| col2a1a | |||||||||||||||||||||||||||||
| Type | Gene1 | Effect | Gene2 | Sentence | Perturbation methods | Time of Interaction in evidence | territories of interaction or Tissue | Evidence for Direct | Authors | Journal | PubYear | Volume | Pages | MedLine Reference | Connectivity | # of References | Found In Pathways | Journal Link | Journal Reference | Mechanism | URN | ISSN | Issue | LocatorString | MedlineTA | PubMonth | p-value [Evol. Bioinformatics 2007:3(197)] | TextPath | Title |
| Binding | col2a1a | neutral | msxd | In mammals, Bmp2, Msx2, Sox9, Col2a1, Runx2 and Col1a1 interact in the developmental pathway leading from neural crest to cartilage and bone (Healy et al., 1999; Mori-Akiyama et al., 2003; Takahashi et al., 2001). | 2 | 1 | Zebrafish_crestin_20080727 | urn:agi-Binding:inout-urn:agi-llid:4488:inout-urn:agi-llid:1280: | digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15689370&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15689370 | ||||||||||||||||||||
| Binding | col2a1a | neutral | runx2a | In mammals, Bmp2, Msx2, Sox9, Col2a1, Runx2 and Col1a1 interact in the developmental pathway leading from neural crest to cartilage and bone (Healy et al., 1999; Mori-Akiyama et al., 2003; Takahashi et al., 2001). | Evol. Bioinformatics | 2 | 2 | Zebrafish_crestin_20080727 | http://www.la-press.com/journals.php?pa=abstract&content_id=323 | urn:agi-Binding:inout-urn:agi-llid:860:inout-urn:agi-llid:1280: | digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15689370&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15689370 | 0.9200 | |||||||||||||||||
| Regulation | col2a1a | positive | sox9a | SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro a1(II) collagen gene. | Genes & Dev | 14871928:10442 | 2 | 6 | Zebrafish_crestin_20080727 | http://www.genesdev.org/cgi/content/full/18/3/290 | v18 i3 p290 | urn:agi-Regulation:inout-urn:agi-llid:1280:out-urn:agi-llid:6662::positive | digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15689370&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15689370 | ||||||||||||||||
| Binding | col2a1a | neutral | sox9a | In mammals, Bmp2, Msx2, Sox9, Col2a1, Runx2 and Col1a1 interact in the developmental pathway leading from neural crest to cartilage and bone (Healy et al., 1999; Mori-Akiyama et al., 2003; Takahashi et al., 2001). | 2 | 1 | Zebrafish_crestin_20080727 | urn:agi-Binding:inout-urn:agi-llid:6662:inout-urn:agi-llid:1280: | digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15689370&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15689370 | ||||||||||||||||||||
| Binding | bmp2a | neutral | col2a1a | In mammals, Bmp2, Msx2, Sox9, Col2a1, Runx2 and Col1a1 interact in the developmental pathway leading from neural crest to cartilage and bone (Healy et al., 1999; Mori-Akiyama et al., 2003; Takahashi et al., 2001). | Evol. Bioinformatics | 10085302 | 2 | 3 | Zebrafish_crestin_20080727 | http://www.la-press.com/journals.php?pa=abstract&content_id=323 | urn:agi-Binding:inout-urn:agi-llid:650:inout-urn:agi-llid:1280: | digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15689370&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15689370 | 0.9200 | ||||||||||||||||
| Binding | col1a1 | neutral | col2a1a | In mammals, Bmp2, Msx2, Sox9, Col2a1, Runx2 and Col1a1 interact in the developmental pathway leading from neural crest to cartilage and bone (Healy et al., 1999; Mori-Akiyama et al., 2003; Takahashi et al., 2001). | Evol. Bioinformatics | 2 | 2 | Zebrafish_crestin_20080727 | http://www.la-press.com/journals.php?pa=abstract&content_id=323 | urn:agi-Binding:inout-urn:agi-llid:1280:inout-urn:agi-llid:1277: | digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15689370&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15689370 | 0.9700 | |||||||||||||||||
| Expression | dharma | positive | col2a1a | Iinjection of mRNAs encoding the b-catenin target genes boz/dha strongly inhibited vega2 expression. | mutant embryos | 22 | hypochord | 1 | Robert K. Ho | Developmental Biology | 1999 | 215 | 190 | ||||||||||||||||
| Expression | foxa2 | positive | col2a1a | Misexpression of axial leads to ectopic activation of snic hedgehog expression in the zebrafish. | mutant embryos | 36 | neuroectoderm | 1 | SW Wilson | Development | 2005 | 132 | 645 | ||||||||||||||||
| Expression | mdka | negative | col2a1a | Overespression of mdka severely affected embryo with complete block of notochord formation in the posterior trunk, lacking col2a1 in n = 41/88, 46%. | overexpression | 16 | neuroectoderm | 2 | Christoph Winkler | GENES & DEVELOPMENT | 2005 | 19 | 897 | ||||||||||||||||
| Expression | sox9a | positive | col2a1a | SOX9 is a transcription factor that activates type II procollagen (Col2a1) gene expression during chondrocyte differentiation. | mesenchyma | Genes & Dev | 11375127:0 | 2 | 46 | Zebrafish_Bmp2b_20080727 | http://www.genesdev.org/cgi/content/full/16/21/2813 | v16 i21 p2813 | urn:agi-Expression:inout-urn:agi-llid:6662:out-urn:agi-llid:1280::positive | digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=16959242&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(06)01086-4 | |||||||||||||||