Expression Table

Gene Name: cmlc1 (cardiac myosin light chain-1 )
Description: calcium ion binding
Key: I = Interpolated; X = Not Detected; ? = Inconsistent data; ! = Expressed but no region
Table built from ZFIN data (http://zfin.org/zf_info/downloads.html): Tue Dec 4 14:01:03 PST 2007
cmlc1StageHoursZFIN expression rangemesodermheartunspecified
Zygote1-cell0    
Cleavage2-cell0.75    
4-cell1.0    
8-cell1.25    
16-cell1.5    
32-cell1.75    
64-cell2.0    
Blastula124-cell2.25    
256-cell2.5    
512-cell2.75    
1k-cell3.0    
High3.33    
Oblong3.66    
Sphere4.0    
Dome4.33    
30% epiboly4.66    
Gastrula50%-epiboly5.25    
Germ-ring5.66    
Shield6.0    
75% epiboly stage8.0    
90% epiboly9.0    
bud stage10.0    
Segmentation1-4 somites10.33    
5-9 somites11.66    
10-13 somites14.0    
14-19 somites16.0    
20-25 somites19.0    
26+ somites22.0    
PharyngulaPrim-524.0    
Prim-1530.0    
Prim-2536.0    
High-pec42.0    
HatchingLong-pec48.0    
Pec-fin60.0    


Literature Evidence



Evidence for InteractionAbnormal cardiac myosin light chain (cmlc) expression in Su(H) morphant embryos.
Target Genecmlc1
Upstream Generbpja
Interaction Typeenhance
Altered modelMASO
Time of Interaction in evidence24
Location of Interaction in evidenceheart
Evidence for Direct3
Binding Site Sequence 
Location of Site 
Last AuthorOates, A.C.
JournalDev. Biol.
Year2007
Vol301
Start Page388



Evidence for Interactionoverexpression of gata5 restores cmlc1 expression in Zoep mutants.
Target Genecmlc1
Upstream Genegata5
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence26
Location of Interaction in evidenceheart
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorDidier Y. R. Stainier
JournalDevelopmental Biology
Year2001
Vol234
Start Page330



Evidence for Interactionoverexpression of gata5 restores cmlc1 expression in Zoep mutants at 26 hp.
Target Genecmlc1
Upstream Genegata5
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence26
Location of Interaction in evidenceheart
Evidence for Direct1, 2
Binding Site Sequence 
Location of Site 
Last AuthorDidier Y. R. Stainier
JournalDevelopmental Biology
Year2001
Vol234
Start Page330



Evidence for InteractionExpression of both generalized cardiac markers, such as cardiac myosin light chain 2 (Cmlc2), the transcription factor, Nkx2.5, and the ventricle-specific marker, ventricular myosin heavy chain (Vmhc), were downregulated in the vast majority of embryos.
Target Genecmlc1
Upstream Genegata6
Interaction Typeenhance
Altered modelMASO
Time of Interaction in evidence26
Location of Interaction in evidencecardiac precursors
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorRoger Patient
JournalThe EMBO Journal
Year2003
Vol22
Start Page4260



Evidence for InteractionZoep mutants exhibit dramatically reduced expression of cmlc1.
Target Genecmlc1
Upstream Geneoep
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence26
Location of Interaction in evidenceheart
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorDidier Y. R. Stainier
JournalDevelopmental Biology
Year2001
Vol234
Start Page330



Evidence for InteractionZoep mutants exhibit dramatically reduced expression of other markers of myocardial differentiation such as cmlc1.
Target Genecmlc1
Upstream Geneoep
Interaction Typeenhance
Altered modelmutant embryos
Time of Interaction in evidence26
Location of Interaction in evidenceheart
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorDidier Y. R. Stainier
JournalDevelopmental Biology
Year2001
Vol234
Start Page330



Evidence for Interactionoverexpression of gata5 rescues cardiac fusion in fautm236a mutants and leads to ectopic expression of cmlc1.
Target Genecmlc1
Upstream Genegata5
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence36
Location of Interaction in evidenceheart
Evidence for Direct2
Binding Site Sequence 
Location of Site 
Last AuthorDidier Y.R. Stainier
JournalGenes & Development
Year1999
Vol13
Start Page2983



Evidence for Interactionoverexpression of gata5 rescues cardiac fusion in fautm236a mutants and leads to ectopic expression of myocardial genes. Expression of cmlc1 , cmlc2(myl7) , nkx2.5 , gata4 , and gata6 in wild-type embryos and fau mutant siblings at 36 hpf , 25 hpf, 5-som
Target Genecmlc1
Upstream Genegata5
Interaction Typeenhance
Altered modeloverexpression
Time of Interaction in evidence36
Location of Interaction in evidenceheart
Evidence for Direct1, 2
Binding Site Sequence 
Location of Site 
Last AuthorDidier Y. R. Stainier
JournalGenes & Development
Year1999
Vol13
Start Page2983



Evidence for InteractionReal-time RT-PCR analyses showing the increased expression of cmlc2 in grlm145 mutants at 48 hpf.
Target Genecmlc1
Upstream Genehey2
Interaction Typerepress
Altered modelmutant embryos
Time of Interaction in evidence48
Location of Interaction in evidenceheart
Evidence for Direct1
Binding Site Sequence 
Location of Site 
Last AuthorTao P.Zhong
JournalPNAS
Year2007
Vol104
Start Page14008