atoh1a






























Type Gene1 Effect Gene2 Sentence Perturbation methods Time of Interaction in evidence territories of interaction or Tissue Evidence for Direct Authors Journal PubYear Volume Pages MedLine Reference Connectivity # of References Found In Pathways Journal Link Journal Reference Mechanism URN ISSN Issue LocatorString MedlineTA PubMonth p-value [Evol. Bioinformatics 2007:3(197)] TextPath Title
Expression atoh1a positive fgf atoh1-dependent and -independent expression of macular genes We next tested whether atoh1 function affects fgf or pax gene expression.









2 2 Zebrafish_atoh1a_20080727


urn:agi-Expression:inout-urn:agi-llid:474:out-urn:agi-protfc:fibroblast%20growth%20factor::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17166920&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17166920




Expression atoh1a positive hlcs Expression of deltaA, deltaB, and atoh1a are all upregulated in the developing lateral line of mib mutant embryos, correlating with the increase in production of HCs (Itoh and Chitnis, 2001).









2 2 Zebrafish_atoh1a_20080727


urn:agi-Expression:inout-urn:agi-llid:474:out-urn:agi-llid:3141::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=18305259&db=pubmed&url=http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=18305259




Expression atoh1a negative pax2a By contrast, knockdown of both atoh1a and atoh1b strongly reduced the level of pax2b expression (Fig. 9H). pax5 and pax2b are both required for normal development and maintenance of hair cells (Whitfield et al., 2002; Kwak et al., 2006), but only the latt









2 2 Zebrafish_atoh1a_20080727


urn:agi-Expression:inout-urn:agi-llid:474:out-urn:agi-llid:5076::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17166920&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17166920




Expression fgf positive atoh1a To test whether Fgf signaling regulates atoh1 expression after placode formation, embryos were treated with SU5402 for various intervals at successively later stages of development.









2 2 Zebrafish_atoh1a_20080727


urn:agi-Expression:inout-urn:agi-protfc:fibroblast%20growth%20factor:out-urn:agi-llid:474::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17166920&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17166920




Regulation fgf3 positive atoh1a fgf3 and fgf8a are upstream activators of atoh1 genes during both phases, and foxi1, pax8 and dlx genes regulate atoh1b in the preplacode.

hair





17166920:6 2 3 Zebrafish_atoh1a_20080727


urn:agi-Regulation:inout-urn:agi-llid:2248:out-urn:agi-llid:474::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17166920&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17166920




Expression fgf8 positive atoh1a In wild-type embryos, fgf8 mis-expression caused a strong dorsalization of the whole embryo , which is visible as a pronounced dorsoventral expansion of spry4 and gbx2 in the injected half . mutant embryos 28 midbrain hindbrain boundary 1 Michael Brand Development 2003 130 6611















Regulation fgf8a positive atoh1a fgf3 and fgf8a are upstream activators of atoh1 genes during both phases, and foxi1, pax8 and dlx genes regulate atoh1b in the preplacode.

hair





17166920:6 2 3 HBx-HCC Group4-cancer-low-L2


urn:agi-Regulation:inout-urn:agi-llid:2253:out-urn:agi-llid:474::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17166920&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17166920




Expression hlcs positive atoh1a These data are consistent with the pulse-chase experiment performed by Harris et al. (2003) and verify that new HCs arise from the transient increase in SC proliferation. notch3, deltaA, and atoh1a expression are elevated during regeneration During latera









2 2 Zebrafish_atoh1a_20080727


urn:agi-Expression:inout-urn:agi-llid:3141:out-urn:agi-llid:474::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=18305259&db=pubmed&url=http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=18305259




Expression pax2a positive atoh1a Partial knockdown of pax8 and pax2b in wild-type embryos resulted in a moderately diminished otic vesicle expressing normal levels of both atoh1a and atoh1b (Fig. 7M,N), although atoh1b was typically expressed in only one or two cells.









2 2 Zebrafish_atoh1a_20080727


urn:agi-Expression:inout-urn:agi-llid:5076:out-urn:agi-llid:474::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17166920&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17166920




Expression pax8 positive atoh1a Partial knockdown of pax8 and pax2b in wild-type embryos resulted in a moderately diminished otic vesicle expressing normal levels of both atoh1a and atoh1b (Fig. 7M,N), although atoh1b was typically expressed in only one or two cells.









2 2 Zebrafish_atoh1a_20080727


urn:agi-Expression:inout-urn:agi-llid:7849:out-urn:agi-llid:474::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17166920&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17166920




Expression pou5f1 positive atoh1a In spg embryos, MHB expressio and rhombomeric expression of wnt8b is strongly reduced. mutant embryos 28 hindbrain 1 Michael Brand Development 2002 129 917















Expression zic1 negative atoh1a Zic1 binds a novel conserved site within the Math1 enhancer, and represses both the expression of endogenous Cath1 (chicken homolog of Math1) and the activity of a Math1 enhancer driven lacZ reporter when expressed in chick neural tubes.








12642498:4 2 2 AllGenes-Pathway


urn:agi-Expression:inout-urn:agi-llid:7545:out-urn:agi-llid:474::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=15223348&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012160604003112




Expression zic4 positive atoh1a Interestingly, reduced anterior r1 atoh1.1 expression was also observed in 24 hpf Zic4 morphants (55/71, data not shown) but not in Zic1 morphants (n = 81), suggesting that Zic4 selectively regulates the expression of atoh1.1 in this region.









2 1 zebrafish_zic1_20080804


urn:agi-Expression:inout-urn:agi-llid:84107:out-urn:agi-llid:474::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=18191121&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(07)01590-4