bon
Type Gene1 Effect Gene2 Sentence Perturbation methods Time of Interaction in evidence territories of interaction or Tissue Evidence for Direct Authors Journal PubYear Volume Pages MedLine Reference Connectivity # of References Found In Pathways Journal Link Journal Reference Mechanism URN ISSN Issue LocatorString MedlineTA PubMonth p-value [Evol. Bioinformatics 2007:3(197)] TextPath Title
Expression bon positive bmp4 otx2 expression is reduced in sqt–/– and bon–/–;sqt–/– embryos. mutant embryos 9 mesoderm 1 Didier Y. R. Stainier Development 2003 130 4989















Expression bon positive dkk1 At 50% epiboly, dkk1 expression is seen in all marginal blastomeres in wild-type embryos. In bon–/– embryos, dkk1 expression exhibits a slight dorsal gap. mutant embryos 5.25 blastoderm 1 Didier Y. R. Stainier Development 2003 130 4989















Expression bon positive foxa1 There are many fewer cas positive cells in bon mutant embryos from late blastula to late gastrula. mutant embryos 14 endoderm 1 Didier Y.R. Stainier Genes & Development 2000 14 1279















Expression bon negative gata3 there are many fewer cas (sox32) positive cells in bon mutant embryos from late blastula to late gastrula . mutant embryos 26 neuroectoderm 1 Laure Bally-Cuif DEVELOPMENTAL DYNAMICS 2003 227 524















Expression bon positive gsc During mid-somitogenesis fkd7 (foxa1) is expressed in the endoderm as well as in the floor plate and hypochord. In bon mutants, there are only a few fkd7-expressing endodermal cells, whereas expression in the floor plate and hypochord is normal. mutant embryos 5.25 blastoderm 1 Schier, A. F. Development 2003 130 5589















Expression bon positive ntl The gata3 expression was significantly enlarged in the mutant bonnie and clyde/mixer from 24 hpf onward.The overall shape of the gata3 cluster was maintained, indicating no anisotropy in the increase in cell number along the AP or DV axes. mutant embryos 5.25 margin 1 Didier Y. R. Stainier Development 2003 130 4989















Expression bon positive otx2 In 36 hpf wild-type embryos, shh is expressed throughout the endoderm; bon mutants exhibit small patches of shh-expressing endoderm. mutant embryos 10 neuroectoderm 1 Didier Y. R. Stainier Development 2003 130 4989















Expression bon positive shha overexpression of bon in wild-type embryos resulted in the formation of ectopic sox17-expressing cells . MASO 10 neuroectoderm 3 Schier, A. F. Development 2003 130 5589















Expression bon negative six3a Expression of the endodermal marker casanova (sox32) is strongly reduced in bon MO embryo. mutant embryos 26 neuroectoderm 1 Laure Bally-Cuif DEVELOPMENTAL DYNAMICS 2003 227 524















Expression bon positive sox17 Expression of gsc in prechordal plateprogenitors is weakly reduced in bon, strongly reduced in Mzsur and absent in MZsur;bon double mutant embryos. overexpression 9 endoderm 2 Derek L. Stemple Current Biology 1999 9 1147















Expression bon positive sox32 In bon–/–;sqt–/– embryos, ntl expression appears reduced around the margin and is absent from the dorsal side. mutant embryos 9 endoderm 1 Schier, A. F. Development 2003 130 5589















Expression eomesa positive bon Ectopic expression of chd was observed in boz mutant embryos following eomes RNA overexpression, which showed that nwk/dhm gene function does not appear to be required for eomes to induce expression of organizer-specific genes. overexpression 4.66 margin 2 David Kimelman Developmental Cell 2005 9 523















Promoter Binding eomesa positive bon Ectopic expression of chd was observed in boz mutant embryos following eomes RNA overexpression, which showed that nwk/dhm gene function does not appear to be required for eomes to induce expression of organizer-specific genes. overexpression 4.66 margin 4 David Kimelman Developmental Cell 2005 9 523















Expression foxh1 positive bon bik, mezzo and bon are expressed in bon but strongly downregulated in foxh1 and foxh1;bon embryos mutant embryos 5.25 margin 1 Schier, A. F. Development 2003 130 5589















Expression ndr1 positive bon overexpression of sqt elicited the ectopic expression of gsc and din in the entire blastoderm at the sphere to shield stage, but did not change the expression of boz/dharma. In the sqt mutant embryos, gsc expression was not detected, but din was expressed mutant embryos 5.25 margin 1 Derek L. Stemple Current Biology 1999 9 1147















Expression oep positive bon Ventral forebrain regions are not present by the severe reduction or absence of shh and nk2.2 expression in ventral neuroectoderm. mutant embryos 5.25 blastomere 1 Schier, A. F. Dev Biol 2007 304 525