ascl1a






























Type Gene1 Effect Gene2 Sentence Perturbation methods Time of Interaction in evidence territories of interaction or Tissue Evidence for Direct Authors Journal PubYear Volume Pages MedLine Reference Connectivity # of References Found In Pathways Journal Link Journal Reference Mechanism URN ISSN Issue LocatorString MedlineTA PubMonth p-value [Evol. Bioinformatics 2007:3(197)] TextPath Title
Expression ascl1a positive arx These loss- and gain-of-function data suggest that MASH1 positively regulates expression of Phox2a, either directly or indirectly.

egg

Mol. Cell. Biol


9435282:5 2 9 Zebrafish_gata2_20080730 http://mcb.asm.org/cgi/content/full/25/12/5134 v25 i12 p5134
urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:401::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15329349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15329349




Regulation ascl1a unknown bmp2a During development of the autonomous nervous system of the mouse, expression of another vertebrate proneural genehomologue, Mash1 , has been proposed to depend on BMP2 signalling (Shah et al., 1996).









2 1 Zebrafish_neurog1_20080801


urn:agi-Regulation:inout-urn:agi-llid:429:out-urn:agi-llid:650::unknown

digtext:http://dev.biologists.org/cgi/reprint/124/22/4557.pdf


url(http%3a//dev.biologists.org/cgi/reprint/124/22/4557.pdf):pdf
Expression ascl1a positive dla Expression of all three Delta genes was affected in the ash1a morphants and more severely reduced or completely absent in the ascl1a/ngn1-double morphants. MASO 19 epiphysis 3 Stephen W. Wilson Development 2003 130 2455















Expression ascl1a positive dlb Expression of all three Delta genes was affected in the ash1a morphants and more severely reduced or completely absent in the ash1a/ngn1-double morphants. MASO 19 epiphysis 3 Stephen W. Wilson Development 2003 130 2455















Expression ascl1a positive dld Expression of all three Delta genes was affected in the ash1a morphants and more severely reduced or completely absent in the ash1a/ngn1-double morphants. MASO 19 epiphysis 3 Stephen W. Wilson Development 2003 130 2455















Expression ascl1a positive foxi3a Figure 5. deltaC is Positively Regulated by ascl1a and Receives Negative Feedback by notch. (A) Misexpression of VP16:ascl1a mRNA was sufficient to generate ectopic deltaC expression outside the epidermal ionocyte domain. foxi3a expression, on the contrar









2 1 Zebrafish_notch3_20080801


urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:504196::positive

digtext:http://comparenetworks.com/partnerAds/IFrameAd.aspx?adid=0&adtypeid=2&siteid=35&subsiteid=0&pagetypeid=0&pageid=0&subpageid=0




Expression ascl1a positive isl1 Injection of an MO encompassing the start site of ash1a-coding sequence (ash1a MO) drastically impaired the expression of islet1 (isl1) in the dorsal hypothalamus and adenohypophysis (in 84.6% embryos). MASO 19 epiphysis 3 Stephen W. Wilson Development 2003 130 2455















Expression ascl1a negative lhx3 View larger version (128K): [in this window] [in a new window] Fig. 3. ascl1a mutants show decreased expression of the lim3, pitx3 and ascl1a, and fail to initiate expression of neurod, pit1 and all adenohypophyseal hormone genes, whereas the hypothalamus









2 3 Zebrafish_ascl1a_20080727


urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:8022::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16481349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16481349




Binding ascl1a neutral mef2ca P19-derived neurons express the neurogenic basic helix-loop-helix transcription factor MASH1 (47) and MEF2C (16), which can physically interact to synergistically activate transcription.




Evol. Bioinformatics



2 2 Zebrafish_Gata4_20080727 http://www.la-press.com/journals.php?pa=abstract&content_id=323

urn:agi-Binding:inout-urn:agi-llid:429:inout-urn:agi-llid:4208:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=9857019&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=9857019

0.7699

Expression ascl1a positive neurod Injection of ash1a MO led to a reduction in the number of neuroD-positive epiphysial cells. MASO 24 epiphysis 3 Stephen W. Wilson Development 2003 130 2455















Regulation ascl1a positive neurog1 Our results demonstrate that Mash1 is required at an early stage in the olfactory neuron lineage to initiate a differentiation program involving Math4C/neurogenin1 and NeuroD.








9108377:8 2 2 Zebrafish_her6_20080730


urn:agi-Regulation:inout-urn:agi-llid:429:out-urn:agi-llid:4762::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15169759&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15169759




Expression ascl1a positive onecut1 At 24 hours, onecut transcripts were detected in around three to four cells on each side of the epiphysis. This expression was strongly reduced in ash1a MO-injected embryos. MASO 24 epiphysis 1 Stephen W. Wilson Development 2003 130 2455















Expression ascl1a positive pax6a We also examined whether ascl1a knockdown could suppress the increased expression of pax6 that we observed in cycling progenitors located in the INL and ONL at 4 dpi (supplemental Table 1, available at www.jneurosci.org as supplemental material) (Fausett









2 1 Zebrafish_ascl1a_20080727


urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:5080::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=18234889&db=pubmed&url=http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=18234889




Expression ascl1a negative pitx3 View larger version (128K): [in this window] [in a new window] Fig. 3. ascl1a mutants show decreased expression of the lim3, pitx3 and ascl1a, and fail to initiate expression of neurod, pit1 and all adenohypophyseal hormone genes, whereas the hypothalamus









2 3 Zebrafish_ascl1a_20080727


urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:5309::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16481349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16481349




Expression ascl1a positive pomca Interestingly, the zebrafish pomc promoter contains E-boxes, consensus binding sites for bHLH transcription factors (Liu et al., 2003), suggesting that Ascl1a might be involved in the transcriptional activation of the pomc gene.









2 3 Zebrafish_ascl1a_20080727


urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:5443::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16481349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16481349




Expression ascl1a positive pou1f1 Ascl1 is required cell autonomously to promote pit1 expression, cell survival and Prl production. (A-C) Lateral views on chimeric embryos at 26 hpf embryos, in situ hybridized for pit1 transcripts in blue and with transplanted wild-type cells in brown (in









2 3 Zebrafish_ascl1a_20080727


urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:5449::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16481349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16481349




Expression ascl1a positive arx These loss- and gain-of-function data suggest that MASH1 positively regulates expression of Phox2a, either directly or indirectly.

egg

Mol. Cell. Biol


9435282:5 2 9 Zebrafish_gata2_20080730 http://mcb.asm.org/cgi/content/full/25/12/5134 v25 i12 p5134
urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:401::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15329349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15329349




Regulation ascl1a unknown bmp2a During development of the autonomous nervous system of the mouse, expression of another vertebrate proneural genehomologue, Mash1 , has been proposed to depend on BMP2 signalling (Shah et al., 1996).









2 1 Zebrafish_neurog1_20080801


urn:agi-Regulation:inout-urn:agi-llid:429:out-urn:agi-llid:650::unknown

digtext:http://dev.biologists.org/cgi/reprint/124/22/4557.pdf


url(http%3a//dev.biologists.org/cgi/reprint/124/22/4557.pdf):pdf
Expression ascl1a positive dla Expression of all three Delta genes was affected in the ash1a morphants and more severely reduced or completely absent in the ascl1a/ngn1-double morphants. MASO 19 epiphysis 3 Stephen W. Wilson Development 2003 130 2455















Expression ascl1a positive dlb Expression of all three Delta genes was affected in the ash1a morphants and more severely reduced or completely absent in the ash1a/ngn1-double morphants. MASO 19 epiphysis 3 Stephen W. Wilson Development 2003 130 2455















Expression ascl1a positive dld Expression of all three Delta genes was affected in the ash1a morphants and more severely reduced or completely absent in the ash1a/ngn1-double morphants. MASO 19 epiphysis 3 Stephen W. Wilson Development 2003 130 2455















Expression ascl1a positive foxi3a Figure 5. deltaC is Positively Regulated by ascl1a and Receives Negative Feedback by notch. (A) Misexpression of VP16:ascl1a mRNA was sufficient to generate ectopic deltaC expression outside the epidermal ionocyte domain. foxi3a expression, on the contrar









2 1 Zebrafish_notch3_20080801


urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:504196::positive

digtext:http://comparenetworks.com/partnerAds/IFrameAd.aspx?adid=0&adtypeid=2&siteid=35&subsiteid=0&pagetypeid=0&pageid=0&subpageid=0




Expression ascl1a positive isl1 Injection of an MO encompassing the start site of ash1a-coding sequence (ash1a MO) drastically impaired the expression of islet1 (isl1) in the dorsal hypothalamus and adenohypophysis (in 84.6% embryos). MASO 19 epiphysis 3 Stephen W. Wilson Development 2003 130 2455















Expression ascl1a negative lhx3 View larger version (128K): [in this window] [in a new window] Fig. 3. ascl1a mutants show decreased expression of the lim3, pitx3 and ascl1a, and fail to initiate expression of neurod, pit1 and all adenohypophyseal hormone genes, whereas the hypothalamus









2 3 Zebrafish_ascl1a_20080727


urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:8022::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16481349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16481349




Binding ascl1a neutral mef2ca P19-derived neurons express the neurogenic basic helix-loop-helix transcription factor MASH1 (47) and MEF2C (16), which can physically interact to synergistically activate transcription.




Evol. Bioinformatics



2 2 Zebrafish_Gata4_20080727 http://www.la-press.com/journals.php?pa=abstract&content_id=323

urn:agi-Binding:inout-urn:agi-llid:429:inout-urn:agi-llid:4208:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=9857019&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=9857019

0.7699

Expression ascl1a positive neurod Injection of ash1a MO led to a reduction in the number of neuroD-positive epiphysial cells. MASO 24 epiphysis 3 Stephen W. Wilson Development 2003 130 2455















Regulation ascl1a positive neurog1 Our results demonstrate that Mash1 is required at an early stage in the olfactory neuron lineage to initiate a differentiation program involving Math4C/neurogenin1 and NeuroD.








9108377:8 2 2 Zebrafish_her6_20080730


urn:agi-Regulation:inout-urn:agi-llid:429:out-urn:agi-llid:4762::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15169759&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15169759




Expression ascl1a positive onecut1 At 24 hours, onecut transcripts were detected in around three to four cells on each side of the epiphysis. This expression was strongly reduced in ash1a MO-injected embryos. MASO 24 epiphysis 1 Stephen W. Wilson Development 2003 130 2455















Expression ascl1a positive pax6a We also examined whether ascl1a knockdown could suppress the increased expression of pax6 that we observed in cycling progenitors located in the INL and ONL at 4 dpi (supplemental Table 1, available at www.jneurosci.org as supplemental material) (Fausett









2 1 Zebrafish_ascl1a_20080727


urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:5080::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=18234889&db=pubmed&url=http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=18234889




Expression ascl1a negative pitx3 View larger version (128K): [in this window] [in a new window] Fig. 3. ascl1a mutants show decreased expression of the lim3, pitx3 and ascl1a, and fail to initiate expression of neurod, pit1 and all adenohypophyseal hormone genes, whereas the hypothalamus









2 3 Zebrafish_ascl1a_20080727


urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:5309::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16481349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16481349




Expression ascl1a positive pomca Interestingly, the zebrafish pomc promoter contains E-boxes, consensus binding sites for bHLH transcription factors (Liu et al., 2003), suggesting that Ascl1a might be involved in the transcriptional activation of the pomc gene.









2 3 Zebrafish_ascl1a_20080727


urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:5443::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16481349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16481349




Expression ascl1a positive pou1f1 Ascl1 is required cell autonomously to promote pit1 expression, cell survival and Prl production. (A-C) Lateral views on chimeric embryos at 26 hpf embryos, in situ hybridized for pit1 transcripts in blue and with transplanted wild-type cells in brown (in









2 3 Zebrafish_ascl1a_20080727


urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:5449::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16481349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16481349




Expression fgf3 positive ascl1a fgf3 is required for adenohypophyseal ascl1a expression and requires Ascl1a to induce pit1 expression. (A-D) Whole-mount in situ hybridization (lateral views with anterior towards the right) showing that adenohypophyseal ascl1 expression (indicated by arr









2 3 Zebrafish_ascl1a_20080727


urn:agi-Expression:inout-urn:agi-llid:2248:out-urn:agi-llid:429::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16481349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16481349




Expression flh positive ascl1a In addition, expression of otx5 was not detected in the flh-mutant epiphysis at 24s. mutant embryos 19 epiphysis 1 Stephen W. Wilson Development 2003 130 2455















Expression flh positive ascl1a We show that Flh is required to maintain the expression of ash1a and to initiate expression of ngn1 and neuroD.









2 5 Zebrafish_otx5_20080731


urn:agi-Expression:inout-urn:agi-llid:344022:out-urn:agi-llid:429::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12702659&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=12702659




Expression gata2 positive ascl1a The timing of Gata2 expression and its proposed role in noradrenergic differentiation raised the question whether Gata2 expression is dependent on Bmps, which have been shown to control the expression of Mash1, Phox2a/b and Hand2 in sympathetic neuron pre









2 2 Zebrafish_gata2_20080730


urn:agi-Expression:inout-urn:agi-llid:2624:out-urn:agi-llid:429::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15329349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15329349




Expression her6 positive ascl1a In the mammalian CNS, the Notch target gene Hes1 is required during neurogenesis to co-ordinately repress transcription of both Mash1 and Ngn1 (Cau et al., 2000).









2 1 Zebrafish_her6_20080730


urn:agi-Expression:inout-urn:agi-llid:3280:out-urn:agi-llid:429::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15169759&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15169759




Regulation hoxb1a unknown ascl1a Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways.




Genes & Dev


15198977:10339 2 4 Zebrafish_hoxb1b_20080731 http://www.genesdev.org/cgi/content/full/18/13/1539 v18 i13 p1539
urn:agi-Regulation:inout-urn:agi-llid:3211:out-urn:agi-llid:429::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=11973267&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=11973267




Expression neurog1 negative ascl1a Comparison of the epiphysial phenotypes of flh mutant and of ash1a/ngn1 double morphants reveals that reduced expression of ash1a and ngn1 can account for most of the neurogenesis defects in the flh-mutant epiphysis but also shows that Flh has additional








12702659:3 2 6 AllGenes-Pathway


urn:agi-Expression:inout-urn:agi-llid:4762:out-urn:agi-llid:429::negative

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=12702659&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=12702659