bmp2b
Type Gene1 Effect Gene2 Sentence Perturbation methods Time of Interaction in evidence territories of interaction or Tissue Evidence for Direct Authors Journal PubYear Volume Pages MedLine Reference Connectivity # of References Found In Pathways Journal Link Journal Reference Mechanism URN ISSN Issue LocatorString MedlineTA PubMonth p-value [Evol. Bioinformatics 2007:3(197)] TextPath Title
Expression bmp2b negative acvr1b We never found a homozygous laftm110b embryo that had a wild-type or ventralized phenotype, consistent with the Laf/Alk8 receptor functioning downstream of the Bmp2b. overexpression 5.25 blastoderm 2 Thierry Lepage Development 2006 133 2189















Expression bmp2b positive alk8 Laf/Alk8 as a type I BMP receptor required for the specification of ventral cell fates. mutant embryos 4.66 hypoblast 1 Mary C. Mullins Development 2001 128 859















Expression bmp2b positive bmp2b In wild-type embryos at 80% epiboly (8.3 hpf), gata5 is expressed in large, flat endodermal cells predominantly on the dorsal side and smaller, rounder mesodermal cells on the ventral side . Swr/bmp2b mutants lack ventral, mesodermal expression of gata5. mutant embryos 6 margin 1 Matthias Hammerschmidt Development 1999 126 2149















Expression bmp2b positive bmp4 At the end of gastrulation, bmp4 expression at the ventral side was completely abolished in swr mutant embryos. mutant embryos 5.25 margin 1 Igor B. Dawid genesis 2000 28 58















Expression bmp2b positive eve1 In swirl/bmp2b dorsalized mutant embryos, ttl1 expression is reduced at bud and later stages. overexpression 8 margin 2 Matthias Hammerschmidt Developmental Dynamics 1999 216 285















Expression bmp2b positive gata4 Bmp2b (hence zygotic BMP) are required to maintain vox levels during gastrulation. mutant embryos 30 liver 1 Didier Y. R. Stainier Development 2007 134 2041















Expression bmp2b positive gata5 prdm1 expression is eliminated at the neural plate border in Bmp2b, expanded in Smad5 and reduced in BMP7 mutant embryos. mutant embryos 8 endoderm 1 Didier Y. R. Stainier Developmental Biology 2001 234 330















Expression bmp2b negative ndr1 Ved expression domain expanded to the dorsal margin in bmp2b RNA-injected embryos at the 80% epiboly stage. overexpression 8 margin 2 Hammerschmidt, M. Curr Biol 2007 17 475















Expression bmp2b positive nkx2.5 At the end of gastrulation, ventral expression of vega2, as that of vega1, was only partly decreased in swr mutant embryos. mutant embryos 14 heart primordium 1 Didier Y. R. Stainier Developmental Biology 2001 234 330















Expression bmp2b positive prdm1a At the end of gastrulation, ventral expression of vega2, as that of vega1, was only partly decreased in swr mutant embryos. mutant embryos 11.66 neural plate border 1 Kristin Bruk Artinger Developmental Biology 2005 278 347















Expression bmp2b negative tbx24 ved expression is down-regulated at late blastula stage in bmp2b signaling mutants. overexpression 8 mesoderm 2 Hammerschmidt, M. Curr. Biol. 2007 17(6) 475















Expression bmp2b positive tbx2b Bmp2b (hence zygotic BMP) are required to maintain vox levels during gastrulation. dominant negative 16 diencephalon 1 Kimelman, D. Development 2006 133 2275















Expression bmp2b positive ved At the end of gastrulation, ventral expression of vega2, as that of vega1, was only partly decreased in swr mutant embryos. mutant embryos 8 ectoderm 2 Hirano, T. Mechanisms of Development 2002 118 125















Expression bmp2b positive vent bmp2b-injected embryos show a significant increase of eve1 mRNA levels. mutant embryos 5.25 margin 1 Igor B. Dawid genesis 2000 28 58















Expression bmp2b negative vox Both bmp2b- and bmp4-injected embryos show a significant increase of eve1 mRNA levels. mutant embryos 5.25 margin 1 Igor B. Dawid genesis 2000 28 58















Expression acvr1 positive bmp2b injected mRNA encoding a constitutively active version of Alk8 can rescue the strong dorsalization of bmp2b/swirl mutants. overexpression 4.66 blastoderm 2 Hammerschmidt, M. Development 2001 128 849















Expression bmp2b positive bmp2b In wild-type embryos at 80% epiboly (8.3 hpf), gata5 is expressed in large, flat endodermal cells predominantly on the dorsal side and smaller, rounder mesodermal cells on the ventral side . Swr/bmp2b mutants lack ventral, mesodermal expression of gata5. mutant embryos 6 margin 1 Matthias Hammerschmidt Development 1999 126 2149















Promoter Binding dharma negative bmp2b overexpression of boz, sqt or cyc is sufficient to induce chd expression. overexpression 4 YSL 4 Wolfgang Driever Development 2003 130 3639















Expression dusp6 positive bmp2b Ectopic expression of mkp3 or mkp3::C292S can suppress or enhance, respectively, the expression of sef (il17rd) at gastrula stage. overexpression 6 YSL 2 Igor B. Dawid Development 2004 131 2769















Expression erm negative bmp2b Misexpression of erm leads also to the local inhibition of bmp2b expression embryos. overexpression 5.25 neuroectoderm 2 Bernard Thisse Development 2004 131 2853















Expression fgf24 negative bmp2b Microinjection of fgf24 leads to inhibition of bmp4 expression at blastula stage. overexpression 4.66 YSL 2 Bernard Thisse Development 2004 131 2853















Expression fgf3 negative bmp2b activation of the FGF/ERK pathway disrupts endoderm formation in the embryo and antagonizes the ability of an activated form of Tar/Acvr1b to induce endoderm at the animal pole. overexpression 4.66 margin 2 Bernard Thisse Development 2004 131 2853















Expression fgf8 negative bmp2b Inhibition of Fgf signalling by injection of RNA encoding the Fgf-antagonist Spry2; dn-fgfr1; a dominant-negative variant of the signal transducer Ras or treatment with the pharmacological Fgfr antagonist SU5402, all results in expanded bmp2b expression. overexpression 4.66 margin 2 Bernard Thisse Development 2004 131 2853















Expression igf1rb negative bmp2b Increased BMP2b expression in embryo injected with DN-IGF-1R. Decreased expression of BMP2b in embryo injected with IGF-1 mRNA. overexpression dominant negative 6 margin 2 LUCY BYRNES Int. J. Dev. Biol. 2004 48 1131















Expression pea3 negative bmp2b In accordance with this, localised overexpression of either erm1 or pea3 RNA causes ectopic expression of the Fgf target-gene spry4 overexpression 10 ectoderm
Bernard Thisse Development 2004 131 2853















Expression smad5 positive bmp2b The Mm169/m169 mutant shows strongly reduced bmp7 staining. mutant embryos 6 margin 1 Matthias Hammerschmidt Development 1999 126 2149















Expression sox32 positive bmp2b We found that shh expression in the endoderm region, but not in the floor-plate region, is absent in 226D7 (Sox32)-MO-injected embryos at the 38-h stage . overexpression 8 mesoderm 2 Hiroyuki Takeda Mechanisms of Development 2001 107 25















Expression spry2 positive bmp2b inhibition of spry2 function by co-injection of spry2 morpholino and DN-Spry2 RNA, which results in an increase of Fgf activity, causes a reduction of bmp2b expression in the ventral blastoderm. dominant negative 8 margin 2, 3 Bernard Thisse Development 2004 131 2853















Expression ved positive bmp2b In ved-injected embryos, vent expression domain is ectopically expanded in a graded pattern, from ventral to dorsal. MASO 5.25 YSL 2, 3 Franco Cotelli Developmental Dynamics 2004 230 494