arx

Type

Gene1

Effect

Gene2

Sentence

Perturbation methods

Time of Interaction in evidence

territories of interaction or Tissue

Evidence for Direct

Authors

Journal

PubYear

Volume

Pages

MedLine Reference

Connectivity

# of References

Found In Pathways

Journal Link

Journal Reference

Mechanism

URN

ISSN

Issue

LocatorString

MedlineTA

PubMonth

p-value [Evol. Bioinformatics 2007:3(197)]

TextPath

Title

Expression

arx

positive

dbh

In this study, we evaluate the molecular mechanisms by which the transcription factor Arix/Phox2a contributes to DBH gene transcription.

bone

Genes & Dev

10644760:2

Zebrafish_gata2_20080730

http://www.genesdev.org/cgi/content/full/19/5/614

v19 i5 p614

urn:agi-Expression:inout-urn:agi-llid:401:out-urn:agi-llid:1621::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17008447&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17008447

Binding

arx

neutral

dbh

To determine where the dHAND-Arix complex binds to the DBH promoter region, EMSA analysis was conducted with unlabeled competitors containing either the two DBH E-box motifs or HD3 ( Fig. 4 D ).

J. Biol. Chem

14506227:10178

Zebrafish_gata2_20080730

http://www.jbc.org/cgi/content/full/278/49/49652

v278 i49 p49652

urn:agi-Binding:inout-urn:agi-llid:401:inout-urn:agi-llid:1621:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15329349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15329349

Binding

arx

neutral

hand2

We have examined the interaction of HAND2 and Phox2a at the DBH promoter.

Xu,H.;Firulli,A.B.;Zhang,X.;Howard,M.J.

2003

262

183-93

14512028:2

Zebrafish_Gata4_20080727

urn:agi-Binding:inout-urn:agi-llid:9464:inout-urn:agi-llid:401:

0012-1606

pmquery:(Zebrafish[all+fields]+or+"Danio+rerio"[all+fields]+or+"Zebra+fish"[all+fields])2003/01/01:2003/12/31[edat]

Dev Biol

Oct

HAND2 synergistically enhances transcription of dopamine-beta-hydroxylase in the presence of Phox2a.

Expression

arx

neutral

ncam1

The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cucx/CDP and is a putative determinant of neurotransmitter phenotype.

Zebrafish_Bmp2b_20080727

urn:agi-Expression:inout-urn:agi-llid:401:out-urn:agi-llid:4684::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=16077092&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=16077092

Expression

arx

positive

ncam1

We have characterised two mouse homeobox genes, named Cux and Phox2, the products of which bind to and regulate the promoter of the Ncam gene in vitro.

Cancer Res

7916260:2

Zebrafish GRN from literatures-7-24-2008

http://cancerres.aacrjournals.org/cgi/content/full/62/22/6625

v62 i22 p6625

urn:agi-Expression:inout-urn:agi-llid:401:out-urn:agi-llid:4684::positive

digtext:C:\Documents and Settings\yuh\My Documents\MedScan Reader Projects\zebrafish development\Tzu-Min's old papers\Thomas F. Schilling 2005.pdf

url(C%3a%5cDocuments%20and%20Settings%5cyuh%5cMy%20Documents%5cMedScan%20Reader%20Projects%5czebrafish%20development%5cTzu-Min%27s%20old%20papers%5cThomas%20F.%20Schilling%202005.pdf):pdf

Binding

arx

neutral

Phox2 proteins bind to the promotor of the subtype-specific noradrenergic marker genes tyrosine hydroxylase (Th) and dopamine-?-hydroxylase (Dbh) and activate their transcription.

Zebrafish_gata2_20080730

urn:agi-Binding:inout-urn:agi-llid:7054:inout-urn:agi-llid:401:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15329349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15329349

Expression

ascl1a

positive

arx

These loss- and gain-of-function data suggest that MASH1 positively regulates expression of Phox2a, either directly or indirectly.

egg

Mol. Cell. Biol

9435282:5

Zebrafish_gata2_20080730

http://mcb.asm.org/cgi/content/full/25/12/5134

v25 i12 p5134

urn:agi-Expression:inout-urn:agi-llid:429:out-urn:agi-llid:401::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15329349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15329349

Expression

foxa2

positive

arx

Transverse sections through the spinal cord of wild-type and mol–/– embryos showing changes in floorplate expression of various genes in the mutants.

mutant embryos

neuroectoderm

SW Wilson

Development

2005

132

645

Expression

gata2

positive

arx

Gata2 is expressed after the onset of Phox2a, Phox2b and Hand2 expression We analysed the developmental expression of Gata factors in the sympathetic lineage of the chick embryo in relation to other developmental marker genes as a first indication of thei

Zebrafish_gata2_20080730

urn:agi-Expression:inout-urn:agi-llid:2624:out-urn:agi-llid:401::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15329349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15329349

Regulation

hand2

positive

arx

HAND2 synergistically enhances transcription of dopamine-?-hydroxylase in the presence of Phox2a.

Zebrafish_gata2_20080730

urn:agi-Regulation:inout-urn:agi-llid:9464:out-urn:agi-llid:401::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=15329349&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=15329349

Expression

hand2

positive

arx

Although the latter result is compatible with a do wnstream function of dHAND, it is not conclusi v e, as dHAND is also able to induce Phox2 gene e xpression.

Zebrafish_bmp4_20080727

urn:agi-Expression:inout-urn:agi-llid:9464:out-urn:agi-llid:401::positive

digtext:http://dev.biologists.org/cgi/reprint/127/18/4073.pdf

url(http%3a//dev.biologists.org/cgi/reprint/127/18/4073.pdf):pdf

Expression

sox3

positive

arx

Loss of Sox3 resulted in substantial reduction in the expression of ngn1 (Figs. 8A, F), phox2a (Figs. 8B, G), elavl3 and elavl4 (which encode homologues of the mammalian RNA-binding factors HuC and HuD respectively; Figs. 8C, D, H, I), and neurofilament.

Zebrafish_sox3_20080730

urn:agi-Expression:inout-urn:agi-llid:6658:out-urn:agi-llid:401::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=18572157&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(08)00882-8