bmp5
Type Gene1 Effect Gene2 Sentence Perturbation methods Time of Interaction in evidence territories of interaction or Tissue Evidence for Direct Authors Journal PubYear Volume Pages MedLine Reference Connectivity # of References Found In Pathways Journal Link Journal Reference Mechanism URN ISSN Issue LocatorString MedlineTA PubMonth p-value [Evol. Bioinformatics 2007:3(197)] TextPath Title
Regulation bmp7 positive acvr1 OP-1 alone increased ActR-I, BMPR-IA, and BMPR-II mRNA levels, but did not change the BMPR-IB level.




Endocrinology


16985:48:00 2 4 Zebrafish_Bmp2b_20080727 http://endo.endojournals.org/cgi/content/full/138/10/4181 v138 i10 p4181
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Expression bmp7 negative acvr1b Prdm1 expression is reduced in snh (BMP7) mutant embryos. overexpression 5.25 blastoderm 2 Thierry Lepage Development 2006 133 2189















Regulation bmp7 positive admp Noggin (Smith and Harland, 1992), Chordin (Sasai et al., 1994), dominant-negative BMP receptor type I (tBR) (Graff et al., 1994 and Suzuki et al., 1994) and dominant-negative BMP7 (CmBMP7) (Hawley et al., 1995) are able to induce admp (Fig. 1B) as well as









2 1 Zebrafish_Chordin_20080727


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Expression bmp7 positive admp When ventral BMP2/4/7 signals are depleted, admp expression increases, allowing for self-regulation.

egg





41577:04:00 2 4 Zebrafish_Bmp2b_20080727


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Expression bmp7 positive alk8 Ved expression is up-regulated during gastrulation in snh/bmp7 signaling mutants. mutant embryos 9 mesoderm 1 Mary C. Mullins Development 2001 128 859















Expression bmp7 positive bmp4 bmp4 does not regulate the expression of itself or other BMPs bmp4 can activate its own expression in Xenopus overexpression experiments (Jones et al., 1992), and in zebrafish, both BMP2b and BMP7 are required for the maintenance of bmp2b, bmp7, and bmp4









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Expression bmp7 negative bmp4 OP-1 downregulated the BMP-4, -5, and -6 mRNA levels by a maximal of 2-fold, 1.5-fold, and 6-fold, respectively.

bone

Cell


63546:07:00 2 12 Zebrafish_Bmp2b_20080727 http://www.cell.com/cgi/content/full/91/1/127.1 v91 i1 p127.1
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Binding bmp7 neutral chd Chordin also binds BMP2, bmp4, and BMP7 in a way similar to noggin ( 20 ).




J. Biol. Chem


54447:20:00 2 5 Zebrafish_Chordin_20080727 http://www.jbc.org/cgi/content/full/278/26/24113 v278 i26 p24113
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digtext:http://www.springerlink.com/content/jha0upj83ar9ja0h/fulltext.html




Expression bmp7 positive cpb1 Similarly, bone morphogenetic proteins (particularly bmp4 and BMP7) are produced in the lateral mesodermand have been implicated in the induction of pancreas-specific gene expression, at least inexplanted endoderm (Kumar et al., 2003).









2 2 Zebrafish GRN from literatures-7-24-2008


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Binding bmp7 neutral fgf8a However, in the chick fgf8a is only expressed in a ventral, posterior domain within each pouch, which abuts the domain of Bmp7 and is not in contact with the placode (Graham and Begbie, 2000), suggesting that fgf8a and Bmp7 interact to define territories









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Binding bmp7 neutral fsta We provide data which show that Follistatin binds BMP-7 and BMP-2 at low affinities and that the binding is reversible.

muscle

Genes & Dev


50001:05:00 2 17 Zebrafish_Bmp2b_20080727 http://www.genesdev.org/cgi/content/full/12/10/1438 v12 i10 p1438
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Binding bmp7 neutral gdf7 Our findings suggest that a GDF7:BMP7 heterodimer functions as a roof plate-derived repellent that establishes the initial ventral trajectory of commissural axons.




J. Biol. Chem


28003:05:00 2 7 Zebrafish GRN from literatures-7-24-2008 http://www.jbc.org/cgi/content/full/280/37/32122 v280 i37 p32122
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Expression bmp7 neutral myf5 However, a 3-day incubation with BMP-7 increased Myf5 expression in wild-type cells, whereas MyoD appaeared to be unaffected.




Cell Sci


13098:43:00 2 3 Zebrafish_myod_20080731 http://jcs.biologists.org/cgi/content/full/117/8/1457 v117 i8 p1457
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Expression bmp7 neutral myod1 CDMP-1 enhanced the suppression of the OP-1-induced expression of the myogeneic differentiation regulator MyoD.




Genes & Dev


54131:06:00 2 3 Zebrafish_myod_20080731 http://www.genesdev.org/cgi/content/full/12/3/290 v12 i3 p290
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Expression bmp7 negative ndr1 Ved expression is down-regulated at late blastula stage in snh/bmp7 mutants. overexpression 8 margin 2 Hammerschmidt, M. Curr Biol 2007 17 475















Binding bmp7 neutral nog1 Toward that end, we have determined the crystal structure of the antagonist Noggin bound to BMP-7.

bone

Genes & Dev


15018:04:00 2 16 Zebrafish_Chordin_20080727 http://www.genesdev.org/cgi/content/full/12/10/1438 v12 i10 p1438
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Binding bmp7 neutral nog1 Pro35 of Noggin makes a similar knob-into-hole interaction with BMP-7 as Ile2 of CV-2 VWC1 with BMP-2.









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Expression bmp7 positive phox2b BMP signaling is required locally inendoderm for epibranchial neurogenesis BMP7 has been shown to induce Phox2b expression in chick explants of pharyngeal ectoderm (Begbie et al., 1999) but it is not known: (1) whether BMP signaling is required for this p









2 5 Zebrafish GRN from literatures-7-24-2008


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Expression bmp7 positive prdm1a Ved expression is up-regulated during gastrulation in snh/bmp7 signaling mutants. mutant embryos 11.66 neural plate border 1 Kristin Bruk Artinger Developmental Biology 2005 278 347















Expression bmp7 positive ved overexpression of BMPs compromises endoderm formation, formation of endoderm precursors is negatively regulated by BMPs on the ventral side. mutant embryos 4 superficial blastomere 1 Cotelli, F. Dev Dyn 2004 230 494















Binding activin neutral bmp7 BMP-7 can interact with activin type I and type II receptors in addition to BMP-2/BMP-4 receptors ( 26 , 28 ).




J. Biol. Chem


27935:23:00 2 5 Zebrafish_Chordin_20080727 http://www.jbc.org/cgi/content/full/272/35/22046 v272 i35 p22046
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Expression acvr1 positive bmp7 injected mRNA encoding a constitutively active version of Alk8 can rescue the strong dorsalization of bmp7/snailhouse mutants overexpression 4.66 blastoderm 2 Hammerschmidt, M. Development 2001 128 849















Binding acvr1 neutral bmp7 OP-1 bound to ALK-2 and ALK-6 efficiently, and to ALK-3 less efficiently, whereas BMP-4 bound to ALK-3 and ALK-6 efficiently.

bone

Endocrinology


10610:06:00 2 21 BMPR2-acvr1 http://endo.endojournals.org/cgi/content/full/143/4/1423 v143 i4 p1423
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Binding bmp2a neutral bmp7 This synergy is best explained by formation of BMP2/7 and 4/7 heterodimers.

bone

Cell Sci


30643:07:00 2 22 Zebrafish_Bmp2b_20080727 http://jcs.biologists.org/cgi/content/full/117/7/1269 v117 i7 p1269
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Expression bmp4 positive bmp7 bmp4 does not regulate the expression of itself or other BMPs bmp4 can activate its own expression in Xenopus overexpression experiments (Jones et al., 1992), and in zebrafish, both BMP2b and BMP7 are required for the maintenance of bmp2b, bmp7, and bmp4









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Expression bmp4 negative bmp7 Because the expression of zebrafish bmp4 is delayed in comparison with the expression of bmp2b and bmp7 (Nikaido et al., 1997) and because no mutants in bmp4 were identified in any of the large-scale morphological screens, the role of bmp4 in zebrafish ha









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Binding bmp4 neutral bmp7 This synergy is best explained by formation of BMP2/7 and 4/7 heterodimers.

egg

Cell Sci


30643:07:00 2 52 Zebrafish GRN from literatures-7-24-2008 http://jcs.biologists.org/cgi/content/full/117/7/1269 v117 i7 p1269
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Expression fgf neutral bmp7 Activating FGF signaling at the 512 cell stage results in an early decrease in bmp2, bmp4, and bmp7 expression at shield stage.









2 2 Zebrafish_Chordin_20080727


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Expression fgf positive bmp7 Like XFD and ?-FGFR-4, early SU5402 FGF inhibition results in an increase in bmp2, bmp4, and bmp7 expression at late blastula and early gastrula stages (Fig. 6C).









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Expression fgf negative bmp7 fgf3 was also found to be expressed in the early epiblast, and ongoing FGF signalling in epiblast cells was required for acquisition of neural fate and for the suppression of bmp4 and Bmp7 expression.




Genes & Dev


53508:06:00 2 4 Zebrafish_Chordin_20080727 http://www.genesdev.org/cgi/content/full/12/7/1046 v12 i7 p1046
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Expression fgf24 negative bmp7 Microinjection of fgf24 leads to inhibition of bmp7 expression at blastula stage. overexpression 4.66 margin 2 Bernard Thisse Development 2004 131 2853















Expression fgf3 negative bmp7 Microinjection of fgf3 leads to inhibition of bmp7 expression at blastula stage. overexpression 4.66 margin 2 Bernard Thisse Development 2004 131 2853















Expression fgf8 negative bmp7 fgf8 overexpression abolishes the blastula stage expression of bmp2b in the ventral blastoderm. overexpression 4.66 margin 2 Bernard Thisse Development 2004 131 2853















Regulation fsta positive bmp7 Here, we report that during chick limb development Follistatin enhances BMP-7 action to induce muscle growth but prevents the ability of BMP-7 to induce apoptosis and muscle loss.









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urn:agi-Regulation:inout-urn:agi-llid:10468:out-urn:agi-llid:655::positive

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Regulation gpc3 unknown bmp7 Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling.









2 1 Zebrafish_wnt5a_20080731


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Expression isl1 positive bmp7 Number of adrenergic and islet-1 immunoreactive cells is increased in avian trunk neural crest cultures in the presence of human recombinant osteogenic protein-1.




Mol. Cell. Biol


64095:55:00 2 3 Zebrafish_bmp4_20080727 http://mcb.asm.org/cgi/content/full/25/12/5134 v25 i12 p5134
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Expression smad5 positive bmp7 The sbn mutant displays severely reduced bmp2b staining mutant embryos 4.66 margin 1 Matthias Hammerschmidt Developmental Biology 2002 250 263















Expression smad5 positive bmp7 Second, it has recently been reported that several null alleles of sbn / smad5 affect the initiation of bmp7 expression but have no effect on the initiation of bmp2b , which contrasts with the effects of rdratgMO ( 37 ).




PNAS


18436:23:00 2 13 Zebrafish_Bmp2b_20080727 http://www.pnas.org/cgi/content/full/100/6/3315 v100 i6 p3315
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Expression smad5 negative bmp7 Furthermore, embryos derived from females homozygous for null mutations in the smad5 locus exhibit reduced levels of the initial bmp7 and bmp2b expression (18, 19).









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