bmp2a

Type

Gene1

Effect

Gene2

Sentence

Perturbation methods

Time of Interaction in evidence

territories of interaction or Tissue

Evidence for Direct

Authors

Journal

PubYear

Volume

Pages

MedLine Reference

Connectivity

# of References

Found In Pathways

Journal Link

Journal Reference

Mechanism

URN

ISSN

Issue

LocatorString

MedlineTA

PubMonth

p-value [Evol. Bioinformatics 2007:3(197)]

TextPath

Title

Expression

bmp2a

negative

acvr1b

overexpression of BMPs compromises endoderm formation, formation of endoderm precursors is negatively regulated by BMPs on the ventral side.

overexpression

5.25

blastoderm

Thierry Lepage

Development

2006

133

2189

Expression

bmp2a

positive

admp

When ventral BMP2/4/7 signals are depleted, admp expression increases, allowing for self-regulation.

egg

16360041:4

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:165679::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=11784095&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012160601904944

Expression

bmp2a

negative

bmp4

In contrast to the situation in Xenopus, where BMP2/4/7 are provided maternally and may create a default state, the delayed zygotic initiation of ubiquitous bmp2b/4/7 expression in the zebrafish embryo could be interpreted as a ventral default setting of

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:652::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=12682283&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12682283

Binding

bmp2a

neutral

bmp4

This synergy is best explained by formation of BMP2/7 and 4/7 heterodimers.

mesoderm

Bauer,H.;Meier,A.;Hild,M.;Stachel,S.;Economides,A.;Hazelett,D.;Harland,R.M.;Hammerschmidt,M.

J. Biol. Chem

1998

204

488-507

15759283:7

Zebrafish_Bmp2b_20080727

http://www.jbc.org/cgi/content/full/275/44/34365

v275 i44 p34365

urn:agi-Binding:inout-urn:agi-llid:652:inout-urn:agi-llid:650:

0012-1606

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])1998/01/01:1999/12/31[edat]

Dev Biol

Dec

url(http%3a//dev.biologists.org/cgi/reprint/126/23/5327.pdf):pdf

Follistatin and noggin are excluded from the zebrafish organizer.

Binding

bmp2a

neutral

bmp7

This synergy is best explained by formation of BMP2/7 and 4/7 heterodimers.

bone

Cell Sci

15759283:7

Zebrafish_Bmp2b_20080727

http://jcs.biologists.org/cgi/content/full/117/7/1269

v117 i7 p1269

urn:agi-Binding:inout-urn:agi-llid:655:inout-urn:agi-llid:650:

digtext:http://dev.biologists.org/cgi/reprint/127/2/343.pdf

url(http%3a//dev.biologists.org/cgi/reprint/127/2/343.pdf):pdf

Binding

bmp2a

neutral

bmpr1a

To determine whether the effect of HGF occurs through known mediators which act downstream of the BMP-2/ALK3 complex, we examined the effect of HGF on BMP-2-induced Smad1 phosphorylation, Smad1/Smad4 complex formation, and Smad1 nuclear translocation.

tubule

PNAS

10633078:5

Zebrafish_Chordin_20080727

http://www.pnas.org/cgi/content/full/103/20/7643

v103 i20 p7643

urn:agi-Binding:inout-urn:agi-llid:657:inout-urn:agi-llid:650:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17483092&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=17483092

Binding

bmp2a

neutral

chd

Chordin also binds BMP2, bmp4, and BMP7 in a way similar to noggin ( 20 ).

J. Biol. Chem

12702725:10220

Zebrafish_bmp4_20080727

http://www.jbc.org/cgi/content/full/278/26/24113

v278 i26 p24113

urn:agi-Binding:inout-urn:agi-llid:8646:inout-urn:agi-llid:650:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17255107&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=17255107

Binding

bmp2a

neutral

col1a1

In mammals, Bmp2, Msx2, Sox9, Col2a1, Runx2 and Col1a1 interact in the developmental pathway leading from neural crest to cartilage and bone (Healy et al., 1999; Mori-Akiyama et al., 2003; Takahashi et al., 2001).

Evol. Bioinformatics

Zebrafish_crestin_20080727

http://www.la-press.com/journals.php?pa=abstract&content_id=323

urn:agi-Binding:inout-urn:agi-llid:650:inout-urn:agi-llid:1277:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15689370&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15689370

0.8900

Binding

bmp2a

neutral

col2a1a

Evol. Bioinformatics

10085302

Zebrafish_crestin_20080727

http://www.la-press.com/journals.php?pa=abstract&content_id=323

urn:agi-Binding:inout-urn:agi-llid:650:inout-urn:agi-llid:1280:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15689370&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15689370

0.9200

Expression

bmp2a

neutral

fgf8a

As bmp2 and bmp4 ventral expression never appaeared when fgf8a was overexpressed, this suggests that FGF-8 prevents the initiation of the expression of bmp2 and bmp4 in the ventral territory.

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:2253::unknown

digtext:http://dev.biologists.org/cgi/reprint/124/21/4253.pdf

url(http%3a//dev.biologists.org/cgi/reprint/124/21/4253.pdf):pdf

Binding

bmp2a

neutral

fsta

We provide data which show that Follistatin binds BMP-7 and BMP-2 at low affinities and that the binding is reversible.

muscle

EMBO

11846481:5

Zebrafish_Bmp2b_20080727

http://emboj.oupjournals.org/cgi/content/full/20/19/5361

v20 i19 p5361

urn:agi-Binding:inout-urn:agi-llid:650:inout-urn:agi-llid:10468:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=9882485&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(98)99003-0

Expression

bmp2a

positive

gata4

Via bead implantations, the Bmp gradient determines the direction of lateral mesodermal cell migration during dorsal convergence in the zebrafish gastrula.

mutant embryos

liver

Didier Y. R. Stainier

Development

2007

134

2041

Expression

bmp2a

positive

gata4

Initially, BMPs (especially BMP-2 and/or BMP-4) transactivate the expression of two major cardiac-specific transcription factors, Csx/Nkx-2.5 and GATA-4.

Mol. Cell. Biol

10490646:10269

AllGenes-Pathway

http://mcb.asm.org/cgi/content/full/19/10/7096

v19 i10 p7096

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:2626::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=18000065&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18000065

Expression

bmp2a

positive

gata5

In chicken embryos, Bmp2 that is located medially to the heart-forming region induced the expression of Nkx2-5 and Gata4/5/6, whereas repression of Bmp signaling by Noggin-expressing cells, which are implanted in precardiac mesoderm, abolished Nkx2-5 and

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:140628::positive

Expression

bmp2a

positive

gata6

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:2627::positive

Expression

bmp2a

positive

her15.1

In this paper, we show that BMP2 enhances Notch-induced transcriptional activation of Hes-5 and Hesr-1 in mouse neuroepithelial cells.

14500836:3

Zebrafish_sox17_20080726

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:256482::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=12351167&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0925477302002526

Expression

bmp2a

positive

hhex

In vivo induction assays show that the ability of BMP2 to activate Hex expression in the endoderm is restricted to a region that is only slightly larger than the endogenous domain of Hex expression.

endoderm

J. Biol. Chem

15063170:6

AllGenes-Pathway

http://www.jbc.org/cgi/content/full/277/47/45435

v277 i47 p45435

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:3087::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=10531010&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(99)80485-0

Regulation

bmp2a

positive

mef2a

In cardiac precursor cells, BMP-2 has recently been shown to induce expression of cardiac transcription factors, including myocyte enhancer factor 2A (MEF-2A).

12663654:1

Zebrafish_Bmp2b_20080727

urn:agi-Regulation:inout-urn:agi-llid:650:out-urn:agi-llid:4205::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17367767&db=pubmed&url=http://cardiovascres.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17367767

Expression

bmp2a

positive

mef2a

In cardiac precursor cells, BMP-2 has recently been shown to induce expression of cardiac transcription factors, including myocyte enhancer factor 2A (MEF-2A).

12663654:1

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:4205::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17367767&db=pubmed&url=http://cardiovascres.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17367767

Expression

bmp2a

positive

msxd

Interestingly the expression of Msx2 was induced by bone morphogenetic protein 2 treatment in Runx2-deficient mesenchymal cells.

mesenchyma

J. Biol. Chem

15175325:5

Zebrafish_ctnnb1_20080728

http://www.jbc.org/cgi/content/full/278/50/50195

v278 i50 p50195

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:4488::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=14551209&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=14551209

Binding

bmp2a

neutral

msxd

Zebrafish_crestin_20080727

urn:agi-Binding:inout-urn:agi-llid:650:inout-urn:agi-llid:4488:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15689370&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15689370

Expression

bmp2a

neutral

myf5

It has been shown that embryonic expression of Xenopus MyoD or Myf5 requires a specific level of BMP signaling (Re'em-Kalma et al. 1995 ; Dosch et al. 1997 ), which is regulated by BMP2, bmp4, and BMP7 expressed in ventral regions of the embryo, and BMP a

Genes & Dev

9450925:10031

Zebrafish_myod_20080731

http://www.genesdev.org/cgi/content/full/12/3/290

v12 i3 p290

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:4617::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=9450925&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=9450925

Expression

bmp2a

neutral

myod1

It has been shown that embryonic expression of Xenopus MyoD or Myf5 requires a specific level of BMP signaling (Re'em-Kalma et al. 1995; Dosch et al. 1997), which is regulated by BMP2, bmp4, and BMP7 expressed in ventral regions of the embryo, and BMP ant

Zebrafish_myod_20080731

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:4654::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=9450925&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=9450925

Expression

bmp2a

negative

ndr1

In embryos in which Bmp signaling was blocked at 18 hpf, gata4 and gata6 expression was greatly reduced in the liver region at 29-30 hpf.

overexpression

margin

Hammerschmidt, M.

Curr Biol

2007

475

Expression

bmp2a

positive

nkx2.5

Inhibition of either SPARC or Bmp2 attenuated in both cases cardiomyogenesis and downregulated nkx2.5 expression.

mesoderm

Mol. Cell. Biol

16165126:5

AllGenes-Pathway

http://mcb.asm.org/cgi/content/full/19/10/7096

v19 i10 p7096

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:1482::positive

Binding

bmp2a

neutral

nog1

Noggin binds to BMP-2/4 with high affinity, and prevents binding to cell surface receptors.

JPET

10657699:2

Zebrafish_myod_20080731

http://jpet.aspetjournals.org/cgi/content/full/314/3/1290

v314 i3 p1290

urn:agi-Binding:inout-urn:agi-llid:9241:inout-urn:agi-llid:650:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=9450925&db=pubmed&url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=9450925

Binding

bmp2a

neutral

runx2a

Evol. Bioinformatics

Zebrafish_crestin_20080727

http://www.la-press.com/journals.php?pa=abstract&content_id=323

urn:agi-Binding:inout-urn:agi-llid:860:inout-urn:agi-llid:650:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15689370&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15689370

0.9400

Binding

bmp2a

neutral

sox9a

Zebrafish_crestin_20080727

urn:agi-Binding:inout-urn:agi-llid:6662:inout-urn:agi-llid:650:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15689370&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15689370

Regulation

bmp2a

positive

tbx2b

Bmp2 within the developing AVC and IC has been shown to induce Tbx2, and we found that Tbx2 misexpression inhibited the expression of both Hey1 and Hey2.

17021042:5

Zebrafish GRN from literatures-7-24-2008

urn:agi-Regulation:inout-urn:agi-llid:650:out-urn:agi-llid:6909::positive

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Mercola-M-2006.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cMercola-M-2006.pdf):pdf

Expression

bmp2a

neutral

tbx2b

It has been reported that BMP-2 regulated tbx2 expression, an endogenous inhibitor of cardiac differentiation, in the mouse developing hearts [9].

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:6909::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17367767&db=pubmed&url=http://cardiovascres.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17367767

Expression

bmp2a

positive

tbx2b

It has been reported that BMP-2 regulated tbx2 expression, an endogenous inhibitor of cardiac differentiation, in the mouse developing hearts [9].

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:6909::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17367767&db=pubmed&url=http://cardiovascres.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17367767

Binding

bmp2a

neutral

twsg1a

Based on previous findings that vertebrate TSG, Chordin, and BMP-2/4 form a ternary complex ( 24 ? 26 ) and on the present finding that mouse TSG binds only heparin in the presence of Chordin and/or BMP-2/4, we suggest that establishment of high local con

bone

J. Biol. Chem

15381701:10271

Zebrafish_Chordin_20080727

http://www.jbc.org/cgi/content/full/279/49/51289

v279 i49 p51289

urn:agi-Binding:inout-urn:agi-llid:650:inout-urn:agi-llid:57045:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17483092&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=17483092

Expression

bmp2a

positive

wnt

We examined BMP-2-dependent expression of Wnt and its receptor frizzled in normal human keratinocytes.

egg

J. Biol. Chem

16442268:2

Zebrafish_ctnnb1_20080728

http://www.jbc.org/cgi/content/full/280/45/37660

v280 i45 p37660

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-go:0042813::positive

Expression

bmp2a

positive

wnt3l

Moreover, BMP-2 enhanced Wntl and Wnt3a expression in our cells.

mesenchyma

J. Biol. Chem

14584895:12

Zebrafish_ctnnb1_20080728

http://www.jbc.org/cgi/content/full/279/36/37704

v279 i36 p37704

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:89780::positive

Expression

bmp2a

positive

zic1

To address the question whether BMP2 signalling affects the extent of zic1 expression, we analysed swirl and chordino mutant embryos.

egg

10415355:1

AllGenes-Pathway

urn:agi-Expression:inout-urn:agi-llid:650:out-urn:agi-llid:7545::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=10415355&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0925-4773(99)00044-1

Binding

activin

neutral

bmp2a

In this study, we have exploited the well characterized model of Xenopus mesoderm induction to determine the intracellular interactions between BMP-2/4 and activin/BVg1 signaling cascades.

9409665:3

Zebrafish_Chordin_20080727

urn:agi-Binding:inout-urn:agi-llid:650:inout-urn:agi-go:0016915:

digtext:http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=inwardhub&_urlversion=4&_method=citationSearch&_piikey=S1534580708001172&_referrer=www.ncbi.nlm.nih.gov/pubmed/18477456?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa...

Expression

acvr1

positive

bmp2a

Since Bmps act as negative regulators of chordin expression (Schulte-Merker et al., 1998), and CA and KM Alk8 affect the expression of bmps2b and -4, it is expected that chordin expression would also be affected.

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:90:out-urn:agi-llid:650::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=11165484&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0925477300005414

Binding

acvr2b

neutral

bmp2a

Consistent with previous observations on the Drosophila type II receptor, punt ( 56 ), we were unable to observe any binding of BMP-2 to ActRII (Fig. 7 A , lane 8 ) or ActRIIB (data not shown) when these receptors were expressed alone.

Evol. Bioinformatics

9872992:10251

Zebrafish_Chordin_20080727

http://www.la-press.com/journals.php?pa=abstract&content_id=323

urn:agi-Binding:inout-urn:agi-llid:93:inout-urn:agi-llid:650:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17483092&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=17483092

6.9999

Regulation

ascl1a

unknown

bmp2a

During development of the autonomous nervous system of the mouse, expression of another vertebrate proneural genehomologue, Mash1 , has been proposed to depend on BMP2 signalling (Shah et al., 1996).

Zebrafish_neurog1_20080801

urn:agi-Regulation:inout-urn:agi-llid:429:out-urn:agi-llid:650::unknown

digtext:http://dev.biologists.org/cgi/reprint/124/22/4557.pdf

url(http%3a//dev.biologists.org/cgi/reprint/124/22/4557.pdf):pdf

Binding

bmp1a

neutral

bmp2a

The copurification suggested that BMP-1 and BMP-2 might physically interact, leading to the idea that Tolloid might increase DPP activity by proteolytically processing DPP precursors ( Shimell et al., 1991 ; Childs and O'Connor, 1994 ; Finelli et al., 199

Cell

101000938:11026

Zebrafish_bmp4_20080727

http://www.cell.com/cgi/content/full/91/3/407

v91 i3 p407

urn:agi-Binding:inout-urn:agi-llid:650:inout-urn:agi-llid:649:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17255107&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=17255107

Regulation

bmp4

unknown

bmp2a

In the canals, Bmp2 and Dlx5 are regulated by bmp4, either directly or indirectly.

Zebrafish_bmp4_20080727

urn:agi-Regulation:inout-urn:agi-llid:652:out-urn:agi-llid:650::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3494&itool=AbstractPlus-nondef&uid=18404215&db=pubmed&url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18404215

Expression

chd

negative

bmp2a

Injection with 4 ng of chd-MO led to expansion of gata2 expression.

MASO

margin

Anming Meng

Developmental Biology

2004

271

130

Regulation

chd

unknown

bmp2a

The present results show that chordin, CHL2, and CV2 regulate BMP-2 signaling by different recognition mechanisms.

17483092:10

Zebrafish_Chordin_20080727

urn:agi-Regulation:inout-urn:agi-llid:8646:out-urn:agi-llid:650::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17483092&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=17483092

Expression

fgf

neutral

bmp2a

Activating FGF signaling at the 512 cell stage results in an early decrease in bmp2, bmp4, and bmp7 expression at shield stage.

Zebrafish_Chordin_20080727

urn:agi-Expression:inout-urn:agi-protfc:fibroblast%20growth%20factor:out-urn:agi-llid:650::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15708554&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00806-1

Expression

fgf

positive

bmp2a

We postulate that FGFs in the cristae induce a canal genesis zone by inducing/upregulating Bmp2 expression.

Genes & Dev

15280215:6

Zebrafish_Chordin_20080727

http://www.genesdev.org/cgi/content/full/12/7/1046

v12 i7 p1046

urn:agi-Expression:inout-urn:agi-protfc:fibroblast%20growth%20factor:out-urn:agi-llid:650::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15708554&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00806-1

Expression

fgf

negative

bmp2a

Activating FGF signaling at the 512 cell stage results in an early decrease in bmp2, bmp4, and bmp7 expression at shield stage.

Zebrafish_Chordin_20080727

urn:agi-Expression:inout-urn:agi-protfc:fibroblast%20growth%20factor:out-urn:agi-llid:650::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15708554&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00806-1

Expression

fgf17

negative

bmp2a

Injection with 10 pg of fgf17b mRNA resulted in great expansion of ntl expression at the shield stage in 97.6% (n = 42) of the injected embryos.

overexpression

margin

Anming Meng

Developmental Biology

2004

271

130

Expression

fgf17

positive

bmp2a

Injection with 1 pg of fgf17b mRNA resulted in reduction of bmp2 and bmp4 expression at the shield stage in over 95% ( n > 28) of the embryos (Figs. 6B, F) , while injection with 4 ng of chd-MO, a morpholino that was able to knock down endogenous Chd acti

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-llid:8822:out-urn:agi-llid:650::positive

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Anming Meng 2004.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cAnming%20Meng%202004.pdf):pdf

Expression

fgf17

negative

bmp2a

We showed in the above experiments that overexpression of fgf17b inhibited expression of bmp2 and bmp4 on the ventral side.

Zebrafish_otx1_20080724

urn:agi-Expression:inout-urn:agi-llid:8822:out-urn:agi-llid:650::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15196956&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012160604002489

Expression

fgf8a

positive

bmp2a

Our study shows that, in addition to the known organizer factors, FGF-8 is a dorsalizingfactor that affects the BMP signaling pathway by negatively regulating the expression of the bmp2 and bmp4 genes.

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:2253:out-urn:agi-llid:650::positive

digtext:http://dev.biologists.org/cgi/reprint/124/21/4253.pdf

url(http%3a//dev.biologists.org/cgi/reprint/124/21/4253.pdf):pdf

Expression

fgf8a

negative

bmp2a

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:2253:out-urn:agi-llid:650::negative

digtext:http://dev.biologists.org/cgi/reprint/124/21/4253.pdf

url(http%3a//dev.biologists.org/cgi/reprint/124/21/4253.pdf):pdf

Expression

gli2a

positive

bmp2a

We hypothesize that Gli2 regulates BMP-2 gene transcription and thus osteoblast differentiation.

16880529:3

AllGenes-Pathway

urn:agi-Expression:inout-urn:agi-llid:2736:out-urn:agi-llid:650::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=18060804&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S1044-7431(07)00257-6

Regulation

hey1

negative

bmp2a

Thus, both Hey1 and Hey2 suppress Bmp2 .

Zebrafish GRN from literatures-7-24-2008

urn:agi-Regulation:inout-urn:agi-llid:23462:out-urn:agi-llid:650::negative

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Mercola-M-2006.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cMercola-M-2006.pdf):pdf

Expression

hey1

positive

bmp2a

Hey1 and Hey2 are proposed to function cell autonomously within prospective chamber myocardium to inhibit Bmp2 expression ( bmp4 in zebra'sh), and thereby suppress AVC and IC identity.

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-llid:23462:out-urn:agi-llid:650::positive

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Mercola-M-2006.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cMercola-M-2006.pdf):pdf

Expression

hey1

negative

bmp2a

Hey1 and Hey2 are proposed to function cell autonomously within prospective chamber myocardium to inhibit Bmp2 expression ( bmp4 in zebra'sh), and thereby suppress AVC and IC identity.

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-llid:23462:out-urn:agi-llid:650::negative

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Mercola-M-2006.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cMercola-M-2006.pdf):pdf

Regulation

hey2

negative

bmp2a

Thus, both Hey1 and Hey2 suppress Bmp2 .

Zebrafish GRN from literatures-7-24-2008

urn:agi-Regulation:inout-urn:agi-llid:23493:out-urn:agi-llid:650::negative

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Mercola-M-2006.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cMercola-M-2006.pdf):pdf

Expression

hey2

positive

bmp2a

Hey1 and Hey2 are proposed to function cell autonomously within prospective chamber myocardium to inhibit Bmp2 expression ( bmp4 in zebra'sh), and thereby suppress AVC and IC identity.

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-llid:23493:out-urn:agi-llid:650::positive

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Mercola-M-2006.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cMercola-M-2006.pdf):pdf

Expression

hey2

negative

bmp2a

Hey1 and Hey2 are proposed to function cell autonomously within prospective chamber myocardium to inhibit Bmp2 expression ( bmp4 in zebra'sh), and thereby suppress AVC and IC identity.

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-llid:23493:out-urn:agi-llid:650::negative

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Mercola-M-2006.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cMercola-M-2006.pdf):pdf

Regulation

msxd

positive

bmp2a

This BMP response was preserved in the presence of the protein synthesis inhibitor, cyclohexamide (Fig. 1B), indicating that Msx2 activation was an immediate early response following BMP2 stimulation.

Zebrafish_smad1_20080729

urn:agi-Regulation:inout-urn:agi-llid:4488:out-urn:agi-llid:650::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=14551209&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=14551209

Expression

notch1a

negative

bmp2a

Activation of the Notch pathway suppresses Bmp2 gene expression A whole-heart in vitro electroporation system was devised to study the effects of misexpressed Notch pathway components (Fig. 2).

Zebrafish GRN from literatures-7-24-2008

urn:agi-Expression:inout-urn:agi-protfc:notch:out-urn:agi-llid:650::negative

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Mercola-M-2006.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cMercola-M-2006.pdf):pdf

Expression

notch2

positive

bmp2a

Because Jagged (also known as Serrate in non-mammalian species) ligands were found to be present in prospective chamber myocardium, these data support the model that Notch2 and Hey proteins cause the progressive restriction of Bmp2 expression to within th

17021042:3

AllGenes-Pathway

urn:agi-Expression:inout-urn:agi-llid:4853:out-urn:agi-llid:650::positive

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Mercola-M-2006.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cDesktop%5czebrafish%20GRN%20Literatures%5cMercola-M-2006.pdf):pdf

Expression

otx2

negative

bmp2a

Overexpression of ?-catenin?N also enhanced expression of the dorsal marker chordin, the axial mesoderm marker no tail (ntl), and the anterior neuroectodermal marker otx2, but it inhibited expression of the ventral markers bmp2, eve1, and gata2 (Figures 4

Zebrafish_lef1_20080801

urn:agi-Expression:inout-urn:agi-llid:5015:out-urn:agi-llid:650::negative

digtext:http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=inwardhub&_urlversion=4&_method=citationSearch&_piikey=S1534580706002978&_referrer=www.ncbi.nlm.nih.gov/pubmed/16890162?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa...

Regulation

prdm1a

unknown

bmp2a

In zebrafish, Prdm1 regulates Bmp2 activity during gastrulation through the repression of chordin (Wilm and Solnica-Krezel, 2005), and is involved in neural crest cell differentiation (Hernandez-Lagunas et al., 2005; Roy and Ng, 2004).

Zebrafish_prdm1_20080731

urn:agi-Regulation:inout-urn:agi-llid:639:out-urn:agi-llid:650::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16790478&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16790478