cdx4
Type Gene1 Effect Gene2 Sentence Perturbation methods Time of Interaction in evidence territories of interaction or Tissue Evidence for Direct Authors Journal PubYear Volume Pages MedLine Reference Connectivity # of References Found In Pathways Journal Link Journal Reference Mechanism URN ISSN Issue LocatorString MedlineTA PubMonth p-value [Evol. Bioinformatics 2007:3(197)] TextPath Title
Regulation cdx4 positive cdx4 Although Cdx1 induction significantly enhanced the expression of several hematopoietic genes in CD41+c-kit+ cells, relative to CD41+c-kit– cells, cdx4 induction had only modest effects.









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urn:agi-Regulation:inout-urn:agi-llid:1044:out-urn:agi-llid:1046::positive

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Expression cdx4 negative cdx4 However, simultaneous reduction of Cdx1 and cdx4 expression by Cdx1 knockdown in the cdx4 +/y or cdx4 GFP/y ESCs decreased only the formation of erythroid progenitors more significantly than single Cdx1 knockdown or cdx4 knockout (Fig. S4), demonstrating









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urn:agi-Expression:inout-urn:agi-llid:1044:out-urn:agi-llid:1046::negative

digtext:http://www.pnas.org/content/105/22/7756.full




Expression cdx4 positive cdx4 Cdx1a and cdx4 act redundantly in the specification of the prospective spinal cordterritory Cdx transcription factors have been shown to act redundantly in the patterning of the mouse paraxial mesoderm (reviewed by Deschamps and van Nes, 2005; Lohnes, 200









2 4 Zebrafish GRN from literatures-7-24-2008


urn:agi-Expression:inout-urn:agi-llid:1046:out-urn:agi-llid:1044::positive

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Ho-RK-2007.pdf


url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cHo-RK-2007.pdf):pdf
Expression cdx4 positive cldn2 Both Cdx1 and Cdx2 activated the claudin-2 promoter in the human intestinal epithelial cell line Caco-2.

epithelia





11934881:2 2 2 Zebrafish_ctnnb1_20080728


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Expression cdx4 positive fgf3 It remains to be elucidated whether the Wnt/Cdx cascade directly controls the expression of fgf3 and fgf8a or the reduction of fgf3 and fgf8a expression is a secondary consequence of the reduction in posterior tissue.









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urn:agi-Expression:inout-urn:agi-llid:1044:out-urn:agi-llid:2248::positive

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Expression cdx4 positive fgf8a It remains to be elucidated whether the Wnt/Cdx cascade directly controls the expression of fgf3 and fgf8a or the reduction of fgf3 and fgf8a expression is a secondary consequence of the reduction in posterior tissue.









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urn:agi-Expression:inout-urn:agi-llid:1044:out-urn:agi-llid:2253::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15708563&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00859-0




Expression cdx4 positive fli1a the expression domains of hoxa9a, which share an anterior expression limit with gata1, are significantly reduced in kggtv205 mutants as early as the 5-somite stage. overexpression 11.66 blood 2 Leonard I. Zon Nature 2003 425 18















Expression cdx4 positive foxa2 These results indicate that zebrafish cdx1b regulates foxa2 expression and may also modulate gata5 expression, thus affecting early endoderm formation.



Cheng,P.Y.;Lin,C.C.;Wu,C.S.;Lu,Y.F.;Lin,C.Y.;Chung,C.C.;Chu,C.Y.;Huang,C.J.;Tsai,C.Y.;Korzh,S.;Wu,J.L.;Hwang,S.P.
2008 135 941-52 18234726:10 2 7 Zebrafish GRN from literatures-7-24-2008


urn:agi-Expression:inout-urn:agi-llid:1044:out-urn:agi-llid:3170::positive 0950-1991 5 digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Hwang-SPL-2007.pdf Development Mar
url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cHwang-SPL-2007.pdf):pdf Zebrafish cdx1b regulates expression of downstream factors of Nodal signaling during early endoderm formation.
Expression cdx4 positive gata1 the expression domains of hoxa9a, which share an anterior expression limit with gata1, are significantly reduced in kggtv205 mutants as early as the 5-somite stage. overexpression 11.66 blood 2 Leonard I. Zon Nature 2003 425 18















Expression cdx4 positive gata2 Both Cdx1 and cdx4 slightly but consistently enhanced the expression of Gata-2, a marker of immature hematopoietic cells (Figure 3).









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urn:agi-Expression:inout-urn:agi-llid:1044:out-urn:agi-llid:2624::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=18252864&db=pubmed&url=http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=18252864




Expression cdx4 positive gata2 Both Cdx1 and cdx4 slightly but consistently enhanced the expression of Gata-2, a marker of immature hematopoietic cells (Figure 3).









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urn:agi-Expression:inout-urn:agi-llid:1046:out-urn:agi-llid:2624::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=18252864&db=pubmed&url=http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=18252864




Expression cdx4 positive gata5 Therefore, perturbations of sox17 -expressing endodermal cell numbers in both epiboly cdx1b morphants and embryos ectopically expressing cdx1b are probably indirectly caused by regulation of gata5 expression by cdx1b (Figs 4, 6).









2 6 Zebrafish GRN from literatures-7-24-2008


urn:agi-Expression:inout-urn:agi-llid:1044:out-urn:agi-llid:140628::positive

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Hwang-SPL-2007.pdf


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Expression cdx4 positive hbbe3 Surprisingly, 12–20% of the cdx4 mRNA injected embryos showed ectopic tal1 expression near the midline in a stripe that ran parallel to the endogenous blood precursors. mutant embryos 24 blood 1 Leonard I. Zon Nature 2003 425 18















Expression cdx4 positive hoxa9a Cdx4 mRNA injected embryos showed ectopic fli1 expression near the midline in a stripe that ran parallel to the endogenous blood precursors. mutant embryos 10.33 paraxial mesoderm 1 Leonard I. Zon Nature 2003 425 18















Expression cdx4 positive hoxa9b Misexpression of cdx1a RNA induced the expansion of hoxa9a expression, but SU5402 inhibited Cdx1a-induced hoxa9a expression (Figs. 7F–H).









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urn:agi-Expression:inout-urn:agi-llid:1044:out-urn:agi-llid:3205::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15708563&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00859-0




Expression cdx4 positive hoxa9b These data indicate that both Cdx1a/cdx4 and FGF signaling are required for the expression of hoxa9a .









2 13 Zebrafish GRN from literatures-7-24-2008


urn:agi-Expression:inout-urn:agi-llid:1046:out-urn:agi-llid:3205::positive

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Masahiko Hibi 2005.pdf


url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cMasahiko%20Hibi%202005.pdf):pdf
Expression cdx4 negative hoxb1a Inhibition of both the Fgf and RA signals by SU5402 and DEAB in the cdx1a/4 morphant embryos suppressed the ectopic hoxb1a expression (r4, n=15/15) and the normal and ectopic expression of krox20 (r5, n=18/18), valentino (r5, 6, n=9/9), hoxb4a (r7-, n=10/









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urn:agi-Expression:inout-urn:agi-llid:1044:out-urn:agi-llid:3211::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17079270&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17079270




Expression cdx4 positive hoxb3a cdx4 induced widespread alterations in Hox expression levels in transduced cells including a marked increase in the expression of HoxB4 (30-fold), HoxB3 (19-fold), HoxB8 (5-fold) and HoxA9 (4.1-fold), all of which have been implicated in haematopoietic st









2 4 Zebrafish_cdx4_20080726


urn:agi-Expression:inout-urn:agi-llid:1046:out-urn:agi-llid:3213::positive

digtext:http://ad.doubleclick.net/adi/nature.com/article;type=lt;artid=nature01973;pos=right;issue=6955;webfo=;prod=yes;natco=natcode-1 natcode-7 natcode-10 natcode-14,;natcl=;subco=natcode-1 natcode-7 natcode-10 natcode-14,;chaco=;keywd=;;sz=160x600;o...




Expression cdx4 negative hoxb4a Hoxb6b display altered expression patterns in kgg tv205 embryos. mutant embryos 14 rhombomere 1 Leonard I. Zon Nature 2003 425 18















Expression cdx4 positive hoxb4a Cdx genes distinctly affect hematopoietic progenitor formation during EB differentiation. (A) Quantitative RT-PCR analysis of inducible Cdx1, Cdx2, and cdx4 gene expression in differentiating day 4 EBs assessed 8 hours after exposure to 1 µg/mL doxycyclin









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urn:agi-Expression:inout-urn:agi-llid:1044:out-urn:agi-llid:55038::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=18252864&db=pubmed&url=http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=18252864




Expression cdx4 negative hoxb4a Deletion of any single Cdx gene led to impaired embryonic hematopoietic progenitor formation with disturbed Hox expression profiles.









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urn:agi-Expression:inout-urn:agi-llid:1044:out-urn:agi-llid:55038::negative

digtext:http://www.pnas.org/content/105/22/7756.full




Expression cdx4 positive hoxb4a cdx4 deficiency leads to reduced hematopoietic progenitor formation and altered Hox gene expression profiles. (A) Hematopoietic progenitor and (B) OP9 colony formation of day 6 EB-derived cells.









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urn:agi-Expression:inout-urn:agi-llid:1046:out-urn:agi-llid:55038::positive

digtext:http://www.pnas.org/content/105/22/7756.full




Expression cdx4 negative hoxb4a Strong inhibition of RA signaling by DEAB in the cdx1a/4 morphant embryos completely abolished the expression of hoxb4a (r7-; n=15/15) and hoxb5a (s1-, n=11/11) and strongly inhibited the expression of valentino (r5, 6), but did not significantly inhibit









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urn:agi-Expression:inout-urn:agi-llid:1044:out-urn:agi-llid:3214::negative

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Regulation cdx4 positive hoxb4a In addition, it has been shown that cdx4 activates HoxB4 in hematopoietic progenitors, and HoxB4 promotes hematopoietic specification from ESCs (8, 21).









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urn:agi-Regulation:inout-urn:agi-llid:1046:out-urn:agi-llid:3214::positive

digtext:http://www.pnas.org/content/105/22/7756.full




Expression cdx4 positive hoxb4a The weak enhancement of HoxB4 expression by cdx4 appaears inadequate to maintain or expand transplantable HSCs on OP9 stromal cultures.




PNAS


16357205:10123 2 5 zebrafish-36 candidates in cell location http://www.pnas.org/cgi/content/full/102/52/19081 v102 i52 p19081
urn:agi-Expression:inout-urn:agi-llid:1046:out-urn:agi-llid:3214::positive

digtext:http://ad.doubleclick.net/adi/nature.com/article;type=lt;artid=nature01973;pos=right;issue=6955;webfo=;prod=yes;natco=natcode-1 natcode-7 natcode-10 natcode-14,;natcl=;subco=natcode-1 natcode-7 natcode-10 natcode-14,;chaco=;keywd=;;sz=160x600;o...




Expression cdx4 positive hoxb5a In kgg tv205 mutants, hoxb5a expression is expanded to include somites two to five, is absent from the notochord and is reduced in the tailbud. mutant embryos 14 paraxial mesoderm 1 Leonard I. Zon Nature 2003 425 18















Expression cdx4 negative hoxb5a The inhibition of Raldh2 by its MO in the cdx1a/4 morphant embryos repressed the expression of hoxb5a (s1-, n=26/26), but did not suppress the normal or ectopic expression of krox20 (r5), hoxb1a (r4), valentino (r5, 6) or hoxb4a (r7-) (Fig. 7E; see Fig. S









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urn:agi-Expression:inout-urn:agi-llid:1044:out-urn:agi-llid:3215::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17079270&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17079270




Expression cdx4 positive hoxb6b Cdx4 mRNA injected embryos showed ectopic fli1 expression near the midline in a stripe that ran parallel to the endogenous blood precursors. mutant embryos 10.33 paraxial mesoderm 1 Leonard I. Zon Nature 2003 425 18















Expression cdx4 positive hoxb7a Surprisingly, 12–20% of the injected embryos showed ectopic scl, gata1 and fli1 expression near the midline in a stripe that ran parallel to the endogenous blood precursors. mutant embryos 10.33 paraxial mesoderm 1 Leonard I. Zon Nature 2003 425 18















Expression cdx4 negative hoxb8a The expression domains of hoxb6b are significantly reduced in kgg tv205 mutants as early as the 3-somite stage. mutant embryos 14 paraxial mesoderm 1 Leonard I. Zon Nature 2003 425 18















Expression cdx4 neutral hoxb8a The cdx4 protein was also shown to regulate Hoxb8 expression ( 13 ).




Mol. Cell. Biol


15684390:10302 2 3 zebrafish-36 candidates in cell location http://mcb.asm.org/cgi/content/full/25/4/1389 v25 i4 p1389
urn:agi-Expression:inout-urn:agi-llid:1046:out-urn:agi-llid:3218::unknown

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Prince-VE-2008.pdf


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Expression cdx4 positive hoxb8a Similarly, overexpressing cdx4 in mice resulted in anteriorly shifted Hoxb8 expression in the neural tube and somites (Charite et al., 1998).









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digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Prince-VE-2008.pdf


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Expression cdx4 positive hoxb8b Hoxb6b display altered expression patterns in kgg tv205 embryos. mutant embryos 14 paraxial mesoderm 1 Leonard I. Zon Nature 2003 425 18















Expression cdx4 positive hoxb9a Consistent with this, our preliminary data show that misexpression of cdx1a activates ectopic expression of hoxb9a in the hindbrain region in an Fgf-dependent manner (data not shown).









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urn:agi-Expression:inout-urn:agi-llid:1044:out-urn:agi-llid:3219::positive

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Hibi-M-2006.pdf


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Expression cdx4 positive hsp70 To overcome this limitation, we generated a transgenic fish line, Tg[hsp70:cdx4] , carrying a 5 2 -end modified zebrafish cdx4 gene under the control of the heat-inducible hsp70 promoter, which enables the rapid and ubiquitous induction of transgene expre









2 3 Zebrafish GRN from literatures-7-24-2008


urn:agi-Expression:inout-urn:agi-llid:1046:out-urn:agi-llid:3303::positive

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Ho-RK-2007.pdf


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Expression cdx4 negative ins The mesoderm is a source of various signals that pattern theendoderm; the expanded domain of pdx1 -positive precursors and insulin -positive cells in cdx1a/cdx4 -deficient embryos is consistent with a model in which Cdx deficiency alters expression of key









2 2 Zebrafish GRN from literatures-7-24-2008


urn:agi-Expression:inout-urn:agi-llid:1046:out-urn:agi-llid:3630::negative

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Prince-VE-2008.pdf


url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cPrince-VE-2008.pdf):pdf
Regulation cdx4 positive nr2e3 In mouse, ectopic expression of cdx4 enhances hematopoietic mesoderm formation and further promotes blood progenitor specification and hematopoietic engraftment in adult mice from murine embryonic stem cells (ESCs) (8).









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urn:agi-Regulation:inout-urn:agi-llid:1046:out-urn:agi-llid:10002::positive

digtext:http://www.pnas.org/content/105/22/7756.full




Expression cdx4 positive runx1 kggtv205 mutants have a severe reduction in the number of haemoglobin-expressing erythroid cells compared with wild-type siblings. mutant embryos 11.66 blood 1 Leonard I. Zon Nature 2003 425 18















Expression cdx4 positive tal1 the expression domains of hoxa9a, which share an anterior expression limit with gata1, are significantly reduced in kggtv205 mutants as early as the 5-somite stage. overexpression 11.66 blood 2 Leonard I. Zon Nature 2003 425 18