crx
Type Gene1 Effect Gene2 Sentence Perturbation methods Time of Interaction in evidence territories of interaction or Tissue Evidence for Direct Authors Journal PubYear Volume Pages MedLine Reference Connectivity # of References Found In Pathways Journal Link Journal Reference Mechanism URN ISSN Issue LocatorString MedlineTA PubMonth p-value [Evol. Bioinformatics 2007:3(197)] TextPath Title
PromoterBinding crx neutral bat1 In the rod opsin proximal promoter region (RPPR) of zebrafish (Danio rerio), the BAT 1 regulatory region contains highly conserved OTX (GATTA) and OTX-like (TATTA) sequences that can be recognized by the mammalian cone-rod homeobox (CRX) protein.

retina





15964232:1 2 2 Zebrafish_Crx_20080727


urn:agi-PromoterBinding:inout-urn:agi-llid:1406:out-urn:agi-llid:7919::unknown

digtext:http://www.ncbi.nlm.nih.gov/pubmed/15964232?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum




Expression crx positive gnat1 In crx morphants, the expression of otx2 in the retina was patchy at 48 hpf, but at 55 and 72 hpf, otx2 expression levels were increased compared to controls. MASO 72 neuroectoderm 3 Pamela A. Raymond Developmental Biology 2004 269 237















Expression crx positive gnat2 In crx morphants, the expression of otx2 in the retina was patchy at 48 hpf, but at 55 and 72 hpf, otx2 expression levels were increased compared to controls. MASO 72 neuroectoderm 3 Pamela A. Raymond Developmental Biology 2004 269 237















Expression crx neutral gngt1 Both Crx and Otx5 bind to the same consensus sequence, suggesting that one or both of these transcription factors may be involved in regulating the expression of gngT1.









2 3 Zebrafish_Crx_20080727


urn:agi-Expression:inout-urn:agi-llid:1406:out-urn:agi-llid:2792::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17306630&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S1567-133X(07)00005-1




Expression crx positive gngt1 Collectively, our results (Fig. 7 and Fig. 8) demonstrate that Otx5 is more important for regulating gngT1 expression in the pineal gland, whereas Crx is more important for regulating gngT1 expression in the retina.









2 3 Zebrafish_Crx_20080727


urn:agi-Expression:inout-urn:agi-llid:1406:out-urn:agi-llid:2792::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17306630&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S1567-133X(07)00005-1




Binding crx neutral neurod In addition, neuroD and the cone-rod homeobox gene Crx are coexpressed in nascent cones and putative cone progenitors, suggesting that neuroD may interact with Crx within developing photoreceptors.




Evol. Bioinformatics



2 2 Zebrafish_Crx_20080727 http://www.la-press.com/journals.php?pa=abstract&content_id=323

urn:agi-Binding:inout-urn:agi-llid:4760:inout-urn:agi-llid:1406:

digtext:http://www3.interscience.wiley.com/blank.html

0.9953

Binding crx neutral nr2e3 Immunoprecipitation assays confirmed this Nr2e3-Crx interaction and identified the DNA-binding domain of each protein as the interaction motif.

retina





15689355:3 2 4 Zebrafish GRN from literatures-7-24-2008


urn:agi-Binding:inout-urn:agi-llid:1406:inout-urn:agi-llid:10002:

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Gothilf-Y-2006a.pdf


url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cGothilf-Y-2006a.pdf):pdf
Expression crx positive opn1mw1 with a lower dose cocktail of crx MO1 plus MO2, otx5 expression was down-regulated in the retina, but not totally abolished, although the pineal expression was unaffected. MASO 72 neuroectoderm 3 Pamela A. Raymond Developmental Biology 2004 269 237















Expression crx positive opn1sw1 In crx morphants, the expansion of the vsx1 expression domain was delayed. At 48 hpf, only the nasal half of the retina expressed vsx1, and the levels were reduced (Fig. 8D), but again as expected, the hindbrain expression domain was not altered by crx MO MASO 72 neuroectoderm 3 Pamela A. Raymond Developmental Biology 2004 269 237















Expression crx positive opn1sw2 In crx morphants, the expansion of the vsx1 expression domain was delayed. MASO 72 neuroectoderm 3 Pamela A. Raymond Developmental Biology 2004 269 237















Expression crx positive opsin Like mammalian Crx and zebrafish crx , XOtx5b can activate the opsin promoter , and over-expression of XOtx5b in retinal progenitors promotes photorecept or cell fate (V iczian et al., 2003) .









2 5 Zebrafish GRN from literatures-7-24-2008


urn:agi-Expression:inout-urn:agi-llid:1406:out-urn:agi-go:0015053::positive

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Pamela A. Raymond 2004.pdf


url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cPamela%20A.%20Raymond%202004.pdf):pdf
Expression crx positive otx2 In crx morphants, expression of gnat1 was reduced in the retina, but not in the pineal. MASO 48 forebrain 3 Pamela A. Raymond Developmental Biology 2004 269 237















Expression crx positive otx5 Expression of opn1sw1 was blocked in the crx morphants. MASO 48 neuroectoderm 3 Pamela A. Raymond Developmental Biology 2004 269 237















Expression crx positive rho In crx morphants, the expansion of the vsx1 expression domain was delayed. MASO 72 neuroectoderm
Pamela A. Raymond Developmental Biology 2004 269 237















Regulation crx unknown sag In mammals, there is no evidence that IRBP is regulated by Crx in the retina or pineal gland, and in both mouse and humans IRBP expression is detected before the onset of Crx expression at E10.5 in mouse and 10.5 weeks postconception in humans (Bibb et al









2 2 Zebrafish_Crx_20080727


urn:agi-Regulation:inout-urn:agi-llid:1406:out-urn:agi-llid:6295::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15081370&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012160604000880




Expression crx positive vsx1 Similar to rho and irbp, in crx morphants, expression of gnat1 was reduced in the retina, but not in the pineal. gnat2 is expressed in cones throughout the retina and in the pineal at 72 hpf, but in crx morphants, only a small ventral–nasal patch of retin MASO 48 hindbrain
Pamela A. Raymond Developmental Biology 2004 269 237















Expression otx2 positive crx The onset of expression of Crx lags behind that of Otx2 consistent with evidence that Otx2 activates Crx transcription.

ganglion





17467693:6 2 2 AllGenes-Pathway


urn:agi-Expression:inout-urn:agi-llid:5015:out-urn:agi-llid:1406::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=16539743&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16539743




Expression otx5 positive crx Injecting an MO against otx5 reduces expression of crx in the retina in a dose-dependent manner, showing that there is an unexpected crossregulatory interaction between the two otx-related genes in this tissue. MASO 48 neuroectoderm
Jennifer O. Liang nature genetics 2001 30 117