acvr1b






























Type Gene1 Effect Gene2 Sentence Perturbation methods Time of Interaction in evidence territories of interaction or Tissue Evidence for Direct Authors Journal PubYear Volume Pages MedLine Reference Connectivity # of References Found In Pathways Journal Link Journal Reference Mechanism URN ISSN Issue LocatorString MedlineTA PubMonth p-value [Evol. Bioinformatics 2007:3(197)] TextPath Title
Binding acvr1b neutral acvr2a If cotransfected with ActRII/IIB and ALK4, Cripto inhibited crosslinking of activin to ALK4 and the association of ALK4 with ActRII/IIB.




J. Biol. Chem


12682303:6 2 13 Zebrafish_FoxH1_20080728 http://www.jbc.org/cgi/content/full/270/11/6308 v270 i11 p6308
urn:agi-Binding:inout-urn:agi-llid:92:inout-urn:agi-llid:91:

digtext:http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=inwardhub&_urlversion=4&_method=citationSearch&_piikey=S1534580701000764&_referrer=www.ncbi.nlm.nih.gov/pubmed/11709181?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP...




Expression acvr1b positive ntl Injection of TARAM-A* (acvr1b) induced very robust expression of ntl in large patches of cells. overexpression 4.33 margin 2 Thierry Lepage Development 2002 129 4901















Expression acvr1b positive og9x Injection of TARAM-A*(acvr1b) induced very robust expression of casanova (sox32) in large patches of cells. overexpression 5.25 margin 2 Thierry Lepage Development 2002 129 4901















Expression acvr1b positive pitx2a We report here that similar to effects of ectopic TGF betas, right-side expression of constitutively active activin-like kinase (ALK) 4 results in LR organ reversals as well as altered pitx2a expression in the lateral plate mesoderm.

mesoderm





15063168:2 2 3 Zebrafish_smad2_20080729


urn:agi-Expression:inout-urn:agi-llid:91:out-urn:agi-llid:5308::positive

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=16684517&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(06)00257-0




ProtModification acvr1b phosphorylation smad The binding of Nodal to its receptor complex (Alk4/ActRIIB/co-receptor EGF-CFC) activates Smad2/3, and phosphorylation of these Smads by Alk4 increases their affinity for Smad4.









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phosphorylation urn:agi-ProtModification:inout-urn:agi-llid:91:out-urn:agi-go:0005075::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=18039968&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=18039968




Binding acvr1b neutral smad The ?4-?5 loop of TaramA, a Smad interacting domain, is identical to that of Alk4 ( ten Dijke et al., 1994b), suggesting that TaramA and Alk4 may interact with similar downstream Smad molecules and may perform similar functions.When CA alk8 and taramA* RN









2 2 Zebrafish_Bmp2b_20080727


urn:agi-Binding:inout-urn:agi-llid:91:inout-urn:agi-go:0005075:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=11165484&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0925477300005414




ProtModification acvr1b phosphorylation smad2 This suggests that Smad2 and Smad3 association with ALK4 is an early event after receptor heteromerization, in activin signaling.

egg

Mol. Endocrin


9892009:1092 2 5 acvr2a B-acvr1b http://mend.endojournals.org/cgi/content/full/13/1/15 v13 i1 p15 (1999) phosphorylation urn:agi-ProtModification:inout-urn:agi-llid:91:out-urn:agi-llid:4087::unknown

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Gerster-T-1999.pdf


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Expression acvr1b positive smad2 Ca-ALK4 induced a strong nuclear accumulation of EGFP-Smad2 during the 20 min washout period, and this was completely abolished by the treatment with AA (Figure 4A).









2 1 Zebrafish_smad2_20080729


urn:agi-Expression:inout-urn:agi-llid:91:out-urn:agi-llid:4087::positive

digtext:http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=inwardhub&_urlversion=4&_method=citationSearch&_piikey=S1534580707000111&_referrer=www.ncbi.nlm.nih.gov/pubmed/17276343?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa...




ProtModification acvr1b phosphorylation smad3a ALK4 is a Ser/Thr kinase that phosphorylates cytoplasmic Smad2 and Smad3 ( Massague and W otton, 2000 ).









2 6 Zebrafish GRN from literatures-7-24-2008

phosphorylation urn:agi-ProtModification:inout-urn:agi-llid:91:out-urn:agi-llid:4088::unknown

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Dougan-ST-2007b.pdf


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Binding acvr1b neutral smad3a Nevertheless, when cells were stimulated by activin, the amount of Smad3 associated with ALK4 increases.




Mol. Endocrin


9892009:1073 2 3 Zebrafish_smad2_20080729 http://mend.endojournals.org/cgi/content/full/13/1/15 v13 i1 p15 (1999)
urn:agi-Binding:inout-urn:agi-llid:91:inout-urn:agi-llid:4088:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=18039968&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=18039968




Expression acvr1b positive sox17 Injection of TARAM-A* induced very robust expression of sox17, ntl,og9x, bon/mixer and casanova in large patches of cells. overexpression 4.33 margin 2 Thierry Lepage Development 2002 129 4901















Expression acvr1b positive sox17 Similarly, whereas injection of very low doses 1-2 pg of tar*/acvr1b caused the ectopic expression of sox17 in about 32% of the embryos, treatment with SU5402 following the injection increased this percentage to 54% (Table 1).









2 9 Zebrafish GRN from literatures-7-24-2008


urn:agi-Expression:inout-urn:agi-llid:91:out-urn:agi-llid:64321::positive

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Lepage-T-2006.pdf


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Expression acvr1b positive sox32 Embryo injected at the eight-cell stage into one blastomere with 40 pg of TARAM-A*(acvr1b) and with 100 pg of mRNA encoding a nuclear b-Gal (blue colour) as a lineage tracer. TARAM-A*(acvr1b) induces confluent patches of mezzo (og9x)-expressing cells. overexpression 4.33 margin 2 Thierry Lepage Development 2002 129 4901















Regulation acvr1b unknown tgfb1 This phenomenon was also observed in MZoep mutant embryos treated with the small compound SB431542 (39), which specifically inhibits ALK4/5/7-mediated TGF-? signaling.









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urn:agi-Regulation:inout-urn:agi-llid:91:out-urn:agi-llid:7040::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=18025082&db=pubmed&url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=18025082




Binding acvr1b neutral tgfb1 Together, these results suggest not only that ALK4 interacts with multiple TGF?s to generate embryonic pattern, but also that ALK4 ligands differentially utilize the ALK4 pathway to regulate distinct aspects of axial pattern, with Vg1 as a modulator of AL









2 1 Zebrafish_smad2_20080729


urn:agi-Binding:inout-urn:agi-llid:91:inout-urn:agi-llid:7040:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=16684517&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(06)00257-0




ProtModification acvr1b phosphorylation ttrap ALK4 phosphorylated TTRAP in vitro (Fig. 6A).









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phosphorylation urn:agi-ProtModification:inout-urn:agi-llid:91:out-urn:agi-llid:51567::unknown

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=18039968&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=18039968




Binding acvr1b neutral ttrap Weobserved binding of Alk4 to TTRAP (Fig. 5D).









2 1 Zebrafish_smad2_20080729


urn:agi-Binding:inout-urn:agi-llid:91:inout-urn:agi-llid:51567:

digtext:http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=18039968&db=pubmed&url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=18039968




Expression bmp2a negative acvr1b overexpression of BMPs compromises endoderm formation, formation of endoderm precursors is negatively regulated by BMPs on the ventral side. overexpression 5.25 blastoderm 2 Thierry Lepage Development 2006 133 2189















Expression bmp2b negative acvr1b We never found a homozygous laftm110b embryo that had a wild-type or ventralized phenotype, consistent with the Laf/Alk8 receptor functioning downstream of the Bmp2b. overexpression 5.25 blastoderm 2 Thierry Lepage Development 2006 133 2189















Expression bmp7 negative acvr1b Prdm1 expression is reduced in snh (BMP7) mutant embryos. overexpression 5.25 blastoderm 2 Thierry Lepage Development 2006 133 2189















Expression fgf17 negative acvr1b activation of the FGF/ERK pathway disrupts endoderm formation in the embryo and antagonizes the ability of an activated form of Tar/Acvr1b to induce endoderm at the animal pole. overexpression 5.25 blastoderm 2 Thierry Lepage Development 2006 133 2189















Expression fgf24 negative acvr1b Microinjection of fgf24 leads to inhibition of bmp2b, bmp4 and bmp7 expression at blastula stage. overexpression 5.25 blastoderm 2 Thierry Lepage Development 2006 133 2189















Expression fgf3 negative acvr1b Microinjection of fgf3 leads to inhibition of bmp2b expression at blastula stage. overexpression 5.25 blastoderm 2 Thierry Lepage Development 2006 133 2189















Expression fgf8 negative acvr1b The fgf8 overexpression (10 pg) induced chd at the shield stage. overexpression 5.25 blastoderm 2 Thierry Lepage Development 2006 133 2189















Regulation mapk1 negative acvr1b FGF/ERK activity antagonizes the ability of tar*/acvr1b to induce endoderm.









2 8 Zebrafish GRN from literatures-7-24-2008


urn:agi-Regulation:inout-urn:agi-llid:5594:out-urn:agi-llid:91::negative

digtext:C:\Documents and Settings\yuh\Desktop\zebrafish GRN Literatures\Lepage-T-2006.pdf


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