bmp4

Type

Gene1

Effect

Gene2

Sentence

Perturbation methods

Time of Interaction in evidence

territories of interaction or Tissue

Evidence for Direct

Authors

Journal

PubYear

Volume

Pages

MedLine Reference

Connectivity

# of References

Found In Pathways

Journal Link

Journal Reference

Mechanism

URN

ISSN

Issue

LocatorString

MedlineTA

PubMonth

p-value [Evol. Bioinformatics 2007:3(197)]

TextPath

Title

Expression

bmp4

positive

acta1

Although bmp4 was required to induce expressions of sarcomeric alpha-actinin, titin, and sarcomeric myosin in cultured stage 6 posterolateral mesoderm (noncardiogenic mesoderm), smooth muscle alpha-actin was expressed without the addition of bmp4.

mesoderm

11977982:4

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:87::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=10491267&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(99)99401-0

Expression

bmp4

positive

admp

When ventral BMP2/4/7 signals are depleted, admp expression increases, allowing for self-regulation.

egg

16360041:4

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:165679::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=11784095&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012160601904944

Regulation

bmp4

unknown

bmp2a

In the canals, Bmp2 and Dlx5 are regulated by bmp4, either directly or indirectly.

Zebrafish_bmp4_20080727

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:650::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=18404215&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18404215

Expression

bmp4

positive

bmp5

BMP5 and bmp4 also appaear to up-regulate BMP5 expression in the dorsal forebrain.

PNAS

10051661:10184

Zebrafish_bmp4_20080727

http://www.pnas.org/cgi/content/full/96/5/2439

v96 i5 p2439

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:653::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=10051661&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=10051661

Expression

bmp4

positive

bmp7

bmp4 does not regulate the expression of itself or other BMPs bmp4 can activate its own expression in Xenopus overexpression experiments (Jones et al., 1992), and in zebrafish, both BMP2b and BMP7 are required for the maintenance of bmp2b, bmp7, and bmp4

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:655::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17727832&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)01214-6

Expression

bmp4

negative

bmp7

Because the expression of zebrafish bmp4 is delayed in comparison with the expression of bmp2b and bmp7 (Nikaido et al., 1997) and because no mutants in bmp4 were identified in any of the large-scale morphological screens, the role of bmp4 in zebrafish ha

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:655::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17727832&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)01214-6

Binding

bmp4

neutral

bmp7

This synergy is best explained by formation of BMP2/7 and 4/7 heterodimers.

egg

Cell Sci

15759283:7

Zebrafish GRN from literatures-7-24-2008

http://jcs.biologists.org/cgi/content/full/117/7/1269

v117 i7 p1269

urn:agi-Binding:inout-urn:agi-llid:655:inout-urn:agi-llid:652:

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\William S. Talbot 2005-1.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cWilliam%20S.%20Talbot%202005-1.pdf):pdf

Binding

bmp4

neutral

bmpr1a

BMP-4 bound to ALK-3 in MC3T3-E1 osteoblasts and human foreskin fibroblasts.

foreskin

Biology of reproduction

8006002:8

Zebrafish_bmp4_20080727

http://www.biolreprod.org/cgi/content/full/67/2/473

v67 i2 p473

urn:agi-Binding:inout-urn:agi-llid:657:inout-urn:agi-llid:652:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17255107&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=17255107

Regulation

bmp4

unknown

chd

Chordin is a Bmp antagonist whose expression is positively regulated by Bapx1, bmp4, and Wnt9a (Fig. 3).

Zebrafish_Bmp2b_20080727

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:8646::unknown

digtext:http://www3.interscience.wiley.com/blank.html

Regulation

bmp4

positive

chd

The same results were obtained when the endogenous level of bmp4 was increased with tolloid overexpression, which antagonizes chordin degradation of bmp4 (data not shown) (Blader et al., 1997).

Zebrafish_bmp4_20080727

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:8646::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11830566&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=11830566

Expression

bmp4

positive

chd

The injection of BMP-4 or pCSKAXwnt-8 leads to an inhibition in the expression of chordin (Fig. 7E,F).

Zebrafish_Chordin_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:8646::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=11025206&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0925477300004123

Binding

bmp4

neutral

chd

Biochemical experiments showed that Bgn binds bmp4 and Chordin, interaction that increased binding of bmp4 to Chordin.

mesoderm

J. Biol. Chem

15775969:5

174

Zebrafish GRN from literatures-7-24-2008

http://www.jbc.org/cgi/content/full/278/36/34181

v278 i36 p34181

urn:agi-Binding:inout-urn:agi-llid:8646:inout-urn:agi-llid:652:

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\William S. Talbot 2005-1.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cWilliam%20S.%20Talbot%202005-1.pdf):pdf

Expression

bmp4

positive

cpb1

Similarly, bone morphogenetic proteins (particularly bmp4 and BMP7) are produced in the lateral mesodermand have been implicated in the induction of pancreas-specific gene expression, at least inexplanted endoderm (Kumar et al., 2003).

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:1360::positive

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Sagerstrom-CG-2007.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cSagerstrom-CG-2007.pdf):pdf

Regulation

bmp4

positive

dcp1a

Coimmunoprecipitation experiments identified the formation of a complex between SMIF and Smad4, which is enhanced by TGF? or bmp4 treatment (Fig. 2d).

Zebrafish_bmp4_20080727

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:55802::positive

digtext:http://ad.doubleclick.net/adi/cellbio.nature.com/curr_back;pos=right;lg=no;;sz=120x600;ord=1217141592288?

Expression

bmp4

neutral

dlx2a

As epithelial Dlx2 expression in the mandibular arch appaears to be partially regulated by bmp4 (Thomas et al., 2000), we also examined bmp4 expression.

Zebrafish_gata3_20080730

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:1746::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15306564&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15306564

Expression

bmp4

positive

dlx2a

It is possible that this is a downstream consequence of the loss of Bmp expression, as bmp4 has been shown to induce the expression of Dlx2 in mouse dental epithelium (Thomas et al. 2000).

Zebrafish_Bmp2a_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:1746::positive

digtext:http://www3.interscience.wiley.com/blank.html

Regulation

bmp4

unknown

dlx2b

In the canals, Bmp2 and Dlx5 are regulated by bmp4, either directly or indirectly.

Zebrafish_bmp4_20080727

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:1749::unknown

Expression

bmp4

positive

dlx2b

Expression of rDlx was also increased in bone after fracture, but at later times than were observed with BMP-4: elevated rDlx expression was detected after 48 h and persisted for 30 days or more.

bone

J. Biol. Chem

10701160:6

Zebrafish_bmp4_20080727

http://www.jbc.org/cgi/content/full/278/36/34387

v278 i36 p34387

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:1749::positive

Expression

bmp4

neutral

fgf8a

The strongest expression of bmp4 being on the right side, which in turn positively regulates fgf8a expression and prevents initiation of Nodal expression in the right LPM (Roderiguez Esteban et al., 1999 and Yokouchi et al., 1999).

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:2253::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17395172&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)00179-0

url(http%3a//dev.biologists.org/cgi/reprint/124/21/4253.pdf):pdf

Expression

bmp4

positive

fgf8a

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:2253::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17395172&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)00179-0

Expression

bmp4

negative

fgf8a

We find that excess bmp4 represses fgf8a transcription in mandibular explants.

ectoderm

11784076:6

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:2253::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=12217322&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012160602907529

Binding

bmp4

neutral

fsta

Inhibitory effect of Ep45 on the binding of BMP-4 to follistatin.

J. Biol. Chem

10480892:1187

Zebrafish_Bmp2b_20080727

http://www.jbc.org/cgi/content/full/274/38/26843

v274 i38 p26843 (1999)

urn:agi-Binding:inout-urn:agi-llid:652:inout-urn:agi-llid:10468:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15581883&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00657-8

Regulation

bmp4

positive

gata2

Here we demonstrate that BMP-4 can stimulate GATA-2 expression, and that expression of a dominant negative BMP-4 receptor can suppress GATA-2 induction by BMP-4 in ventral mesoderm.

mesoderm

J. Biol. Chem

8822915:3

Zebrafish_gata3_20080730

http://www.jbc.org/cgi/content/full/277/26/23872

v277 i26 p23872

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:2624::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=14610062&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=14610062

Expression

bmp4

neutral

gata2

Mutations that abolish this binding also block BMP-4 mediated induction of the gata2 promoter.

Zebrafish_gata2_20080730

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:2624::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=16061939&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16061939

Expression

bmp4

positive

gata2

Here we demonstrate that BMP-4 can stimulate GATA-2 expression, and that expression of a dominant negative BMP-4 receptor can suppress GATA-2 induction by BMP-4 in ventral mesoderm.

mesoderm

PNAS

8822915:3

AllGenes-Pathway

http://www.pnas.org/cgi/content/full/100/15/8811

v100 i15 p8811

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:2624::positive

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Evans-T-2005b.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cEvans-T-2005b.pdf):pdf

Regulation

bmp4

positive

gata4

Administration of 100 ng/ml bmp4 to these cultures results in the loss of all these markers and the up-regulation of the lateral plate marker, GATA4 (Fig. 6 A, lane 1).

Genes & Dev

9450925:10104

Zebrafish_myod_20080731

http://www.genesdev.org/cgi/content/full/12/3/290

v12 i3 p290

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:2626::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=9450925&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=9450925

Expression

bmp4

positive

gata4

Initially, BMPs (especially BMP-2 and/or BMP-4) transactivate the expression of two major cardiac-specific transcription factors, Csx/Nkx-2.5 and GATA-4.

Mol. Cell. Biol

10490646:10269

AllGenes-Pathway

http://mcb.asm.org/cgi/content/full/19/10/7096

v19 i10 p7096

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:2626::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12835401&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=12835401

Expression

bmp4

neutral

gata5

These results indicate that both Bmp2b and Oep regulate gata5 expression in the myocardial precursors, and that gata5 does not require Bmp2b or Oep to promote early myocardial differentiation.

11397003:10

AllGenes-Pathway

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:140628::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=11397003&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(01)90259-3

Expression

bmp4

positive

hand2

Exposure of gut-derived neural crest-derived cells to bmp4 significantly increased the expression of HAND2 in all gut segments.

12450220:7

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:9464::positive

digtext:http://dev.biologists.org/cgi/reprint/127/18/4073.pdf

url(http%3a//dev.biologists.org/cgi/reprint/127/18/4073.pdf):pdf

Expression

bmp4

positive

kdr

Bone morphogenetic protein 4 (bmp4) is crucial for the formation of FLK1-expressing (FLK1(+)) mesodermal cells.

mesoderm

16887829:0

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:3791::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15721310&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0006-291X(05)00167-1

Expression

bmp4

positive

lef1

In addition, the finding that the expression of Lef1 can be activated by bone morphogenetic protein 4 (BMP-4) suggests a regulatory role of this transcription factor in BMP-mediated inductive tissue interactions.

mesenchyma

Cell Sci

8647435:5

AllGenes-Pathway

http://jcs.biologists.org/cgi/content/full/114/19/3419

v114 i19 p3419

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:51176::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12502739&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=12502739

Expression

bmp4

neutral

lft1

We have recently shown that KV-expressed bmp4 is necessary for lefty1 expression in the posterior notochord at early segmentation (Chocron et al., 2007).

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:7044::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=18222420&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)01565-5

Expression

bmp4

positive

lft1

Our data lead to a model in which bmp4 is required to prevent nodal expression in the right LPM by inducing lefty1 expression (Fig. 8).

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:7044::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17395172&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)00179-0

Binding

bmp4

neutral

lft1

In addition, overexpression studies in Xenopus embryos revealed a strong interaction between bmp4 and Lefty1 during LR patterning (Branford et al., 2000).

Zebrafish_Bmp2b_20080727

urn:agi-Binding:inout-urn:agi-llid:7044:inout-urn:agi-llid:652:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17395172&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)00179-0

Expression

bmp4

positive

lft2

Our results with the knock down of bmp4 (Fig. 6) demonstrate that the left-sided bmp4 expression in the LPM is required for lefty1 and lefty2 expression and cardiac jogging.

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:10637::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17395172&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)00179-0

Regulation

bmp4

positive

msxd

bmp4 appaears to regulate expression of a putative downstream gene, Msx2, in the optic vesicle.

lens

J. Biol. Chem

9851982:6

Zebrafish_bmp4_20080727

http://www.jbc.org/cgi/content/full/275/3/2063

v275 i3 p2063

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:4488::positive

digtext:http://ad.doubleclick.net/adi/cellbio.nature.com/curr_back;pos=right;lg=no;;sz=120x600;ord=1217141592288?

Expression

bmp4

positive

msxe

We show that changes in Bmp-4 expression precede changes in Msx-1 expression.

epithelia

Science

9707326:6

Zebrafish_Bmp2b_20080727

http://www.sciencemag.org/cgi/content/full/282/5391/1136

v282 i5391 p1136

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:4487::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=16959242&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(06)01086-4

Regulation

bmp4

negative

myf5

bmp4 is a potent antagonist of Shh-mediated Myf5 and MyoD activation in epaxial progenitors, and in the absence of bmp4 signaling, Myf5 and MyoD are expressed ectopically throughout the dermomyotome (Pourquie et al. 1996).

Zebrafish_myod_20080731

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:4617::negative

digtext:http://arjournals.annualreviews.org/doi/full/10.1146/annurev.cellbio.18.012502.105758

Expression

bmp4

neutral

myf5

It has been shown that embryonic expression of Xenopus MyoD or Myf5 requires a specific level of BMP signaling (Re'em-Kalma et al. 1995 ; Dosch et al. 1997 ), which is regulated by BMP2, bmp4, and BMP7 expressed in ventral regions of the embryo, and BMP a

Genes & Dev

9450925:10031

Zebrafish_myod_20080731

http://www.genesdev.org/cgi/content/full/12/3/290

v12 i3 p290

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:4617::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=9450925&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=9450925

Expression

bmp4

positive

myf5

Our experiments indicate that, in the chick embryo, expression of the MyoD and myf5genes is also controlled by the same bmp4/Noggin patterningsystem but at a much later stage of development, i.e. after so-mitogenesis.

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:4617::positive

digtext:http://dev.biologists.org/cgi/reprint/124/22/4605.pdf

url(http%3a//dev.biologists.org/cgi/reprint/124/22/4605.pdf):pdf

Regulation

bmp4

negative

myod1

Zebrafish_myod_20080731

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:4654::negative

digtext:http://arjournals.annualreviews.org/doi/full/10.1146/annurev.cellbio.18.012502.105758

Expression

bmp4

neutral

myod1

It has been shown that embryonic expression of Xenopus MyoD or Myf5 requires a specific level of BMP signaling (Re'em-Kalma et al. 1995; Dosch et al. 1997), which is regulated by BMP2, bmp4, and BMP7 expressed in ventral regions of the embryo, and BMP ant

Zebrafish_myod_20080731

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:4654::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=9450925&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=9450925

Expression

bmp4

positive

myod1

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:4654::positive

digtext:http://dev.biologists.org/cgi/reprint/124/22/4605.pdf

url(http%3a//dev.biologists.org/cgi/reprint/124/22/4605.pdf):pdf

Expression

bmp4

negative

myod1

Interestingly, administration of 50 ng/ml of bmp4 abolished MyoD expression whereas that of Pax3 was only diminished (Fig. 5 B, cf. lanes 3 and 4).

Genes & Dev

9450925:10097

AllGenes-Pathway

http://www.genesdev.org/cgi/content/full/12/3/290

v12 i3 p290

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:4654::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=9450925&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=9450925

Expression

bmp4

negative

nkx2.5

bmp4 inhibits early Nkx2.5 expression but not cardiogenesis: injected Gata4 elevates endogenous Gata4 and gata5 mRNA levels. (A) Nkx2.5 and Nkx2.3 are present in uninjected animal caps (stage 16).

Zebrafish_sox17_20080726

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:1482::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12835401&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=12835401

Expression

bmp4

positive

nkx3.2

bmp4 beads placed proximally lead to complete lossof Bapx1 expression.

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:579::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=14729484&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012160603006481

Expression

bmp4

negative

nkx3.2

In our mandible experiments, bmp4 was found to inhibit mesenchymal Bapx1 expression; thus, the signals that regulate Bapx1 expression appaear to have different roles in different tissues.

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:579::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=14729484&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012160603006481

Expression

bmp4

neutral

nkx3.2

FGF signaling is required for maintaining barx1 expression, and that ectopic bmp4 induces expression of barx1 in the intermediate region of the second pharyngeal arch.

Zebrafish_crestin_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:56033::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=18158147&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)01536-9

Expression

bmp4

positive

nkx3.2

FGF signaling is required for maintaining barx1 expression, and that ectopic bmp4 induces expression of barx1 in the intermediate region of the second pharyngeal arch.

Zebrafish_crestin_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:56033::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=18158147&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)01536-9

Expression

bmp4

positive

nog1

Surprisingly, BMP-4 up-regulates expression of noggin which encodes a BMP-4 antagonist.

ectoderm

J. Biol. Chem

9927604:5

Zebrafish_bmp4_20080727

http://www.jbc.org/cgi/content/full/277/3/2089

v277 i3 p2089

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:9241::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=9722173&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0303-7207(98)00033-1

Binding

bmp4

neutral

nog1

Noggin binds to BMP-2/4 with high affinity, and prevents binding to cell surface receptors.

egg

Mol. Cell. Biol

10657699:2

Zebrafish_otx1_20080724

http://mcb.asm.org/cgi/content/full/19/10/7096

v19 i10 p7096

urn:agi-Binding:inout-urn:agi-llid:9241:inout-urn:agi-llid:652:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15196956&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012160604002489

url(http%3a//dev.biologists.org/cgi/reprint/124/21/4253.pdf):pdf

Expression

bmp4

negative

olig3

Conversely, in din mutants, the lateral olig3 domain is reduced ( Fig. 6 d and e ), and overexpression of bmp2b suppresses olig3 expression (not shown; n = 10).

PNAS

15731351:10131

Zebrafish_oligo2_20080801

http://www.pnas.org/cgi/content/full/102/12/4377

v102 i12 p4377

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:167826::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=15731351&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15731351

Expression

bmp4

negative

otx2

In contrast, bmp4 completely suppresses expression of otx2 and opl in intact caps (compare Fig. 5C, lanes 4 and 5), consistent with its role as a ventral inducer and antagonist of neural development.

Zebrafish_Otx2_20080724

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:5015::negative

digtext:http://www3.interscience.wiley.com/blank.html

Expression

bmp4

positive

pax3

Because Pax3 is expressed in both the neural tube and the paraxial mesoderm, to evaluate whether bmp4 administration affects the expression of Pax3 in somitic cells in response to signals from the axial tissues, we combined quail axial tissues with chick

Zebrafish_myod_20080731

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:5077::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=9450925&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=9450925

Expression

bmp4

negative

pax3

These findings indicate that bmp4 signals can block somitic myogenesis in response to signals from the axial tissues downstream of somitic Pax3 gene expression.

Zebrafish_myod_20080731

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:5077::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=9450925&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=9450925

Expression

bmp4

positive

ptprf

Under these conditions, bmp4 addition induces the generation of a lar ge number of catecholaminer gic cells.

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:5792::positive

digtext:http://dev.biologists.org/cgi/reprint/127/18/4073.pdf

url(http%3a//dev.biologists.org/cgi/reprint/127/18/4073.pdf):pdf

Expression

bmp4

positive

shha

Implantation of bmp4 beads in the anterior neuropore of stage 10 chicken embryos repressed fgf8a and SHH expression.

egg

Biology of reproduction

11955708:1

AllGenes-Pathway

http://www.biolreprod.org/cgi/content/full/68/2/423

v68 i2 p423

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:6469::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12502739&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=12502739

Expression

bmp4

negative

shha

Implantation of bmp4 beads in the anterior neuropore of stage 10 chicken embryos repressed fgf8a and SHH expression.

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:6469::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=12217322&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012160602907529

Regulation

bmp4

positive

sim1

Lateral plate derived bmp4 specifies the lateral somitic compartment resulting in sim1 activation and the inhibition of the onset of myogenesis.

Zebrafish_bmp4_20080727

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:6492::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=9722173&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0303-7207(98)00033-1

Regulation

bmp4

positive

smad1

bmp4 treatment also resulted in sustained elevation of Smad1.

stroma

Genes & Dev

12959928:7

Zebrafish_smad1_20080729

http://www.genesdev.org/cgi/content/full/18/15/1838

v18 i15 p1838

phosphorylation

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:4086::positive:phosphorylation

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12393873&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=12393873

Regulation

bmp4

negative

smad1

BMP-4 increased phosphorylation of endogenous Smad1 as describedpreviously (Fig. 7, lane 2), and SANE reduced BMP-dependent Smad1 phosphorylation in a dose-dependent manner (Fig. 7, lanes 3 and 4, upper panel) without changing the level of Smad1 protein (

Zebrafish_smad1_20080729

phosphorylation

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:4086::negative:phosphorylation

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12393873&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=12393873

Expression

bmp4

neutral

smad1

D-J: Ventral smad1 expression is positively regulated by Bmp2b, but not by bmp4.

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:4086::unknown

digtext:http://www3.interscience.wiley.com/blank.html

Expression

bmp4

positive

smad1

Injection studies and mutant analyses suggest that the ventral smad1 expression is positively regulated by Bmp2b, but not by bmp4 signaling, whereas smad5 expression is independent of Bmp2b.

egg

J. Biol. Chem

10590480:4

AllGenes-Pathway

http://www.jbc.org/cgi/content/full/276/49/46533

v276 i49 p46533

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:4086::positive

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\MATTHIAS HAMMERSCHMIDT 1999.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cMATTHIAS%20HAMMERSCHMIDT%201999.pdf):pdf

Binding

bmp4

neutral

smad1

Model for the interaction of Bmp2b, Smad1, and Smad5 during dorsoventral pattern formation. bmp2b, activated by an as yet unknown factor (?), starts to be expressed after midblastula transition (phase 1).

Evol. Bioinformatics

Zebrafish_Bmp2b_20080727

http://www.la-press.com/journals.php?pa=abstract&content_id=323

urn:agi-Binding:inout-urn:agi-llid:652:inout-urn:agi-llid:4086:

digtext:http://www3.interscience.wiley.com/blank.html

0.8400

Regulation

bmp4

positive

smad4

We found that the bmp4-induced Smad4/5 complex formation has DNA-binding ability.

Cell Sci

12857787:10187

Zebrafish_bmp4_20080727

http://jcs.biologists.org/cgi/content/full/116/16/3363

v116 i16 p3363

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:4089::positive

digtext:http://ad.doubleclick.net/adi/cellbio.nature.com/curr_back;pos=right;lg=no;;sz=120x600;ord=1217141592288?

Binding

bmp4

neutral

smad5

T o in v estigate whether smad5 and bmp2b interact genetically , sbn , swr double mutant embryos were generated.

Evol. Bioinformatics

Zebrafish GRN from literatures-7-24-2008

http://www.la-press.com/journals.php?pa=abstract&content_id=323

urn:agi-Binding:inout-urn:agi-llid:652:inout-urn:agi-llid:4090:

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Matthias Hammerschmidt 1999-1.pdf

0.8499

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cMatthias%20Hammerschmidt%201999-1.pdf):pdf

Expression

bmp4

neutral

smad7

In addition to overexpression we also present genetic evidence that smad7 expression is dependent on BMP2b signaling.

Zebrafish_smad2_20080729

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:4092::unknown

digtext:http://www3.interscience.wiley.com/blank.html

Expression

bmp4

positive

tbx6

Wnt8 and Bmp2b are required for tbx6 expression.

Zebrafish_tbx6_20080804

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:6911::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15240553&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15240553

Regulation

bmp4

positive

ttna

mesoderm

11977982:4

Zebrafish_bmp4_20080727

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:7273::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=10491267&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(99)99401-0

Expression

bmp4

positive

ttna

mesoderm

11977982:4

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:7273::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=10491267&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(99)99401-0

Expression

bmp4

positive

twsg1a

Co-immunoprecipitation of chordin and bmp4 is greatly enhanced in the presence of Tsg (Fig. 2f).

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:57045::positive

digtext:http://ad.doubleclick.net/adi/nature.com/article;type=lt;artid=410475a0;pos=right;issue=6827;webfo=;prod=;natco=;natcl=;subco=;chaco=;keywd=;;sz=160x600;ord=1217142367093?

Binding

bmp4

neutral

twsg1a

We provide evidence that Tsg interacts genetically with bmp4.

bone

Mol. Cell. Biol

14681194:5

Zebrafish_bmp4_20080727

http://mcb.asm.org/cgi/content/full/23/8/2969

v23 i8 p2969

urn:agi-Binding:inout-urn:agi-llid:652:inout-urn:agi-llid:57045:

digtext:http://ad.doubleclick.net/adi/nature.com/article;type=lt;artid=410475a0;pos=right;issue=6827;webfo=;prod=;natco=;natcl=;subco=;chaco=;keywd=;;sz=160x600;ord=1217142367093?

Expression

bmp4

positive

vegfaa

BMP-4 significantly stimulated VEGF synthesis time-dependently up to 48 h.

bone

Endocrin. Metabol

11255225:1

Zebrafish_bmp4_20080727

http://ajpendo.physiology.org/cgi/content/full/284/6/E1202

v284 i6 pE1202

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-llid:7422::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15721310&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0006-291X(05)00167-1

Expression

bmp4

positive

wnt

High levels of BMP-4 induce the expression of the Wnt antagonist sizzled in the ventral marginal zone, independent of Xwnt-8 signaling.

mesoderm

10495269:3

Zebrafish_myod_20080731

urn:agi-Expression:inout-urn:agi-llid:652:out-urn:agi-go:0042813::positive

digtext:http://arjournals.annualreviews.org/doi/full/10.1146/annurev.cellbio.18.012502.105758

Expression

bmp4

negative

zfhx1

kheper (zfhx1) expression was strongly reduced in the bmp4 RNA-injected embryos.

overexpression

neuroectoderm

Naomasa Miki

Developmental Biology

2000

228

Regulation

acvr1

positive

bmp4

A constitutively active Alk8-TGFbeta-receptor can ectopically induce bmp2b and bmp4 and rescues the dorsalization of MZspg.

16775002:9

Zebrafish_gsc _20080801

urn:agi-Regulation:inout-urn:agi-llid:90:out-urn:agi-llid:652::positive

Expression

acvr1

neutral

bmp4

Together, these results show that Mrdr and alk8 strongly interact to positively regulate the onset of bmp2b/4 expression.

Zebrafish_gdf6a_07302008

urn:agi-Expression:inout-urn:agi-llid:90:out-urn:agi-llid:652::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=12601179&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12601179

Expression

acvr1

positive

bmp4

This indicates that pou2 acts upstream of Alk8, a maternally provided receptor implicated in the activation of zygotic bmp2b and bmp4 transcription.

PNAS

16775002:10

AllGenes-Pathway

http://www.pnas.org/cgi/content/full/100/6/3315

v100 i6 p3315

urn:agi-Expression:inout-urn:agi-llid:90:out-urn:agi-llid:652::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=11165484&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0925477300005414

Expression

acvr1

negative

bmp4

In contrast, KM Alk8 down regulates ventral bmp2b expression in shield stage embryos (data not shown).

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:90:out-urn:agi-llid:652::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=11165484&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0925477300005414

Binding

bmp1a

neutral

bmp4

BMP1 Prodomain Sequences Specifically Bind BMP2/4 with High Affinity—To more closely explore the ability of BMP1 prodomain sequences to interact with TGF-?-like BMPs, BMP1 prodomain, free of other sequences other than a COOH-terminal His tag, was produced

Zebrafish_bmp4_20080727

urn:agi-Binding:inout-urn:agi-llid:652:inout-urn:agi-llid:649:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17255107&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=17255107

Expression

bmp2a

negative

bmp4

In contrast to the situation in Xenopus, where BMP2/4/7 are provided maternally and may create a default state, the delayed zygotic initiation of ubiquitous bmp2b/4/7 expression in the zebrafish embryo could be interpreted as a ventral default setting of

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:652::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=12682283&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12682283

Binding

bmp2a

neutral

bmp4

This synergy is best explained by formation of BMP2/7 and 4/7 heterodimers.

mesoderm

Bauer,H.;Meier,A.;Hild,M.;Stachel,S.;Economides,A.;Hazelett,D.;Harland,R.M.;Hammerschmidt,M.

J. Biol. Chem

1998

204

488-507

15759283:7

Zebrafish_Bmp2b_20080727

http://www.jbc.org/cgi/content/full/275/44/34365

v275 i44 p34365

urn:agi-Binding:inout-urn:agi-llid:652:inout-urn:agi-llid:650:

0012-1606

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])1998/01/01:1999/12/31[edat]

Dev Biol

Dec

url(http%3a//dev.biologists.org/cgi/reprint/126/23/5327.pdf):pdf

Follistatin and noggin are excluded from the zebrafish organizer.

Expression

bmp2b

positive

bmp4

At the end of gastrulation, bmp4 expression at the ventral side was completely abolished in swr mutant embryos.

mutant embryos

5.25

margin

Igor B. Dawid

genesis

2000

Expression

bmp7

positive

bmp4

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:655:out-urn:agi-llid:652::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17727832&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)01214-6

Expression

bmp7

negative

bmp4

OP-1 downregulated the BMP-4, -5, and -6 mRNA levels by a maximal of 2-fold, 1.5-fold, and 6-fold, respectively.

bone

Cell

10942522:7

Zebrafish_Bmp2b_20080727

http://www.cell.com/cgi/content/full/91/1/127.1

v91 i1 p127.1

urn:agi-Expression:inout-urn:agi-llid:655:out-urn:agi-llid:652::negative

Expression

bmpr1a

negative

bmp4

On the contrary, the overexpression of Alk3tr partially blocked the Rdr-mediated induction of bmp4 expression in late blastulae, as well as in early gastrula (shield stage) (Fig. 3G,H).

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:657:out-urn:agi-llid:652::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=11091070&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0925477300004706

Expression

bmpr1b

negative

bmp4

In contrast to Alk3tr, Alk6tr efficiently blocked the up-regulation of bmp2b early expression by Rdr (Fig. 4H).

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:658:out-urn:agi-llid:652::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=11091070&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0925477300004706

Expression

bmpr2a

positive

bmp4

Bmpr2a and bmpr2b indirectly regulate bmp4 expression downstream of Nodal signalling Several lines of evidence suggest that BMPs regulate the heart positional information with respect to the midline.

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:659:out-urn:agi-llid:652::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=18222420&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)01565-5

Expression

bmpr2b

positive

bmp4

Bmpr2a and bmpr2b indirectly regulate bmp4 expression downstream of Nodal signalling Several lines of evidence suggest that BMPs regulate the heart positional information with respect to the midline.

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:659:out-urn:agi-llid:652::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=18222420&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)01565-5

Expression

bon

positive

bmp4

otx2 expression is reduced in sqt–/– and bon–/–;sqt–/– embryos.

mutant embryos

mesoderm

Didier Y. R. Stainier

Development

2003

130

4989

Regulation

chd

negative

bmp4

In both organisms, the activity of the TGF-beta family member DPP/bmp4 is antagonized by SOG/CHORDIN.

germ

Cell

8791529:1

Zebrafish GRN from literatures-7-24-2008

http://www.cell.com/cgi/content/full/88/6/747

v88 i6 p747

urn:agi-Regulation:inout-urn:agi-llid:8646:out-urn:agi-llid:652::negative

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\William S. Talbot 2001.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cWilliam%20S.%20Talbot%202001.pdf):pdf

Expression

ctnnb1

negative

bmp4

zebrafish recessive maternal effect mutant, ichabod, that results in severe anterior and dorsal defects during early development using in-situ hybridization.

mutant

blastomere

Weinberg, E. S.

Development

2000

127

3899

Expression

ctnnb1

positive

bmp4

Oncogenic ?-catenin is required for bmp4 expression.

Cancer Res

12019147:10150

Zebrafish_Chordin_20080727

http://cancerres.aacrjournals.org/cgi/content/full/62/10/2744

v62 i10 p2744

urn:agi-Expression:inout-urn:agi-protfc:catenin:out-urn:agi-llid:652::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17686615&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0925-4773(07)00101-3

Expression

ctnnb1

negative

bmp4

W e suggest a molecular pathway for initiation of dorso v entral asymmetry of bmp2b expression in which b -catenin signaling acti v ates boz , which, in turn, represses bmp2b transcription in the prospecti v e organizer .