-8

Binding

ctnnb1

neutral

gsk3b

In addition, our results show a novel complex of estrogen receptor alpha, GSK3, and beta-catenin.

egg

J. Biol. Chem

15033165:6

HBx-HCC Group4-pre-cancer-L4

http://www.jbc.org/cgi/content/full/277/20/18191

v277 i20 p18191 (2002)

urn:agi-Binding:inout-urn:agi-llid:2932:inout-urn:agi-llid:1499:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11940574&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=11940574

Regulation

ctnnb1

unknown

hhex

While our data do not exclude a direct activating effect of Wnt/?-catenin on hhex expression, they reveal that Boz is a required permissivefactor to allow Wnt/?-catenin dependent activation of hhex.

Zebrafish_Bmp2b_20080727

urn:agi-Regulation:inout-urn:agi-llid:1499:out-urn:agi-llid:3087::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15581885&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00710-9

Expression

ctnnb1

positive

hhex

Results Bozozok is essential for early hhex expression Previous studies have shown that hhex lies downstream of the maternal Wnt/?-catenin pathway, as LiCl treatment and ?-catenin overexpression lead to ectopic hhex expression throughout the YSL (Ho et al

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:3087::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15581885&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00710-9

Binding

ctnnb1

neutral

hnf1a

We demonstrate that expressed Bcr is able to bind the transcription factor Tcf1 to disrupt the Tcf1/beta-catenin complex.

lymph

Blood

16442529:3

Zebrafish_ctnnb1_20080728

http://www.bloodjournal.org/cgi/content/full/106/5/1726

v106 i5 p1726

urn:agi-Binding:inout-urn:agi-llid:6927:inout-urn:agi-llid:1499:

Binding

ctnnb1

neutral

icat

We have determined the crystal structure at 2.5 A resolution of a complex between beta-catenin and ICAT, a protein that prevents the interaction between beta-catenin and Tcf/Lef family transcription factors.

Genes & Dev

12408824:2

Zebrafish_ctnnb1_20080728

http://www.genesdev.org/cgi/content/full/14/14/1741

v14 i14 p1741

urn:agi-Binding:inout-urn:agi-llid:56998:inout-urn:agi-llid:1499:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11751639&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=11751639

Binding

ctnnb1

neutral

invs

Inversin forms a complex with catenins and N-cadherin in polarized epithelial cells.

Zebrafish_lft1_20080801

urn:agi-Binding:inout-urn:agi-protfc:catenin:inout-urn:agi-llid:27130:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15716348&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15716348

Binding

ctnnb1

neutral

iqgap1

GST-Rac1 inhibited the binding of IQGAP1 to beta-catenin in a dose-dependent manner in vitro, whereas neither GDP.GST-Cdc42, GDP.

germ

J. Biol. Chem

10473551:5

Zebrafish_rho_20080804

http://www.jbc.org/cgi/content/full/277/14/12324

v277 i14 p12324

urn:agi-Binding:inout-urn:agi-llid:8826:inout-urn:agi-llid:1499:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=14519384&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0955067403001017

Expression

ctnnb1

positive

isl1

Here we demonstrate that beta-catenin is required for Isl1 expression in cardiac progenitors, directly regulating the Isl1 promoter.

17519333:2

AllGenes-Pathway

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:3670::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11159911&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=11159911

Expression

ctnnb1

positive

jun

For instance, since ?-catenin was also described to stimulate the expression of c-jun and fra-1 transcription factors ( 26 ), this could result in the activation of the AP-1 binding site observed within the akt2 promoter/enhancer.

Carcinogenesis

15888491:10175

Zebrafish_pea3_20080801

http://carcin.oxfordjournals.org/cgi/content/full/26/9/1503

v26 i9 p1503

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:3725::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12702582&db=pubmed&url=http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=12702582

Binding

ctnnb1

neutral

jun

Li Nuclear Dvl, c-Jun, {beta}-catenin, and TCF form a complex leading to stabiLization of {beta}-catenin-TCF interaction J.

Zebrafish_Bmp2b_20080727

urn:agi-Binding:inout-urn:agi-protfc:catenin:inout-urn:agi-llid:3725:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15269175&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15269175

Binding

ctnnb1

neutral

jun

Here we show that phosphorylated c-Jun interacts with the HMG-box transcription factor TCF4 to form a ternary complex containing c-Jun, TCF4 and beta-catenin.

Gan,X.Q.;Wang,J.Y.;Xi,Y.;Wu,Z.L.;Li,Y.P.;Li,L.

2008

180

1087-100

16007074:3

Zebrafish_ctnnb1_20080728

urn:agi-Binding:inout-urn:agi-llid:3725:inout-urn:agi-llid:1499:

1540-8140

J Cell Biol

Mar

Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction.

Expression

ctnnb1

positive

lef1

T-cell factor (TCF) target-gene expression is induced by accumulated beta-catenin, and is the main transforming event in these cells.

egg

J. Biol. Chem

12776180:2

Zebrafish_Axin1_20080727

http://www.jbc.org/cgi/content/full/277/3/1884

v277 i3 p1884

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-protfc:LEF::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11940574&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=11940574

Binding

ctnnb1

neutral

lef1

A number of genes have been shown to be activated by the ?-catenin/LEF complex.

J. Cell Biol

11266469:10033

137

Zebrafish GRN from literatures-7-24-2008

http://www.jcb.org/cgi/content/full/152/4/785

v152 i4 p785

urn:agi-Binding:inout-urn:agi-protfc:LEF:inout-urn:agi-protfc:catenin:

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Randall T. Moon 2001.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cRandall%20T.%20Moon%202001.pdf):pdf

Binding

ctnnb1

neutral

lef1

ICAT inhibits the interaction between beta-catenin and TCF transcription factors.

lymph

Surendran,K.;Simon,T.C.

J. Biol. Chem

2003

284

F653-62

11712074:0

462

Wnt signaling

http://www.jbc.org/cgi/content/full/279/20/20794

v279 i20 p20794

urn:agi-Binding:inout-urn:agi-protfc:LEF:inout-urn:agi-llid:1499:

0363-6127

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2002/01/01:2002/12/31[edat]

Am J Physiol Renal Physiol

Apr

url(http%3a//cgd.aacrjournals.org/cgi/reprint/8/12/1349.pdf):pdf

CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury.

Regulation

ctnnb1

positive

lef1

LEF-1-beta-cat transactivation in vitro was also repressed by inhibitor of beta-catenin and Tcf-4 (ICAT), a physiological inhibitor of Wnt/Wg signaling that interacts with ARM repeats 11 and 12, and by the nonsteroidal anti-inflammatory compound, sulindac

epithelia

J. Biol. Chem

11751639:5

Zebrafish_lef1_20080801

http://www.jbc.org/cgi/content/full/278/14/11937

v278 i14 p11937

urn:agi-Regulation:inout-urn:agi-llid:1499:out-urn:agi-llid:51176::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11751639&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=11751639

PromoterBinding

ctnnb1

neutral

lef1

Thus, these data indicate that pitx2a and ?-catenin directly interact to regulate the LEF-1 promoter.

Cell Sci

15728254:10206

Zebrafish_pitx2aa_20080801

http://jcs.biologists.org/cgi/content/full/118/6/1129

v118 i6 p1129

urn:agi-PromoterBinding:inout-urn:agi-protfc:catenin:out-urn:agi-llid:51176::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11948188&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=11948188

Expression

ctnnb1

positive

lef1

pitx2a and ?-catenin directly interact to regulate LEF-1 expression

Cell Sci

15728254:10268

cancer-from literatures

http://jcs.biologists.org/cgi/content/full/118/6/1129

v118 i6 p1129

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:51176::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11948188&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=11948188

Expression

ctnnb1

positive

lef1

We show a new mechanism where LEF-1 expression is regulated through pitx2a, LEF-1 and beta-catenin direct physical interactions.

epithelia

Genes & Dev

15728254:11

AllGenes-Pathway

http://www.genesdev.org/cgi/content/full/11/18/2359

v11 i18 p2359

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:51176::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=11335111&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0925477301003318

Binding

ctnnb1

neutral

lef1

LEF-1 forms a ternary complex with ?-catenin and Smad3 on TBE3.

Cancer Res

12591729:10116

Zebrafish_sox3_20080730

http://cancerres.aacrjournals.org/cgi/content/full/63/4/801

v63 i4 p801

urn:agi-Binding:inout-urn:agi-protfc:catenin:inout-urn:agi-llid:51176:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17050627&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17050627

Binding

ctnnb1

neutral

lef1

Cells with stabilized beta-catenin contained a constitutive beta-catenin-Lef-1 complex.

hair

Aoki,M.;Hecht,A.;Kruse,U.;Kemler,R.;Vogt,P.K.

Genes & Dev

1999

139-44

9065403:4

105

Zebrafish_Axin2_20080727

http://www.genesdev.org/cgi/content/full/11/18/2359

v11 i18 p2359

urn:agi-Binding:inout-urn:agi-llid:51176:inout-urn:agi-llid:1499:

0027-8424

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])1998/01/01:1999/12/31[edat]

Proc Natl Acad Sci U S A

Jan

Nuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoid-enhancing factor 1.

Expression

ctnnb1

positive

lim1

zebrafish recessive maternal effect mutant, ichabod, that results in severe anterior and dorsal defects during early development using in-situ hybridization.

mutant

blastomere

Weinberg, E. S.

Development

2000

127

3899

Expression

ctnnb1

positive

mmp7

Kirchner. 1999. ?-Catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer.

J. Cell Biol

15716380:10286

Zebrafish_pea3_20080801

http://www.jcb.org/cgi/content/full/168/4/633

v168 i4 p633

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:4316::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12702582&db=pubmed&url=http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=12702582

Expression

ctnnb1

neutral

mmp7

The cytoplasmic and nuclear beta-catenin expression was thus in positive correlation with the expression of MMP-7 (both P < 0.01).

lymph node

Kolligs,F.T.;Bommer,G.;Goke,B.

2002

131-44

15634446:7

Zebrafish_wnt5a_20080731

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:4316::unknown

0012-2823

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2002/01/01:2002/12/31[edat]

Digestion

Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis.

Expression

ctnnb1

positive

mmp7

Delta-beta-catenin expression markedly increased expression of MMP-2, MMP-3, MMP-7, MMP-9, MT3-MMP, and ADAMTS5.

cartilar

Mol. Biol. Cell

15760903:10

Zebrafish_ctnnb1_20080728

http://www.molbiolcell.org/cgi/content/full/17/3/1261

v17 i3 p1261

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:4316::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=12147710&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12147710

Expression

ctnnb1

positive

msxd

To address this issue, we examined the ability of beta-catenin to activate Msx2 expression in the presence of the BMP antagonist noggin.

J. Biol. Chem

14551209:10248

Zebrafish_smad1_20080729

http://www.jbc.org/cgi/content/full/278/49/48805

v278 i49 p48805

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:4488::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=14551209&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=14551209

Expression

ctnnb1

positive

myca

Expression of cyclin D1 and c-myc genes is transcriptionally activated by beta-catenin.

cortex

Gastr. Liver Phys

15921235:3

SPN -> CTNNB1 signaling pathway

http://ajpgi.physiology.org/cgi/content/full/281/5/G1279

v281 i5 pG1279

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:4609::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=10656974&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0167-4889(99)00158-5

Expression

ctnnb1

positive

myf5

Cossu The Wnt/{beta}-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis Development, September 15, 2006; 133(18): 3723 - 3732. [Abstract] [Full Text] [PDF]

Zebrafish_wnt11_20080731

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:4617::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12810597&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=12810597

Expression

ctnnb1

positive

myf5

Zygotic Wnt/beta-catenin signaling preferentially regulates the expression of Myf5 gene in the medoderm of Xenopus.

Zebrafish_myod_20080731

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:4617::positive

digtext:http://arjournals.annualreviews.org/doi/full/10.1146/annurev.cellbio.18.012502.105758

Expression

ctnnb1

positive

ndr1

Injection of b-catenin RNA elicited the ectopic expression of boz/dharma at the sphere and shield stages

overexpression

4.66

margin

Hirano, T.

Mechanisms of Development

2000

293

Expression

ctnnb1

positive

ndr1

At the onset of zygotic transcription, eta-catenin activates expression of nodal -related genes together with the homeobox genes bozozok / dharma / nieuwkoid ( bozozok ) in zebrafish, and siamois , twin in Xenopus ; these genes cooperatively promote organ

Genes & Dev

11124801:10016

AllGenes-Pathway

http://www.genesdev.org/cgi/content/full/14/24/3087

v14 i24 p3087

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:4838::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11124801&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=11124801

Expression

ctnnb1

positive

ndr2

Overexpression of ?-catenin induces cyc expression at 6 h (A), but not at 4 h (E, sphere) or 5 h (C, 40% epiboly). (G-J) Analysis of gsc expression at 5 hours in embryos from a ndr1 +/- intercross injected with ?-catenin or lacZ mRNA. ?-catenin mRNA (G),

Zebrafish_ndr1_20080801

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:54205::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12642489&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=12642489

Expression

ctnnb1

positive

ndr2

Genes & Dev

11124801:10016

AllGenes-Pathway

http://www.genesdev.org/cgi/content/full/14/24/3087

v14 i24 p3087

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:4838::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11124801&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=11124801

Expression

ctnnb1

neutral

ndrg1

However, studies of the mutant also showed that during later development, ?-catenin contributes to the expression of zygotic ndr1 at the dorsal side of the embryo, which will make it difficult to separate out the two pathways.

Zebrafish_ndr1_20080801

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:10397::unknown

digtext:http://ad.doubleclick.net/adi/nature.com/article;type=nv;artid=438926b;pos=right;issue=7070;webfo=;prod=;natco=;natcl=;subco=;chaco=;keywd=;;sz=160x600;ord=1217570453291?

Regulation

ctnnb1

positive

nkd1

It has also been established that vertebrate Nkd1 is induced by canonical Wnt/?-catenin signaling ([Ishikawa et al., 2004], [Schmidt et al., 2006], [Yan et al., 2001a] and [Yan et al., 2001b]).

Zebrafish_wnt11_20080731

urn:agi-Regulation:inout-urn:agi-llid:1499:out-urn:agi-llid:85407::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17689523&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)00792-0

Expression

ctnnb1

neutral

nkd1

These results provide further support for the notion that nkd1 expression is positively regulated by canonical Wnt/?-catenin signaling.

Zebrafish_wnt11_20080731

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:85407::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17689523&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)00792-0

Expression

ctnnb1

positive

nkd1

Activation of the canonical Wnt/?-catenin signaling pathway through overexpression of constitutively active ?-catenin induced robust expression of nkd1 in the early embryo (Fig. 2B).

Zebrafish_wnt11_20080731

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:85407::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17689523&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)00792-0

Binding

ctnnb1

neutral

nlka

Yet, like WRM-1, ?-catenin can also form trimeric complexes with TCF and Nlk, to allow phosphorylation of TCF.

J. Biol. Chem

14960582:10327

Wnt signaling

http://www.jbc.org/cgi/content/full/279/17/17232

v279 i17 p17232

urn:agi-Binding:inout-urn:agi-llid:51701:inout-urn:agi-llid:1499:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=10656974&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0167-4889(99)00158-5

Expression

ctnnb1

positive

NS1

Activation of the wnt pathway by expression of Delta N-beta-catenin increased NS1 expression and viral burst size in 293T and H1299 lung cancer cells, showing that the Tcf mutant P4 promoter can respond to wnt signals in the context of the virus.

12767988:4

Zebrafish_ctnnb1_20080728

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-protfc:NS1::positive

Expression

ctnnb1

positive

ntl

zebrafish recessive maternal effect mutant, ichabod, that results in severe anterior and dorsal defects during early development using in-situ hybridization.

mutant

blastomere

Weinberg, E. S.

Development

2000

127

3899

Expression

ctnnb1

positive

ntl

Since downregulation of E-cadherin alone is not sufficient to induce ectopic activation of T-lacZ and Brachyury expression in WT primitive streak cultures, signaling through the ?-catenin pathway is still dependent on the activity of localized Wnt signals

Zebrafish_tbx6_20080804

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:6862::positive

digtext:http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=inwardhub&_urlversion=4&_method=citationSearch&_piikey=S153458070100017X&_referrer=www.ncbi.nlm.nih.gov/pubmed/11703922?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa...

Expression

ctnnb1

positive

otx1

zebrafish recessive maternal effect mutant, ichabod, that results in severe anterior and dorsal defects during early development using in-situ hybridization.

mutant

blastomere

Weinberg, E. S.

Development

2000

127

3899

Expression

ctnnb1

positive

pea3

To establish a role for PEA3 to beta-catenin-induced COX-2, we transfected RKO cells with beta-catenin and found that beta-catenin increased PEA3 expression.

J. Biol. Chem

14976201:7

AllGenes-Pathway

http://www.jbc.org/cgi/content/full/276/23/20108

v276 i23 p20108

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:2118::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11274170&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=11274170

Binding

ctnnb1

neutral

pitx2a

This synergism results from a direct physical interaction between pitx2a and ?-catenin.

Cell Sci

15728254:10270

Zebrafish_pitx2aa_20080801

http://jcs.biologists.org/cgi/content/full/118/6/1129

v118 i6 p1129

urn:agi-Binding:inout-urn:agi-protfc:catenin:inout-urn:agi-llid:5308:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11948188&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=11948188

Expression

ctnnb1

positive

prnp

Wild-type and mutant human beta-catenin transgenes were expressed under the control of a murine PrP promoter fragment that drives high level postnatal expression in the CNS.

12460454:2

Zebrafish_ctnnb1_20080728

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:5621::positive

Binding

ctnnb1

neutral

PSeng1a

For instance, PS1 binds to beta-catenin and modulates beta-catenin signaling.

blastoderm

Uemura,K.;Kitagawa,N.;Kohno,R.;Kuzuya,A.;Kageyama,T.;Shibasaki,H.;Shimohama,S.

Pharm. Rev

2003

166-75

11504726:1

Zebrafish_ctnnb1_20080728

http://pharmrev.aspetjournals.org/cgi/content/full/54/3/469

v54 i3 p469

urn:agi-Binding:inout-urn:agi-llid:5663:inout-urn:agi-llid:1499:

0360-4012

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2003/01/01:2003/12/31[edat]

J Neurosci Res

Jul

Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling.

Regulation

ctnnb1

positive

ptgs2a

Here we show that while beta-catenin only weakly activates the COX-2 promoter, PEA3 family transcription factors are potent activators of COX-2 transcription.

epithelia

J. Biol. Chem

11274170:2

HBx-HCC 1.5M-up

http://www.jbc.org/cgi/content/full/278/21/19396

v278 i21 p19396

urn:agi-Regulation:inout-urn:agi-llid:1499:out-urn:agi-llid:5743::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11274170&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=11274170

Expression

ctnnb1

neutral

ptgs2a

The ability of ?-catenin to activate transcription in complex with other transcription factors has led to speculation that ?-catenin might directly regulate the COX-2 promoter.

Zebrafish_pea3_20080801

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:5743::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11274170&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=11274170

Expression

ctnnb1

positive

ptgs2a

This was demonstrated further by the observation that ectopic expression of transcriptionally competent beta-catenin stimulated expression of COX-2.

epithelia

J. Biol. Chem

12147254:4

HBx-HCC 1.5M-up

http://www.jbc.org/cgi/content/full/277/18/15843

v277 i18 p15843

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:5743::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11274170&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=11274170

Regulation

ctnnb1

unknown

rhoua

Since eta-catenin is downstream of Wnt-1 in the Wnt signaling pathway and can mediate transcriptional activation of Wnt-1 induced genes (Polakis 1999 ), the effect of eta-catenin on Wrch-1 expression was assessed.

Genes & Dev

11459829:10062

Zebrafish_rho_20080804

http://www.genesdev.org/cgi/content/full/15/14/1796

v15 i14 p1796

urn:agi-Regulation:inout-urn:agi-llid:1499:out-urn:agi-llid:58480::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11459829&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=11459829

Binding

ctnnb1

neutral

ruvbl1

Pontin52 binds beta-catenin in the region of Armadillo repeats 2-5 and, more importantly, also binds the TATA box binding protein.

J. Biol. Chem

9843967:4

Zebrafish_ctnnb1_20080728

http://www.jbc.org/cgi/content/full/275/42/32871

v275 i42 p32871

urn:agi-Binding:inout-urn:agi-llid:8607:inout-urn:agi-llid:1499:

Binding

ctnnb1

neutral

smad

Moreover, by using a heterogeneous promoter reporter system, we showed that this complex containing Smads/TCF4/beta-catenin complex was able to up-regulate transcription at isolated SBE or TCF sites.

J. Biol. Chem

15292219:10

Zebrafish_sox17_20080726

http://www.jbc.org/cgi/content/full/279/39/40267

v279 i39 p40267

urn:agi-Binding:inout-urn:agi-llid:1499:inout-urn:agi-go:0005075:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15680368&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00800-0

Binding

ctnnb1

neutral

smad4

Direct cross-talk between Wnts and BMP-2 was also indicated by the up-regulated interaction between beta-catenin and SMAD-4 in response to BMP-2.

J. Biol. Chem

12077113:6

HBx-HCC Group4-pre-cancer-L4

http://www.jbc.org/cgi/content/full/278/49/48805

v278 i49 p48805

urn:agi-Binding:inout-urn:agi-llid:4089:inout-urn:agi-llid:1499:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=14551209&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=14551209

Binding

ctnnb1

neutral

smarca4

Here we demonstrate an interaction between beta-catenin and Brg-1, a component of mammalian SWI/SNF and Rsc chromatin-remodelling complexes.

Blood

11532957:4

Zebrafish_Axin2_20080727

http://www.bloodjournal.org/cgi/content/full/106/1/193

v106 i1 p193

urn:agi-Binding:inout-urn:agi-llid:6597:inout-urn:agi-llid:1499:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=12711682&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12711682

Expression

ctnnb1

positive

sox17

This axial specification is mediated in part by a ?-catenin/TCF system through a pathway that involves direct VegT regulation of sox17 expression (Clements and Woodland, 2003; Engleka et al., 2003 and Zorn et al., 1999b).

Zebrafish_sox17_20080726

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:64321::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15302595&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S001216060400363X

Binding

ctnnb1

neutral

sox17

In addition, a previous study showed that Sox3 and sox17 bind to ?-catenin and inhibit Tcf/Lef-mediated signaling activity of ?-catenin (Zorn et al. 1999 ).

Genes & Dev

15132997:10038

Zebrafish_sox17_20080726

http://www.genesdev.org/cgi/content/full/18/9/1072

v18 i9 p1072

urn:agi-Binding:inout-urn:agi-llid:64321:inout-urn:agi-llid:1499:

digtext:http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=inwardhub&_urlversion=4&_method=citationSearch&_piikey=S1097276500802002&_referrer=www.ncbi.nlm.nih.gov/pubmed/10549281?ordinalpos=25&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP...

Expression

ctnnb1

positive

sox3

Chromatin immunoprecipitation identifies sox3 as a binding target of Lef1 in vivo Our analysis of proneural and neuronal markers indicating that progenitor genes may be downstream targets of lef1 gene function, and our observation that sox3 mRNA could res

Zebrafish_sox3_20080730

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:6658::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17050627&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17050627

Binding

ctnnb1

neutral

sox9a

Thus, it is likely that Sox9 binds to ?-catenin and excludes Tcf/Lef from interacting with ?-catenin.

Genes & Dev

15132997:10260

Zebrafish_sox17_20080726

http://www.genesdev.org/cgi/content/full/18/9/1072

v18 i9 p1072

urn:agi-Binding:inout-urn:agi-llid:6662:inout-urn:agi-llid:1499:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15680368&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00800-0

Expression

ctnnb1

positive

sp5

These data prompted us to test whether sp5 expression is regulated by Wnt/?-catenin signaling during gastrulation as well and whether sp5 and sp5-like have redundant functions in dorsoventral mesoderm patterning.

Zebrafish_sp5l_20080730

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:221833::positive

digtext:http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=inwardhub&_urlversion=4&_method=citationSearch&_piikey=S0960982205001065&_referrer=www.ncbi.nlm.nih.gov/pubmed/15797017?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa...

Binding

ctnnb1

neutral

sufu

A recent report suggested that murine Sufu can bind beta-catenin, export it from the nucleus, and thereby repress beta-catenin/T-cell factor (Tcf)-mediated transcription.

J. Biol. Chem

15077159:2

Zebrafish_ctnnb1_20080728

http://www.jbc.org/cgi/content/full/276/43/40113

v276 i43 p40113

urn:agi-Binding:inout-urn:agi-llid:51684:inout-urn:agi-llid:1499:

Binding

ctnnb1

neutral

tbp

In the final step of the beta-catenin-Lef/Tcf signaling pathway, nuclear beta-catenin binds pontin52-TATA binding protein and displaces Groucho-related gene or CREB-binding protein corepressors from Lef/Tcf resulting in stimulation of transcription.

J. Biol. Chem

11212302:8

HBx-HCC Group4-pre-cancer-L4

http://www.jbc.org/cgi/content/full/276/23/20436

v276 i23 p20436

urn:agi-Binding:inout-urn:agi-llid:6908:inout-urn:agi-llid:1499:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=14638683&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=14638683

Expression

ctnnb1

positive

tcf7l2

We show here that beta-catenin can directly induce transcription from the TCF4 promoter, the effect being enhanced by the p300 coactivator.

egg

Genes & Dev

15806138:3

Zebrafish_ctnnb1_20080728

http://www.genesdev.org/cgi/content/full/14/11/1319

v14 i11 p1319

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:6925::positive

Binding

ctnnb1

neutral

tcf7l2

Here we report the crystal structure of a beta-catenin-Tcf4 complex at 2.0 A resolution.

epithelia

Gan,X.Q.;Wang,J.Y.;Xi,Y.;Wu,Z.L.;Li,Y.P.;Li,L.

Mol. Cell. Biol

2008

180

1087-100

11713475:4

129

Zebrafish_Axin1_20080727

http://mcb.asm.org/cgi/content/full/20/5/1733

v20 i5 p1733

urn:agi-Binding:inout-urn:agi-llid:6925:inout-urn:agi-llid:1499:

1540-8140

digtext:http://ad.doubleclick.net/adi/genetics.nature.com/curr_back;pos=right;issue=$!issue;lg=no;;sz=120x600;ord=1217128774875?

J Cell Biol

Mar

url(http%3a//dev.biologists.org/cgi/reprint/127/24/5285.pdf):pdf

Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction.

Expression

ctnnb1

positive

tob1a

Immunoprecipitation experiments in mammalian cells revealed that the amount of HA-LEF1 coimmunoprecipitated with Flag-?-catenin decreased in the presence of the increasing amount of Myc-Tob1a (Figure 3E), although neither the Flag-?-catenin level nor the

Zebrafish_lef1_20080801

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:10140::positive

digtext:http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=inwardhub&_urlversion=4&_method=citationSearch&_piikey=S1534580706002978&_referrer=www.ncbi.nlm.nih.gov/pubmed/16890162?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa...

Binding

ctnnb1

neutral

tob1a

Tob1 binds to ?-catenin and precludes ?-catenin from binding the coactivator LEF1 (left).

Zebrafish_lef1_20080801

urn:agi-Binding:inout-urn:agi-llid:1499:inout-urn:agi-llid:10140:

Regulation

ctnnb1

unknown

tp53

Accumulation of p53 can be regulated by ?-catenin levels, and c-Myc is a known ?-catenin target gene.

Zebrafish_Axin2_20080727

urn:agi-Regulation:inout-urn:agi-llid:1499:out-urn:agi-llid:7157::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=12798297&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012160603001234

Regulation

ctnnb1

positive

tp53

Deregulated beta-catenin can cause the activation of p53, a key tumor suppressor mutated in most cancers.

Mol. Biol. Cell

15064706:2

HBx-HCC 1.5M-up

http://www.molbiolcell.org/cgi/content/full/14/7/2844

v14 i7 p2844

urn:agi-Regulation:inout-urn:agi-llid:1499:out-urn:agi-llid:7157::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=12798297&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012160603001234

Expression

ctnnb1

positive

tp53

Beta-catenin cytoplasmic accumulation seemed to drive p53 over expression already in the early stages of carcinogenesis, while nuclear beta-catenin translocation appaeared to be related to a pattern of invasion of neoplastic cells.

stroma

EMBO

12871177:5

zebrafish-36 candidates in cell location

http://emboj.oupjournals.org/cgi/content/full/18/11/3054

v18 i11 p3054

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:7157::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=12798297&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012160603001234

Expression

ctnnb1

negative

vent

In contrast, injection of b-catenin RNA elicited the ectopic expression of boz/dharma, sqt, gsc, and din at the sphere and shield stages

drug induce overexpression

blastoderm

Igor B. Dawid

genesis

2000

Expression

ctnnb1

positive

vim

In addition, the human vimentin promoter was found to be up-regulated by beta-catenin and TCF-4 cotransfection.

mammary

J. Biol. Chem

12750294:4

Zebrafish_ctnnb1_20080728

http://www.jbc.org/cgi/content/full/280/22/21036

v280 i22 p21036

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:7431::positive

Expression

ctnnb1

neutral

wnt

Cytosolic f3-catenin levels are strongly elevated in cells expressing Wnt-i , Wnt-2, Wnt-3, and Wnt-3a but not in those expressing other Wnts.

Zebrafish_wnt5a_20080731

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-go:0042813::unknown

digtext:http://cgd.aacrjournals.org/cgi/reprint/8/12/1349.pdf

url(http%3a//cgd.aacrjournals.org/cgi/reprint/8/12/1349.pdf):pdf

Expression

ctnnb1

positive

wnt

beta-Catenin acts as a downstream transcriptional activator of the Wingless-Wnt signaling pathway.

mesoderm

Genes & Dev

11012986:0

zebrafish-36 candidates in cell location

http://www.genesdev.org/cgi/content/full/11/24/3286

v11 i24 p3286

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-go:0042813::positive

Expression

ctnnb1

negative

wnt

LZIC is closely related to ICAT, a physiological inhibitor of the Wnt pathway that interacts physically and functionally with beta-catenin to prevent the transcription of Wnt target genes.

Clements,W.K.;Kimelman,D.

2005

283

322-34

15932753:4

zebrafish-36 candidates in cell location

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-go:0042813::negative

0012-1606

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2005/01/01:2005/06/30[edat]

Dev Biol

Jul

LZIC regulates neuronal survival during zebrafish development.

Binding

ctnnb1

neutral

wnt

We have studied the mechanisms and consequences of interactions between the Gq and Wnt/beta-catenin pathways.

Genes & Dev

12239346:1

Zebrafish_ctnnb1_20080728

http://www.genesdev.org/cgi/content/full/17/16/1963

v17 i16 p1963

urn:agi-Binding:inout-urn:agi-llid:1499:inout-urn:agi-go:0042813:

Expression

ctnnb1

neutral

wnt1

Genes & Dev

11459829:10062

AllGenes-Pathway

http://www.genesdev.org/cgi/content/full/15/14/1796

v15 i14 p1796

urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:7471::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11459829&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=11459829

Expression

ctnnb1

neutral

wnt5b

Because we find that expression of wnt5b is regulated by Wnt/?-catenin signaling, we hypothesize that these separate Wnt pathways establish a negative feedback loop whose function might be to ensure proper levels, duration or location of ?-catenin signali

Zebrafish_Axin1_20080727

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:81029::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17185322&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17185322

Expression

ctnnb1

positive

wnt5b

We propose that injury of the tail fin activates as yet unknown signals that result in upregulation of wnt10a and wnt5b. wnt5b expression is also regulated by Wnt/?-catenin signaling activated by wnt10a.

Zebrafish_Axin1_20080727

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:81029::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17185322&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17185322

Regulation

btg2

positive

ccnb1

On the other hand, TIS21 inhibits degradations of cyclin A and cyclin B1 at G2/M phase, and directly binds to Cdc2, resulting in the failure of mitotic exit and then increasing the tumor cell death, when stimulated by high concentration of EGF.

J. Biol. Chem

16456675:10

Zebrafish_delta_20080728

http://www.jbc.org/cgi/content/full/280/22/21256

v280 i22 p21256

urn:agi-Regulation:inout-urn:agi-llid:7832:out-urn:agi-llid:891::positive